The incretin concept today

W. Creutzfeldt1
1Medizinische Universitätsklinik, Robert-Koch-Straße 40, D-3400, Göttingen, Federal Republic of Germany

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Bernard, C.: Leçons sur le diabète. Paris: J. B. Baillère 1877

Scow, R.O., Cornfield, J.: Quantitative relations between the oral and intravenous glucose tolerance curves. Am. J. Physiol.179, 435?438 (1954)

Moore, B., Edie, D.S., Abram, D.H.: On the treatment of diabetes mellitus by acid extract of duodenal mucous membrane. Biochem. J.1, 28?38 (1906)

Zunz, E., La Barre, J.: Contributions à l'étude des variations physiologiques de la sécrétion interne du pancréas: relations entre les sécretions externe et interne du pancréas. Arch. Int. Physiol. Biochim.31, 20?44 (1929)

La Barre, J., Still, D.U.: Studies on the physiology of secretin. III Further studies on the effects of secretin on the blood sugar. Am. J. Physiol.91, 649?653 (1930)

La Barre, J.: La sécretine: Son rôle physiologique, ses propriétés thérapeutiques. Paris: Masson 1936

Heller, H.: Über den blutzuckerwirksamen Stoff im Sekretinextrakten. Naunyn Schmiedebergs Arch. Pharmacol.145, 343?358 (1929)

Heller, H.: Über das insulinotrope Hormon der Darmschleimhaut (Duodenin). Naunyn Schmiedebergs Arch. Pharmacol.177, 127?133 (1935)

McIntyre, N., Holdsworth, D.D., Turner, D.S.: New interpretation of oral glucose tolerance. LancetII 1964, 20?21

Elrick, H., Stimmler, L., Hlad, D.J., Arai, Y.: Plasma insulin responses to oral and intravenous glucose administration. J. Clin. Endocrinol. Metab.24, 1076?1082 (1964)

Perley, D.J., Kipnis, D.M.: Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J. Clin. Invest.46, 1954?1962 (1967)

Unger, D.H., Eisentraut, D.M.: Entero-insular axis. Arch. Intern. Med.123, 261?266 (1969)

Bernard, C.: Chiens rendus diabetique. C. R. Soc. Biol. (Paris)1, 60 (1849)

Woods, D.C., Porte jr., D.: Neural control of the endocrine pancreas. Physiol. Rev.54, 596?619 (1974)

La Barre, J.: Sur l'augmentation de la teneur en insuline du sang veineux pancréatique après excitation du nerf vague. C. R. Soc. Biol. (Paris)96, 193?196 (1927)

Bloom, D.R.(ed.): Gut hormones. Edinburgh: Churchill Livingstone 1978

Daniel, D.E.: Peptidergic nerves in the gut. Gastroenterology75, 142?144 (1978)

Creutzfeldt, W.: Effects of gastrointestinal hormones ? physiological or pharmacological? In: Stimulus-secretion coupling in the gastrointestinal tract. Case, D.M., Goebell, H. (Eds.), pp. 415?428. Lancaster: MTP 1976

Larsson, L.-I, Fahrenkrug, J., Holst, D.J., Schaffalitzky de Muckadell, O.B.: Innervation of the pancreas by vasoactive intestinal polypeptide (VIP) immunoreactive nerves. Life Sci.22, 773?780 (1978)

Ohneda, A., Ishii, S., Horigome, K., Chiba, M., Sakai, T., Kai, Y., Watanabe, K., Yamagata, S.: Effect of intrapancreatic administration of vasoactive intestinal peptide upon the release of insulin and glucagon in dogs. Horm. Metab. Res.9, 447?452 (1977)

Schebalin, M., Said, D.I., Makhlouf, M.: Stimulation of insulin und glucagon secretion by vasoactive intestinal peptide. Am. J. Physiol.232, E197-E200 (1977)

Bataille, D., Jarrousse, C., Vauclin, N., Gespach, C., Rosselin, G.: Effect of vasoactive intestinal peptide (VIP) and gastric inhibitory peptide (GIP) on insulin and glucagon release by perifused newborn rat pancreas. In: Glucagon. Foa, P.P., Bajaj, J.S., Foa, N.L. (Eds.), pp. 255?269. New York, Heidelberg, Berlin: Springer 1977

Jakob, A., Largiadèr, F., Froesch, D.R.: Glucose turnover and insulin secretion in dogs with orthotopic pancreatic allograft. Diabetologia6, 441?444 (1970)

