Promoting brain remodelling and plasticity for stroke recovery: therapeutic promise and potential pitfalls of clinical translation
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Carmichael, 2006, Cellular and molecular mechanisms of neural repair after stroke: making waves, Ann Neurol, 59, 735, 10.1002/ana.20845
Murphy, 2009, Plasticity during stroke recovery: from synapse to behaviour, Nat Rev Neurosci, 10, 861, 10.1038/nrn2735
Zhang, 2009, Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic, Lancet Neurol, 8, 491, 10.1016/S1474-4422(09)70061-4
Hermann, 2009, Implications of vascular endothelial growth factor for postischemic neurovascular remodeling, J Cereb Blood Flow Metab, 29, 1620, 10.1038/jcbfm.2009.100
Cramer, 2000, Recovery recapitulates ontogeny, Trends Neurosci, 23, 265, 10.1016/S0166-2236(00)01562-9
Dimyan, 2011, Neuroplasticity in the context of motor rehabilitation after stroke, Nat Rev Neurol, 7, 76, 10.1038/nrneurol.2010.200
Zörner, 2010, Anti-Nogo on the go: from animal models to a clinical trial, Ann N Y Acad Sci, 1198, E22, 10.1111/j.1749-6632.2010.05566.x
Schäbitz, 2010, AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke, Stroke, 41, 2545, 10.1161/STROKEAHA.110.579508
Savitz, 2011, Stem cell therapy as an Emerging Paradigm for Stroke (STEPS) II, Stroke, 42, 825, 10.1161/STROKEAHA.110.601914
Papadopoulos, 2002, Functional recovery and neuroanatomical plasticity following middle cerebral artery occlusion and IN-1 antibody treatment in the adult rat, Ann Neurol, 51, 433, 10.1002/ana.10144
Wiessner, 2003, Anti-Nogo-A antibody infusion 24 hours after experimental stroke improved behavioral outcome and corticospinal plasticity in normotensive and spontaneously hypertensive rats, J Cereb Blood Flow Metab, 23, 154, 10.1097/00004647-200302000-00003
Liu, 2008, Contralesional axonal remodeling of the corticospinal system in adult rats after stroke and bone marrow stromal cell treatment, Stroke, 39, 2571, 10.1161/STROKEAHA.107.511659
Kilic, 2008, Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice, J Pineal Res, 45, 142, 10.1111/j.1600-079X.2008.00568.x
Bacigaluppi, 2009, Delayed post-ischaemic neuroprotection following systemic neural stem cell transplantation involves multiple mechanisms, Brain, 132, 2239, 10.1093/brain/awp174
Andres, 2011, Human neural stem cells enhance structural plasticity and axonal transport in the ischaemic brain, Brain, 134, 1777, 10.1093/brain/awr094
Zhang, 2002, Sildenafil induces neurogenesis and promotes functional recovery after stroke in rats, Stroke, 33, 2675, 10.1161/01.STR.0000034399.95249.59
Markus, 2005, Recovery and brain reorganization after stroke in adult and aged rats, Ann Neurol, 58, 950, 10.1002/ana.20676
Shen, 2007, Therapeutic benefit of bone marrow stromal cells administered 1 month after stroke, J Cereb Blood Flow Metab, 27, 6, 10.1038/sj.jcbfm.9600311
Reitmeir, 2011, Post-acute delivery of erythropoietin induces stroke recovery by promoting perilesional tissue remodelling and contralesional pyramidal tract plasticity, Brain, 134, 84, 10.1093/brain/awq344
Tsai, 2011, Delayed anti-Nogo-A therapy improves function after chronic stroke in adult rats, Stroke, 42, 186, 10.1161/STROKEAHA.110.590083
Li, 2009, MRI identification of white matter reorganization enhanced by erythropoietin treatment in a rat model of focal ischemia, Stroke, 40, 936, 10.1161/STROKEAHA.108.527713
Liu, 2009, Remodeling of the corticospinal innervation and spontaneous behavioral recovery after ischemic stroke in adult mice, Stroke, 40, 2546, 10.1161/STROKEAHA.109.547265
Jiang, 2010, MRI evaluation of white matter recovery after brain injury, Stroke, 41, S112, 10.1161/STROKEAHA.110.595629
Reitmeir, 2012, Vascular endothelial growth factor induces contralesional corticobulbar plasticity and functional neurological recovery in the ischemic brain, Acta Neuropathol, 123, 273, 10.1007/s00401-011-0914-z
Liu, 2010, Bone marrow stromal cells enhance inter- and intracortical axonal connections after ischemic stroke in adult rats, J Cereb Blood Flow Metab, 30, 1288, 10.1038/jcbfm.2010.8
