Iron Absorption and Transport

Halloran, 1997, Alternative pathway transport of iron in transferrin free media, Blood, 90, 9a McCord, 1998, Iron, free radicals and oxidative injury, Semin Hematol, 35, 5 Widdowson, 1951, Chemical development “in utero”, Arch Dis Child, 26, 205, 10.1136/adc.26.127.205 Crosby, 1963, The rate of iron accumulation in iron storage disease, Blood, 22, 429, 10.1182/blood.V22.4.429.429 Green, 1968, Body iron excretion in man. A collaborative study, Am J Med, 45, 336, 10.1016/0002-9343(68)90069-7 Fletcher, 1969, The transport of iron by the human placenta, Clin Sci, 36, 209 Smith, 1955, Persistence and utilization of maternal iron for blood formation during infancy, J Clin Invest, 34, 1391, 10.1172/JCI103188 Hunter, 1972, Hemoglobin and hematocrit values in iron deficiency in infancy, Pediatrics, 81, 710, 10.1016/S0022-3476(72)80090-8 Burman, 1974, Iron metabolism in infancy and childhood, 543 Dubach, 1955, Studies in iron transportation and metabolism. IX. The excretion of iron as measured by the isotope technique, J Lab Clin Med, 45, 599 Finch, 1959, Body iron exchange in man, J Clin Invest, 38, 392, 10.1172/JCI103813 Heinrich, 1970, Physical half life of radiochemically pure 59Fe and its metabolic turnover rate in man, Experientia, 26, 467, 10.1007/BF01898443 Weintraub, 1965, Iron excretion by the skin. Selective localization of iron59 in epithelial cells, Am J Pathol, 46, 121 Cole, 1972, Hematologic characteristics and menstrual blood loss, J Obstet Gynaecol Br Commonw, 79, 994, 10.1111/j.1471-0528.1972.tb11877.x Hallberg, 1966, Menstrual blood loss and iron deficiency, Acta Med Scand, 180, 639, 10.1111/j.0954-6820.1966.tb02880.x World Health Organization Nutritional anaemias. Report of a WHO Group Experts. WHO Technical Report no. 503; 1972. McCance, 1938, The absorption and excretion of iron following oral and intravenous administration, J Physiol (Lond), 94, 148, 10.1113/jphysiol.1938.sp003669 Gisinger, 1955, Die Beeinflussung der renalen Eisen und Kupferausscheidung, 36, 491 Sears, 1966, Urinary iron excretion and renal metabolism of hemoglobin in hemolytic diseases, Blood, 28, 708, 10.1182/blood.V28.5.708.708 McCance, 1937, Absorption and excretion of iron, Lancet, 2, 680, 10.1016/S0140-6736(00)56469-1 Conrad, 1964, The role of the intestine in iron kinetics, J Clin Invest, 4, 963, 10.1172/JCI104982 Finch, 1959, Body iron exchange in man, J Clin Invest, 38, 392, 10.1172/JCI103813 Brown, 1958, In vitro absorption of iron everted products of rat intestine, Am J Physiol, 194, 319, 10.1152/ajplegacy.1958.194.2.319 Conrad, 1963, Intestinal mucosal mechanisms controlling iron absorption, Blood, 22, 406, 10.1182/blood.V22.4.406.406 Wheby, 1964, Studies on iron absorption. Intestinal regulatory mechanisms, J Clin Invest, 43, 1433, 10.1172/JCI105019 Beaton, 1974, Epidemiology of iron deficiency, 477 Bothwell, 1962, Siderosis in the Bantu, Br Med J, 1, 522, 10.1136/bmj.1.5277.522 Smith, 1958, Absorption of inorganic iron from graded doses: Its significance in relation to iron absorption tests and the mucosal block theory, Br J Haematol, 4, 428, 10.1111/j.1365-2141.1958.tb06044.x Bothwell, 1958, Iron absorption. I. Factors influencing absorption, J Lab Clin Med, 51, 24 Moore, 1961, Iron metabolism and nutrition, Harvey Lect, 55, 67 Benjamin, 1967, Bicarbonate induced iron complexes and iron absorption: one effect of pancreatic secretions, Gastroenterology, 53, 389, 10.1016/S0016-5085(19)34204-0 