Nanobiotechnology with S-Layer Proteins as Building Blocks

Papapostolou, 2009, Engineering and exploiting protein assemblies in synthetic biology, Mol Biosyst, 5, 723, 10.1039/b902440a Sleytr, 2005, Crystalline bacterial cell surface layers (S-layers): a versatile self-assembly system, 583 Egelseer, 2010, S-layers, microbial, biotechnological applications, Vol. 7, 4424 Egelseer, 2008, Genetically engineered S-layer proteins and S-layer-specific heteropolysaccharides as components of a versatile molecular construction kit for applications in nanobiotechnology, 55 Ilk, 2008, Surfaces functionalized with self-assembling S-layer fusion proteins for nanobiotechnological applications, Colloids Surf A Physicochem Eng Aspects, 321, 163, 10.1016/j.colsurfa.2007.12.038 Pum, 2009, Protein-based nanobioelectronics, 167 Sára, 2006, S-layer proteins: potential application in nano(bio)technology, 307 Sára, 2005, S-layers as patterning elements for application in nanobiotechnology, J Nanosci Nanotechnol, 5, 1939, 10.1166/jnn.2005.502 Schuster, 2005, Nanotechnology with S-layer proteins, Methods Mol Biol, 300, 101 Schuster, B. & Sletyr, U. B. (in press). Nanotechnology with S-layer proteins. In Protein nanotechnology: protocols, instrumentation and applications (Gerrard, J., ed.). Humana Press, Heidelberg Schuster, 2006, Biomimetic S-layer supported lipid membranes, Curr Nanosci, 2, 143, 10.2174/157341306776875749 Schuster, 2008, Fabrication and characterization of functionalized S-layer supported lipid membranes, 105 Schuster, 2009, Composite S-layer lipid structures, J Struct Biol, 168, 207, 10.1016/j.jsb.2009.03.004 Sleytr, 2010, Nanobiotechnological applications of S-layers, 459 Sleytr, 2007, S-layers as a basic building block in a molecular construction kit, FEBS J, 274, 323, 10.1111/j.1742-4658.2006.05606.x Sleytr, 2004, S-layers, Vol. 7, 77 Sleytr, 1999, Crystalline bacterial cell surface layers (S-layers): from supramolecular cell structure to biomimetics and nanotechnology, Angew. Chem. Int. Ed., 38, 1034, 10.1002/(SICI)1521-3773(19990419)38:8<1034::AID-ANIE1034>3.0.CO;2-# Sleytr, U. B., Pum, D., Egelseer, E., Ilk, N. & Schuster, B. (in press). S-layer proteins. In Handbook of biofunctional surfaces (Knoll, W., ed.). Pan Stanford Publishing Sleytr, 2001, Molecular nanotechnology and nanobiotechnology with two-dimensional protein crystals (S-layers), 333 Sleytr, 2002, Self-assembly protein systems: microbial S-layers, Vol. 7, 285 Houwink, 1952, Eine Struktur in der Zellwand einer Bakterie, Physikalische Verhandlung, 98 Sleytr, 1967, Die elektronenmikroskopische Feinstruktur von Zellwand, Cytoplasmamembran und Geißeln von Bacillus stearothermophilus, dargestellt mit Hilfe der Gefrierätztechnik, Mikroskopie, 22, 233 Sleytr, 1968, Die Feinstruktur der Zellwandoberfläche von zwei thermophilen Clostridienarten, dargestellt mit Hilfe der Gefrierätztechnik, Mikroskopie, 23, 1 Sleytr, 1978, Regular arrays of macromolecules on bacterial cell walls: structure, chemistry, assembly, and function, Int Rev Cytol, 53, 1, 10.1016/S0074-7696(08)62240-8 1988 Claus, 2005, Molecular organization of selected prokaryotic S-layer proteins, Can J Microbiol, 51, 731, 10.1139/w05-093 Messner, 2010, Occurence, structure, chemistry, genetics, morphogenesis, and function of S-layers, 53 Sleytr, 1996 Sleytr, 1996, Crystalline surface layers on eubacteria and archaeobacteria, 211 Baumeister, 1992, Structural features of archaebacterial cell envelopes, J Bioenerg Biomembr, 24, 567, 10.1007/BF00762349 Baumeister, 1989, Principles of organization in eubacterial and archaebacterial surface proteins, Can J Microbiol, 35, 215, 10.1139/m89-034 Hovmöller, 1988, The structure of crystalline bacterial surface layers, Prog Biophys Mol Biol, 51, 131, 10.1016/0079-6107(88)90012-0 Sleytr, 1975, Heterologous reattachment of regular arrays of glycoproteins on bacterial surfaces, Nature, 257, 400, 10.1038/257400a0 Sleytr, 1999, Bacterial S-layers, Trends Microbiol, 7, 253, 10.1016/S0966-842X(99)01513-9 Sleytr, 1982, Bacterial cell walls and membranes, Vol. 3, 41 Sleytr, 1983, Crystalline surface layers on bacteria, Annu Rev Microbiol, 37, 311, 10.1146/annurev.mi.37.100183.001523 Sleytr, 1989, Self-assembly of crystalline bacterial cell surface layers (S-layers), 13 Sleytr, 1988, Analysis of crystalline bacterial surface layers by freeze-teching, metal shadowing, negative staining and ultrathin sectioning, Methods Microbiol, 20, 29, 10.1016/S0580-9517(08)70046-1 Sleytr, 1975, Analysis of regular arrays of subunits on bacterial surfaces: evidence for a dynamic process of assembly, J Ultrastruct Res, 50, 103, 10.1016/S0022-5320(75)90012-X Beveridge, 1994, Bacterial S-layers, Curr Opin Struct Biol, 4, 204, 10.1016/S0959-440X(94)90309-3 Hovmöller, 1993, Crystallographic image processing applications for S-layers, Vol. 252, 13 Müller, 1996, Conformational change of the hexagonally packed intermediate layer of Deinococcus radiodurans monitored by atomic force microscopy, J Bacteriol, 178, 3025, 10.1128/jb.178.11.3025-3030.1996 Pum, 2010, S-layer protein lattices studied by scanning force microscopy, 459 Engelhardt, 2007, Are S-layers exoskeletons? The basic function of protein surface layers revisited, J Struct Biol, 160, 115, 10.1016/j.jsb.2007.08.003 Veith, 2009, Acidianus, Sulfolobus and Metallosphaera surface layers: structure, composition and gene expression, Mol Microbiol, 73, 58, 10.1111/j.1365-2958.2009.06746.x Bergey, 1994 Gram, 1884, Über die isolierte Färbung der Schizomyceten in Schnitt- und Trockenpräparaten, Fortschr Med, 2, 185 Beveridge, 2001, Use of the gram stain in microbiology, Biotech Histochem, 76, 111, 10.1080/bih.76.3.111.118 Sára, 2000, S-layer proteins, J Bacteriol, 182, 859, 10.1128/JB.182.4.859-868.2000 Sleytr, 2000, Crystalline bacterial cell surface layers (S-layers), Vol. 2, 899 Sleytr, 2001, Characterization and use of crystalline bacterial cell surface layers, Prog Surf Sci, 68, 231, 10.1016/S0079-6816(01)00008-9 Engelhardt, 2007, Mechanism of osmoprotection by archaeal S-layers: a theoretical study, J Struct Biol, 160, 190, 10.1016/j.jsb.2007.08.004 Lortal, 1992, S-layer of Lactobacillus helveticus ATCC 12046: isolation, chemical characterization and re-formation after extraction with lithium chloride, J Gen Microbiol, 138, 611, 10.1099/00221287-138-3-611 Thompson, 1998, Campylobacter fetus surface layer proteins are transported by a type I secretion system, J Bacteriol, 180, 6450, 10.1128/JB.180.24.6450-6458.1998 Messner, 1988, Separation and purification of S-layers from gram-positive and gram-negative bacteria, 97 Sleytr, 1976, Ultrastructure of the cell walls of two closely related clostridia that possess different regular arrays of surface subunits, J Bacteriol, 126, 869, 10.1128/JB.126.2.869-882.1976 Bröckl, 1991, Analysis and nucleotide sequence of the genes encoding the surface-layer glycoproteins of the hyperthermophilic methanogens Methanothermus fervidus and Methanothermus sociabilis, Eur J Biochem, 199, 147, 10.1111/j.1432-1033.1991.tb16102.x Kosma, 1995, Glycan structure of a heptose-containing S-layer glycoprotein of