Why are enzymes less active in organic solvents than in water?

1996 Wescott, 1994, Biochim. Biophys. Acta, 1206, 1, 10.1016/0167-4838(94)90065-5 Carrea, 1995, Trends Biotechnol., 13, 63, 10.1016/S0167-7799(00)88907-6 Zaks, 1988, J. Biol. Chem., 263, 3194, 10.1016/S0021-9258(18)69054-4 Zaks, 1988, J. Biol. Chem., 263, 8017, 10.1016/S0021-9258(18)68435-2 Margolin, 1996, Trends Biotechnol., 14, 223, 10.1016/0167-7799(96)10031-7 Boudart, 1973, 693 Kamat, 1992, Enzyme Microb. Technol., 14, 265, 10.1016/0141-0229(92)90149-I Wescott, 1993, J. Am. Chem. Soc., 115, 1629, 10.1021/ja00058a002 Wangikar, 1996, Biotechnol. Bioeng., 50, 329, 10.1002/(SICI)1097-0290(19960505)50:3<329::AID-BIT11>3.0.CO;2-I Schmitke, 1996, J. Am. Chem. Soc., 118, 3360, 10.1021/ja9539958 Lapanje, 1978 Fitzpatnck, 1993, 90, 8653 Fitzpatrick, 1994, Biochem. Biophys. Res. Commun., 198, 675, 10.1006/bbrc.1994.1098 Yennawar, 1994, Biochemistry, 33, 7326, 10.1021/bi00189a038 Griebenow, 1997, Biotechnol. Bioeng., 54 Dong, 1995, J. Pharm. Sci., 84, 415, 10.1002/jps.2600840407 Griebenow, 1995, 92, 10969 Fersht, 1985 Wangikar, 1995, Biochemistry, 34, 12302, 10.1021/bi00038a026 Xu, 1994, Biotechnol. Bioeng., 43, 515, 10.1002/bit.260430612 Rupley, 1991, Adv. Protein Chem., 41, 37, 10.1016/S0065-3233(08)60197-7 Gregory, 1995, 191 Affleck, 1992, 89, 5167 Zaks, 1985, 82, 3192 Bell, 1995, Trends Biotechnol., 13, 468, 10.1016/S0167-7799(00)89004-6 Kitaguchi, 1989, J. Am. Chem. Soc., 111, 9272, 10.1021/ja00208a044 Blackwood, 1994, Biochim. Biophys. Acta, 1206, 161, 10.1016/0167-4838(94)90203-8 Xu, 1996, J. Am. Chem. Soc., 118, 9815, 10.1021/ja961596m Dabulis, 1993, Biotechnol. Bioeng., 41, 566, 10.1002/bit.260410509 Khmelnitsky, 1994, J. Am. Chem. Soc., 116, 2647, 10.1021/ja00085a066 Russell, 1987, J. Biol. Chem., 263, 11624, 10.1016/S0021-9258(18)37828-1 Broos, 1995, J. Chem. Soc., Chem. Commun., 255, 10.1039/c39950000255 Okahata, 1992, Bull. Chem. Soc. Jpn., 65, 2411, 10.1246/bcsj.65.2411 Paradkar, 1994, J. Am. Chem. Soc., 116, 5009, 10.1021/ja00090a065 Almarsson, 1996, Biotechnol. Bioeng., 49, 87, 10.1002/(SICI)1097-0290(19960105)49:1<87::AID-BIT11>3.3.CO;2-R Mingarro, 1996, Biochemistry, 35, 9935, 10.1021/bi960191b