Icaritin, a metabolite of Icarrin, Alleviates non-alcoholic fatty liver disease via inhibition of lipogenesis and ER stress

European Journal of Pharmacology - Tập 937 - Trang 175378 - 2022
Peng Yu1, Zhen Qian1, Hongmei Yang2, Tianyang Xu3, Yulin Dai4, Laihui Song1, Jinling Liang1, Yuying Shi1, Zhiguo Zhang5, Lijing Li1
1College of Pharmacy, Changchun University of Chinese Medicine, Changchun, China
2Northeast Asia Institute of Chinese Medicine, Changchun University of Chinese Medicine, Changchun, China
3Innovation and Practice Center, Changchun University of Chinese Medicine, Changchun, China
4Jilin Ginseng Academy, Changchun University of Chinese Medicine, Changchun, China
5Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, State Key Laboratory of Medical Genomics, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China

Tài liệu tham khảo

Arab, 2021, NAFLD: challenges and opportunities to address the public health problem in Latin America, Ann. Hepatol., 24, 10.1016/j.aohep.2021.100359 Cai, 2019, Progress and challenges in the prevention and control of nonalcoholic fatty liver disease, Med. Res. Rev., 39, 328, 10.1002/med.21515 Chang, 2012, Oral absorption and excretion of icaritin, an aglycone and also active metabolite of prenylflavonoids from the Chinese medicine Herba Epimedii in rats, Phytomedicine, 19, 1024, 10.1016/j.phymed.2012.05.017 Chao, 2019, Homeostasis of glucose and lipid in non-alcoholic fatty liver disease, Int. J. Mol. Sci., 20, 298, 10.3390/ijms20020298 Chen, 2022, Role of Ca(2+) channels in non-alcoholic fatty liver disease and their implications for therapeutic strategies, Int. J. Mol. Med., 50, 10.3892/ijmm.2022.5169 Chong, 2017, Endoplasmic reticulum stress and oxidative stress: a vicious nexus implicated in bowel disease pathophysiology, Int. J. Mol. Sci., 18, 771, 10.3390/ijms18040771 Denechaud, 2008, Role of ChREBP in hepatic steatosis and insulin resistance, FEBS Lett., 582, 68, 10.1016/j.febslet.2007.07.084 Dif, 2006, Insulin activates human sterol-regulatory-element-binding protein-1c (SREBP-1c) promoter through SRE motifs, Biochem. J., 400, 179, 10.1042/BJ20060499 Foretz, 1999, ADD1/SREBP-1c is required in the activation of hepatic lipogenic gene expression by glucose, Mol. Cell Biol., 19, 3760, 10.1128/MCB.19.5.3760 Grefhorst, 2020, The role of lipophagy in the development and treatment of non-alcoholic fatty liver disease, Front. Endocrinol., 11 Hallsworth, 2019, Lifestyle modification in NAFLD/NASH: facts and figures, JHEP. Rep., 1, 468, 10.1016/j.jhepr.2019.10.008 Hetz, 2015, Proteostasis control by the unfolded protein response, Nat. Cell Biol., 17, 829, 10.1038/ncb3184 Hetz, 2018, The unfolded protein response and cell fate control, Mol. Cell, 69, 169, 10.1016/j.molcel.2017.06.017 Hossain, 2018, Discovery of pancreastatin inhibitor PSTi8 for the treatment of insulin resistance and diabetes: studies in rodent models of diabetes mellitus, Sci. Rep., 8, 8715, 10.1038/s41598-018-27018-8 Im, 2021, A systematic review of animal models of NAFLD finds high-fat, high-fructose diets most closely resemble human NAFLD, Hepatology, 74, 1884—1901, 10.1002/hep.31897 Jiang, 2015, Mechanism of enhanced antiosteoporosis effect of circinal-icaritin by self-assembled nanomicelles in vivo with suet oil and sodium deoxycholate, Int. J. Nanomed., 10, 2377, 10.2147/IJN.S76191 Kim, 2018, ER stress drives lipogenesis and steatohepatitis via caspase-2 activation of S1P, Cell, 175, 133, 10.1016/j.cell.2018.08.020 Lan, 2018, 3,7-Bis(2-hydroxyethyl)icaritin, a potent inhibitor of phosphodiesterase-5, prevents monocrotaline-induced pulmonary arterial hypertension via NO/cGMP activation in rats, Eur. J. Pharmacol., 829, 102, 10.1016/j.ejphar.2018.04.011 Latos-Brozio, 2019, Structure-activity relationships analysis of monomeric and polymeric polyphenols (quercetin, rutin and catechin) obtained by various polymerization methods, Chem. Biodivers., 16 Lazarus, 2022, Advancing the global public health agenda for NAFLD: a consensus statement, Nat. Rev. Gastroenterol. Hepatol., 19, 60, 10.1038/s41575-021-00523-4 Lebeaupin, 2018, Endoplasmic reticulum stress signalling and the pathogenesis of non-alcoholic fatty liver disease, J. Hepatol., 69, 927, 10.1016/j.jhep.2018.06.008 Li, 2015, Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii, Life Sci., 126, 57, 10.1016/j.lfs.2015.01.006 Li, 2014, Direct visualization of de novo lipogenesis in single living cells, Sci. Rep., 4, 6807, 10.1038/srep06807 Li, 2018, Icariin stimulates osteogenic differentiation and suppresses adipogenic differentiation of rBMSCs via estrogen receptor signaling, Mol. Med. Rep., 18, 3483 Li, 2020, Multiple organs involved in the pathogenesis of non-alcoholic fatty liver disease, Cell Biosci., 10, 140, 10.1186/s13578-020-00507-y Li, 2020, Icariin treatment reduces