Association of the Dopamine D4 Receptor (DRD4) Gene and Approach-Related Personality Traits: Meta-Analysis and New Data

Biological Psychiatry - Tập 63 - Trang 197-206 - 2008
Marcus R. Munafò1, Binnaz Yalcin2, Saffron A. Willis-Owen3, Jonathan Flint2
1Department of Experimental Psychology, University of Bristol, Bristol, United Kingdom
2Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
3National Heart and Lung Institute, Imperial College London, London, United Kingdom

Tài liệu tham khảo

Heath, 1994, Testing a model for the genetic structure of personality: A comparison of the personality systems of Cloninger and Eysenck, J Pers Soc Psychol, 66, 762, 10.1037/0022-3514.66.4.762 Plomin, 1994, The genetic basis of complex human behaviors, Science, 264, 1733, 10.1126/science.8209254 Ebstein, 1996, Dopamine D4 receptor (D4DR) exon III polymorphism associated with the human personality trait of novelty seeking, Nat Genet, 12, 78, 10.1038/ng0196-78 Lesch, 1996, Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region, Science, 274, 1527, 10.1126/science.274.5292.1527 Munafo, 2003, Genetic polymorphisms and personality in healthy adults: A systematic review and meta-analysis, Mol Psychiatry, 8, 471, 10.1038/sj.mp.4001326 Munafo, 2004, Meta-analysis of genetic association studies, Trends Genet, 20, 439, 10.1016/j.tig.2004.06.014 Fanous, 2002, Neuroticism, major depression and gender: A population-based twin study, Psychol Med, 32, 719, 10.1017/S003329170200541X Hettema, 2006, A population-based twin study of the relationship between neuroticism and internalizing disorders, Am J Psychiatry, 163, 857, 10.1176/ajp.2006.163.5.857 Hettema, 2004, Genetic and environmental sources of covariation between generalized anxiety disorder and neuroticism, Am J Psychiatry, 161, 1581, 10.1176/appi.ajp.161.9.1581 Costa, 1997, Stability and change in personality assessment: The revised NEO Personality Inventory in the year 2000, J Pers Assess, 68, 86, 10.1207/s15327752jpa6801_7 Eysenck, 1975 Cloninger, 1986, A unified biosocial theory of personality and its role in the development of anxiety states, Psychiatr Dev, 4, 167 Nigg, 1998, Parent personality traits and psychopathology associated with antisocial behaviors in childhood attention-deficit hyperactivity disorder, J Child Psychol Psychiatry, 39, 145, 10.1017/S0021963097001984 Martel, 2006, Child ADHD and personality/temperament traits of reactive and effortful control, resiliency, and emotionality, J Child Psychol Psychiatry, 47, 1175, 10.1111/j.1469-7610.2006.01629.x Flint, 2007, The endophenotype concept in psychiatric genetics, Psychol Med, 37, 163, 10.1017/S0033291706008750 Nigg, 2006, Temperament and developmental psychopathology, J Child Psychol Psychiatry, 47, 395, 10.1111/j.1469-7610.2006.01612.x Evenden, 1999, Impulsivity: A discussion of clinical and experimental findings, J Psychopharmacol, 13, 180, 10.1177/026988119901300211 Comings, 2000, Reward deficiency syndrome: Genetic aspects of behavioral disorders, Prog Brain Res, 126, 325, 10.1016/S0079-6123(00)26022-6 Netter, 2006, Dopamine challenge tests as an indicator of psychological traits, Hum Psychopharmacol, 21, 91, 10.1002/hup.754 Asghari, 1994, Dopamine D4 receptor repeat: Analysis of different native and mutant forms of the human and rat genes, Mol Pharmacol, 46, 364 Asghari, 1995, Modulation of intracellular cyclic AMP levels by different human dopamine D4 receptor variants, J Neurochem, 65, 1157, 10.1046/j.1471-4159.1995.65031157.x Ekelund, 2001, No association of the −521 C/T polymorphism in the promoter of DRD4 with novelty seeking, Mol Psychiatry, 6, 618, 10.1038/sj.mp.4000943 Strobel, 2002, No association between dopamine D4 receptor gene exon III and −521C/T polymorphism and novelty seeking, Mol