Reduced Expression of MYC Increases Longevity and Enhances Healthspan
Tài liệu tham khảo
Akbar, 2011, Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?, Nat. Rev. Immunol., 11, 289, 10.1038/nri2959
Anisimov, 2004, Body weight is not always a good predictor of longevity in mice, Exp. Gerontol., 39, 305, 10.1016/j.exger.2003.12.007
Bartke, 2012, Metabolic characteristics of long-lived mice, Front. Genet., 3, 288, 10.3389/fgene.2012.00288
Brown, 2008, Evolution of the holozoan ribosome biogenesis regulon, BMC Genomics, 9, 442, 10.1186/1471-2164-9-442
Brown-Borg, 2012, Expression of oxidative phosphorylation components in mitochondria of long-living Ames dwarf mice, Age (Dordr.), 34, 43, 10.1007/s11357-011-9212-x
Cho, 2008, A new mechanism for the aging of hematopoietic stem cells: aging changes the clonal composition of the stem cell compartment but not individual stem cells, Blood, 111, 5553, 10.1182/blood-2007-11-123547
Dai, 2009, Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging, Circulation, 119, 2789, 10.1161/CIRCULATIONAHA.108.822403
Dang, 2012, MYC on the path to cancer, Cell, 149, 22, 10.1016/j.cell.2012.03.003
de Alboran, 2001, Analysis of C-MYC function in normal cells via conditional gene-targeted mutation, Immunity, 14, 45, 10.1016/S1074-7613(01)00088-7
Dey, 2013, PERK-ing up autophagy during MYC-induced tumorigenesis, Autophagy, 9, 612, 10.4161/auto.23486
Eilers, 2008, Myc’s broad reach, Genes Dev., 22, 2755, 10.1101/gad.1712408
Fujimoto, 2011, Not just fat: the structure and function of the lipid droplet, Cold Spring Harb. Perspect. Biol., 3, 3, 10.1101/cshperspect.a004838
Gems, 2013, Genetics of longevity in model organisms: debates and paradigm shifts, Annu. Rev. Physiol., 75, 621, 10.1146/annurev-physiol-030212-183712
Gomes, 2013, Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging, Cell, 155, 1624, 10.1016/j.cell.2013.11.037
Goronzy, 2005, T cell development and receptor diversity during aging, Curr. Opin. Immunol., 17, 468, 10.1016/j.coi.2005.07.020
Greer, 2013, Myc-dependent genome instability and lifespan in Drosophila, PLoS ONE, 8, e74641, 10.1371/journal.pone.0074641
Heiman, 2003, Body composition of prolactin-, growth hormone, and thyrotropin-deficient Ames dwarf mice, Endocrine, 20, 149, 10.1385/ENDO:20:1-2:149
Herkert, 2010, Transcriptional repression: the dark side of myc, Genes Cancer, 1, 580, 10.1177/1947601910379012
Hoeijmakers, 2009, DNA damage, aging, and cancer, N. Engl. J. Med., 361, 1475, 10.1056/NEJMra0804615
Ikeno, 2003, Delayed occurrence of fatal neoplastic diseases in Ames dwarf mice: correlation to extended longevity, J. Gerontol. A Biol. Sci. Med. Sci., 58, 291, 10.1093/gerona/58.4.B291
Jang, 2011, Skeletal muscle stem cells: effects of aging and metabolism on muscle regenerative function, Cold Spring Harb. Symp. Quant. Biol., 76, 101, 10.1101/sqb.2011.76.010652
Jhuang, 2010, Automated home-cage behavioural phenotyping of mice, Nat. Commun., 1, 68, 10.1038/ncomms1064
Johnson, 2013, mTOR is a key modulator of ageing and age-related disease, Nature, 493, 338, 10.1038/nature11861