Charley, 1969, The chelation of iron by sugars, Biochem Biophys Acta, 69, 313, 10.1016/0006-3002(63)91264-2 Conrad, 1968, Ascorbic acid chelates in iron absorption: a role for HCL and bile, Gastroenterology, 55, 35, 10.1016/S0016-5085(19)34096-X Conrad, 1966, Polymerization and intraluminal factors in the absorption of hemoglobin iron, J Lab Clin Med, 68, 659 Moore, 1944, Absorption of ferrous and ferric radioactive iron by human subjects and by dogs, J Clin Invest, 23, 755, 10.1172/JCI101548 Brise, 1962, Iron absorption studies, Acta Med Scand (Suppl), 376, 7 Leibel, 1979, Biochemical and behavioral aspects of sideropenia, Br J Haematol, 41, 145, 10.1111/j.1365-2141.1979.tb05842.x deAlarcon, 1979, Iron absorption in the thalassemia syndrome and its inhibition by tea, N Engl J Med, 300, 5, 10.1056/NEJM197901043000102 Spiro, 1974, Inorganic chemistry, 1 O’Rourke, 1967, Geopha-gia during pregnancy, Obstet Gynecol, 29, 581 Bruhn, 1971, Reported incidence of pica among migrant families, J Am Diet Assoc, 58, 417, 10.1016/S0002-8223(21)13833-7 Cook, 1972, Food iron absorption measured by an extrusive tag, J Clin Invest, 51, 805, 10.1172/JCI106875 Martinez-Torrest, 1973, Nutritional factors in iron deficiency, Clin Haematol, 2, 339 Conrad, 1991, A role for mucin in the absorption of inorganic iron and other metal cations. A study in rats, Gastroenterology, 100, 129, 10.1016/0016-5085(91)90592-9 Jacobs, 1970, The formation of iron complexes with bile and bile constituents, Gut, 11, 723, 10.1136/gut.11.9.732 Davis, 1962, Iron absorption in pancreatic disease, Lancet, 2, 6, 10.1016/S0140-6736(62)92929-X Tonz, 1965, Iron absorption in cystic fibrosis, Lancet, 2, 1096, 10.1016/S0140-6736(65)90064-4 vanCampen, 1974, Regulations of iron absorption, Fed Proc, 33, 100 Callender, 1957, Absorption of haemoglobin iron, Br J Haematol, 3, 186, 10.1111/j.1365-2141.1957.tb05785.x Conrad, 1967, Human absorption of hemoglobin iron, Gastroenterology, 53, 5, 10.1016/S0016-5085(19)34256-8 Parmley, 1981, Ultrastructural cytochemistry and radioautography of hemoglobin iron absorption, Exp Mol Pathol, 34, 131, 10.1016/0014-4800(81)90070-8 Raffin, 1974, Intestinal absorption of hemoglobin iron-heme cleavage by mucosal heme oxygenase, J Clin Invest, 54, 1344, 10.1172/JCI107881 Turnbull, 1962, Iron absorption IV. The absorption of hemoglobin iron, J Clin Invest, 41, 1894, 10.1172/JCI104646 Grasbeck, 1979, An intestinal receptor for heme, Scand J Haematol, 23, 5, 10.1111/j.1600-0609.1979.tb02845.x Majuri, 1987, A rosette receptor assay with haem-microbeads-demonstrations of a haem receptor on K562 cells, Eur J Haematol, 38, 21, 10.1111/j.1600-0609.1987.tb01418.x Mills, 1995, Genetics and regulation of heme iron transport in Shigella dysenterica and detection of an analogous system in Escherichia coli 0157.H7, J Bacteriol, 177, 3004, 10.1128/jb.177.11.3004-3009.1995 Conrad, 1987, Iron absorption, 1437 Weintraub, 1968, Absorption of hemoglobin iron: the role of hemesplitting substance in the intestinal mucosa, J Clin Invest, 47, 531, 10.1172/JCI105749 Hallberg, 1967, Absorption of hemoglobin iron in man, Acta Med Scand, 181, 335, 10.1111/j.0954-6820.1967.tb15161.x Uzel, 1998, Absorption of heme iron, Semin Hematol, 35, 27 Fairbanks, 1971, 37 Sprinz, 1968, Biopsy of small bowel of Thai people with special reference to recovery from Asiatic cholera and an intestinal malabsorption syndrome, Am J Clin Pathol, 38, 43, 10.1093/ajcp/38.1.43 Schade, 