Psychiatry, 7, 537, 10.1038/sj.mp.4001027 Okuyama, 1999, A genetic polymorphism in the promoter region of DRD4 associated with expression and schizophrenia, Biochem Biophys Res Commun, 258, 292, 10.1006/bbrc.1999.0630 Ronai, 2001, Genotyping the −521C/T functional polymorphism in the promoter region of dopamine D4 receptor (DRD4) gene, Electrophoresis, 22, 1102, 10.1002/1522-2683()22:6<1102::AID-ELPS1102>3.0.CO;2-3 Bobb, 2005, Molecular genetic studies of ADHD: 1991 to 2004, Am J Med Genet B Neuropsychiatr Genet, 132, 109 Faraone, 2005, Molecular genetics of attention-deficit/hyperactivity disorder, Biol Psychiatry, 57, 1313, 10.1016/j.biopsych.2004.11.024 Schinka, 2002, DRD4 and novelty seeking: Results of meta-analyses, Am J Med Genet, 114, 643, 10.1002/ajmg.10649 Willis-Owen, 2005, The serotonin transporter length polymorphism, neuroticism, and depression: A comprehensive assessment of association, Biol Psychiatry, 58, 451, 10.1016/j.biopsych.2005.04.050 2004 Benjamin, 1996, Population and familial association between the D4 dopamine receptor gene and measures of novelty seeking, Nat Genet, 12, 81, 10.1038/ng0196-81 Malhotra, 1996, The association between the dopamine D4 receptor (D4DR) 16 amino acid repeat polymorphism and novelty seeking, Mol Psychiatry, 1, 388 Ebstein, 1997, Additional evidence for an association between the dopamine D4 receptor (D4DR) exon III repeat polymorphism and the human personality trait of novelty seeking, Mol Psychiatry, 2, 472, 10.1038/sj.mp.4000333 Gelernter, 1997, D4 dopamine-receptor (DRD4) alleles and novelty seeking in substance-dependent, personality-disorder, and control subjects, Am J Hum Genet, 61, 1144, 10.1086/301595 Jonsson, 1997, Lack of evidence for allelic association between personality traits and the dopamine D4 receptor gene polymorphisms, Am J Psychiatry, 154, 697, 10.1176/ajp.154.5.697 Ono, 1997, Association between dopamine D4 receptor (D4DR) exon III polymorphism and novelty seeking in Japanese subjects, Am J Med Genet, 74, 501, 10.1002/(SICI)1096-8628(19970919)74:5<501::AID-AJMG9>3.0.CO;2-Q Jonsson, 1998, Lack of association between dopamine D4 receptor gene and personality traits, Psychol Med, 28, 985, 10.1017/S0033291798006837 Pogue-Geile, 1998, Human novelty-seeking personality traits and dopamine D4 receptor polymorphisms: A twin and genetic association study, Am J Med Genet, 81, 44, 10.1002/(SICI)1096-8628(19980207)81:1<44::AID-AJMG9>3.0.CO;2-N Poston, 1998, D4 dopamine receptor gene exon III polymorphism and obesity risk, Eat Weight Disord, 3, 71, 10.1007/BF03339991 Hill, 1999, Personality traits and dopamine receptors (D2 and D4): Linkage studies in families of alcoholics, Am J Med Genet, 88, 634, 10.1002/(SICI)1096-8628(19991215)88:6<634::AID-AJMG11>3.0.CO;2-M Kuhn, 1999, Allelic variants of dopamine receptor D4 (DRD4) and serotonin receptor 5HT2c (HTR2c) and temperament factors: Replication tests, Am J Med Genet, 88, 168, 10.1002/(SICI)1096-8628(19990416)88:2<168::AID-AJMG14>3.0.CO;2-P Strobel, 1999, Association between the dopamine D4 receptor (DRD4) exon III polymorphism and measures of novelty seeking in a German population, Mol Psychiatry, 4, 378, 10.1038/sj.mp.4000535 Tomitaka, 1999, Association between novelty seeking and dopamine receptor D4 (DRD4) exon III polymorphism in Japanese subjects, Am J Med Genet, 88, 469, 10.1002/(SICI)1096-8628(19991015)88:5<469::AID-AJMG6>3.0.CO;2-F Benjamin, 2000, Association between tridimensional personality questionnaire (TPQ) traits and three functional polymorphisms: Dopamine receptor D4 (DRD4), serotonin transporter promoter region (5-HTTLPR) and catechol O-methyltransferase (COMT), Mol Psychiatry, 5, 96, 10.1038/sj.mp.4000640 Comings, 2000, A multivariate analysis of 59 candidate genes