Bacillus thermoaerophilus, Glycobiology, 5, 791, 10.1093/glycob/5.8.791 Pei, 1988, Purification and characterization of a family of high molecular weight surface-array proteins from Campylobacter fetus, J Biol Chem, 263, 6416, 10.1016/S0021-9258(18)68801-5 Lechner, 1987, The primary structure of a procaryotic glycoprotein. Cloning and sequencing of the cell surface glycoprotein gene of halobacteria, J Biol Chem, 262, 9724, 10.1016/S0021-9258(18)47994-X Trachtenberg, 2000, The cell surface glycoprotein layer of the extreme halophile Halobacterium salinarum and its relation to Haloferax volcanii: cryo-electron tomography of freeze-substituted cells and projection studies of negatively stained envelopes, J Struct Biol, 130, 10, 10.1006/jsbi.2000.4215 Sleytr, 1993, Crystalline bacterial cell surface layers, Mol Microbiol, 10, 911, 10.1111/j.1365-2958.1993.tb00962.x Sumper, 1995, Bacterial glycoproteins, 455 Messner, 1992, Crystalline bacterial cell-surface layers, Vol. 33, 213 Sára, 1996, Crystalline bacterial cell surface layers (S-layers): from cell structure to biomimetics, Prog Biophys Mol Biol, 65, 83, 10.1016/S0079-6107(96)00007-7 Kuen, 1996, Analysis of S-layer proteins and genes, 77 Messner, 2009, Bacterial surface layer glycoproteins and “non-classical” secondary cell wall polymers, 109 Messner, 2008, S-layer nanoglycobiology of bacteria, Carbohydr Res, 343, 1934, 10.1016/j.carres.2007.12.025 Akca, 2002, Genes and derived amino acid sequences of S-layer proteins from mesophilic, thermophilic, and extremely thermophilic methanococci, Extremophiles, 6, 351, 10.1007/s00792-001-0264-1 Avall-Jääskeläinen, 2005, Lactobacillus surface layers and their applications, FEMS Microbiol Rev, 29, 511, 10.1016/j.fmrre.2005.04.003 Eidhin, 2006, Sequence and phylogenetic analysis of the gene for surface layer protein, slpA, from 14 PCR ribotypes of Clostridium difficile, J Med Microbiol, 55, 69, 10.1099/jmm.0.46204-0 Kato, 2005, Typing by sequencing the slpA gene of Clostridium difficile strains causing multiple outbreaks in Japan, J Med Microbiol, 54, 167, 10.1099/jmm.0.45807-0 Poilane, 2007, Molecular characterization of Clostridium difficile clinical isolates in a geriatric hospital, J Med Microbiol, 56, 386, 10.1099/jmm.0.46608-0 Radnedge, 2003, Genome differences that distinguish Bacillus anthracis from Bacillus cereus and Bacillus thuringiensis, Appl Environ Microbiol, 69, 2755, 10.1128/AEM.69.5.2755-2764.2003 Tu, 2004, Campylobacter fetus of reptile origin as a human pathogen, J Clin Microbiol, 42, 4405, 10.1128/JCM.42.9.4405-4407.2004 Huber, 2005, The three S-layer-like homology motifs of the S-layer protein SbpA of Bacillus sphaericus CCM 2177 are not sufficient for binding to the pyruvylated secondary cell wall polymer, Mol Microbiol, 55, 197, 10.1111/j.1365-2958.2004.04351.x Ilk, 2002, Molecular characterization of the S-layer gene, sbpA, of Bacillus sphaericus CCM 2177 and production of a functional S-layer fusion protein with the ability to recrystallize in a defined orientation while presenting the fused allergen, Appl Environ Microbiol, 68, 3251, 10.1128/AEM.68.7.3251-3260.2002 Jarosch, 2001, Analysis of the structure-function relationship of the S-layer protein SbsC of Bacillus stearothermophilus ATCC 12980 by producing truncated forms, Microbiology, 147, 1353, 10.1099/00221287-147-5-1353 Kroutil, 2009, Towards the structure of the C-terminal part of the S-layer protein SbsC, Acta Crystallogr Sect F Struct Biol Cryst Commun, 65, 1042, 10.1107/S1744309109035386 Pavkov, 2008, The structure and binding behavior of the bacterial cell surface layer protein SbsC, Structure, 16, 1226, 10.1016/j.str.2008.05.012 Horejs, 2008, Structure prediction of an S-layer protein by the mean force method, J Chem Phys, 128, 1, 10.1063/1.2826375 Kinns, 2010, Identifying assembly-inhibiting and assembly-tolerant sites in the SbsB S-layer protein from Geobacillus stearothermophilus, J Mol Biol, 395, 742, 10.1016/j.jmb.2009.10.012 Howorka, 2000, Surface-accessible residues in the monomeric and assembled forms of a bacterial surface layer protein, J Biol Chem, 275, 37876, 10.1074/jbc.M003838200 Kinns, 2008, The surface location of individual residues in a bacterial S-layer protein, J Mol Biol, 377, 589, 10.1016/j.jmb.2008.01.019 Vilen, 2009, Surface location of individual residues of SlpA provides insight into the Lactobacillus brevis S-layer, J Bacteriol, 191, 3339, 10.1128/JB.01782-08 Lupas, 1994, Domain structure of the Acetogenium kivui surface layer revealed by electron crystallography and sequence analysis, J Bacteriol, 176, 1224, 10.1128/jb.176.5.1224-1233.1994 Cava, 2004, Binding to pyruvylated compounds as an ancestral mechanism to anchor the outer envelope in primitive bacteria, Mol Microbiol, 52, 677, 10.1111/j.1365-2958.2004.04011.x Chauvaux, 1999, Distinct affinity of binding sites for S-layer homologous domains in Clostridium thermocellum and Bacillus anthracis cell envelopes, J Bacteriol, 181, 2455, 10.1128/JB.181.8.2455-2458.1999 Ilk, 1999, Structural and functional analyses of the secondary cell wall polymer of Bacillus sphaericus CCM 2177 that serves as an S-layer-specific anchor, J Bacteriol, 181, 7643, 10.1128/JB.181.24.7643-7646.1999 Lemaire, 1998, Identification of a region responsible for binding to the cell wall within the S-layer protein of Clostridium thermocellum, Microbiology, 144, 211, 10.1099/00221287-144-1-211 Mader, 2004, Interaction of the crystalline bacterial cell surface layer protein SbsB and the secondary cell wall polymer of Geobacillus stearothermophilus PV72 assessed by real-time surface plasmon resonance biosensor technology, J Bacteriol, 186, 1758, 10.1128/JB.186.6.1758-1768.2004 Mesnage, 2000, Bacterial SLH domain proteins are non-covalently anchored to the cell surface via a conserved mechanism involving wall polysaccharide pyruvylation, EMBO J, 19, 4473, 10.1093/emboj/19.17.4473 Mesnage, 1999, The S-layer homology domain as a means for anchoring heterologous proteins on the cell surface of Bacillus anthracis, J Appl Microbiol, 87, 256, 10.1046/j.1365-2672.1999.00880.x Ries, 1997, Evidence that the N-terminal part of the S-layer protein from Bacillus stearothermophilus PV72/p2 recognizes a secondary cell wall polymer, J Bacteriol, 179, 3892, 10.1128/jb.179.12.3892-3898.1997 Rünzler, 2004, Biophysical characterization of the entire bacterial surface layer protein SbsB and its two distinct functional domains, J Biol Chem, 279, 5207, 10.1074/jbc.M308819200 May, 2006, Mutagenesis of conserved charged amino acids in SLH domains of Thermoanaerobacterium thermosulfurigenes EM1 affects attachment to cell wall sacculi, Arch Microbiol, 185, 263, 10.1007/s00203-006-0092-x Petersen, 2008, Structural characterization of the acid-degraded secondary cell wall polymer of Geobacillus stearothermophilus PV72/p2, Carbohydr Res, 343, 1346, 10.1016/j.carres.2008.03.029 Moll, 2002, S-layer-streptavidin fusion proteins as template for nanopatterned molecular arrays, Proc Natl Acad Sci USA, 99, 14646, 10.1073/pnas.232299399 Egelseer, 1998, The S-layer proteins of two Bacillus stearothermophilus wild-type