Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

Nature - Tập 475 Số 7354 - Trang 106-109 - 2011
Gina M. DeNicola1, Florian A. Karreth1, Timothy J. Humpton1, Aarthi Gopinathan1, Cong Wei2, Kristopher K. Frese1, Dipti Mangal2, Kenneth H. Yu2, Charles J. Yeo3, Eric S. Calhoun4, Francesca Scrimieri5, Jordan M. Winter6, Ralph H. Hruban5, Christine A. Iacobuzio‐Donahue5, Scott E. Kern5, Ian A. Blair2, David A. Tuveson1
1Li Ka Shing Centre, Cancer Research UK Cambridge Institute, Robinson Way, Cambridge, CB2 0RE, UK
2Center for Cancer Pharmacology, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA
3Department of Surgery, Jefferson Medical College, Philadelphia, 19107, Pennsylvania, USA
4Department of Biology, Alma College, Alma, 48801, Michigan, USA
5Department of Oncology, The Sol Goldman Pancreatic Cancer Research Center, the Johns Hopkins Medical Institutions, Baltimore, 21287, Maryland, USA
6Department of Surgery, The Sol Goldman Pancreatic Cancer Research Center, the Johns Hopkins Medical Institutions, Baltimore, 21287, Maryland, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Shibutani, S., Takeshita, M. & Grollman, A. P. Insertion of specific bases during DNA synthesis past the oxidation-damaged base 8-oxodG. Nature 349, 431–434 (1991)

Itoh, K. et al. Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain. Genes Dev. 13, 76–86 (1999)

Wakabayashi, N. et al. Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation. Nature Genet. 35, 238–245 (2003)

Nguyen, T., Nioi, P. & Pickett, C. B. The Nrf2-antioxidant response element signaling pathway and its activation by oxidative stress. J. Biol. Chem. 284, 13291–13295 (2009)

Venugopal, R. & Jaiswal, A. K. Nrf2 and Nrf1 in association with Jun proteins regulate antioxidant response element-mediated expression and coordinated induction of genes encoding detoxifying enzymes. Oncogene 17, 3145–3156 (1998)

Hayes, J. D. & McMahon, M. NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer. Trends Biochem. Sci. 34, 176–188 (2009)

Tuveson, D. A. et al. Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects. Cancer Cell 5, 375–387 (2004)

Lee, A. C. et al. Ras proteins induce senescence by altering the intracellular levels of reactive oxygen species. J. Biol. Chem. 274, 7936–7940 (1999)

Mitsushita, J., Lambeth, J. D. & Kamata, T. The superoxide-generating oxidase Nox1 is functionally required for Ras oncogene transformation. Cancer Res. 64, 3580–3585 (2004)

Cakir, Y. & Ballinger, S. W. Reactive species-mediated regulation of cell signaling and the cell cycle: the role of MAPK. Antioxid. Redox Signal. 7, 726–740 (2005)

Recktenwald, C. V., Kellner, R., Lichtenfels, R. & Seliger, B. Altered detoxification status and increased resistance to oxidative stress by K-ras transformation. Cancer Res. 68, 10086–10093 (2008)

Irani, K. et al. Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science 275, 1649–1652 (1997)

Tanaka, H. et al. E2F1 and c-Myc potentiate apoptosis through inhibition of NF-κB activity that facilitates MnSOD-mediated ROS elimination. Mol. Cell 9, 1017–1029 (2002)

Murphy, D. J. et al. Distinct thresholds govern Myc’s biological output in vivo . Cancer Cell 14, 447–457 (2008)

Birney, E. et al. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature 447, 799–816 (2007)

Karreth, F. A., DeNicola, G. M., Winter, S. P. & Tuveson, D. A. C-Raf inhibits MAPK activation and transformation by B-RafV600E . Mol. Cell 36, 477–486 (2009)

Keum, Y. S. et al. Mechanism of action of sulforaphane: inhibition of p38 mitogen-activated protein kinase isoforms contributing to the induction of antioxidant response element-mediated heme oxygenase-1 in human hepatoma HepG2 cells. Cancer Res. 66, 8804–8813 (2006)

Kwak, M. K., Itoh, K., Yamamoto, M. & Kensler, T. W. Enhanced expression of the transcription factor Nrf2 by cancer chemopreventive agents: role of antioxidant response element-like sequences in the nrf2 promoter. Mol. Cell. Biol. 22, 2883–2892 (2002)

Hingorani, S. R. et al. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell 4, 437–450 (2003)

Jackson, E. L. et al. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras . Genes Dev. 15, 3243–3248 (2001)

Chan, K., Lu, R., Chang, J. C. & Kan, Y. W. NRF2, a member of the NFE2 family of transcription factors, is not essential for murine erythropoiesis, growth, and development. Proc. Natl Acad. Sci. USA 93, 13943–13948 (1996)

Kawaguchi, Y. et al. The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors. Nature Genet. 32, 128–134 (2002)

Park, J. H. et al. Evidence for the aldo-keto reductase pathway of polycyclic aromatic trans-dihydrodiol activation in human lung A549 cells. Proc. Natl Acad. Sci. USA 105, 6846–6851 (2008)

Zhu, P., Oe, T. & Blair, I. A. Determination of cellular redox status by stable isotope dilution liquid chromatography/mass spectrometry analysis of glutathione and glutathione disulfide. Rapid Commun. Mass Spectrom. 22, 432–440 (2008)

Carroll, J. S. et al. Chromosome-wide mapping of estrogen receptor binding reveals long-range regulation requiring the forkhead protein FoxA1. Cell 122, 33–43 (2005)

He, X., Chen, M. G., Lin, G. X. & Ma, Q. Arsenic induces NAD(P)H-quinone oxidoreductase I by disrupting the Nrf2·Keap1·Cul3 complex and recruiting Nrf2·Maf to the antioxidant response element enhancer. J. Biol. Chem. 281, 23620–23631 (2006)

Sun, J. et al. Hemoprotein Bach1 regulates enhancer availability of heme oxygenase-1 gene. EMBO J. 21, 5216–5224 (2002)

Suvorova, E. S. et al. Cytoprotective Nrf2 pathway is induced in chronically txnrd 1-deficient hepatocytes. PLoS ONE 4, e6158 (2009)

Rasband, W. S. ImageJ. (U. S. National Institutes of Health, 1997–2011) 〈 http://imagej.nih.gov/ij/ 〉.

Hahn, S. A. et al. Allelotype of pancreatic adenocarcinoma using xenograft enrichment. Cancer Res. 55, 4670–4675 (1995)

Sun, C. et al. Characterization of the mutations of the K-ras, p53, p16, and SMAD4 genes in 15 human pancreatic cancer cell lines. Oncol. Rep. 8, 89–92 (2001)