in personality traits: The temperament and character inventory, Clin Genet, 58, 375, 10.1034/j.1399-0004.2000.580508.x Gebhardt, 2000, Non-association of dopamine D4 and D2 receptor genes with personality in healthy individuals, Psychiatr Genet, 10, 131, 10.1097/00041444-200010030-00005 Herbst, 2000, Do the dimensions of the temperament and character inventory map a simple genetic architecture? Evidence from molecular genetics and factor analysis, Am J Psychiatry, 157, 1285, 10.1176/appi.ajp.157.8.1285 Okuyama, 2000, Identification of a polymorphism in the promoter region of DRD4 associated with the human novelty seeking personality trait, Mol Psychiatry, 5, 64, 10.1038/sj.mp.4000563 Persson, 2000, Dopamine D4 receptor gene polymorphism and personality traits in healthy volunteers, Eur Arch Psychiatry Clin Neurosci, 250, 203, 10.1007/s004060070025 Swift, 2000, Novelty seeking traits and D4 dopamine receptors, Am J Med Genet, 96, 222, 10.1002/(SICI)1096-8628(20000403)96:2<222::AID-AJMG18>3.0.CO;2-B Mitsuyasu, 2001, Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits, J Hum Genet, 46, 26, 10.1007/s100380170120 Ronai, 2001, Association between novelty seeking and the −521 C/T polymorphism in the promoter region of the DRD4 gene, Mol Psychiatry, 6, 35, 10.1038/sj.mp.4000832 Bookman, 2002, DRD4 promoter SNPs and gender effects on extraversion in African Americans, Mol Psychiatry, 7, 786, 10.1038/sj.mp.4001075 Jonsson, 2002, No association between dopamine D4 receptor gene variants and novelty seeking, Mol Psychiatry, 7, 18, 10.1038/sj.mp.4000950 Lee, 2003, D2 and D4 dopamine receptor gene polymorphisms and personality traits in a young Korean population, Am J Med Genet B Neuropsychiatr Genet, 121, 44, 10.1002/ajmg.b.20054 Lee, 2003, Allelic variants interaction of dopamine receptor D4 polymorphism correlate with personality traits in young Korean female population, Am J Med Genet B Neuropsychiatr Genet, 118, 76, 10.1002/ajmg.b.10047 Strobel, 2003, Lack of association between polymorphisms of the dopamine D4 receptor gene and personality, Neuropsychobiology, 47, 52, 10.1159/000068876 Buskila, 2004, An association between fibromyalgia and the dopamine D4 receptor exon III repeat polymorphism and relationship to novelty seeking personality traits, Mol Psychiatry, 9, 730, 10.1038/sj.mp.4001573 Szekely, 2004, Human personality dimensions of persistence and harm avoidance associated with DRD4 and 5-HTTLPR polymorphisms, Am J Med Genet B Neuropsychiatr Genet, 126, 106, 10.1002/ajmg.b.20134 Tsai, 2004, Association study of catechol-O-methyltransferase gene and dopamine D4 receptor gene polymorphisms and personality traits in healthy young Chinese females, Neuropsychobiology, 50, 153, 10.1159/000079107 Eichhammer, 2005, Variation at the DRD4 promoter modulates extraversion in Caucasians, Mol Psychiatry, 10, 520, 10.1038/sj.mp.4001658 Golimbet, 2005, [Polymorphic markers of the dopamine D4 receptor gene promoter region and personality traits in mentally healthy individuals from the Russian population], Genetika, 41, 966 Golimbet, 2006, [Dopamine system genes and personality traits of extraversion and novelty seeking], Zh Vyssh Nerv Deiat Im I P Pavlova, 56, 457 Ham, 2006, Personality, dopamine receptor D4 exon III polymorphisms, and academic achievement in medical students, Neuropsychobiology, 53, 203, 10.1159/000094729 Serretti, 2006, Temperament and character in mood disorders: Influence of DRD4, SERTPR, TPH and MAO-A polymorphisms, Neuropsychobiology, 53, 9, 10.1159/000089916 Tochigi, 2006, Association between dopamine D4 receptor (DRD4) exon III polymorphism and neuroticism in the Japanese population, Neurosci Lett, 398, 333, 10.1016/j.neulet.2006.01.020 Ekelund, 1999, Association between novelty seeking