strains are bound via their N-terminal region to a secondary cell wall polymer of identical chemical composition, J Bacteriol, 180, 1488, 10.1128/JB.180.6.1488-1495.1998 Jarosch, 2000, S-layer gene sbsC of Bacillus stearothermophilus ATCC 12980: molecular characterization and heterologous expression in Escherichia coli, Microbiology, 146, 273, 10.1099/00221287-146-2-273 Schäffer, 1999, The diacetamidodideoxyuronic-acid-containing glycan chain of Bacillus stearothermophilus NRS 2004/3a represents the secondary cell-wall polymer of wild-type B. stearothermophilus strains, Microbiology, 145, 1575, 10.1099/13500872-145-7-1575 Schäffer, 2002, The surface layer (S-layer) glycoprotein of Geobacillus stearothermophilus NRS 2004/3a. Analysis of its glycosylation, J Biol Chem, 277, 6230, 10.1074/jbc.M108873200 Egelseer, 2001, Characterization of an S-layer glycoprotein produced in the course of S-layer variation of Bacillus stearothermophilus ATCC 12980 and sequencing and cloning of the sbsD gene encoding the protein moiety, Arch Microbiol, 177, 70, 10.1007/s00203-001-0363-5 Weis, 1997, Cell-surface carbohydrate recognition by animal and viral lectins, Curr Opin Struct Biol, 7, 624, 10.1016/S0959-440X(97)80070-X Ferner-Ortner, 2007, High-affinity interaction between the S-layer protein SbsC and the secondary cell wall polymer of Geobacillus stearothermophilus ATCC 12980 determined by surface plasmon resonance technology, J Bacteriol, 189, 7154, 10.1128/JB.00294-07 Antikainen, 2002, Domains in the S-layer protein CbsA of Lactobacillus crispatus involved in adherence to collagens, laminin and lipoteichoic acids and in self-assembly, Mol Microbiol, 46, 381, 10.1046/j.1365-2958.2002.03180.x Smit, 2001, The S-layer protein of Lactobacillus acidophilus ATCC 4356: identification and characterisation of domains responsible for S-protein assembly and cell wall binding, J Mol Biol, 305, 245, 10.1006/jmbi.2000.4258 Masuda, 1980, Reassembly of the regularly arranged subunits in the cell wall os Lactobacillus brevis and their reattachment to cell walls, Microbiol Immunol, 24, 299, 10.1111/j.1348-0421.1980.tb02833.x Masuda, 1985, Reassembly of a regularly arranged protein in the cell wall of Lactobacillus buchneri and its reattachment to cell walls: chemical modification studies, Microbiol Immunol, 29, 927 Doig, 1993, Distribution of surface-exposed and non-accessible amino acid sequences among the two major structural domains of the S-layer protein of Aeromonas salmonicida, J Mol Biol, 233, 753, 10.1006/jmbi.1993.1550 Dworkin, 1995, A lipopolysaccharide-binding domain of the Campylobacter fetus S-layer protein resides within the conserved N terminus of a family of silent and divergent homologs, J Bacteriol, 177, 1734, 10.1128/jb.177.7.1734-1741.1995 Yang, 1992, Reattachment of surface array proteins to Campylobacter fetus cells, J Bacteriol, 174, 1258, 10.1128/jb.174.4.1258-1267.1992 Bingle, 1997, Linker mutagenesis of the Caulobacter crescentus S-layer protein: toward a definition of an N-terminal anchoring region and a C-terminal secretion signal and the potential for heterologous protein secretion, J Bacteriol, 179, 601, 10.1128/jb.179.3.601-611.1997 Bingle, 2000, Secretion of the Caulobacter crescentus S-layer protein: further localization of the C-terminal secretion signal and its use for secretion of recombinant proteins, J Bacteriol, 182, 3298, 10.1128/JB.182.11.3298-3301.2000 Ford, 2007, S-layer anchoring and localization of an S-layer-associated protease in Caulobacter crescentus, J Bacteriol, 189, 2226, 10.1128/JB.01690-06 Boot, 1995, Identification, cloning, and nucleotide sequence of a silent S-layer protein gene of Lactobacillus acidophilus ATCC 4356 which has extensive similarity with the S-layer protein gene of this species, J Bacteriol, 177, 7222, 10.1128/jb.177.24.7222-7230.1995 Boot, 1996, Interchange of the active and silent S-layer protein genes of Lactobacillus acidophilus by inversion of the chromosomal slp segment, Mol Microbiol, 21, 799, 10.1046/j.1365-2958.1996.401406.x Calabi, 2001, Molecular characterization of the surface layer proteins from Clostridium difficile, Mol Microbiol, 40, 1187, 10.1046/j.1365-2958.2001.02461.x Cerquetti, 2000, Characterization of surface layer proteins from different Clostridium difficile clinical isolates, Microb Pathog, 28, 363, 10.1006/mpat.2000.0356 Dworkin, 1997, Molecular mechanisms of Campylobacter fetus surface layer protein expression, Mol Microbiol, 26, 433, 10.1046/j.1365-2958.1997.6151958.x Jakava-Viljanen, 2002, Isolation of three new surface layer protein genes (slp) from Lactobacillus brevis ATCC 14869 and characterization of the change in their expression under aerated and anaerobic conditions, J Bacteriol, 184, 6786, 10.1128/JB.184.24.6786-6795.2002 Karjalainen, 2001, Molecular and genomic analysis of genes encoding surface-anchored proteins from Clostridium difficile, Infect Immun, 69, 3442, 10.1128/IAI.69.5.3442-3446.2001 Mignot, 2002, Developmental switch of S-layer protein synthesis in Bacillus anthracis, Mol Microbiol, 43, 1615, 10.1046/j.1365-2958.2002.02852.x Sára, 1996, Dynamics in oxygen-induced changes in S-layer protein synthesis from Bacillus stearothermophilus PV72 and the S-layer-deficient variant T5 in continuous culture and studies of the cell wall composition, J Bacteriol, 178, 2108, 10.1128/jb.178.7.2108-2117.1996 Sára, 1994, Comparative studies of S-layer proteins from Bacillus stearothermophilus strains expressed during growth in continuous culture under oxygen-limited and non-oxygen-limited conditions, J Bacteriol, 176, 7182, 10.1128/jb.176.23.7182-7189.1994 Thompson, 2000, Pathogenesis of Campylobacter fetus infections, 321 Avall-Jääskeläinen, 2002, Surface display of foreign epitopes on the Lactobacillus brevis S-layer, Appl Environ Microbiol, 68, 5943, 10.1128/AEM.68.12.5943-5951.2002 Scholz, 2001, S-layer variation in Bacillus stearothermophilus PV72 is based on DNA rearrangements between the chromosome and the naturally occurring megaplasmids, J Bacteriol, 183, 1672, 10.1128/JB.183.5.1672-1679.2001 Egelseer, 2000, ISBst12, a novel type of insertion-sequence element causing loss of S-layer-gene expression in Bacillus stearothermophilus ATCC 12980, Microbiology, 146, 2175, 10.1099/00221287-146-9-2175 Gustafson, 1994, Mutagenesis of the paracrystalline surface protein array of Aeromonas salmonicida by endogenous insertion elements, J Mol Biol, 237, 452, 10.1006/jmbi.1994.1247 Sleytr, 1997, Basic and applied S layer research: an overview, FEMS Microbiol Rev, 20, 5, 10.1016/S0168-6445(97)00039-9 Luckevich, 1989, Characterization of a dynamic S layer on Bacillus thuringiensis, J Bacteriol, 171, 6656, 10.1128/jb.171.12.6656-6667.1989 Tsukagoshi, 1984, Molecular cloning of a major cell wall protein gene from protein-producing Bacillus brevis 47 and its expression in Escherichia coli and Bacillus subtilis, J Bacteriol, 158, 1054, 10.1128/JB.158.3.1054-1060.1984 Breitwieser, 1992, Evidence for an S-layer protein pool in the peptidoglycan of Bacillus stearothermophilus, J Bacteriol, 174, 8008, 10.1128/jb.174.24.8008-8015.1992 Boot, 1996, The