Kujoth, 2005, Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging, Science, 309, 481, 10.1126/science.1112125
Ladiges, 2009, Lifespan extension in genetically modified mice, Aging Cell, 8, 346, 10.1111/j.1474-9726.2009.00491.x
Lanza, 2012, Chronic caloric restriction preserves mitochondrial function in senescence without increasing mitochondrial biogenesis, Cell Metab., 16, 777, 10.1016/j.cmet.2012.11.003
Lee, 2011, Fasting vs dietary restriction in cellular protection and cancer treatment: from model organisms to patients, Oncogene, 30, 3305, 10.1038/onc.2011.91
Li, 2013, Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes, Am. J. Physiol. Endocrinol. Metab., 305, E942, 10.1152/ajpendo.00304.2013
Martin-Montalvo, 2013, Metformin improves healthspan and lifespan in mice, Nat. Commun., 4, 2192, 10.1038/ncomms3192
Mateyak, 1997, Phenotypes of c-Myc-deficient rat fibroblasts isolated by targeted homologous recombination, Cell Growth Differ., 8, 1039
Matheu, 2004, Increased gene dosage of Ink4a/Arf results in cancer resistance and normal aging, Genes Dev., 18, 2736, 10.1101/gad.310304
Meyer, 2008, Reflecting on 25 years with MYC, Nat. Rev. Cancer, 8, 976, 10.1038/nrc2231
Neff, 2013, Rapamycin extends murine lifespan but has limited effects on aging, J. Clin. Invest., 123, 3272, 10.1172/JCI67674
Pearson, 2008, Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span, Cell Metab., 8, 157, 10.1016/j.cmet.2008.06.011
Peck, 2013, Antagonism between FOXO and MYC regulates cellular powerhouse, Front. Oncol., 3, 96, 10.3389/fonc.2013.00096
Salmon, 2010, Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?, Free Radic. Biol. Med., 48, 642, 10.1016/j.freeradbiomed.2009.12.015
Syed, 2011, Rodent models of aging bone: an update, Curr. Osteoporos. Rep., 9, 219, 10.1007/s11914-011-0074-z
Teleman, 2008, Nutritional control of protein biosynthetic capacity by insulin via Myc in Drosophila, Cell Metab., 7, 21, 10.1016/j.cmet.2007.11.010
Trumpp, 2001, c-Myc regulates mammalian body size by controlling cell number but not cell size, Nature, 414, 768, 10.1038/414768a
Tsuchiya, 2004, Additive regulation of hepatic gene expression by dwarfism and caloric restriction, Physiol. Genomics, 17, 307, 10.1152/physiolgenomics.00039.2004
Vafa, 2002, c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability, Mol. Cell, 9, 1031, 10.1016/S1097-2765(02)00520-8
Wang, 2011, Immunoaging induced by hematopoietic stem cell aging, Curr. Opin. Immunol., 23, 532, 10.1016/j.coi.2011.05.004
Wang, 2011, The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation, Immunity, 35, 871, 10.1016/j.immuni.2011.09.021
Whitfield, 2012, Tumor microenvironment: becoming sick of Myc, Cell. Mol. Life Sci., 69, 931, 10.1007/s00018-011-0860-x
Wu, 2013, Increased mammalian lifespan and a segmental and tissue-specific slowing of aging after genetic reduction of mTOR expression, Cell Rep., 4, 913, 10.1016/j.celrep.2013.07.030
Yuan, 2009, Aging in inbred strains of mice: study design and interim report on median lifespans and circulating IGF1 levels, Aging Cell, 8, 277, 10.1111/j.1474-9726.2009.00478.x
