A multicentre randomized controlled trial of moderate hypothermia to prevent intracranial hypertension in acute liver failure

Bernal, 2013, Acute liver failure, N Engl J Med, 369, 2525, 10.1056/NEJMra1208937 Stravitz, 2007, Intensive care of patients with acute liver failure: recommendations of the U.S. Acute Liver Failure Study Group, Crit Care Med, 35, 2498, 10.1097/01.CCM.0000287592.94554.5F Vaquero, 2012, Therapeutic hypothermia in the management of acute liver failure, Neurochem Int, 60, 723, 10.1016/j.neuint.2011.09.006 Traber, 1989, Effect of body temperature on brain edema and encephalopathy in the rat after hepatic devascularization, Gastroenterology, 96, 885, 10.1016/S0016-5085(89)80092-7 Cordoba, 1999, Mild hypothermia modifies ammonia-induced brain edema in rats after portacaval anastomosis, Gastroenterology, 116, 686, 10.1016/S0016-5085(99)70191-5 Rose, 2000, Mild hypothermia delays the onset of coma and prevents brain edema and extracellular brain glutamate accumulation in rats with acute liver failure, Hepatology, 31, 872, 10.1053/he.2000.5923 Jalan, 2004, Moderate hypothermia in patients with acute liver failure and uncontraolled intracranial hypertension, Gastroenterology, 127, 1338, 10.1053/j.gastro.2004.08.005 Jalan, 1999, Moderate hypothermia for uncontrolled intracranial hypertension in acute liver failure, Lancet, 354, 1164, 10.1016/S0140-6736(98)12440-6 Jalan, 2001, Restoration of cerebral blood flow autoregulation and reactivity to carbon dioxide in acute liver failure by moderate hypothermia, Hepatology, 34, 50, 10.1053/jhep.2001.25386 Stravitz, 2009, Therapeutic hypothermia for acute liver failure, Crit Care Med, 37, S258, 10.1097/CCM.0b013e3181aa5fb8 Crossley, 2014, A systematic review of therapeutic hypothermia for adult patients following traumatic brain injury, Crit Care, 18, R75, 10.1186/cc13835 Kim, 2014, Effect of prehospital induction of mild hypothermia on survival and neurological status among adults with cardiac arrest: a randomized clinical trial, JAMA, 311, 45, 10.1001/jama.2013.282173 Perman, 2014, Clinical applications of targeted temperature management, Chest, 145, 386, 10.1378/chest.12-3025 Nielsen, 2013, Targeted temperature management at 33°C versus 36°C after cardiac arrest, N Engl J Med, 369, 2197, 10.1056/NEJMoa1310519 Polderman, 2004, Application of therapeutic hypothermia in the intensive care unit. Opportunities and pitfalls of a promising treatment modality–Part 2: practical aspects and side effects, Intensive Care Med, 30, 757, 10.1007/s00134-003-2151-y Kuchena, 2014, Postcardiac arrest temperature management: infectious risks, Curr Opin Crit Care, 20, 507, 10.1097/MCC.0000000000000125 Larsen, 2016, High-volume plasma exchange in patients with acute liver failure: an open randomised controlled trial, J Hepatol, 64, 69, 10.1016/j.jhep.2015.08.018 Lee, 2009, Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure, Gastroenterology, 137, 856, 10.1053/j.gastro.2009.06.006 Bernal, 2007, Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure, Hepatology, 46, 1844, 10.1002/hep.21838 Kitzberger, 2009, Severity of organ failure is an independent predictor of intracranial hypertension in acute liver failure, Clin Gastroenterol Hepatol, 7, 1000, 10.1016/j.cgh.2009.05.019 Campbell, 1995, Estimating sample sizes for binary, ordered categorical, and continuous outcomes in two group comparisons, BMJ, 311, 1145, 10.1136/bmj.311.7013.1145 Vaquero, 2003, Infection and the progression of hepatic encephalopathy in acute liver failure, Gastroenterology, 125, 755, 10.1016/S0016-5085(03)01051-5 Wendon, 1994, Cerebral blood flow and metabolism in fulminant liver failure, Hepatology, 19, 1407, 10.1002/hep.1840190614 Slack, 2014, Ammonia clearance with haemofiltration in adults with liver disease, Liver Int, 34, 42, 10.1111/liv.12221 Murphy, 2004, The effect of hypertonic sodium chloride on intracranial pressure in patients with acute liver failure, Hepatology, 39, 464, 10.1002/hep.20056 Belanger, 2006, Neurobiological characterization of an azoxymethane mouse model of acute liver failure, Neurochem Int, 48, 434, 10.1016/j.neuint.2005.11.022 Sawara, 2009, Alterations in expression of genes coding for proteins of the neurovascular unit in ischemic liver failure, Neurochem Int, 55, 119, 10.1016/j.neuint.2009.01.023 Jalan, 2004, Moderate hypothermia in patients with acute liver failure and uncontrolled intracranial hypertension, Gastroenterology, 127, 1338, 10.1053/j.gastro.2004.08.005 Geurts, 2014, Therapeutic hypothermia and the risk of infection: a systematic review and meta-analysis, Crit Care Med, 42, 231, 10.1097/CCM.0b013e3182a276e8 Karvellas, 2015, Therapeutic hypothermia in acute liver failure: a multicenter retrospective cohort analysis, Liver Transpl, 21, 4, 10.1002/lt.24021 Germani, 2012, Liver transplantation for acute liver failure in Europe: outcomes over 20 years from the ELTR database, J Hepatol, 57, 288, 10.1016/j.jhep.2012.03.017 Bernal, 2009, Outcome after wait-listing for emergency liver transplantation in acute liver failure: a single centre experience, J Hepatol, 50, 306, 10.1016/j.jhep.2008.09.012