Lactobacillus acidophilus S-layer protein gene expression site comprises two consensus promoter sequences, one of which directs transcription of stable mRNA, J Bacteriol, 178, 5388, 10.1128/jb.178.18.5388-5394.1996 Chu, 1993, Transcriptional analysis of the Aeromonas salmonicida S-layer protein gene vapA, J Bacteriol, 175, 7968, 10.1128/jb.175.24.7968-7975.1993 Fisher, 1988, Transcriptional analysis of the major surface array gene of Caulobacter crescentus, J Bacteriol, 170, 4706, 10.1128/jb.170.10.4706-4713.1988 Boot, 1996, Expression, secretion and antigenic variation of bacterial S-layer proteins, Mol Microbiol, 21, 1117, 10.1046/j.1365-2958.1996.711442.x Peters, 1987, Nucleotide sequence analysis of the gene encoding the Deinococcus radiodurans surface protein, derived amino acid sequence, and complementary protein chemical studies, J Bacteriol, 169, 5216, 10.1128/jb.169.11.5216-5223.1987 Faraldo, 1992, Sequence of the S-layer gene of Thermus thermophilus HB8 and functionality of its promoter in Escherichia coli, J Bacteriol, 174, 7458, 10.1128/jb.174.22.7458-7462.1992 Carl, 1990, Characterization of the gene encoding the protective paracrystalline-surface-layer protein of Rickettsia prowazekii: presence of a truncated identical homolog in Rickettsia typhi, Proc Natl Acad Sci USA, 87, 8237, 10.1073/pnas.87.21.8237 Noonan, 1995, Molecular analysis of an A-protein secretion mutant of Aeromonas salmonicida reveals a surface layer-specific protein secretion pathway, J Mol Biol, 248, 316, 10.1016/S0022-2836(95)80053-0 Awram, 1998, The Caulobacter crescentus paracrystalline S-layer protein is secreted by an ABC transporter (type I) secretion apparatus, J Bacteriol, 180, 3062, 10.1128/JB.180.12.3062-3069.1998 Kawai, 1998, Serratia marcescens S-layer protein is secreted extracellularly via an ATP-binding cassette exporter, the Lip system, Mol Microbiol, 27, 941, 10.1046/j.1365-2958.1998.00739.x Blight, 1994, Heterologous protein secretion and the versatile Escherichia coli haemolysin translocator, Trends Biotechnol, 12, 450, 10.1016/0167-7799(94)90020-5 Wandersman, 1992, Secretion across the bacterial outer membrane, Trends Genet, 8, 317, 10.1016/0168-9525(92)90264-5 Sleytr, 1980, The dynamic process of assembly of two-dimensional arrays of macromolecules on bacterial cell walls, 36 Gruber, 1988, Localized insertion of new S-layer during growth of Bacillus stearothermophilus strains, Arch Microbiol, 149, 485, 10.1007/BF00446749 Smit, 1982, Cell surface patterning and morphogenesis: biogenesis of a periodic surface array during Caulobacter development, J Cell Biol, 95, 41, 10.1083/jcb.95.1.41 Harris, 1970, Function of dislocations in cell walls and membranes, Nature, 228, 827, 10.1038/228827a0 Messner, 1986, Ultrastructure of the cell envelope of the archaebacteria Thermoproteus tenax and Thermoproteus neutrophilus, J Bacteriol, 166, 1046, 10.1128/jb.166.3.1046-1054.1986 Pum, 1991, Role of the S layer in morphogenesis and cell division of the archaebacterium Methanocorpusculum sinense, J Bacteriol, 173, 6865, 10.1128/jb.173.21.6865-6873.1991 Györvary, 2003, Self-assembly and recrystallization of bacterial S-layer proteins at silicon supports imaged in real time by atomic force microscopy, J Microsc, 212, 300, 10.1111/j.1365-2818.2003.01270.x Pum, 1994, Large-scale reconstruction of crystalline bacterial surface layer proteins at the air-water interface and on lipids, Thin Solid Films, 244, 882, 10.1016/0040-6090(94)90592-4 Pum, 1995, Anisotropic crystal growth of the S-layer of Bacillus sphaericus CCM 2177 at the air/water interface, Colloids Surf A Physicochem Eng Aspects, 102, 99, 10.1016/0927-7757(95)03190-O Pum, 1995, Monomolecular reassembly of a crystalline bacterial cell surface layer (S layer) on untreated and modified silicon surfaces, Supramol Sci, 2, 193, 10.1016/0968-5677(96)89675-1 Messner, 1986, Characterization of the ultrastructure and the self-assembly of the surface layer of Bacillus stearothermophilus strain NRS 2004/3a, J Ultrastruct Mol Struct Res, 97, 73, 10.1016/S0889-1605(86)80008-8 Sleytr, 1976, Self-assembly of the hexagonally and tetragonally arranged subunits of bacterial surface layers and their reattachment to cell walls, J Ultrastruct Res, 55, 360, 10.1016/S0022-5320(76)80093-7 Jaenicke, 1985, Stability and self-assembly of the S-layer protein of the cell wall of Bacillus stearothermophilus, Biol Chem Hoppe Seyler, 366, 663, 10.1515/bchm3.1985.366.2.663 Pum, 1993, Large-scale recrystallization of the S-layer of Bacillus coagulans E38-66 at the air/water interface and on lipid films, J Bacteriol, 175, 2762, 10.1128/jb.175.9.2762-2766.1993 Györvary, 2003, Biomimetic nanostructure fabrication: non-lithographic lateral patterning and self-assembly of functional bacterial S-layers at silicon supports, Nano Lett, 3, 315, 10.1021/nl025936f Lopez, 2009, Surface dependence of protein nanocrystal formation, Small, 6, 396, 10.1002/smll.200901169 Moreno-Flores, 2008, From native to non-native two-dimensional protein lattices through underlying hydrophilic/hydrophobic nanoprotrusions, Angew Chem Int Ed Engl, 47, 4707, 10.1002/anie.200800151 Ulman, 1996, Formation and structure of self-assembled monolayers, Chem Rev, 96, 1533, 10.1021/cr9502357 Györvary, 2004, Formation of nanoparticle arrays on S-layer protein lattices, J Nanosci Nanotechnol, 4, 115, 10.1166/jnn.2004.229 Schuster, 2000, S-layer-supported lipid membranes, J Biotechnol, 74, 233 Schuster, 2005, 2D-protein crystals (S-layers) as support for lipid membranes, Vol. 1, 247 Küpcü, 1995, Liposomes coated with crystalline bacterial cells surface protein (S-layer) as immobilization structures for macromolecules, Biochim Biophys Acta, 1235, 263, 10.1016/0005-2736(95)80013-6 Mader, 1999, Stabilizing effect of an S-layer on liposomes towards thermal or mechanical stress, Biochim Biophys Acta, 1418, 106, 10.1016/S0005-2736(99)00030-9 Mader, 2000, S-layer-coated liposomes as a versatile system for entrapping and binding target molecules, Biochim Biophys Acta, 1463, 142, 10.1016/S0005-2736(99)00190-X Toca-Herrera, 2005, Recrystallization of bacterial S-layers on flat polyelectrolyte surfaces and hollow polyelectrolyte capsules, Small, 1, 339, 10.1002/smll.200400035 Pum, 1997, Deep UV patterning of monolayers of crystalline S layer protein on silicon surfaces, Colloids Surf B, 8, 157, 10.1016/S0927-7765(96)01318-5 Chung, 2010, Self-catalyzed growth of S layers via an amorphous-to-crystalline transition limited by folding kinetics, Proc Natl Acad Sci USA, 107, 16536, 10.1073/pnas.1008280107 Fagan, 2009, Structural insights into the molecular organization of the S-layer from Clostridium difficile, Mol Microbiol, 71, 1308, 10.1111/j.1365-2958.2009.06603.x Norville, 2007, 7A projection map of the S-layer protein sbpA obtained with trehalose-embedded monolayer crystals, J Struct Biol, 160, 313, 10.1016/j.jsb.2007.06.002 Pavkov, 2003, Crystallization and preliminary structure determination of the C-terminal truncated domain of the S-layer protein SbsC, Acta Crystallogr D Biol Crystallogr, 59, 1466, 10.1107/S0907444903010990 Whitelam, 2010, Control of