Antinociceptive potentiation and attenuation of tolerance by intrathecal β-arrestin 2 small interfering RNA in rats

Morgan, 1989, The rational use of intrathecal and extradural opioids, Br J Anaesth, 63, 165, 10.1093/bja/63.2.165

Martini, 2007, The role of mu opioid receptor desensitization and endocytosis in morphine tolerance and dependence, Curr Opin Neurobiol, 17, 556, 10.1016/j.conb.2007.10.004

Mayer, 1999, Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions, Proc Natl Acad Sci USA, 96, 7731, 10.1073/pnas.96.14.7731

Wong, 2000, Morphine tolerance increases [3H]MK 801 binding affinity and constitutive neuronal nitric oxide synthase expression in rat spinal cord, Br J Anaesth, 85, 587, 10.1093/bja/85.4.587

Mao, 2002, Chronic morphine induces downregulation of spinal glutamate transporters: implications in morphine tolerance and abnormal pain sensitivity, J Neurosci, 22, 8312, 10.1523/JNEUROSCI.22-18-08312.2002

Gintzler, 2000, Opioid tolerance and the emergence of new opioid receptor-coupled signaling, Mol Neurobiol, 21, 21, 10.1385/MN:21:1-2:021

Whistler, 1998, Morphine-activated opioid receptors elude desensitization by beta-arrestin, Proc Natl Acad Sci USA, 95, 9914, 10.1073/pnas.95.17.9914

Bohn, 1999, Enhanced morphine analgesia in mice lacking beta-arrestin 2, Science, 286, 2495, 10.1126/science.286.5449.2495

Attramadal, 1992, Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family, J Biol Chem, 267, 17882, 10.1016/S0021-9258(19)37125-X

Sterne-Marr, 1995, Regulation of G protein-coupled receptors by receptor kinases and arrestins, Vitam Horm, 51, 193, 10.1016/S0083-6729(08)61039-0

Bohn, 2002, Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice, J Neurosci, 22, 10494, 10.1523/JNEUROSCI.22-23-10494.2002

Ohsawa, 2003, Involvement of beta-arrestin-2 in modulation of the spinal antinociception induced by mu-opioid receptor agonists in the mouse, Neurosci Lett, 346, 13, 10.1016/S0304-3940(03)00591-3

Przewlocka, 2002, Knockdown of spinal opioid receptors by antisense targeting beta-arrestin reduces morphine tolerance and allodynia in rat, Neurosci Lett, 325, 107, 10.1016/S0304-3940(02)00246-X

Lin, 2003, Antinociceptive potentiation and attenuation of tolerance by intrathecal electric stimulation in rats, Anesth Analg, 96, 1711, 10.1213/01.ANE.0000061471.11925.73

Ahn, 2003, Desensitization, internalization, and signaling functions of beta-arrestins demonstrated by RNA interference, Proc Natl Acad Sci USA, 100, 1740, 10.1073/pnas.262789099

Ahn, 2004, Phosphorylation of serine 2 within the RNA polymerase II C-terminal domain couples transcription and 3′ end processing, Mol Cell, 13, 67, 10.1016/S1097-2765(03)00492-1

Zhang, 1998, Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness, Proc Natl Acad Sci USA, 95, 7157, 10.1073/pnas.95.12.7157

Lowe, 2002, Mu-opioid receptors desensitize less rapidly than delta-opioid receptors due to less efficient activation of arrestin, J Biol Chem, 277, 15729, 10.1074/jbc.M200612200

Bohn, 2000, Mu-opioid receptor desensitization by beta-arrestin-2 determines morphine tolerance but not dependence, Nature, 408, 720, 10.1038/35047086

Raehal, 2011, The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics, Neuropharmacology, 60, 58, 10.1016/j.neuropharm.2010.08.003

Bohn, 2004, Relative opioid efficacy is determined by the complements of the G protein-coupled receptor desensitization machinery, Mol Pharmacol, 66, 106, 10.1124/mol.66.1.106

Zuo, 2005, The role of opioid receptor internalization and beta-arrestins in the development of opioid tolerance, Anesth Analg, 101, 728, 10.1213/01.ANE.0000160588.32007.AD

Kissin, 2009, Patient-controlled-analgesia analgesimetry and its problems, Anesth Analg, 108, 1945, 10.1213/ane.0b013e3181a1a481

Bailey, 2005, Opioids: cellular mechanisms of tolerance and physical dependence, Curr Opin Pharmacol, 5, 60, 10.1016/j.coph.2004.08.012

Dietis, 2009, Simultaneous targeting of multiple opioid receptors: a strategy to improve side-effect profile, Br J Anaesth, 103, 38, 10.1093/bja/aep129

Christie, 1997, Where is the locus in opioid withdrawal?, Trends Pharmacol Sci, 18, 134, 10.1016/S0165-6147(97)01045-6

Liu, 2009, Effect of fentanyl on expression of mu-receptor and beta-arrestin 2 in periaqueductal gray of rats tolerant to morphine, Zhonghua Yi Xue Za Zhi, 89, 1356

Li, 2009, Improvement of morphine-mediated analgesia by inhibition of beta-arrestin 2 expression in mice periaqueductal gray matter, Int J Mol Sci, 10, 954, 10.3390/ijms10030954

Jiang, 2006, Decreased morphine analgesia in rat overexpressing beta-arrestin 2 at periaqueductal gray, Neurosci Lett, 400, 150, 10.1016/j.neulet.2006.02.071

Miyamoto, 1993, Sites of action of naloxone in precipitating withdrawal jumping in morphine-dependent mice: investigations by the ED50 value and CNS content of naloxone, Drug Alcohol Depend, 32, 163, 10.1016/0376-8716(93)80009-4

Delander, 1983, Spinal antagonism of tolerance and dependence induced by systemically administered morphine, Eur J Pharmacol, 94, 35, 10.1016/0014-2999(83)90439-9

Bell, 1986, Electrophysiological evidence for a presynaptic mechanism of morphine withdrawal in the neonatal rat spinal cord, Brain Res, 382, 299, 10.1016/0006-8993(86)91339-9

Hao, 2009, Transgene-mediated enkephalin expression attenuates signs of naloxone-precipitated morphine withdrawal in rats with neuropathic pain, Behav Brain Res, 197, 84, 10.1016/j.bbr.2008.08.005

Ohyama, 2009, Unraveling inner ear induction by gene manipulation using Pax2-Cre BAC transgenic mice, Brain Res, 1277, 84, 10.1016/j.brainres.2009.02.036