Lindkaer Jensen, S., Vagn Nielsen, O., Kühl, C.: The enteral insulin-stimulation after pancreas transplantation in the pig. Diabetologia12, 617?620 (1976)

Creutzfeldt, W., Feurle, G., Ketterer, H.: Effect of gastrointestinal hormones on insulin and glucagon secretion. N. Engl. J. Med.282, 1139?1141 (1970)

Rehfeld, D.F.: Gastrointestinal hormones and insulin secretion. Scand. J. Gastroenterol.7, 289?292 (1972)

Creutzfeldt, W.: Insulin-releasing factors of the gastroinestinal mucosa (incretin). Gastroenterology67, 748?750 (1974)

Moody, D.J.: Insulin releasing polypeptides. In: Diabetes. Bajaj, D.S. (Ed.), pp. 76?82. Amsterdam: Excerpta Medica Intern. Congr. Ser.413, 1977

Brown, D.C., Otte, D.C.: Gastrointestinal hormones and the control of insulin secretion. Diabetes27, 782?787 (1978)

Schaffalitzky de Muckadell, O.B., Fahrenkrug, J., Holst, D.J., Lauritsen, D.B.: Release of vasoactive intestinal polypeptide (VIP) by intraduodenal stimuli. Scand. J. Gastroenterol.12, 793?799 (1977)

Moody, D.J., Jacobsen, H., Sundby, F.: Gastric glucagon and gut glucagon-like immunoreactants. In: Gut hormones. Bloom, D.R. (Ed.), pp 369?378. Edinburgh: Churchill Livingstone 1978

Moody, D.J., Sundby, F., Jacobsen, H., Lauritsen, D.B.: The tissue distribution and plasma levels of glicentin (gut GLI-I). Scand. J. Gastroenterol. [Suppl. 49]13, 127 (1978)

Rehfeld, D.F., Stadil, F.: The effect of gastrin on basal- and glucose-stimulated insulin secretion in man. J. Clin. Invest.52, 1415?1426 (1973)

Fahrenkrug, J., Schaffalitzky de Muckadell, O.B., Kühl, C.: Effect of secretin on basal- and glucose stimulated insulin secretion in man. Diabetologia14, 229?234 (1978)

Dupré, J., Ross, D.A., Watson, D., Brown, D.C.: Stimulation of insulin secretion by gastric inhibitory polypeptide in man. J. Clin. Endocrinol. Metab.37, 826?828 (1973)

Brown, D.C., Dryburgh, D.R., Ross, D.A., Dupré, J.: Identification and actions of gastric inhibitory polypeptide. Recent Prog. Horm. Res.31, 487?532 (1975)

Andersen, D.K., Elahi, D., Brown, D.C., Debas, D.T., Tobin, D.D., Andres, R.: Insulin and glucagon responses to infusion of gastric inhibitory polypeptide (GIP) in man during controlled glycemia. Scand. J. Gastroenterol. [Suppl. 49]13, 7 (1978)

Rehfeld, D.F., Stadil, F.: The glucose-induced gastrointestinal stimulation of insulin secretion in man: relation to age and to gastrin release. Eur. J. Clin. Invest.5, 273?283 (1975)

Rehfeld, D.F., Holst, D.J., Kühl, C.: The effect of gastrin on basal and aminoacid-stimulated insulin and glucagon secretion in man. Eur. J. Clin. Invest8, 5?9 (1978)

Pederson, D.A., Schubert, D.E., Brown, D.C.: Gastric inhibitory polypeptide. Its physiologic release and insulinotropic action in the dog. Diabetes24, 1050?1056 (1975)

Arnold, R., Ebert, R., Creutzfeldt, W., Becker, D.D., Börger, H.: Inhibition of gastric acid secretion by gastric inhibitory polypeptide (GIP) in man. Scand. J. Gastroenterol. [Suppl. 49]13, 11 (1978)

Rabinovitch, A., Dupré, J.: Effects of the gastric inhibitory polypeptide present in impure pancreozymin-cholecystokinin on plasma insulin and glucagon in the rat. Endocrinology94, 1139?1144 (1974)

Danielsson, Å., Lernmark, Å.: Effects of pancreozymin and secretin on insulin release and the role of the exocrine pancreas. Diabetologia10, 407?409 (1974)

Agosti, A., Bertaccini, G., de Caro, G., Improta, G., Melchiorri, P., Sopranzi, N.: Insulin stimulating effect of some caerulein-like peptides in the dog. Pharmacol. Res. Commun.2, 49?53 (1970)