pathways and yields of protein crystallization through the interplay of nonspecific and specific attractions, Phys Rev Lett, 105, 10.1103/PhysRevLett.105.088102 Horejs, 2010, Surface layer protein characterization by small angle x-ray scattering and a fractal mean force concept: from protein structure to nanodisk assemblies, J Chem Phys, 133, 10.1063/1.3489682 Horejs, 2011, Atomistic structure of monomolecular surface layer self-assemblies: towards functionalized nanostructures, ACS Nano, 5, 2288, 10.1021/nn1035729 Horejs, 2011, Monte Carlo study of the molecular mechanisms of S-layer self-assembly, J Chem Phys, 134, 10.1063/1.3565457 Baumeister, 1987, Three-dimensional structure of bacterial surface layers, Vol. 6, 109 Sára, 1987, Molecular sieving through S layers of Bacillus stearothermophilus strains, J Bacteriol, 169, 4092, 10.1128/jb.169.9.4092-4098.1987 Scherrer, 1971, Molecular sieving by the Bacillus megaterium cell wall and protoplast, J Bacteriol, 107, 718, 10.1128/JB.107.3.718-735.1971 Sára, 1992, Permeability and charge-dependent adsorption properties of the S-layer lattice from Bacillus coagulans E38-66, J Bacteriol, 174, 3487, 10.1128/jb.174.11.3487-3493.1992 Sára, 1988, Isoporous ultrafiltration membranes from bacterial cell envelope layers, J Membr Sci, 36, 179, 10.1016/0376-7388(88)80015-2 Sára, 1988, Membrane biotechnology: two-dimensional protein crystals for ultrafiltration purposes, 615 Sára, 1987, Production and characteristics of ultrafiltration membranes with uniform pores from two-dimensional arrays of proteins, J Membr Sci, 33, 27, 10.1016/S0376-7388(00)80050-2 Sleytr, 1988 Küpcü, 1991, Chemical modification of crystalline ultrafiltration membranes and immobilization of macromolecules, J Membr Sci, 61, 167, 10.1016/0376-7388(91)80013-V Sára, 1990, Crystalline bacterial cell surface layers used as ultrafiltration membranes and immobilization matrix, Genet Eng Biotechnol, 10, 10 Sára, 1993, Crystalline protein layers as isoporous molecular sieves and immobilisation and affinity matrices, 71 Sára, 1993, S-layers as immobilization and affinity matrices Sleytr, 1993 Küpcü, 1993, Influence of covalent attachment of low molecular weight substances on the rejection and adsorption properties of crystalline proteinaceous ultra filtration membranes, Desalination, 90, 65, 10.1016/0011-9164(93)80165-J Weigert, 1996, Ultrafiltration membranes prepared from crystalline bacterial cell surface layers as model systems for studying the influence of surface properties on protein adsorption, J Membr Sci, 121, 185, 10.1016/S0376-7388(96)00176-7 Breitwieser, 1996, 2-D protein crystals as an immobilization matrix for producing reaction zones in dipstick-style immunoassays, Biotechniques, 21, 918, 10.2144/96215rr05 Küpcü, 1996, Two-dimensional paracrystalline glycoprotein S-layers as a novel matrix for the immobilization of human IgG and their use as microparticles in immunoassays, J Immunol Methods, 196, 73, 10.1016/0022-1759(96)00119-6 Sára, 1989, Use of regularly structured bacterial cell envelope layers as matrix for the immobilization of macromolecules, Appl Microbiol Biotechnol, 30, 184, 10.1007/BF00264009 Weiner, 1994, Novel protein A affinity matrix prepared from two-dimensional protein crystals, Biotechnol Bioeng, 43, 321, 10.1002/bit.260430409 Crowther, 1977, An analysis of the fine structure of the surface layers from two strains of Clostridia, including correction for distorted images, J Ultrastruct Res, 58, 41, 10.1016/S0022-5320(77)80006-3 Sleytr, 1986, Structural and chemical characterization of S-layers of selected strains of Bacillus stearothermophilus and Desulfotomaculum nigrificans, Arch Microbiol, 146, 19, 10.1007/BF00690152 Bock, 1994, Primary structure of the O-glycosidically linked glycan chain of the crystalline surface layer glycoprotein of Thermoanaerobacter thermohydrosulfuricus L111-69. Galactosyl tyrosine as a novel linkage unit, J Biol Chem, 269, 7137, 10.1016/S0021-9258(17)37258-7 Christian, 1988, Structure of a glycan from the surface-layer glycoprotein of Clostridium thermohydrosulfuricum strain L111-69, Carbohydr Res, 176, 160, 10.1016/0008-6215(88)84069-2 Pum, 1993, Two-dimensional (glyco)protein crystals as patterning elements and immobilisation matrices for the development of biosensors, 141 Küpcü, 1995, The crystalline cell surface layer of Thermoanaerobacter thermohydrosulfuricus L111-69 as an immobilization matrix: influence of the morphological properties and the pore size of the matrix on activity loss of covalently bound enzymes, Biotechnol Appl Biochem, 21, 275 Weber, 2001, Development of affinity microparticles for extracorporeal blood purification based on crystalline bacterial cell surface proteins, Ther Apher, 5, 433, 10.1046/j.1526-0968.2001.00354.x Sára, 1996, Biotechnological applications of S-layers, 133 Breitwieser, 1998, A novel dipstick developed for rapid Bet v 1-specific IgE detection: recombinant allergen immobilized via a monoclonal antibody to crystalline bacterial cell-surface layers, Allergy, 53, 786, 10.1111/j.1398-9995.1998.tb03975.x Sleytr, 2004, Molecular nanotechnology and nanobiotechnology with 2-D protein crystals, Vol. 5, 693 Sleytr, 1997, Bacterial and archaeal S-layer proteins: structure-function relationships and their biotechnological applications, Trends Biotechnol, 15, 20, 10.1016/S0167-7799(96)10063-9 Völkel, 2003, Immunochemical detection of prion protein on dipsticks prepared with crystalline bacterial cell-surface layers, Transfusion, 43, 1677, 10.1111/j.0041-1132.2003.00567.x Neubauer, 1993, An amperometric glucose sensor based on isoporous crystalline protein membranes as immobilization matrix, Anal Lett, 26, 1347, 10.1080/00032719308017417 Neubauer, 1994, A multistep enzyme sensor for sucrose based on S-layer microparticles as immobilization matrix, Anal Lett, 27, 849, 10.1080/00032719408007356 Schäffer, 2007, Novel biocatalysts based on S-layer self-assembly of Geobacillus stearothermophilus NRS 2004/3a: a nanobiotechnological approach, Small, 3, 1549, 10.1002/smll.200700200 Tschiggerl, 2008, Exploitation of the S-layer self-assembly system for site directed immobilization of enzymes demonstrated for an extremophilic laminarinase from Pyrococcus furiosus, J Biotechnol, 133, 403, 10.1016/j.jbiotec.2007.09.018 Douglas, 1986, Nanometer molecular lithography, Appl Phys Lett, 48, 676, 10.1063/1.96741 Douglas, 1998, Mineral formation by bacteria in natural microbial communities, FEMS Microbiol Ecol, 26, 79, 10.1111/j.1574-6941.1998.tb00494.x Bergkvist, 2004, Bionanofabrication of ordered nanoparticle arrays: effect of particle properties and adsorption conditions, J Phys Chem B, 108, 8241, 10.1021/jp049280l Dieluweit, 2005, Monodisperse gold nanoparticles formed on bacterial crystalline surface layers (S-layers) by electroless deposition, Mater Sci Eng C, 25, 727, 10.1016/j.msec.2005.07.004 Mertig, 1999, Fabrication of highly orineted nanocluster arrays by biomolecular templating, Eur Phys J D, 9, 45, 10.1007/s100530050397 Mertig, 2001, Formation and manipulation of regular metallic nanoparticle arrays on bacterial surface