Zahn, 2007, AGEMAP: a gene expression database for aging in mice, PLoS Genet., 3, e201, 10.1371/journal.pgen.0030201
Algire, 2012, Metformin reduces endogenous reactive oxygen species and associated DNA damage, Cancer Prev. Res. (Phila.), 5, 536, 10.1158/1940-6207.CAPR-11-0536
Arum, 2013, Prevention of neuromusculoskeletal frailty in slow-aging Ames dwarf mice: longitudinal investigation of interaction of longevity genes and caloric restriction, PLoS ONE, 8, e72255, 10.1371/journal.pone.0072255
Bartke, 2004, Life extension in the dwarf mouse, Curr. Top. Dev. Biol., 63, 189, 10.1016/S0070-2153(04)63006-7
Bartke, 2013, Somatotropic signaling: trade-offs between growth, reproductive development, and longevity, Physiol. Rev., 93, 571, 10.1152/physrev.00006.2012
Bokov, 2011, Does reduced IGF-1R signaling in Igf1r+/- mice alter aging?, PLoS ONE, 6, e26891, 10.1371/journal.pone.0026891
Bonkowski, 2006, Long-lived growth hormone receptor knockout mice show a delay in age-related changes of body composition and bone characteristics, J. Gerontol. A Biol. Sci. Med. Sci., 61, 562, 10.1093/gerona/61.6.562
Cheadle, 2003, Analysis of microarray data using Z score transformation, J. Mol. Diagn., 5, 73, 10.1016/S1525-1578(10)60455-2
Conover, 2007, Loss of pregnancy-associated plasma protein A extends lifespan in mice, Aging Cell, 6, 727, 10.1111/j.1474-9726.2007.00328.x
Conover, 2004, Metalloproteinase pregnancy-associated plasma protein A is a critical growth regulatory factor during fetal development, Development, 131, 1187, 10.1242/dev.00997
Coschigano, 2003, Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased life span, Endocrinology, 144, 3799, 10.1210/en.2003-0374
Cufí, 2012, Metformin lowers the threshold for stress-induced senescence: a role for the microRNA-200 family and miR-205, Cell Cycle, 11, 1235, 10.4161/cc.11.6.19665
Dai, 2014, Rapamycin drives selection against a pathogenic heteroplasmic mitochondrial DNA mutation, Hum. Mol. Genet., 23, 637, 10.1093/hmg/ddt450
Danilovich, 1999, Deficits in female reproductive function in GH-R-KO mice; role of IGF-I, Endocrinology, 140, 2637, 10.1210/endo.140.6.6992
Debacq-Chainiaux, 2009, Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo, Nat. Protoc., 4, 1798, 10.1038/nprot.2009.191
Donato, 2013, Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice, Aging Cell, 12, 772, 10.1111/acel.12103
Ecarot-Charrier, 1983, Osteoblasts isolated from mouse calvaria initiate matrix mineralization in culture, J. Cell Biol., 96, 639, 10.1083/jcb.96.3.639
Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues, J. Biol. Chem., 226, 497, 10.1016/S0021-9258(18)64849-5
Garcia, 2008, Effect of Ames dwarfism and caloric restriction on spontaneous DNA mutation frequency in different mouse tissues, Mech. Ageing Dev., 129, 528, 10.1016/j.mad.2008.04.013
Garcia-Cao, 2012, Systemic elevation of PTEN induces a tumor-suppressive metabolic state, Cell, 149, 49, 10.1016/j.cell.2012.02.030
Garlick, 1980, A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H]phenylalanine, Biochem. J., 192, 719, 10.1042/bj1920719