Ohneda, A., Horigome, K., Ishii, S., Kai, Y., Chiba, M.: Effect of caerulein upon insulin and glucagon secretion in dog. Horm. Metab. Res.10, 7?11 (1978)

Rehfeld, D.F.: Effect of gastrin and its C-terminal tetrapeptide on insulin secretion in man. Acta Endocrinol. (Kbh.)66, 169?176 (1971)

Thomas, D.B., Sinar, D., Mazzaferri, D.L., Cataland, S., Mekhjian, D.S., Caldwell, D.H., Fromkes, D.J.: Selective release of gastric inhibitory polypeptide by intraduodenal amino acid perfusion in man. Gastroenterology74, 1261?1265 (1978)

Schauder, P., Brown, D.C., Frerichs, H., Creutzfeldt, W.: Gastric inhibitory polypeptide: effect on glucose-induced insulin release from isolated rat pancreatic islets in vitro. Diabetologia11, 483?484 (1975)

Pederson, D.A., Brown, D.C.: The insulinotropic action of gastric inhibitory polypeptide in the perfused isolated rat pancreas. Endocrinology99, 780?785 (1976)

Brown, D.C., Pedersen, D.A.: GI hormones and insulin secretion. In: Endocrinology. roceedings of the Vth International Congress of Endocrinology, Vol. 2, pp. 568?570. Amsterdam: Excerpta Medica 1977

Cleator, D.G.M., Gourlay, D.H.: Release of immunoreactive gastric inhibitory polypeptide (IR-GIP) by oral ingestion of food substances. Am. J. Surg.130, 128?135 (1975)

Falko, D.M., Crockett, D.E., Cataland, S., Mazzaferri, D.L.: Gastric inhibitory polypeptide (GIP) stimulated by fat ingestion in man. J. Clin. Endocrinol. Metab.41, 260?265 (1975)

Thomas, D.B., Mazzaferri, D.L., Crockett, D.E., Mekhjian, D.S., Gruemer, D.D., Cataland, S.: Stimulation of secretion of gastric inhibitory polypeptide and insulin by intraduodenal amino acid perfusion. Gastroenterology70, 523?527 (1976)

Tbert, R., Illmer, K., Creutzfeldt, W.: Release of gastric inhibitory polypeptide (GIP) by intraduodenal acidification in rat and man and abolishment of the incretin effect of acid by GIP-antiserum in rats. Gastroenterology (in press)

Finke, U., Ebert, R., Creutzfeldt, W.: Different forms of immunoreactive gastric inhibitory polypeptide (IR-GIP) in human serum and intestinal mucosa. Diabetologa15, 32 (1978)

Shay, H., Gershon-Cohen, J., Fels, D.S.: The effect of duodenal stimulation in man upon alimentary and adrenaline hyperglycemia. Ann. Intern. Med.11, 1563?1589 (1938)

Dupré, J., Curtis, D.D., Unger, D.H., Waddell, D.W., Beck, D.C.: Effects of secretin, pancreozymin, or gastrin on the response of the endocrine pancreas to administration of glucose or arginine in man. J. Clin. Invest.48, 745?757 (1969)

Creutzfeldt, W., Ebert, R., Arnold, R., Frerichs, H., Brown, D.C.: Gastric inhibitory polypeptide (GIP), gastrin and insulin: response to test meal in coeliac disease and after duodenopancreatectomy. Diabetologia12, 279?286 (1976)

Creutzfeldt, W., Ebert, R.: Release of gastric inhibitory polypeptide (GIP) to a test meal under normal and pathological conditions in man. In: Diabetes. Bajaj, J. S. (Ed.), pp. 63?75. Amsterdam: Excerpta Medica Intern. Congr. Ser. 413, 1977

Ebert, R., Creutzfeldt, W.: Aspect of GIP pathology. In: Gut hormones. Bloom, D.R. (Ed.), pp. 294?300. Edinburgh: Churchill Livingstone 1978

Puls, W., Keup, U., Krause, D.P., Thomas, G., Hoffmeister, F.: Glucosidase inhibition. Naturwissenschaften64, 36 (1977)

Schmidt, D.D., Frommer, W., Junge, B., Müller, I., Wingen der, W., Truscheit, E., Schäfer, D.:?-glucosidase inhibitors. Naturwissenschaften64, 535?536 (1977)