and the type 4 dopamine receptor gene in a large Finnish cohort sample, Am J Psychiatry, 156, 1453 Elovainio, 2005, Does the level of LDL cholesterol moderate a relationship between DRD4 and novelty seeking?, Biol Psychol, 68, 79, 10.1016/j.biopsycho.2004.03.017 Elovainio, 2005, Relationship between DRD4 polymorphism and lipid metabolism: What is the role of novelty seeking?, Neuropsychobiology, 51, 53, 10.1159/000082856 Keltikangas-Jarvinen, 2003, Association between the type 4 dopamine receptor gene polymorphism and novelty seeking, Psychosom Med, 65, 471, 10.1097/01.PSY.0000041547.31072.25 Keltikangas-Jarvinen, 2004, Nature and nurture in novelty seeking, Mol Psychiatry, 9, 308, 10.1038/sj.mp.4001433 Lahti, 2005, Novelty seeking: Interaction between parental alcohol use and dopamine D4 receptor gene exon III polymorphism over 17 years, Psychiatr Genet, 15, 133, 10.1097/00041444-200506000-00010 Van Gestel, 2002, Epistatic effect of genes from the dopamine and serotonin systems on the temperament traits of novelty seeking and harm avoidance, Mol Psychiatry, 7, 448, 10.1038/sj.mp.4001005 Vandenbergh, 1997, No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore Longitudinal Study of Aging participants, Mol Psychiatry, 2, 417, 10.1038/sj.mp.4000309 Kim, 2006, Lack of association between polymorphisms of the dopamine receptor D4 and dopamine transporter genes and personality traits in a Korean population, Yonsei Med J, 47, 787, 10.3349/ymj.2006.47.6.787 Strobel, 2003, Further evidence for a modulation of novelty seeking by DRD4 exon III, 5-HTTLPR, and COMT val/met variants, Mol Psychiatry, 8, 371, 10.1038/sj.mp.4001253 Comings, 1999, Studies of the 48 bp repeat polymorphism of the DRD4 gene in impulsive, compulsive, addictive behaviors: Tourette syndrome, ADHD, pathological gambling, and substance abuse, Am J Med Genet, 88, 358, 10.1002/(SICI)1096-8628(19990820)88:4<358::AID-AJMG13>3.0.CO;2-G Munafo, 2007, Association of the DRD2 gene Taq1A polymorphism and alcoholism: A meta-analysis of case-control studies and evidence of publication bias, Mol Psychiatry, 12, 454, 10.1038/sj.mp.4001938 Munafo, 2004, Assessing publication bias in genetic association studies: Evidence from a recent meta-analysis, Psychiatry Res, 129, 39, 10.1016/j.psychres.2004.06.011 Ioannidis, 2001, Replication validity of genetic association studies, Nat Genet, 29, 306, 10.1038/ng749 Pergadia, 2006, Genetic and environmental influences on extreme personality dispositions in adolescent female twins, J Child Psychol Psychiatry, 47, 902, 10.1111/j.1469-7610.2005.01568.x Rende, 1993, Genetic and environmental influences on depressive symptomatology in adolescence: Individual differences and extreme scores, J Child Psychol Psychiatry, 34, 1387, 10.1111/j.1469-7610.1993.tb02097.x Munafo, 2005, Does measurement instrument moderate the association between the serotonin transporter gene and anxiety-related personality traits?, Mol Psychiatry, 10, 415, 10.1038/sj.mp.4001627 Schinka, 2004, A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety, Mol Psychiatry, 9, 197, 10.1038/sj.mp.4001405 Sen, 2004, Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits, Am J Med Genet B Neuropsychiatr Genet, 127, 85, 10.1002/ajmg.b.20158 Munafo, 2005, Promise and pitfalls in the meta-analysis of genetic association studies: A response to Sen and Schinka, Mol Psychiatry, 10, 895, 10.1038/sj.mp.4001706 Schinka, 2005, Measurement scale does moderate the association between the serotonin transporter gene and trait anxiety: Comments on Munafo et al, Mol Psychiatry, 10, 892, 10.1038/sj.mp.4001708 Sen, 2005, 5-HTTLPR and anxiety-related personality traits meta-analysis revisited: Response to Munafo and colleagues, Mol Psychiatry, 10, 893, 10.1038/sj.mp.4001705