1969, An effect of intestinal motility on iron absorption, Proc Soc Exp Biol Med, 130, 757, 10.3181/00379727-130-33649 Hahn, 1943, Radioactive iron absorption by the gastrointestinal tract. Influence of anemia, anoxia and antecedent feeding, Distribution in growing dogs. J Exp Med, 78, 169 Charlton, 1965, The role of the intestinal mucosa in iron absorption, J Clin Invest, 44, 543, 10.1172/JCI105167 Chirasiri, 1966, The effect of acute hemorrhage and acute haemolysis on intestinal iron absorption in the rat, Br J Haematol, 12, 611, 10.1111/j.1365-2141.1966.tb00144.x Conrad, 1987, Small intestine regulation of iron absorption in the rat, J Lab Clin Med, 110, 418 Brittin, 1971, Duodenal ferritin synthesis in iron-replete and iron-deficient rats: response to small doses of iron, J Lab Clin Med, 77, 54 Bernier, 1970, Ferritin production in the rat small intestine, Br J Haematol, 19, 361, 10.1111/j.1365-2141.1970.tb01633.x Cumming, 1970, The relationship between body iron stores and ferritin turnover in rat liver and intestinal mucosa, Br J Haematol, 18, 653, 10.1111/j.1365-2141.1970.tb01590.x Parmley, 1985, Ultrastructural localization of transferrin, transferrin receptor and iron binding sites on human placental and duodenal microvilli, Br J Haematol, 60, 81, 10.1111/j.1365-2141.1985.tb07388.x Pietrangelo, 1992, Regulation of transferrin, transferrin receptor and ferritin genes in human intestine, Gastroenterology, 102, 802, 10.1016/0016-5085(92)90161-Q Conrad, 1990, A newly identified iron binding protein in the duodenal mucosa of rats, J Biol Chem, 265, 5273, 10.1016/S0021-9258(19)34117-1 Teichmann, 1990, Iron uptake by human upper small intestine microvillus membrane vesicles: indication for a facilitated transport mechanism mediated by a membrane iron-binding protein, J Clin Invest, 86, 2145, 10.1172/JCI114953 Conrad, 1993, A concise review: iron absorption—the mucin-mobilferrin-integrin pathway. A competitive pathway for metal absorption, Am J Hematol, 42, 67, 10.1002/ajh.2830420114 Conrad, 1993, Rat duodenal iron binding protein mobilferrin is a homologue of calreticulin, Gastroenterology, 104, 1700, 10.1016/0016-5085(93)90648-V Conrad, 1992, A newly identified iron binding protein in duodenal mucosa, Blood, 79, 244, 10.1182/blood.V79.1.244.244 Conrad, 1993, Function of integrin in duodenal mucosal uptake of iron, Blood, 81, 517, 10.1182/blood.V81.2.517.517 Umbreit, 1996, Paraferritin: a protein complex with ferrireductase activity is associated with iron absorption in rats, Biochemistry, 35, 6460, 10.1021/bi951927s Umbreit, 1998, Iron absorption and cellular transport: the mobilferrin/paraferritin paradigm, Semin Hematol, 35, 13 Rothenberg, 1996, β2 knockout mice develop parenchymal iron overload: a putative role for class I genes of the major histocompatability complex in iron metabolism, Proc Natl Acad Sci U S A, 91, 1529, 10.1073/pnas.93.4.1529 Sadasivan, 1996, Roles for calreticulin and a novel glycoprotein: tapasin in the interaction of MRC class I molecules with TAP, Immunity, 5, 103, 10.1016/S1074-7613(00)80487-2 Rojiani, 1991, In vitro interaction of a polypeptide homologous to human Ro/SS-A antigen (calreticulin) with a highly conserved amino acid sequence in the cytoplasmic domain of integrin alpha subunits, Biochemistry, 30, 9859, 10.1021/bi00105a008 Guan, 1991, Evidence for complex formation between rabbit lung flavin-containing monoox-ygenase and calreticulin, Biochemistry, 30, 9892, 