Hamrick, 2008, Caloric restriction decreases cortical bone mass but spares trabecular bone in the mouse skeleton: implications for the regulation of bone mass by body weight, J. Bone Miner. Res., 23, 870, 10.1359/jbmr.080213
Harper, 2007, Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone, Aging Cell, 6, 1, 10.1111/j.1474-9726.2006.00255.x
Harrison, 2009, Rapamycin fed late in life extends lifespan in genetically heterogeneous mice, Nature, 460, 392, 10.1038/nature08221
Harvey, 2013, Decreased systemic IGF-1 in response to calorie restriction modulates murine tumor cell growth, nuclear factor-κB activation, and inflammation-related gene expression, Mol. Carcinog., 52, 997, 10.1002/mc.21940
Holzenberger, 2003, IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice, Nature, 421, 182, 10.1038/nature01298
Hsieh, 2009, Dermal fibroblasts from long-lived Ames dwarf mice maintain their in vivo resistance to mitochondrial generated reactive oxygen species (ROS), Aging (Albany, N.Y. Online), 1, 784
Jeyapalan, 2013, How to measure RNA expression in rare senescent cells expressing any specific protein such as p16Ink4a, Aging (Albany, N.Y. Online), 5, 120
Jeyapalan, 2007, Accumulation of senescent cells in mitotic tissue of aging primates, Mech. Ageing Dev., 128, 36, 10.1016/j.mad.2006.11.008
Kaeberlein, 2013, mTOR inhibition: from aging to autism and beyond, Scientifica (Cairo), 2013, 849186
Kamentsky, 2011, Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software, Bioinformatics, 27, 1179, 10.1093/bioinformatics/btr095
Kendziorski, 2005, On the utility of pooling biological samples in microarray experiments, Proc. Natl. Acad. Sci. USA, 102, 4252, 10.1073/pnas.0500607102
Kreiling, 2011, Age-associated increase in heterochromatic marks in murine and primate tissues, Aging Cell, 10, 292, 10.1111/j.1474-9726.2010.00666.x
Kristan, 2007, Chronic calorie restriction increases susceptibility of laboratory mice (Mus musculus) to a primary intestinal parasite infection, Aging Cell, 6, 817, 10.1111/j.1474-9726.2007.00345.x
Kurki, 2012, Distinct effects of calorie restriction on adipose tissue cytokine and angiogenesis profiles in obese and lean mice, Nutr. Metab. (Lond), 9, 64, 10.1186/1743-7075-9-64
Lee, 2012, Fasting cycles retard growth of tumors and sensitize a range of cancer cell types to chemotherapy, Sci. Transl. Med., 4, 124, 10.1126/scitranslmed.3003293
Ma, 2006, Suppression of insulin receptor substrate 1 (IRS-1) promotes mammary tumor metastasis, Mol. Cell. Biol., 26, 9338, 10.1128/MCB.01032-06
Masternak, 2012, Metabolic effects of intra-abdominal fat in GHRKO mice, Aging Cell, 11, 73, 10.1111/j.1474-9726.2011.00763.x
Mercken, 2012, Of mice and men: the benefits of caloric restriction, exercise, and mimetics, Ageing Res. Rev., 11, 390, 10.1016/j.arr.2011.11.005
Miller, 2007, An Aging Interventions Testing Program: study design and interim report, Aging Cell, 6, 565, 10.1111/j.1474-9726.2007.00311.x
Miller, 2011, Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice, J. Gerontol. A Biol. Sci. Med. Sci., 66, 191, 10.1093/gerona/glq178
Miyoshi, 2013, Effect of the anti-diabetic drug metformin in hepatocellular carcinoma in vitro and in vivo, Int. J. Oncol.