Crockett, D.E., Cataland, S., Falko, D.M., Mazzaferri, D.L.: The insulinotropic effect of endogenous gastric inhibitory polypeptide in normal subjects. J. Clin. Endocrinol. Metab.42, 1098?1103 (1976)

Andersen, D.K., Elahi, D., Brown, D.C., Tobin, D.D., Andres, R.: Oral glucose augmentation of insulin secretion. J. Clin. Invest.62, 152?161 (1978)

Ebert, R., Creutzfeldt, W., Talaulicar, M., Willms, B.: Inhibition of fat, but not glucose induced release of gastric inhibitory polypeptide (GIP) by insulin or glucose. Diabetologia15, 229 (1978)

Lammer, D.N., Mazzaferri, D.L., Cataland, S., Mekhjian, D.S.: Effect of atropine on glucose-stimulated gastric inhibitory polypeptide. Diabetes27, 638?642 (1978)

Henderson, D.R., Jefferys, D.B., Jones, D.H., Stanley, D.: The effect of atropine on the insulin release caused by oral and intravenous glucose in human subjects. Acta Endocrinol. (Kbh.)83, 772?780 (1976)

Arnold, R., Creutzfeldt, W., Ebert, R., Becker, D.D., Börger, D.W., Schafmayer, A.: Serum gastric inhibitory polypeptide (GIP) in duodenal ulcer disease: relationship to glucose tolerance, insulin and gastrin release. Scand. J. Gastroenterol.13, 41?47 (1978)

Cataland, S., O'Dorisio, D.M., Brooks, R., Mekhjian, D.S.: Stimulation of gastric inhibitory polypeptide in normal and duodenal ulcer patients. Gastroenterology73, 19?22 (1977)

Lauritsen, K.B., Moody, A.J.: The response of gastric inhibitory polypeptide (GIP) and insulin to glucose in duodenal ulcer patients. Diabetologia14, 149?153 (1978)

Buchanan, D.D., McKiddie, D.T., Lindsay, D.C., Manderson, D.G.: Carbohydrate metabolism in duodenal ulcer patients. Gut8, 325?331 (1967)

Humphrey, D.S., Dykes, D.R.W., Johnston, D.: Glucose tolerance and insulin secretion in patients with chronic duodenal ulcer. Br. Med. J.1972 IV, 393?396

Crockett, D.E., Mazzaferri, D.L., Cataland, S.: Gastric inhibitory polypeptide in maturity-onset diabetes mellitus. Diabetes25, 931?935 (1976)

Bloom, D.R.: GIP in diabetes. Diabetologia11, 334 (1975)

Ross, D.A., Brown, D.C., Dupré, J.: Hypersecretion of gastric inhibitory polypeptide following oral glucose in diabetes mellitus. Diabetes26, 525?529 (1977)

Ebert, R., Frerichs, H., Creutzfeldt, W.: Serum gastric inhibitory polypeptide (GIP) response in patients with maturity onset diabetes and in juvenile diabetics. Diabetologia12, 388 (1976)

Ebert, R., Willms, B., Brown, J.C., Creutzfeldt, W.: Serum gastric inhibitory polypeptide (GIP) levels in obese subjects and after weight reduction. Eur. J. Clin. Invest.6, 327 (1976)

Creutzfeldt, W., Ebert, R., Willms, B., Frerichs, H., Brown, J.C.: Gastric inhibitory polypeptide (GIP) and insulin in obesity: increased response to stimulation and defective feedback control of serum levels. Diabetologia14, 15?24 (1978)

Willms, B., Ebert, R., Creutzfeldt, W.: Gastric inhibitory polypeptide (GIP) and insulin in obesity: II. Reversal of increased response to stimulation by starvation or food restriction. Diabetologia14, 379?387 (1978)

Gregor, D.H., Martin, D.M., Williamson, D.R., Lacy, D.E., Kipnis, D.M.: A study of the diabetic syndrome produced in rats by antiinsulin serum. Diabetes12, 73?81 (1963)

Goyal, D.K., McGuigan, D.E.: Is gastrin a major determinant of basal lower esophageal sphincter pressure? J. Clin. Invest.57, 291?300 (1976)

Ebert, R., Illmer, K., Creutzfeldt, W.: Abolishment of the incretin effect in rats by infusion of gastric inhibitory polypeptide (GIP) antibodies. Scand. J. Gastroenterol. [Suppl. 49]13, 53 (1978)