10.1021/bi00105a012 Conrad, 1994, Alternate iron transport pathway. Mobilferrin and integrin in K562 cells, J Biol Chem, 269, 7169, 10.1016/S0021-9258(17)37263-0 Fleming, 1997, Microcytic anaemia mice have a mutations in Nramp2. A candidate iron transporter gene, Nat Genet, 4, 383, 10.1038/ng0897-383 Gunshin, 1997, Cloning and characterization of a mammalian proton-coupled metal iron transporter, Nature, 388, 482, 10.1038/41343 Hantke, 1997, Ferrous iron uptake by a magnesium transport system is toxin for Escherichia coli and Salmonella typhimurin, J Bacteriol, 179, 6201, 10.1128/jb.179.19.6201-6204.1997 Conrad, 1998, Separate pathways for cellular uptake of ferrous and ferric iron?, Br J Haematol, 102, 153 Fleming, 1998, Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport, Proc Natl Acad Sci USA, 95, 1148, 10.1073/pnas.95.3.1148 Coppolino, 1997, Calreticulin is essential for integrin-mediated calcium signaling and cell adhesion, Nature, 386, 843, 10.1038/386843a0 Gutierrez, 1997, Functional expression cloning and characterization of SFT, a stimulator of iron transport, J Cell Biol, 139, 895, 10.1083/jcb.139.4.895 Inman, 1994, Extracellular ferrireductase activity of K562 cells is coupled to transferrin independent iron transport, Biochemistry, 33, 11850, 10.1021/bi00205a022 Crichton, 1991, 124 von Heilmeyer, 1961, Kongeitale Atransferrinamie bei einem sieben Jahre alten Kind, Dtsh Med Wochenschr, 86, 1745, 10.1055/s-0028-1113001 Vulpe, 1999, Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport is defective in the sla mouse, Nat Genet, 21, 195, 10.1038/5979 Weintraub, 1965, Regulation of the intestinal absorption of iron by the rate of erythropoiesis, Br J Haematol, 2, 432, 10.1111/j.1365-2141.1965.tb06605.x Beutler, 1958, A comparison of the plasma iron, iron binding capacity, sternal marrow iron and other methods in the clinical evaluation of iron stores, Ann Intern Med, 48, 60, 10.7326/0003-4819-48-1-60 Bezwoda, 1979, The relationship between marrow iron stores, plasma ferritin concentrations, and iron absorption, Scand J Haematol, 22, 113, 10.1111/j.1600-0609.1979.tb00411.x Conrad, 1962, Iron kinetics in Laennec’s cirrhosis, Gastroenterology, 43, 385, 10.1016/S0016-5085(19)34982-0 Weintraub, 1964, Role of hepatic iron stores in the control of iron absorption, J Clin Invest, 43, 40, 10.1172/JCI104892 Finch, 1982, Effect of transfused reticulocytes on iron exchange, Blood, 59, 364, 10.1182/blood.V59.2.364.364 Cavill, 1975, Internal regulation of iron absorption, Nature, 256, 328, 10.1038/256328a0 Beutler, 1960, The regulation of iron absorption. I. A search for humoral factors, J Lab Clin Med, 55, 274 Conrad, 1962, The natural history of iron deficiency induced by phlebotomy, Blood, 22, 173, 10.1182/blood.V20.2.173.173 Jacobs, 1966, Intestinal iron transport: Studies using a loop of gut with an artificial circulation, Am J Physiol, 210, 694, 10.1152/ajplegacy.1966.210.4.694 Cortell, 1967, The effects of endotoxins on iron absorption, Am J Physiol, 213, 43, 10.1152/ajplegacy.1967.213.1.43 Pirzio-Biroli, 1960, Iron absorption. III. The influence of iron stores on iron absorption in the normal subject, J Lab Clin Med, 55, 216 Chow, 1963, Pituitary gland and iron absorption, Endocrinology, 72, 871, 10.1210/endo-72-6-871 Mendel, 1961, Studies on iron absorption. I. The relationships between the rate of erythropoiesis, hypoxia and iron absorption, Blood, 18, 727, 10.1182/blood.V18.6.727.727 Weintraub, 1964, The