Gut Microbial Carbohydrate Metabolism Hinders Weight Loss in Overweight Adults Undergoing Lifestyle Intervention With a Volumetric Diet

Aune, 2016, BMI and all cause mortality: systematic review and non-linear dose-response meta-analysis of 230 cohort studies with 3.74 million deaths among 30.3 million participants, BMJ, 353, i2156, 10.1136/bmj.i2156 Knowler, 2002, Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin, N Engl J Med, 346, 393, 10.1056/NEJMoa012512 Magkos, 2016, Effects of moderate and subsequent progressive weight loss on metabolic function and adipose tissue biology in humans with obesity, Cell Metab, 23, 591, 10.1016/j.cmet.2016.02.005 Wright, 2013, Program compliance, weight loss and health profile changes in WHO obesity classes after very low energy dietary intervention, Global Epidemic Obes, 1, 4, 10.7243/2052-5966-1-4 Heymsfield, 2017, Mechanisms, pathophysiology, and management of obesity, N Engl J Med, 376, 254, 10.1056/NEJMra1514009 Fernandes, 2014, Adiposity, gut microbiota and faecal short chain fatty acids are linked in adult humans, Nutr Diabetes, 4, e121, 10.1038/nutd.2014.23 Vrieze, 2012, Transfer of intestinal microbiota from lean donors increases insulin sensitivity in individuals with metabolic syndrome, Gastroenterology, 143, 913, 10.1053/j.gastro.2012.06.031 Ello-Martin, 2005, The influence of food portion size and energy density on energy intake: implications for weight management, Am J Clin Nutr, 82, 236S, 10.1093/ajcn/82.1.236S Look AHEAD Research Group, 2006, Obesity (Silver Spring), 14, 737, 10.1038/oby.2006.84 Caporaso, 2010, QIIME allows analysis of high-throughput community sequencing data, Nat Methods, 7, 335, 10.1038/nmeth.f.303 Langille, 2013, Predictive functional profiling of microbial communities using 16S rRNA marker gene sequences, Nat Biotechnol, 31, 814, 10.1038/nbt.2676 Kanehisa, 2000, KEGG: Kyoto Encyclopedia of Genes and Genomes, Nucleic Acids Res, 28, 27, 10.1093/nar/28.1.27 Tatusov, 2000, The COG database: a tool for genome-scale analysis of protein functions and evolution, Nucleic Acids Res, 28, 33, 10.1093/nar/28.1.33 Lombard, 2014, The Carbohydrate-Active Enzymes database (CAZy) in 2013, Nucleic Acids Res, 42, D490, 10.1093/nar/gkt1178 Segata, 2011, Metagenomic biomarker discovery and explanation, Genome Biol, 12, R60, 10.1186/gb-2011-12-6-r60 Wu, 2017, Phascolarctobacterium faecium abundant colonization in human gastrointestinal tract, Exp Ther Med, 14, 3122, 10.3892/etm.2017.4878 Lecomte, 2015, Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters, PLoS One, 10, e0126931, 10.1371/journal.pone.0126931 Contreras, 2000, Importance of Dialister pneumosintes in human periodontitis, Oral Microbiol Immunol, 15, 269, 10.1034/j.1399-302x.2000.150410.x Doan, 2000, Molecular identification of Dialister pneumosintes in subgingival plaque of humans, J Clin Microbiol, 38, 3043, 10.1128/JCM.38.8.3043-3047.2000 Wade, 1997, Molecular detection of novel anaerobic species in dentoalveolar abscesses, Clin Infect Dis, 25, S235, 10.1086/516215 Gregg, 2008, Divergent modes of glycan recognition by a new family of carbohydrate-binding modules, J Biol Chem, 283, 12604, 10.1074/jbc.M709865200 Koropatkin, 2010, SusG: a unique cell-membrane-associated α-amylase from a prominent human gut symbiont targets complex starch molecules, Structure, 18, 200, 10.1016/j.str.2009.12.010 Nagy, 2002, The membrane-bound α-glucuronidase from Pseudomonas cellulosa hydrolyzes 4-O-methyl-d-glucuronoxylooligosaccharides but not 4-O-methyl-d-glucuronoxylan, J Bacteriol, 184, 4925, 10.1128/JB.184.17.4925-4929.2002 Carapito, 2009, Molecular basis of arabinobio-hydrolase activity in phytopathogenic fungi: crystal structure and catalytic mechanism of Fusarium graminearum GH93 exo-α-l-arabinanase, J Biol Chem, 284, 12285, 10.1074/jbc.M900439200 Yatsunenko, 2012, Human gut microbiome viewed across age and geography, Nature, 486, 222, 10.1038/nature11053