Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress
Tài liệu tham khảo
Arab, 2021, NAFLD: challenges and opportunities to address the public health problem in Latin America, Ann. Hepatol., 24, 10.1016/j.aohep.2021.100359
Cai, 2019, Progress and challenges in the prevention and control of nonalcoholic fatty liver disease, Med. Res. Rev., 39, 328, 10.1002/med.21515
Chang, 2012, Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the Chinese medicine Herba Epimedii in rats, Phytomedicine, 19, 1024, 10.1016/j.phymed.2012.05.017
Chao, 2019, Homeostasis of glucose and lipid in non-alcoholic fatty liver disease, Int. J. Mol. Sci., 20, 298, 10.3390/ijms20020298
Chen, 2022, Role of Ca(2+) channels in non-alcoholic fatty liver disease and their implications for therapeutic strategies, Int. J. Mol. Med., 50, 10.3892/ijmm.2022.5169
Chong, 2017, Endoplasmic reticulum stress and oxidative stress: a vicious nexus implicated in bowel disease pathophysiology, Int. J. Mol. Sci., 18, 771, 10.3390/ijms18040771
Denechaud, 2008, Role of ChREBP in hepatic steatosis and insulin resistance, FEBS Lett., 582, 68, 10.1016/j.febslet.2007.07.084
Dif, 2006, Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs, Biochem. J., 400, 179, 10.1042/BJ20060499
Foretz, 1999, ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose, Mol. Cell Biol., 19, 3760, 10.1128/MCB.19.5.3760
Grefhorst, 2020, The role of lipophagy in the development and treatment of non-alcoholic fatty liver disease, Front. Endocrinol., 11
Hallsworth, 2019, Lifestyle modification in NAFLD/NASH: facts and figures, JHEP. Rep., 1, 468, 10.1016/j.jhepr.2019.10.008
Hetz, 2015, Proteostasis control by the unfolded protein response, Nat. Cell Biol., 17, 829, 10.1038/ncb3184
Hetz, 2018, The unfolded protein response and cell fate control, Mol. Cell, 69, 169, 10.1016/j.molcel.2017.06.017
Hossain, 2018, Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus, Sci. Rep., 8, 8715, 10.1038/s41598-018-27018-8
Im, 2021, A systematic review of animal models of NAFLD finds high-fat, high-fructose diets most closely resemble human NAFLD, Hepatology, 74, 1884—1901, 10.1002/hep.31897
Jiang, 2015, Mechanism of enhanced antiosteoporosis effect of circinal-icaritin by self-assembled nanomicelles in vivo with suet oil and sodium deoxycholate, Int. J. Nanomed., 10, 2377, 10.2147/IJN.S76191
Kim, 2018, ER stress drives lipogenesis and steatohepatitis via caspase-2 activation of S1P, Cell, 175, 133, 10.1016/j.cell.2018.08.020
Lan, 2018, 3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NO/cGMP activation in rats, Eur. J. Pharmacol., 829, 102, 10.1016/j.ejphar.2018.04.011
Latos-Brozio, 2019, Structure-activity relationships analysis of monomeric and polymeric polyphenols (quercetin, rutin and catechin) obtained by various polymerization methods, Chem. Biodivers., 16
Lazarus, 2022, Advancing the global public health agenda for NAFLD: a consensus statement, Nat. Rev. Gastroenterol. Hepatol., 19, 60, 10.1038/s41575-021-00523-4
Lebeaupin, 2018, Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease, J. Hepatol., 69, 927, 10.1016/j.jhep.2018.06.008
Li, 2015, Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii, Life Sci., 126, 57, 10.1016/j.lfs.2015.01.006
Li, 2014, Direct visualization of de novo lipogenesis in single living cells, Sci. Rep., 4, 6807, 10.1038/srep06807
Li, 2018, Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling, Mol. Med. Rep., 18, 3483
Li, 2020, Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease, Cell Biosci., 10, 140, 10.1186/s13578-020-00507-y
Li, 2020, Icariin treatment reduces blood glucose levels in type 2 diabetic rats and protects pancreatic function, Exp. Ther. Med., 19, 2690
Lin, 2021, AMPK/PGC-1alpha/GLUT4-mediated effect of icariin on hyperlipidemia-induced non-alcoholic fatty liver disease and lipid metabolism disorder in mice, Biochemistry (Mosc.), 86, 1407, 10.1134/S0006297921110055