Shen, 2007, One-year follow-up after bone marrow stromal cell treatment in middle-aged female rats with stroke, Stroke, 38, 2150, 10.1161/STROKEAHA.106.481218
Ding, 2008, Magnetic resonance imaging investigation of axonal remodeling and angiogenesis after embolic stroke in sildenafil-treated rats, J Cereb Blood Flow Metab, 28, 1440, 10.1038/jcbfm.2008.33
Cui, 2010, Niacin treatment of stroke increases synaptic plasticity and axon growth in rats, Stroke, 41, 2044, 10.1161/STROKEAHA.110.589333
Papadopoulos, 2009, Motor recovery and axonal plasticity with short-term amphetamine after stroke, Stroke, 40, 294, 10.1161/STROKEAHA.108.519769
Liu, 2011, Bone marrow stromal cells promote skilled motor recovery and enhance contralesional axonal connections after ischemic stroke in adult mice, Stroke, 42, 740, 10.1161/STROKEAHA.110.607226
Herz, 2011, Intracerebroventricularly delivered VEGF promotes contralesional corticorubral plasticity after focal cerebral ischemia via mechanisms involving anti-inflammatory actions, Neurobiol Dis, 45, 1077, 10.1016/j.nbd.2011.12.026
Freund, 2006, Nogo-A-specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates, Nat Med, 12, 790, 10.1038/nm1436
Zhang, 2006, Delayed treatment with sildenafil enhances neurogenesis and improves functional recovery in aged rats after focal cerebral ischemia, J Neurosci Res, 83, 1213, 10.1002/jnr.20813
Zhang, 2001, Proliferation and differentiation of progenitor cells in the cortex and the subventricular zone in the adult rat after focal cerebral ischemia, Neuroscience, 105, 33, 10.1016/S0306-4522(01)00117-8
Arvidsson, 2002, Neuronal replacement from endogenous precursors in the adult brain after stroke, Nat Med, 8, 963, 10.1038/nm747
Chen, 2003, Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke, Ann Neurol, 53, 743, 10.1002/ana.10555
Thored, 2007, Long-term neuroblast migration along blood vessels in an area with transient angiogenesis and increased vascularization after stroke, Stroke, 38, 3032, 10.1161/STROKEAHA.107.488445
Zhang, 2009, Patterns and dynamics of subventricular zone neuroblast migration in the ischemic striatum of the adult mouse, J Cereb Blood Flow Metab, 29, 1240, 10.1038/jcbfm.2009.55
Zhang, 2004, Stroke transiently increases subventricular zone cell division from asymmetric to symmetric and increases neuronal differentiation in the adult rat, J Neurosci, 24, 5810, 10.1523/JNEUROSCI.1109-04.2004
Bacigaluppi, 2008, Neural stem/precursor cells for the treatment of ischemic stroke, J Neurol Sci, 265, 73, 10.1016/j.jns.2007.06.012
Zhang, 2011, Ascl1 lineage cells contribute to ischemia-induced neurogenesis and oligodendrogenesis, J Cereb Blood Flow Metab, 31, 614, 10.1038/jcbfm.2010.134
Doeppner, 2011, Acute hepatocyte growth factor treatment induces long-term neuroprotection and stroke recovery via mechanisms involving neural precursor cell proliferation and differentiation, J Cereb Blood Flow Metab, 31, 1251, 10.1038/jcbfm.2010.211
Jin, 2010, Transgenic ablation of doublecortin-expressing cells suppresses adult neurogenesis and worsens stroke outcome in mice, Proc Natl Acad Sci USA, 107, 7993, 10.1073/pnas.1000154107
Bliss, 2007, Cell transplantation therapy for stroke, Stroke, 38, 817, 10.1161/01.STR.0000247888.25985.62
Teng, 2008, Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke, J Cereb Blood Flow Metab, 28, 764, 10.1038/sj.jcbfm.9600573
Lee, 2008, Antiinflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke, Brain, 131, 616, 10.1093/brain/awm306
Forsythe, 1996, Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1, Mol Cell Biol, 16, 4604, 10.1128/MCB.16.9.4604
Marti, 2000, Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia, Am J Pathol, 156, 965, 10.1016/S0002-9440(10)64964-4
Wang, 2005, VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena, Brain, 128, 52, 10.1093/brain/awh325
Kilic, 2006, The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia, FASEB J, 20, 1185, 10.1096/fj.05-4829fje
Ridgway, 2006, Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis, Nature, 444, 1083, 10.1038/nature05313
