Leucine Stimulates Translation Initiation in Skeletal Muscle of Postabsorptive Rats via a Rapamycin-Sensitive Pathway

The Journal of Nutrition - Tập 130 - Trang 2413-2419 - 2000
Joshua C. Anthony1, Fumiaki Yoshizawa1, Tracy Gautsch Anthony1, Thomas C. Vary1, Leonard S. Jefferson1, Scot R. Kimball1
1Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033

Tài liệu tham khảo

Anthony, 2000, Orally administered leucine stimulates protein synthesis in skeletal muscle of postabsorptive rats in association with increased eIF4F formation, J. Nutr, 130, 139, 10.1093/jn/130.2.139 Anthony, 1999, Leucine supplementation enhances skeletal muscle recovery in rats following exercise, J. Nutr, 129, 1102, 10.1093/jn/129.6.1102 Bu, 1993, Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes the interactions of the p25 and p220 subunits, J. Biol. Chem, 268, 4975, 10.1016/S0021-9258(18)53491-8 Burnett, 1998, RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1, Proc. Natl. Acad. Sci. U.S.A, 95, 1432, 10.1073/pnas.95.4.1432 Buse, 1979, In vitro effect of branched chain amino acids on the ribosomal cycle in muscles of fasted rats, Horm. Metab. Res, 11, 289 Buse, 1975, Leucine: a possible regulator of protein turnover in muscle, J. Clin. Investig, 56, 1250, 10.1172/JCI108201 Cheatham, 1994, Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70S6 kinase, DNA synthesis, and glucose transporter translocation, Mol. Cell. Biol, 14, 4902 Chung, 1994, PDGF- and insulin-dependent pp70S6k activation mediated by phosphatidylinositol-3-OH kinase, Nature (Lond.), 370, 71, 10.1038/370071a0 Garlick, 1980, A rapid and convenient technique for measuring the rate of protein synthesis in tissues by injection of [3H] phenylalanine, Biochem. J, 192, 719, 10.1042/bj1920719 Gautsch, 1998, Eukaryotic initiation factor 4E availability regulates skeletal muscle protein synthesis during recovery from exercise, Am. J. Physiol, 274, C406, 10.1152/ajpcell.1998.274.2.C406 Hara, 1998, Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 trough a common effector mechanism, J. Biol. Chem, 273, 14484, 10.1074/jbc.273.23.14484 Kimball, 1997, Insulin stimulates protein synthesis in skeletal muscle by enhancing the association of eIF4E and eIF4G, Am. J. Physiol, 272, C754, 10.1152/ajpcell.1997.272.2.C754 Kimball, 1999, Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6, J. Biol. Chem, 274, 11647, 10.1074/jbc.274.17.11647 Kimball, 1992, Age-dependent decrease in the amount of eukaryotic initiation factor 2 in various tissues, Biochem. J, 286, 263, 10.1042/bj2860263 Li, 1978, Influence of amino acid availability on protein turnover in perfused skeletal muscle, Biochem. Biophys. Acta, 544, 351, 10.1016/0304-4165(78)90103-4 Lynch, 2000, Regulation of amino acid-sensitive TOR signaling by leucine analogs in adipocytes, J. Cell. Biochem, 77, 234, 10.1002/(SICI)1097-4644(20000501)77:2<234::AID-JCB7>3.0.CO;2-I MacLean, 1991, Plasma and muscle amino acid and ammonia responses during prolonged exercise in humans, J. Appl. Physiol, 70, 2095, 10.1152/jappl.1991.70.5.2095 Minich, 1994, Chromatographic resolution of in vivo phosphorylated and non-phosphorylated eukaryotic translation initiation factor eIF4E: increased cap affinity of the phosphorylated form, Proc. Natl. Acad. Sci. U.S.A, 91, 7668, 10.1073/pnas.91.16.7668 Nagasawa, 1996, Plasma Nτ-methylhistidine concentration is a sensitive index of myofibrillar protein degradation during starvation in rats, Biosci. Biotechnol. Biochem, 60, 501, 10.1271/bbb.60.501 Pain, 1996, Initiation of protein synthesis in eukaryotic cells, Eur. J. Biochem, 236, 747, 10.1111/j.1432-1033.1996.00747.x Patti, 1998, Bidirectional modulation of insulin action by amino acids, J. Clin. Investig, 101, 1519, 10.1172/JCI1326 Shigemitsu, 1999, Structural requirement of leucine for activation of p70 S6 kinase, FEBS Lett, 447, 303, 10.1016/S0014-5793(99)00304-X Sonenberg, N. (1996) mRNA 59 cap-binding protein eIF4E and control of cell growth. In: Translational Control (Hershey, J.W.B., Mathews, M. B., & Sonenberg, N., eds.), pp. 245–289. Cold Spring Harbor Laboratory Press, Plainview, NY. Voorma, 1994, Initiation of protein synthesis in eukaryotes, Mol. Biol. Rep, 19, 139, 10.1007/BF00986956 Xu, 1998, Branched-chain amino acids are essential in the regulation of PHAS-I and p70 S6 kinase by pancreatic β-cells, J. Biol. Chem, 273, 28178, 10.1074/jbc.273.43.28178 Yoshizawa, 1995, Translational regulation of protein synthesis in the liver and skeletal muscle of mice in response to refeeding, J. Nutr. Biochem, 6, 130, 10.1016/0955-2863(95)00018-U Yoshizawa, 1997, Modulation of translation initiation in rat skeletal muscle and liver in response to food-intake, Biochem. Biophys. Res. Commun, 240, 825, 10.1006/bbrc.1997.7652 Yoshizawa, 1998, Effect of dietary protein on translation initiation in rat skeletal muscle and liver, Am. J. Physiol, 275, E814