layers: an advanced TEM study, Eur Phys J D, 16, 317, 10.1007/s100530170119 Shenton, 1997, Biocrystal templating of CdS superlattices using self-assembled bacterial S-layers, Nature, 389, 585, 10.1038/39287 Wahl, 2001, Electron-beam induced formation of highly ordered palladium and platinum nanoparticle arrays on the S-layer of Bacillus sphaericus NCTC 9602, Adv Mater Sci Technol, 13, 736 Hall, 2001, Site-specific organization of gold nanoparticles by biomolecular templating, Chemphyschem, 3, 184, 10.1002/1439-7641(20010316)2:3<184::AID-CPHC184>3.0.CO;2-J Mark, 2006, Self-assembly of dendrimer-encapsulated nanoparticle arrays using 2-D microbial S-layer protein biotemplates, Biomacromolecules, 7, 1884, 10.1021/bm0603185 Mark, 2006, Bionanofabrication of metallic and semiconductor nanoparticle arrays using S-layer protein lattices with different lateral spacings and geometries, Langmuir, 22, 3763, 10.1021/la053115v Badelt-Lichtblau, 2009, Genetic engineering of the S-layer protein SbpA of Lysinibacillus sphaericus CCM 2177 for the generation of functionalized nanoarrays, Bioconjug Chem, 20, 895, 10.1021/bc800445r Sleytr, 2007, S-Layers as a tool kit for nanobiotechnological applications, FEMS Microbiol Lett, 267, 131, 10.1111/j.1574-6968.2006.00573.x Huber, 2006, Heterotetramers formed by an S-layer-streptavidin fusion protein and core-streptavidin as nanoarrayed template for biochip development, Small, 2, 142, 10.1002/smll.200500147 Breitwieser, 2002, A recombinant bacterial cell surface (S-layer)-major birch pollen allergen-fusion protein (rSbsC/Bet v1) maintains the ability to self-assemble into regularly structured monomolecular lattices and the functionality of the allergen, Protein Eng, 15, 243, 10.1093/protein/15.3.243 Völlenkle, 2004, Construction of a functional S-layer fusion protein comprising an immunoglobulin G-binding domain for development of specific adsorbents for extracorporeal blood purification, Appl Environ Microbiol, 70, 1514, 10.1128/AEM.70.3.1514-1521.2004 Ilk, 2004, A functional chimaeric S-layer-enhanced green fluorescent protein to follow the uptake of S-layer-coated liposomes into eukaryotic cells, Biochem J, 379, 441, 10.1042/bj20031900 Pleschberger, 2004, An S-layer heavy chain camel antibody fusion protein for generation of a nanopatterned sensing layer to detect the prostate-specific antigen by surface plasmon resonance technology, Bioconjug Chem, 15, 664, 10.1021/bc049964w Tschiggerl, 2008, Display of a peptide mimotope on a crystalline bacterial cell surface layer (S-layer) lattice for diagnosis of Epstein-Barr virus infection, Bioconjug Chem, 19, 860, 10.1021/bc7003523 Kainz, 2010, Absorption, steady-state fluorescence, fluorescence lifetime, and 2D self-assembly properties of engineered fluorescent S-layer fusion proteins of Geobacillus stearothermophilus NRS 2004/3a, Biomacromolecules, 11, 207, 10.1021/bm901071b Kainz, 2010, Fluorescence energy transfer in the bi-fluorescent S-layer tandem fusion protein ECFP-SgsE-YFP, J Struct Biol, 172, 276, 10.1016/j.jsb.2010.07.002 Riedmann, 2003, Construction of recombinant S-layer proteins (rSbsA) and their expression in bacterial ghosts–a delivery system for the nontypeable Haemophilus influenzae antigen Omp26, FEMS Immunol Med Microbiol, 37, 185, 10.1016/S0928-8244(03)00070-1 Mesnage, 1999, Production and cell surface anchoring of functional fusions between the SLH motifs of the Bacillus anthracis S-layer proteins and the Bacillus subtilis levansucrase, Mol Microbiol, 31, 927, 10.1046/j.1365-2958.1999.01232.x Mesnage, 1999, Cell surface-exposed tetanus toxin fragment C produced by recombinant Bacillus anthracis protects against tetanus toxin, Infect Immun, 67, 4847, 10.1128/IAI.67.9.4847-4850.1999 Bingle, 1997, Cell-surface display of a Pseudomonas aeruginosa strain K pilin peptide within the paracrystalline S-layer of Caulobacter crescentus, Mol Microbiol, 26, 277, 10.1046/j.1365-2958.1997.5711932.x Simon, 2001, Recombinant vaccines against infectious hematopoietic necrosis virus: production line by the Caulobacter crescentus S-layer protein secretion system and evaluation in laboratory trials, Dis Aquat Organ, 44, 400, 10.3354/dao044017 Duncan, 2005, Appl Biochem Biotechnol, 127, 95, 10.1385/ABAB:127:2:095 Nomellini, 2007, S-layer-mediated display of the immunoglobulin G-binding domain of streptococcal protein G on the surface of Caulobacter crescentus: development of an immunoactive reagent, Appl Environ Microbiol, 73, 3245, 10.1128/AEM.02900-06 Nomellini, 2010, Development of an HIV-1 specific microbicide using Caulobacter crescentus S-layer mediated display of CD4 and MIP1alpha, PLoS One, 5, e10366, 10.1371/journal.pone.0010366 Patel, 2010, Genetic engineering of Caulobacter crescentus for removal of cadmium from water, Appl Biochem Biotechnol, 160, 232, 10.1007/s12010-009-8540-0 Huber, 2006, S-layer-streptavidin fusion proteins and S-layer-specific heteropolysaccharides as part of a biomolecular construction kit for application in nanobiotechnology, Microelectron Eng, 83, 1589, 10.1016/j.mee.2006.01.109 Pleschberger, 2003, Generation of a functional monomolecular protein lattice consisting of an S-layer fusion protein comprising the variable domain of a camel heavy chain antibody, Bioconjug Chem, 14, 440, 10.1021/bc025603+ Bohle, 2004, A novel approach to specific allergy treatment: the recombinant fusion protein of a bacterial cell surface (S-layer) protein and the major birch pollen allergen Bet v 1 (rSbsC-Bet v 1) combines reduced allergenicity with immunomodulating capacity, J Immunol, 172, 6642, 10.4049/jimmunol.172.11.6642 Gerstmayr, 2007, A novel approach to specific allergy treatment: the recombinant allergen-S-layer fusion protein rSbsC-Bet v 1 matures dendritic cells that prime Th0/Th1 and IL-10-producing regulatory T cells, J Immunol, 179, 7270, 10.4049/jimmunol.179.11.7270 Ferner-Ortner-Beckmann, J., Tesarz, M., Egelseer, E. M., Sleytr, U. B. & Ilk, N. (submitted). S-layer-based biocatalysts carrying multimeric extremozymes. Small Kuen, 1994, Sequence analysis of the sbsA gene encoding the 130-kDa surface-layer protein of Bacillus stearothermophilus strain PV72, Gene, 145, 115, 10.1016/0378-1119(94)90332-8 Fouet, 2002, Bacillus anthracis cell envelope components, Curr Top Microbiol Immunol, 271, 87, 10.1007/978-3-662-05767-4_5 Smit, 1992, The S-layer of Caulobacter crescentus: three-dimensional image reconstruction and structure analysis by electron microscopy, J Bacteriol, 174, 6527, 10.1128/jb.174.20.6527-6538.1992 Smit, 1981, Periodic surface array in Caulobacter crescentus: fine structure and chemical analysis, J Bacteriol, 146, 1135, 10.1128/JB.146.3.1135-1150.1981 Gilchrist, 1992, Nucleotide sequence analysis of the gene encoding the Caulobacter crescentus paracrystalline surface layer protein, Can J Microbiol, 38, 193, 10.1139/m92-033 Walker, 1992, Isolation and comparison of the paracrystalline surface layer proteins of freshwater caulobacters, J Bacteriol, 174, 1783, 10.1128/jb.174.6.1783-1792.1992 Apweiler, 1999, On the frequency of protein glycosylation, as deduced from analysis of the SWISS-PROT