Hellström, 2007, Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis, Nature, 445, 776, 10.1038/nature05571
Al Haj Zen, 2010, Inhibition of delta-like-4-mediated signaling impairs reparative angiogenesis after ischemia, Circ Res, 107, 283, 10.1161/CIRCRESAHA.110.221663
Takeshita, 2007, Critical role of endothelial Notch1 signaling in postnatal angiogenesis, Circ Res, 100, 70, 10.1161/01.RES.0000254788.47304.6e
Zacharek, 2009, Simvastatin increases notch signaling activity and promotes arteriogenesis after stroke, Stroke, 40, 254, 10.1161/STROKEAHA.108.524116
Arkuszewski, 2009, Perfusion computed tomography in prediction of functional outcome in patients with acute ischaemic stroke, Nucl Med Rev Cent East Eur, 12, 89
Chen, 2005, Endothelial nitric oxide synthase regulates brain-derived neurotrophic factor expression and neurogenesis after stroke in mice, J Neurosci, 25, 2366, 10.1523/JNEUROSCI.5071-04.2005
Wang, 2006, Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration, J Neurosci, 26, 5996, 10.1523/JNEUROSCI.5380-05.2006
Chopp, 2007, Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke, Stroke, 38, 827, 10.1161/01.STR.0000250235.80253.e9
Uchiba, 2004, Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo, Circ Res, 95, 34, 10.1161/01.RES.0000133680.87668.FA
Thiyagarajan, 2008, Activated protein C promotes neovascularization and neurogenesis in postischemic brain via protease–activated receptor 1, J Neurosci, 28, 12788, 10.1523/JNEUROSCI.3485-08.2008
Pannasch, 2011, Astroglial networks scale synaptic activity and plasticity, Proc Natl Acad Sci USA, 108, 8467, 10.1073/pnas.1016650108
Busch, 2007, The role of extracellular matrix in CNS regeneration, Curr Opin Neurobiol, 17, 120, 10.1016/j.conb.2006.09.004
Carmichael, 2005, Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex, Exp Neurol, 193, 291, 10.1016/j.expneurol.2005.01.004
Shen, 2008, Downregulation of neurocan expression in reactive astrocytes promotes axonal regeneration and facilitates the neurorestorative effects of bone marrow stromal cells in the ischemic rat brain, Glia, 56, 1747, 10.1002/glia.20722
Shen, 2010, Astrocytic endogenous glial cell derived neurotrophic factor production is enhanced by bone marrow stromal cell transplantation in the ischemic boundary zone after stroke in adult rats, Glia, 58, 1074, 10.1002/glia.20988
Zacharek, 2007, Angiopoietin1/Tie2 and VEGF/Flk1 induced by MSC treatment amplifies angiogenesis and vascular stabilization after stroke, J Cereb Blood Flow Metab, 27, 1684, 10.1038/sj.jcbfm.9600475
Xin, 2010, Increasing tPA activity in astrocytes induced by multipotent mesenchymal stromal cells facilitate neurite outgrowth after stroke in the mouse, PLoS One, 5, e9027, 10.1371/journal.pone.0009027
Shen, 2011, Endogenous tissue plasminogen activator mediates bone marrow stromal cell-induced neurite remodeling after stroke in mice, Stroke, 42, 459, 10.1161/STROKEAHA.110.593863
Xin, 2011, Multipotent mesenchymal stromal cells increase tPA expression and concomitantly decrease PAI-1 expression in astrocytes through the sonic hedgehog signaling pathway after stroke (in vitro study), J Cereb Blood Flow Metab, 31, 2181, 10.1038/jcbfm.2011.116
Chow, 2009, Laminar and compartmental regulation of dendritic growth in mature cortex, Nat Neurosci, 12, 116, 10.1038/nn.2255
Li, 2010, An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke, Nat Neurosci, 13, 1496, 10.1038/nn.2674
Carmichael, 2002, Synchronous neuronal activity is a signal for axonal sprouting after cortical lesions in the adult, J Neurosci, 22, 6062, 10.1523/JNEUROSCI.22-14-06062.2002
Clarkson, 2010, Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke, Nature, 468, 305, 10.1038/nature09511
Clarkson, 2011, AMPA receptor-induced local brain-derived neurotrophic factor signaling mediates motor recovery after stroke, J Neurosci, 31, 3766, 10.1523/JNEUROSCI.5780-10.2011
Zhang, 2005, Functional recovery in aged and young rats after embolic stroke: treatment with a phosphodiesterase type 5 inhibitor, Stroke, 36, 847, 10.1161/01.STR.0000158923.19956.73
Gillani, 2010, Cognitive recovery in the aged rat after stroke and anti-Nogo-A immunotherapy, Behav Brain Res, 208, 415, 10.1016/j.bbr.2009.12.015