blood glucose levels in type 2 diabetic rats and protects pancreatic function, Exp. Ther. Med., 19, 2690 Lin, 2021, AMPK/PGC-1alpha/GLUT4-mediated effect of icariin on hyperlipidemia-induced non-alcoholic fatty liver disease and lipid metabolism disorder in mice, Biochemistry (Mosc.), 86, 1407, 10.1134/S0006297921110055 Liu, 2017, Icariin improves osteoporosis, inhibits the expression of PPARgamma, C/EBPalpha, FABP4 mRNA, N1ICD and jagged1 proteins, and increases Notch2 mRNA in ovariectomized rats, Exp. Ther. Med., 13, 1360, 10.3892/etm.2017.4128 Lyssimachou, 2015, The mammalian “obesogen" tributyltin targets hepatic triglyceride accumulation and the transcriptional regulation of lipid metabolism in the liver and brain of zebrafish, PLoS One, 10, 10.1371/journal.pone.0143911 Ma, 2011, The genus Epimedium: an ethnopharmacological and phytochemical review, J. Ethnopharmacol., 134, 519, 10.1016/j.jep.2011.01.001 Murag, 2021, Recent epidemiology of non-alcoholic fatty liver disease, Gut Liver, 15, 206, 10.5009/gnl20127 Pao, 2021, Suppression of endoplasmic reticulum stress by 4-PBA protects against hyperoxia-induced acute lung injury via up-regulating claudin-4 expression, Front. Immunol., 12, 10.3389/fimmu.2021.674316 Qian, 2012, Metabolite profiles of icariin in rat plasma by ultra-fast liquid chromatography coupled to triple-quadrupole/time-of-flight mass spectrometry, J. Pharm. Biomed. Anal., 66, 392, 10.1016/j.jpba.2012.03.053 Rabasseda, 2014, A report from the liver meeting 2014 (November 7-11 - boston, Massachusetts, USA), Drugs Today, 50, 763, 10.1358/dot.2014.50.11.2256386 Rellmann, 2019, 4-Phenylbutyric acid reduces endoplasmic reticulum stress in chondrocytes that is caused by loss of the protein disulfide isomerase ERp57, Oxid. Med. Cell. Longev., 10.1155/2019/6404035 Romero-Gomez, 2017, Treatment of NAFLD with diet, physical activity and exercise, J. Hepatol., 67, 829, 10.1016/j.jhep.2017.05.016 Rutkowski, 2008, UPR pathways combine to prevent hepatic steatosis caused by ER stress-mediated suppression of transcriptional master regulators, Dev. Cell, 15, 829, 10.1016/j.devcel.2008.10.015 Sehgal, 2017, Inhibition of the sarco/endoplasmic reticulum (ER) Ca(2+)-ATPase by thapsigargin analogs induces cell death via ER Ca(2+) depletion and the unfolded protein response, J. Biol. Chem., 292, 19656, 10.1074/jbc.M117.796920 Soret, 2020, In vitro and in vivo models of non-alcoholic fatty liver disease: a critical appraisal, J. Clin. Med., 10, 36, 10.3390/jcm10010036 Thiam, 2021, Lipid droplet nucleation, Trends Cell Biol., 31, 108, 10.1016/j.tcb.2020.11.006 Xu, 2018, Flavonoid compound icariin enhances BMP-2 induced differentiation and signalling by targeting to connective tissue growth factor (CTGF) in SAMP6 osteoblasts, PLoS One, 13, 10.1371/journal.pone.0200367 Xu, 2017, Pharmacokinetics, tissue distribution, and metabolism study of Icariin in rat, BioMed Res. Int., 10.1155/2017/4684962 Younossi, 2019, The global epidemiology of NAFLD and NASH in patients with type 2 diabetes: a systematic review and meta-analysis, J. Hepatol., 71, 793, 10.1016/j.jhep.2019.06.021 Zhang, 2009, A novel semisynthesized small molecule icaritin reduces incidence of steroid-associated osteonecrosis with inhibition of both thrombosis and lipid-deposition in a dose-dependent manner, Bone, 44, 345, 10.1016/j.bone.2008.10.035 Zhang, 2017, Icariin influences adipogenic differentiation of stem cells affected by osteoblast-osteoclast co-culture and clinical research adipogenic, Biomed. Pharmacother., 88, 436, 10.1016/j.biopha.2017.01.050 Zhang, 2017, Oral absorption, distribution, metabolism, and excretion of icaritin in rats by Q-TOF and UHPLC-MS/MS, Drug Test. Anal., 9, 1604, 10.1002/dta.2188 Zhang, 2017, Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1, Mol. Metabol., 6, 138, 10.1016/j.molmet.2016.11.002 Zhang, 2016, Berberine prevents progression from hepatic steatosis to steatohepatitis and fibrosis by reducing endoplasmic reticulum stress, Sci. Rep., 6 Zhang, 2014, Berberine activates thermogenesis in white and brown adipose tissue, Nat. Commun., 5, 5493, 10.1038/ncomms6493 Zhang, 2016, Icaritin inhibits collagen degradation-related factors and facilitates collagen accumulation in atherosclerotic lesions: a potential action for plaque stabilization, Int. J. Mol. Sci., 17, 10.3390/ijms17020169 Zhao, 2010, Liquid chromatography-tandem mass spectrometry analysis of metabolites in rats after administration of prenylflavonoids from Epimediums, J. Chromatogr., B: Anal. Technol. Biomed. Life Sci., 878, 1113, 10.1016/j.jchromb.2010.03.023 Zhao, 2017, The beneficial effects of quercetin, curcumin, and resveratrol in obesity, Oxid. Med. Cell. Longev., 10.1155/2017/1459497 Zhou, 2014, ER stress and hepatic lipid metabolism, Front. Genet., 5, 112, 10.3389/fgene.2014.00112