Transforming “cold” tumors into “hot” ones via tumor-microenvironment-responsive siRNA micelleplexes for enhanced immunotherapy

Matter - Tập 5 - Trang 2285-2305 - 2022
Yunfei Yi1, Mian Yu1, Chan Feng2,3, Huisong Hao1, Weiwei Zeng1, Chuchu Lin1, Hongzhong Chen1, Feng Lv4, Dunwan Zhu4, Xiaoyuan Ji5, Lin Mei1,4, Meiying Wu1, Wei Tao2
1School of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, China
2Center for Nanomedicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA
3Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310016, China
4Tianjin Key Laboratory of Biomedical Materials, Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy, Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
5Academy of Medical Engineering and Translational Medicine, Medical College, Tianjin University, Tianjin 300072, China

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