Efeitos da terapia combinada com ácido zoledrônico e propranolol na resistência mecânica em um modelo de rato com osteoporose por desuso

Johnell, 2006, An estimate of the worldwide prevalence and disability associated with osteoporotic fractures, Osteoporos Int., 17, 1726, 10.1007/s00198-006-0172-4 Khajuria, 2014, Prophylactic effects of propranolol versus standard therapy on a new model of disuse osteoporosis in rats, Sci Pharm., 82, 357, 10.3797/scipharm.1310-06 Li, 2013, Antiosteoporosis effect of Radix Scutellariae extract on density and microstructure of long bones in tail‐suspended sprague‐dawley rats, Evidence‐Based Complementary and Alternative Medicine, 2013, 753703, 10.1155/2013/753703 Russell, 2008, Mechanisms of action of bisphosphonates: similarities and differences and their potential influence on clinical efficacy, Osteoporos Int., 19, 733, 10.1007/s00198-007-0540-8 Khajuria, 2011, Drugs for the management of osteoporosis: a review, Rev Bras Reumatol., 51, 365 Black, 2007, Once‐yearly zoledronic acid for treatment of postmenopausal osteoporosis, N Engl J Med., 356, 1809, 10.1056/NEJMoa067312 Khajuria, 2014, The combination therapy with zoledronic acid and propranolol improves the trabecular microarchitecture and mechanical property in an rat model of postmenopausal osteoporosis, J Osteoporos., 2014, 586431, 10.1155/2014/586431 Khajuria, 2013, Osteoprotective effect of propranolol in ovariectomized rats: a comparison with zoledronic acid and alfacalcidol, J Orthop Sci., 18, 832, 10.1007/s00776-013-0433-y Khajuria, 2013, Comparative evaluation of zoledronic acid, alfacalcidol, and propranolol in pharmacological correction of experimental osteoporosis, Lat Am J Pharm., 32, 968 Bonnet, 2008, Low dose beta‐blocker prevents ovariectomy‐induced bone loss in rats without affecting heart functions, J Cell Physiol., 217, 819, 10.1002/jcp.21564 Levasseur, 2003, Sympathetic nervous system as transmitter of mechanical loading in bone, Joint Bone Spine, 70, 515, 10.1016/j.jbspin.2003.07.006 Kondo, 2005, Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system, J Biol Chem., 280, 30192, 10.1074/jbc.M504179200 Bonnet, 2007, Protective effect of b‐blockers in postmenopausal women: influence on fractures, bone density, micro and macroarchitecture, Bone, 40, 1209, 10.1016/j.bone.2007.01.006 De Vries, 2007, Use of b‐blockers and the risk of hip/femur fracture in the United Kingdom and The Netherlands, Calcif Tissue Int., 80, 69, 10.1007/s00223-006-0213-1 Meisinger, 2007, Beta‐blocker use and risk of fractures in men and women from the general population: the Monica/Kora Augsburg cohort study, Osteoporos Int., 18, 1189, 10.1007/s00198-007-0354-8 Johnston, 2007, The effects of combination of alendronate and human parathyroid hormone (1‐34) on bone strength are synergistic in the lumbar vertebra and additive in the femur of C57BL/6J mice, Endocrinology, 148, 4466, 10.1210/en.2007-0229 Yang, 2011, Ibandronate does not reduce the anabolic effects of PTH in ovariectomized rat tibiae: a microarchitectural and mechanical study, Bone, 48, 1154, 10.1016/j.bone.2011.02.007 Campbell, 2011, The bone architecture is enhanced with combined PTH and alendronate treatment compared to monotherapy while maintaining the state of surface mineralization in the OVX rat, Bone, 49, 225, 10.1016/j.bone.2011.04.008 Rodrigues, 2012, Low dose of propranolol down‐modulates bone resorption by inhibiting inflammation and osteoclast differentiation, Br J Pharmacol., 165, 2140, 10.1111/j.1476-5381.2011.01686.x Huang, 2009, Functional alpha1‐ and beta2‐adrenergic receptors in human osteoblasts, J Cell Physiol., 220, 267, 10.1002/jcp.21761 Sahana, 2012, Improvement in bone properties by risedronate adsorbed hydroxyapatite novel nanoparticle formulation in rat model of postmenopausal osteoporosis, J Biomed Nanotechnol., 9, 1 Mosekilde, 2000, Treatment with risedronate or alendronate prevents hind‐limb immobilization‐induced loss of bone density and strength in adult female rats, Bone, 27, 639, 10.1016/S8756-3282(00)00375-6 Trebacz, 2001, Disuse‐induced deterioration of bone strength is not stopped after free remobilization in young adult rats, J Biomech., 34, 1631, 10.1016/S0021-9290(01)00138-5 Kannus, 1994, Reduced bone mineral density in men with a previous femur fracture, J Bone Miner Res., 9, 1729, 10.1002/jbmr.5650091109 Kannus, 1994, Osteoporosis in men with a history of tibial fracture, J Bone Miner Res., 9, 423, 10.1002/jbmr.5650090319