Liu, 2017, Icariin improves osteoporosis, inhibits the expression of PPARgamma, C/EBPalpha, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats, Exp. Ther. Med., 13, 1360, 10.3892/etm.2017.4128
Lyssimachou, 2015, The mammalian “obesogen" tributyltin targets hepatic triglyceride accumulation and the transcriptional regulation of lipid metabolism in the liver and brain of zebrafish, PLoS One, 10, 10.1371/journal.pone.0143911
Ma, 2011, The genus Epimedium: an ethnopharmacological and phytochemical review, J. Ethnopharmacol., 134, 519, 10.1016/j.jep.2011.01.001
Murag, 2021, Recent epidemiology of non-alcoholic fatty liver disease, Gut Liver, 15, 206, 10.5009/gnl20127
Pao, 2021, Suppression of endoplasmic reticulum stress by 4-PBA protects against hyperoxia-induced acute lung injury via up-regulating claudin-4 expression, Front. Immunol., 12, 10.3389/fimmu.2021.674316
Qian, 2012, Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry, J. Pharm. Biomed. Anal., 66, 392, 10.1016/j.jpba.2012.03.053
Rabasseda, 2014, A report from the liver meeting 2014 (November 7-11 - boston, Massachusetts, USA), Drugs Today, 50, 763, 10.1358/dot.2014.50.11.2256386
Rellmann, 2019, 4-Phenylbutyric acid reduces endoplasmic reticulum stress in chondrocytes that is caused by loss of the protein disulfide isomerase ERp57, Oxid. Med. Cell. Longev., 10.1155/2019/6404035
Romero-Gomez, 2017, Treatment of NAFLD with diet, physical activity and exercise, J. Hepatol., 67, 829, 10.1016/j.jhep.2017.05.016
Rutkowski, 2008, UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators, Dev. Cell, 15, 829, 10.1016/j.devcel.2008.10.015
Sehgal, 2017, Inhibition of the sarco/endoplasmic reticulum (ER) Ca(2+)-ATPase by thapsigargin analogs induces cell death via ER Ca(2+) depletion and the unfolded protein response, J. Biol. Chem., 292, 19656, 10.1074/jbc.M117.796920
Soret, 2020, In vitro and in vivo models of non-alcoholic fatty liver disease: a critical appraisal, J. Clin. Med., 10, 36, 10.3390/jcm10010036
Thiam, 2021, Lipid droplet nucleation, Trends Cell Biol., 31, 108, 10.1016/j.tcb.2020.11.006
Xu, 2018, Flavonoid compound icariin enhances BMP-2 induced differentiation and signalling by targeting to connective tissue growth factor (CTGF) in SAMP6 osteoblasts, PLoS One, 13, 10.1371/journal.pone.0200367
Xu, 2017, Pharmacokinetics, tissue distribution, and metabolism study of Icariin in rat, BioMed Res. Int., 10.1155/2017/4684962
Younossi, 2019, The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis, J. Hepatol., 71, 793, 10.1016/j.jhep.2019.06.021
Zhang, 2009, A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner, Bone, 44, 345, 10.1016/j.bone.2008.10.035
Zhang, 2017, Icariin influences adipogenic differentiation of stem cells affected by osteoblast-osteoclast co-culture and clinical research adipogenic, Biomed. Pharmacother., 88, 436, 10.1016/j.biopha.2017.01.050
Zhang, 2017, Oral absorption, distribution, metabolism, and excretion of icaritin in rats by Q-TOF and UHPLC-MS/MS, Drug Test. Anal., 9, 1604, 10.1002/dta.2188
Zhang, 2017, Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1, Mol. Metabol., 6, 138, 10.1016/j.molmet.2016.11.002
Zhang, 2016, Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress, Sci. Rep., 6
Zhang, 2014, Berberine activates thermogenesis in white and brown adipose tissue, Nat. Commun., 5, 5493, 10.1038/ncomms6493
Zhang, 2016, Icaritin inhibits collagen degradation-related factors and facilitates collagen accumulation in atherosclerotic lesions: a potential action for plaque stabilization, Int. J. Mol. Sci., 17, 10.3390/ijms17020169
Zhao, 2010, Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums, J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 878, 1113, 10.1016/j.jchromb.2010.03.023
Zhao, 2017, The beneficial effects of quercetin, curcumin, and resveratrol in obesity, Oxid. Med. Cell. Longev., 10.1155/2017/1459497
Zhou, 2014, ER stress and hepatic lipid metabolism, Front. Genet., 5, 112, 10.3389/fgene.2014.00112