Melanoma contains CD133 and ABCG2 positive cells with enhanced tumourigenic potential

Park, 1971, Mouse myeloma tumor stem cells: a primary cell culture assay, J Natl Cancer Inst, 46, 411 Reya, 2001, Stem cells, cancer, and cancer stem cells, Nature, 414, 105, 10.1038/35102167 Bonnet, 1997, Human acute myeloid leukemia is organized as a heirarchy that originates from a primitive hematopoietic cell, Nat Med, 3, 730, 10.1038/nm0797-730 Passegue, 2003, Normal and leukemic hematopoiesis: are leukaemias a stem cell disorder or a reacquisition of stem cell characteristics?, PNAS, 30, S11842, 10.1073/pnas.2034201100 Al-Hajj, 2003, Prospective identification of tumorigenic breast cancer cells, PNAS, 100, 3983, 10.1073/pnas.0530291100 Galli, 2004, Isolation and characterization of tumorigenic, stem-like neural precursors from human glioblastoma, Cancer Res, 64, 7011, 10.1158/0008-5472.CAN-04-1364 Singh, 2004, Identification of human brain tumour initiating cells, Nature, 432, 396, 10.1038/nature03128 Rizzo, 2005, Prostate epithelial stem cell, Cell Proliferation, 38, 363, 10.1111/j.1365-2184.2005.00356.x De Vries, 2003, Changing epidemiology of malignant cutaneous melanoma in Europe 1953-1997: rising trends in incidence and mortality but recent stabilizations in western Europe and decreases in Scandinavia, In J Cancer, 107, 119 Barbero, 2003, Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes, Arthritis Rheum, 48, 1315, 10.1002/art.10950 Jemal, 2003, Cancer statistics 2003, CA Cancer J Clin, 53, 5, 10.3322/canjclin.53.1.5 Morton, 2003, Surgical excision of distant metastasis, 547, 572 Seftor, 2002, Expression of multiple molecular phenotypes by aggressive melanoma tumor cells: role in vasculogenic mimicry, Crit Rev Oncol Hematol, 44, 17, 10.1016/S1040-8428(01)00199-8 Seftor, 2002, Molecular determinants of human uveal melanoma invasion and metastasis, Clin Exp Metastasis, 19, 233, 10.1023/A:1015591624171 Bittner, 2000, Molecular classification of cutaneous malignant melanoma by gene expression profiling, Nature, 406, 536, 10.1038/35020115 Grichnik, 2006, Melanoma, a tumor based on a mutant stem cell?, J Investigative Dermatology, 126, 142, 10.1038/sj.jid.5700017 Hemmati, 2003, Cancerous stem cells can arise from pediatric brain tumors, PNAS, 100, 15178, 10.1073/pnas.2036535100 Florek, 2005, Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer, Cell Tissue Res, 319, 15, 10.1007/s00441-004-1018-z Zhou, 2001, The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype, Nat Med, 7, 1028, 10.1038/nm0901-1028 Doyle, 2003, Multidrug resistance mediated by the breast cancer resistance protein BCRP (ABCG2), Oncogene, 22, 7340, 10.1038/sj.onc.1206938 La Porta, 2002, Higher levels of melanin and inhibition of cdk2 activity in primary human melanoma cells WM115 overexpressing nPKCdelta, Melanoma Res, 12, 297, 10.1097/00008390-200208000-00001 Dirks, 2005, Short tandem repeat DNA typing provides an international reference standard for authentication of human cell lines, ALTEX, 22, 103 Towbin, 1979, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, PNAS, 76, 4350, 10.1073/pnas.76.9.4350 Vescovi, 1999, Isolation and cloning of multipotential stem cells from the embryonic human CNS and establishment of transplantable human neural stem cell lines by epigenetic stimulation, Exp Neurol, 156, 71, 10.1006/exnr.1998.6998 Fang, 2005, A Tumorigenic Subpopulation with Stem Cell Properties in Melanomas, Cancer Res, 65, 9328, 10.1158/0008-5472.CAN-05-1343 Uchida, 2000, Direct isolation of human central nervous system stem cells, PNAS, 97, 14720, 10.1073/pnas.97.26.14720 Corbeil, 1998, AC133 hematopoietic stem cell antigen: human homologue of mouse kidney prominin or distinct member of a novel protein family?, Blood, 91, 2625, 10.1182/blood.V91.7.2625 Toma, 2001, Isolation of multipotent adult stem cells from the dermis of mammalian skin, Nat Cell Biol, 3, 778, 10.1038/ncb0901-778 Barbero, 2003, Plasticity of clonal populations of dedifferentiated adult human articular chondrocytes, Arthritis Rheum, 48, 1315, 10.1002/art.10950 Leong, 2002, Activated Notch4 inhibits angiogenesis: role of beta 1-integrin activation, Mol Cell Biol, 22, 2830, 10.1128/MCB.22.8.2830-2841.2002 Downes, 2001, SOX18 and the transcriptional regulation of blood vessel development, Trends Cardiovasc Med, 11, 318, 10.1016/S1050-1738(01)00131-1 Fogt, 2004, Identification of lymphatic vessels in malignant, adenomatous and normal colonic mucosa using the novel immunostain D2-40, Oncol Rep, 11, 47 Fogt, 2004, Proliferation of D2-40-expressing intestinal lymphatic vessels in the lamina propria in inflammatory bowel disease, Int J Mol Med, 13, 211 Rak, 2006, Is cancer stem cell a cell, or a multicellular unit capable of inducing angiogenesis?, Medical hypothesis, 66, 601, 10.1016/j.mehy.2005.09.004 Lee, 2006, Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines, Cancer Cell, 9, 391, 10.1016/j.ccr.2006.03.030 Cavazzin, 2006, Unique expression and localization of aquaporin-4 and aquaporin-9 in murine and human neural stem cells and in their glial progeny, Glia, 53, 167, 10.1002/glia.20256