Müller, 2013, Concurrent inhibition of PI3K and mTORC1/mTORC2 overcomes resistance to rapamycin induced apoptosis by down-regulation of Mcl-1 in mantle cell lymphoma, Int. J. Cancer, 133, 1813, 10.1002/ijc.28206
Murasko, 2005, Response of aged mice to primary virus infections, Immunol. Rev., 205, 285, 10.1111/j.0105-2896.2005.00273.x
Nagy, 1998, Dissecting the role of N-myc in development using a single targeting vector to generate a series of alleles, Curr. Biol., 8, 661, 10.1016/S0960-9822(98)70254-4
Nyegaard, 2010, Lack of functional pregnancy-associated plasma protein-A (PAPPA) compromises mouse ovarian steroidogenesis and female fertility, Biol. Reprod., 82, 1129, 10.1095/biolreprod.109.079517
Ortega-Molina, 2012, Pten positively regulates brown adipose function, energy expenditure, and longevity, Cell Metab., 15, 382, 10.1016/j.cmet.2012.02.001
Prevel, 2013, Beneficial role of rapamycin in experimental autoimmune myositis, PLoS ONE, 8, e74450, 10.1371/journal.pone.0074450
Sanchez-Alavez, 2011, Sex- and age-specific differences in core body temperature of C57Bl/6 mice, Age (Dordr.), 33, 89, 10.1007/s11357-010-9164-6
Selman, 2008, Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice, FASEB J., 22, 807, 10.1096/fj.07-9261com
Selman, 2009, Ribosomal protein S6 kinase 1 signaling regulates mammalian life span, Science, 326, 140, 10.1126/science.1177221
Spindler, 2007, Conserved and tissue-specific genic and physiologic responses to caloric restriction and altered IGFI signaling in mitotic and postmitotic tissues, Annu. Rev. Nutr., 27, 193, 10.1146/annurev.nutr.27.061406.093743
Steinbaugh, 2012, Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan, Am. J. Physiol. Endocrinol. Metab., 303, E488, 10.1152/ajpendo.00110.2012
Storey, 2003, Statistical significance for genomewide studies, Proc. Natl. Acad. Sci. USA, 100, 9440, 10.1073/pnas.1530509100
Swain, 2009, Key research opportunities in immune system aging, J. Gerontol. A Biol. Sci. Med. Sci., 64, 183, 10.1093/gerona/gln068
Taguchi, 2007, Brain IRS2 signaling coordinates life span and nutrient homeostasis, Science, 317, 369, 10.1126/science.1142179
Vezeridis, 2006, Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation, Biochem. Biophys. Res. Commun., 348, 1082, 10.1016/j.bbrc.2006.07.146
Wang, 2012, Fibroblasts from long-lived mutant mice exhibit increased autophagy and lower TOR activity after nutrient deprivation or oxidative stress, Aging Cell, 11, 668, 10.1111/j.1474-9726.2012.00833.x
Wang, 2006, Adipocytokines and lipid levels in Ames dwarf and calorie-restricted mice, J. Gerontol. A Biol. Sci. Med. Sci., 61, 323, 10.1093/gerona/61.4.323
Wang, 2010, Adult-onset, short-term dietary restriction reduces cell senescence in mice, Aging (Albany, N.Y. Online), 2, 555
Ward, 2005, Effects of age and caloric restriction on lipid peroxidation: measurement of oxidative stress by F2-isoprostane levels, J. Gerontol. A Biol. Sci. Med. Sci., 60, 847, 10.1093/gerona/60.7.847
Weindruch, 1988
Westbrook, 2009, Alterations in oxygen consumption, respiratory quotient, and heat production in long-lived GHRKO and Ames dwarf mice, and short-lived bGH transgenic mice, J. Gerontol. A Biol. Sci. Med. Sci., 64, 443, 10.1093/gerona/gln075
Withers, 1998, Disruption of IRS-2 causes type 2 diabetes in mice, Nature, 391, 900, 10.1038/36116
Xiao, 2010, Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway, Cardiovasc. Res., 87, 504, 10.1093/cvr/cvq066
Xu, 2014, Longevity effect of IGF-1R(+/-) mutation depends on genetic background-specific receptor activation, Aging Cell, 13, 19, 10.1111/acel.12145
Yan, 2013, Calorie restriction can reverse, as well as prevent, aging cardiomyopathy, Age (Dordr.), 35, 10.1007/s11357-012-9508-5
Yang, 2009, Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution, J. Immunol., 183, 3040, 10.4049/jimmunol.0900562
Yoshino, 2011, Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice, Cell Metab., 14, 528, 10.1016/j.cmet.2011.08.014
Zheng, 2014, Metformin induces renal medullary interstitial cell apoptosis in type 2 diabetic mice, J. Diabetes, 6, 132, 10.1111/1753-0407.12105