Darsalia, 2005, Stroke-induced neurogenesis in aged brain, Stroke, 36, 1790, 10.1161/01.STR.0000173151.36031.be
Gao, 2009, Attenuation of brain response to vascular endothelial growth factor-mediated angiogenesis and neurogenesis in aged mice, Stroke, 40, 3596, 10.1161/STROKEAHA.109.561050
Chen, 2011, Adverse effects of bone marrow stromal cell treatment of stroke in diabetic rats, Stroke, 42, 3551, 10.1161/STROKEAHA.111.627174
Sacco, 2008, Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke, N Engl J Med, 359, 1238, 10.1056/NEJMoa0805002
Hennigan, 2009, Deficits in LTP and recognition memory in the genetically hypertensive rat are associated with decreased expression of neurotrophic factors and their receptors in the dentate gyrus, Behav Brain Res, 197, 371, 10.1016/j.bbr.2008.09.037
Duan, 2000, Hypercholesterolemia inhibits angiogenesis in response to hindlimb ischemia: nitric oxide-dependent mechanism, Circulation, 102, 370
ElAli, 2011, Increased blood–brain barrier permeability and brain edema after focal cerebral ischemia induced by hyperlipidemia: role of lipid peroxidation and calpain–1/2, matrix metalloproteinase–2/9, and rhoA overactivation, Stroke, 42, 3238, 10.1161/STROKEAHA.111.615559
Chen, 2007, Niaspan increases angiogenesis and improves functional recovery after stroke, Ann Neurol, 62, 49, 10.1002/ana.21160
Chang, 2009, Age-related influence of the HDL receptor SR-BI on synaptic plasticity and cognition, Neurobiol Aging, 30, 407, 10.1016/j.neurobiolaging.2007.07.006
Hwang, 2010, Sex differences in high-fat diet-induced obesity, metabolic alterations and learning, and synaptic plasticity deficits in mice, Obesity, 18, 463, 10.1038/oby.2009.273
Cui, 2010, Niacin treatment of stroke increases synaptic plasticity and axon growth in rats, Stroke, 41, 2044, 10.1161/STROKEAHA.110.589333
Kilic, 2005, Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice via inhibition of extracellular-regulated kinase-1/-2, Neuroscience, 134, 901, 10.1016/j.neuroscience.2005.04.063
Ehrenreich, 2009, Recombinant human erythropoietin in the treatment for acute ischemic stroke, Stroke, 40, e649, 10.1161/STROKEAHA.109.564872
Zechariah, 2010, Combination of tissue-plasminogen activator with erythropoietin induces blood–brain barrier permeability, extracellular matrix disaggregation and DNA fragmentation after focal cerebral ischemia in mice, Stroke, 41, 1008, 10.1161/STROKEAHA.109.574418
Jia, 2010, Erythropoietin in combination with tissue plasminogen activator exacerbates brain hemorrhage when treatment is initiated 6 hours after stroke, Stroke, 41, 2071, 10.1161/STROKEAHA.110.586198
Kilic, 2010, Role of Nogo-A in neuronal survival in the reperfused ischemic brain, J Cereb Blood Flow Metab, 30, 969, 10.1038/jcbfm.2009.268
Zhang, 2000, VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain, J Clin Invest, 106, 829, 10.1172/JCI9369
Rosell, 2008, Multiphasic roles of matrix metalloproteinases after stroke, Curr Opin Pharmacol, 8, 82, 10.1016/j.coph.2007.12.001
Reich, 2008, Death receptor Fas (CD95) signaling in the central nervous system: tuning neuroplasticity?, Trends Neurosci, 31, 478, 10.1016/j.tins.2008.06.007
Corsini, 2009, The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair, Cell Stem Cell, 5, 178, 10.1016/j.stem.2009.05.004
Zuliani, 2006, Control of neuronal branching by the death receptor CD95 (Fas/Apo-1), Cell Death Differ, 13, 31, 10.1038/sj.cdd.4401720
Doeppner, 2011, Enhancement of endogenous neurogenesis in ephrin-B3 deficient mice after transient focal cerebral ischemia, Acta Neuropathol, 122, 429, 10.1007/s00401-011-0856-5
Lo, 2008, A new penumbra: transitioning from injury into repair after stroke, Nat Med, 14, 497, 10.1038/nm1735
Cramer, 1997, A functional MRI study of subjects recovered from hemiparetic stroke, Stroke, 28, 2518, 10.1161/01.STR.28.12.2518
Gerloff, 2006, Multimodal imaging of brain reorganization in motor areas of the contralesional hemisphere of well recovered patients after capsular stroke, Brain, 129, 791, 10.1093/brain/awh713