database, Biochim Biophys Acta, 1473, 4, 10.1016/S0304-4165(99)00165-8 Spiro, 2002, Protein glycosylation: nature, distribution, enzymatic formation, and disease implications of glycopeptide bonds, Glycobiology, 12, 43R, 10.1093/glycob/12.4.43R Samuelson, 2002, Display of proteins on bacteria, J Biotechnol, 96, 129, 10.1016/S0168-1656(02)00043-3 Zarschler, 2010, Cell surface display of chimeric glycoproteins via the S-layer of Paenibacillus alvei, Carbohydr Res, 345, 1422, 10.1016/j.carres.2010.04.010 Kern, 2008, BslA, a pXO1-encoded adhesin of Bacillus anthracis, Mol Microbiol, 68, 504, 10.1111/j.1365-2958.2008.06169.x Kern, 2010, BslA, the S-layer adhesin of B. anthracis, is a virulence factor for anthrax pathogenesis, Mol Microbiol, 75, 324, 10.1111/j.1365-2958.2009.06958.x Ní Eidhin, 2008, Active immunization of hamsters against Clostridium difficile infection using surface-layer protein, FEMS Immunol Med Microbiol, 52, 207, 10.1111/j.1574-695X.2007.00363.x Ford, 1992, Immunization of channel catfish with crude, acid-extracted preparation of motile aeromonad S-layer protein, Biomed Lett, 47, 355 Poobalane, 2010, Production and efficacy of an Aeromonas hydrophila recombinant S-layer protein vaccine for fish, Vaccine, 28, 3540, 10.1016/j.vaccine.2010.03.011 Malcolm, 1993, Crystalline bacterial cell surface layers (S-layers) as combined carrier/adjuvants for conjugated vaccines, 195 Smith, 1993, Induction of T-cell immunity to oligosaccharide antigens immobilized on crystalline bacterial surface layers (S-layers), Vaccine, 11, 919, 10.1016/0264-410X(93)90378-B Jahn-Schmid, 1997, Bet v 1, the major birch pollen allergen, conjugated to crystalline bacterial cell surface proteins, expands allergen-specific T cells of the Th1/Th0 phenotype in vitro by induction of IL-12, Int Immunol, 9, 1867, 10.1093/intimm/9.12.1867 Jahn-Schmid, 1996, Immunoreactivity of allergen (Bet v 1) conjugated to crystalline bacterial cell surface layers (S-layers), Immunotechnology, 2, 103, 10.1016/1380-2933(96)00041-3 Jahn-Schmid, 1996, Toward selective elicitation of TH1-controlled vaccination responses: vaccine applications of bacterial surface layer proteins, J Biotechnol, 44, 225, 10.1016/0168-1656(95)00124-7 Gerstmayr, 2009, Natural self-assembly of allergen-S-layer fusion proteins is no prerequisite for reduced allergenicity and T cell stimulatory capacity, Int Arch Allergy Immunol, 149, 231, 10.1159/000199718 Umelo-Njaka, 2001, Expression and testing of Pseudomonas aeruginosa vaccine candidate proteins prepared with the Caulobacter crescentus S-layer protein expression system, Vaccine, 19, 1406, 10.1016/S0264-410X(00)00362-5 Mock, 2001, Anthrax, Annu Rev Microbiol, 55, 647, 10.1146/annurev.micro.55.1.647 Ausiello, 2006, Surface layer proteins from Clostridium difficile induce inflammatory and regulatory cytokines in human monocytes and dendritic cells, Microbes Infect, 8, 2640, 10.1016/j.micinf.2006.07.009 Brun, 2008, Clostridium difficile TxAC314 and SLP-36kDa enhance the immune response toward a co-administered antigen, J Med Microbiol, 57, 725, 10.1099/jmm.0.47736-0 O´Brien, 2005, Passive immunization of hamsters against Clostridium difficile infection using antibodies to surface layer proteins, FEMS Microbiol Lett, 246, 199, 10.1016/j.femsle.2005.04.005 Rahman, 2000, Outer membrane proteins of Aeromonas hydrophila induce protective immunity in goldfish, Fish Shellfish Immunol, 10, 379, 10.1006/fsim.1999.0245 Baba, 1988, Immune protection in carp. Cyprinus carpido L. after immunization with Aeromonas hydrophila crude lipopolysaccaride, J Fish Dis, 11, 237, 10.1111/j.1365-2761.1988.tb00544.x Azad, 2000, Uptake and processing of biofilm and free-cell vaccines of Aeromonas hydrophila in indian major carps and common carp following oral vaccination–antigen localization by a monoclonal antibody, Dis Aquat Organ, 43, 103, 10.3354/dao043103 Lamers, 1985, The reaction of the immune system of fish vaccination: development of immunological memory in carp. Cyprinus carpio L., following direct immersion in Aeromonas hydrophila bacterin, J Fish Dis, 8, 253, 10.1111/j.1365-2761.1985.tb00941.x Leung, 1997, Mini-Tn5 induced growth- and protease- deficient mutants of Aeromonas hydrophila as live vaccines for blue gourami, Trichogaster trichopterus (Pallas), Aquaculture, 158, 11, 10.1016/S0044-8486(97)00185-3 Messner, 1996, Vaccine development based on S-layer technology, 161 Sleytr, 1991 Brown, 1993, Vaccine design Powell, 1995, Vaccine design: the subunit and adjuvant approach, 10.1007/978-1-4615-1823-5 Malcolm, 1993, Surface layers of Bacillus alvei as a carrier for a Streptococcus pneunoniae conjugate vaccine, 219 Messner, 1996, Chemical composition and biosynthesis of S-layer, 35 Messner, 1996, Vaccine development based on S-layer technology, 161 Hianik, 1999, Interaction of crystalline bacterial cell surface proteins with lipid bilayers in liposomes, Colloids Surf A, 147, 331, 10.1016/S0927-7757(98)00665-7 Küpcü, 1998, Microcalorimetric study on the phase behaviour of S-layer coated liposomes, Mol Membr Biol, 15, 69, 10.3109/09687689809027520 Krivanek, 2002, Affinity interactions on a liposome surface detected by ultrasound velocimetry, Bioelectrochemistry, 55, 57, 10.1016/S1567-5394(01)00161-X Bhatnagar, 2006, Anti-tumor effects of the bacterium Caulobacter crescentus in murine tumor models, Cancer Biol Ther, 5, 485, 10.4161/cbt.5.5.2553 Georgiou, 1997, Display of heterologous proteins on the surface of microorganisms: from the screening of combinatorial libraries to live recombinant vaccines, Nat Biotechnol, 15, 29, 10.1038/nbt0197-29 Nomellini, 2004, Secrtetion or presentation of recombinant proteins and peptides mediated by the S-layer of Caulobacter crescentus, 477 Ratner, 2004, Biomaterials: where we have been and where we are going, Annu Rev Biomed Eng, Vol. 6, 41, 10.1146/annurev.bioeng.6.040803.140027 Zhang, 2008, Blood compatibility of surfaces with superlow protein adsorption, Biomaterials, 29, 4285, 10.1016/j.biomaterials.2008.07.039 Goodsell, 2004 Whitesides, 1991, Molecular selfassembly and nanochemistry: a chemical strategy for the synthesis of nanostructures, Science, 254, 1312, 10.1126/science.1962191 Galdiero, 2010, The presence of a single N-terminal histidine residue enhances the fusogenic properties of a membranotropic peptide derived from herpes simplex virus type 1 glycoprotein H, J Biol Chem, 285, 17123, 10.1074/jbc.M110.114819 Galdiero, 2007, Beta-barrel membrane bacterial proteins: structure, function, assembly and interaction with lipids, Curr Protein Pept Sci, 8, 63, 10.2174/138920307779941541 Gerstein, 1998, Comparing genomes in terms of protein structure: surveys of a finite parts list, FEMS Microbiol Rev, 22, 277, 10.1111/j.1574-6976.1998.tb00371.x Sleytr, 2000, Crystalline bacterial cell surface layers (S-layers): a versatile self-assembly system, 177 Viviani, 2007, Cytokines and neuronal ion channels in health and disease, Int Rev Neurobiol, 82, 247, 10.1016/S0074-7742(07)82013-7 Ellis, 2004, Highlighting the pitfalls and possibilities of drug research, Nat Rev Drug Discov, 3, 238, 10.1038/nrd1332 De Rosa, 