significance of iron turnover in the control of iron absorption, Blood, 24, 19, 10.1182/blood.V24.1.19.19 Conrad, 1965, Iron metabolism in rats with phenyl hydrazine individual hemolytic disease, Blood, 25, 990, 10.1182/blood.V25.6.990.990 Erlandson, 1962, Studies on congenital hemolytic syndromes. IV. Gastrointestinal absorption of iron, Blood, 19, 359, 10.1182/blood.V19.3.359.359 Marx, 1979, Normal iron absorption and decrease red cell iron uptake in the aged, Blood, 53, 204, 10.1182/blood.V53.2.204.204 Fisher, 1963, A possible humoral regulator of iron absorption, Proc Soc Exp Biol Med, 112, 228, 10.3181/00379727-112-28001 Brittin, 1968, Enhancement of intestinal iron absorption by a humoral factor in parabiotic rats, Proc Soc Exp Biol Med, 128, 178, 10.3181/00379727-128-32973 Ponka, 1998, Function and regulation of transferrin and ferritin, Semin Hematol, 35, 35 Klausner, 1984, Rapid internalization of the transferrin receptor in K562 cells is triggered by ligand binding or treatment with a phorbol ester, Proc Nat Acad Sci U S A, 81, 3005, 10.1073/pnas.81.10.3005 Young, 1984, The effect of the iron transferrin saturation on its binding and uptake by rabbit reticulocytes, Biochem J, 219, 505, 10.1042/bj2190505 Guterrez, 1997, Functional expressing cloning and characterization of SFT, a stimulator of iron transport, J Cell Biol, 139, 895, 10.1083/jcb.139.4.895 Hodgson, 1994, Receptor-independent uptake of transferrin bound iron by reticulocytes, Arch Biochem Biophy, 308, 318, 10.1006/abbi.1994.1045 Richardson, 1994, Two saturable mechanisms of iron uptake from transferrin in human melanoma cells. The effect of transferrin concentration, chelators and metabolic probes on transferrin and iron uptake, J Cell Physiol, 161, 160, 10.1002/jcp.1041610119 Morgan, 1981, Inhibition of reticulocyte iron uptake by NH4C1 and CH3NH2, Biochem Biophys Acta, 642, 119, 10.1016/0005-2736(81)90143-7 Conrad, 1994, Hereditary hemochromatosis. A prevalent disorder of iron metabolism with an elusive etiology, Am J Hematol, 47, 218, 10.1002/ajh.2830470313 Bezwoda, 1983, The relative dietary importance of haem and non haem iron, S Afr Med J, 64, 552 Carpenter, 1992, Contributions of heme and nonheme iron to human nutrition, Crit Rev Food Sci Nutr, 31, 333, 10.1080/10408399209527576 Wyllie, 1982, An electron microscopic study of heme uptake by rat duodenum, Lab Invest, 47, 471 Conrad, 1993, Regulation of iron absorption: Proteins involved in duodenal mucosal uptake and transport, J Am Coll Nutr, 12, 720, 10.1080/07315724.1993.10718365 McKie, 1996, Expression of genes involved in iron metabolism in moose intestine, Am J Physiol, 271, G772 Canonne-Hergaux, 1999, Cellular and subcellular localization of the Nramp 2 iron transporter in the intestinal brush border and regulation by dietary iron, Blood, 93, 4406, 10.1182/blood.V93.12.4406 Hamill, 1991, Congenital atransfer-rinemia. A case report and review of the literature, Am J Clin Pathol, 96, 215, 10.1093/ajcp/96.2.215 Alvarez-Hernando, 1998, The effect of apotransferrin on iron release from Caco-2 cells, an intestinal epithelial cell line, Blood, 91, 3974, 10.1182/blood.V91.10.3974 Conrad, 1996, Mobilferrin is an intermediate in iron transport between transferrin and hemoglobin in K562 cells, J Clin Invest, 98, 1449, 10.1172/JCI118933 Umbreit, 1997, The alternate iron transport pathway: Mobilferrin and integrin in reticulocytes, Br J Haematol, 96, 521, 10.1046/j.1365-2141.1997.d01-2069.x