1996, Archaeal lipids: structural features and supramolecular organization, Thin Solid Films, 284–285, 13, 10.1016/S0040-6090(96)08832-3 Hanford, 2002, Archaeal tetraether lipids, Appl Biochem Biotechnol, 97, 45, 10.1385/ABAB:97:1:45 Stetter, 1999, Extremophiles and their adaptation to hot environments, FEBS Lett, 452, 22, 10.1016/S0014-5793(99)00663-8 Schuster, 2009, Tailor-made crystalline structures of truncated S-layer proteins on heteropolysaccharides, Soft Matter, 5, 334, 10.1039/B810211B Schuster, 2008, S-layer stabilized lipid membranes (Review), Biointerphases, 3, FA3, 10.1116/1.2889067 Diederich, 1996, Reciprocal influence between the protein and lipid components of a lipid-protein membrane model, Colloids Surf B, 6, 335, 10.1016/0927-7765(96)01267-2 Wetzer, 1997, S-layer stabilized solid supported lipid bilayers, J Struct Biol, 119, 123, 10.1006/jsbi.1997.3867 Weygand, 2002, Structural reorganization of phospholipid headgroups upon recrystallization of an S-layer lattice, J Phys Chem B, 106, 5793, 10.1021/jp0146418 Weygand, 2000, Coupling of protein sheet crystals (S-layers) to phospholipid monolayers, J Mater Chem, 10, 141, 10.1039/a905196a Weygand, 1999, Bacterial S-layer protein coupling to lipids: x-ray reflectivity and grazing incidence diffraction studies, Biophys J, 76, 458, 10.1016/S0006-3495(99)77213-9 Wetzer, 1998, S-layer reconstitution at phospholipid monolayers, Langmuir, 14, 6899, 10.1021/la980547f Schuster, 1999, Probing the stability of S-layer-supported planar lipid membranes, Eur Biophys J, 28, 583, 10.1007/s002490050240 Hirn, 1999, The effect of S-layer protein adsorption and crystallization on the collective motion of a planar lipid bilayer studied by dynamic light scattering, Biophys J, 77, 2066, 10.1016/S0006-3495(99)77048-7 Schuster, 2005, Biomimetic design of nanopatterned membranes, NanoBiotechnology, 1, 153, 10.1385/NBT:1:2:153 Schuster, 2006, S-Layer proteins as key components of a versatile molecular construction kit for biomedical Nanotechnology, Mini Rev Med Chem, 6, 909, 10.2174/138955706777935026 Lee, 2004, Structural effects of small molecules on phospholipid bilayers investigated, Fluid Phase Equilibria, 225, 63, 10.1016/j.fluid.2004.07.008 Györvary, 1999, Lateral diffusion of lipids in silane-, dextrane- and S-layer protein-supported mono- and bilayers, Langmuir, 15, 1337, 10.1021/la980827v Schuster, 1998, Self-assembled alpha-hemolysin pores in an S-layer-supported lipid bilayer, Biochim Biophys Acta, 1370, 280, 10.1016/S0005-2736(97)00274-5 Schuster, 1998, Voltage clamp studies on S-layer-supported tetraether lipid membranes, Biochim Biophys Acta, 1369, 51, 10.1016/S0005-2736(97)00206-X Schuster, 2003, Interplay of phospholipase A2 with S-layer-supported lipid monolayers, Langmuir, 19, 3393, 10.1021/la026771t Gufler, 2004, Highly robust lipid membranes on crystalline S-layer supports investigated by electrochemical impedance spectroscopy, Biochim Biophys Acta, 1661, 154, 10.1016/j.bbamem.2003.12.009 Schuster, 2004, S-layer proteins as supporting scaffoldings for functional lipid membranes, IEEE Trans Nanobioscience, 3, 16, 10.1109/TNB.2004.824267 Schuster, 2002, The effect of hydrostatic pressure on S-layer-supported lipid membranes, Biochim Biophys Acta, 1563, 29, 10.1016/S0005-2736(02)00370-X Bayley, 2001, Stochastic sensors inspired by biology, Nature, 413, 226, 10.1038/35093038 Bhakdi, 1991, Alpha-toxin of Staphylococcus aureus, Microbiol Rev, 55, 733, 10.1128/MMBR.55.4.733-751.1991 Revah, 1991, Mutations in the channel domain alter desensitization of a neuronal nicotinic receptor, Nature, 353, 846, 10.1038/353846a0 Schuster, 2002, Single channel recordings of alpha-hemolysin reconstituted in S-layer-supported lipid bilayers, Bioelectrochemistry, 55, 5, 10.1016/S1567-5394(01)00148-7 Keizer, 2008, Prolonged stochastic single ion channel recordings in S-layer protein stabilized lipid bilayer membranes, Colloids Surf B Biointerfaces, 65, 178, 10.1016/j.colsurfb.2008.04.015 Castellana, 2006, Solid supported lipid bilayers: from biophysical studies to sensor design, Surf Sci Rep, 61, 429, 10.1016/j.surfrep.2006.06.001 Chan, 2007, Model membrane systems and their applications, Curr Opin Chem Biol, 11, 581, 10.1016/j.cbpa.2007.09.020 Katsaras, 2008, Structure from substrate supported lipid bilayers, Biointerphases, 3, FB55, 10.1116/1.2992133 Knoll, 2008, Solid supported lipid membranes: new concepts for the biomimetic functionalization of solid surfaces, Biointerphases, 3, FA125, 10.1116/1.2913612 Reimhult, 2008, Membrane biosensor platforms using nano- and microporous supports, Trends Biotechnol, 26, 82, 10.1016/j.tibtech.2007.11.004 Steinem, 2010, Multicomponent membranes on solid substrates: interfaces for protein binding, Curr Opin Colloid Interface Sci, 15, 479, 10.1016/j.cocis.2010.06.004 Schuster, 2001, S-layer ultrafiltration membranes: a new support for stabilizing functionalized lipid membranes, Langmuir, 17, 499, 10.1021/la0008784 Schuster, 2003, New method for generating tetraether lipid membranes on porous supports, Langmuir, 19, 2392, 10.1021/la026691p Bangham, 1965, Diffusion of univalent ions across the lamellae of swollen phospholipids, J Mol Biol, 13, 238, 10.1016/S0022-2836(65)80093-6 Cui, 2006, Lipid microvesicles: on the four decades of liposome research, Vol. 4, 1 Tien, 2000 Amselem, 1994, Emulsomes, a novel drug delivery technology, Proc Int Symp Control Release Bioactive Mater, 21, 1369 Vyas, 2006, Development and characterization of emulsomes for sustained and targeted delivery of an antiviral agent to liver, J Pharm Pharmacol, 58, 321, 10.1211/jpp.58.3.0005 Andresen, 2005, Advanced strategies in liposomal cancer therapy: problems and prospects of active and tumor specific drug release, Prog Lipid Res, 44, 68, 10.1016/j.plipres.2004.12.001 Hollmann, 2007, Characterization of liposomes coated with S-layer proteins from lactobacilli, Biochim Biophys Acta, 1768, 393, 10.1016/j.bbamem.2006.09.009 Pum, 2006, Bacterial surface layer proteins: a simple but versatile biological self-assembly system in nature, 277 Schuster, 2010, Biomimetic S-layer stabilized lipid membranes, 1 Dieluweit, 1998, Formation of a gold superlattice on an S-layer with square lattice symmetry, Supramol Sci, 5, 15, 10.1016/S0968-5677(97)00073-4 Wahl, 2005, Multivariate statistical analysis of two-dimensional metal cluster arrays grown in vitro on a bacterial surface layer, Chem Mater, 17, 1887, 10.1021/cm048497p Maslyuk, 2008, Electronic structure of bacterial surface protein layers, Phys Rev B, 77, 45419, 10.1103/PhysRevB.77.045419 Vyalikh, 2004, Electronic structure of regular bacterial surface layers, Phys Rev Lett, 93, 10.1103/PhysRevLett.93.238103 Vyalikh, 2009, Site-specific electronic structure of bacterial surface protein layers, Appl Phys A, 94, 455, 10.1007/s00339-008-4913-4 Göbel, 2009, S-layer templated bioinspired synthesis of silica, Colloids Surf B Biointerfaces, 75, 565, 10.1016/j.colsurfb.2009.09.037 Kröger, 2002, Self-Assembly of highly phosphorylated silaffins and their function in biosilica morphoGenesis, Science, 298, 584, 10.1126/science.1076221