Importance of in vitro experimental conditions on protein release kinetics, stability and polymer degradation in protein encapsulated poly (d,l-lactic acid-co-glycolic acid) microspheres

Langer, 1990, New methods of drug delivery, Science, 249, 1527, 10.1126/science.2218494

Maulding, 1987, Prolonged delivery of peptides by microcapsules, J. Control. Release, 6, 167, 10.1016/0168-3659(87)90074-5

Eldridge, 1991, Biodegradable microspheres as a vaccine delivery system, Mol. Immunol., 28, 287, 10.1016/0161-5890(91)90076-V

Lewis, 1990, Controlled release of bioactive agents from lactide/glycolide polymer, 1

Ogawa, 1988, In vivo release profiles of leuprolide acetate from microcapsules prepared with polylactic acids or copoly (lactic/glycolic) acids and in vivo degradation of these polymers, Chem. Pharm. Bull., 36, 2576, 10.1248/cpb.36.2576

Wyse, 1989, Instability of porcine somatropin in polyglycolic acid microspheres, 16

Cohen, 1991, Controlled delivery systems for proteins based on poly (lactic/glycolic) microsphere, Pharm. Res., 8, 713, 10.1023/A:1015841715384

Alonso, 1993, Determinatnts of release rate of tetanus vaccine frm polyester microspheres, Pharm. Res., 10, 945, 10.1023/A:1018942118148

Lu, 1994, Controlled protein release from biodegradable polyester microspheres: protein stability problems

Lu, 1995, Protein release from poly(lactic-co-glycolic acid) microspheres: protein stability problems, J. Pharm. Sci. Tech.

Johnson, 1991, Stability of atriopeptin III in poly(d,l-lactide-co-glycolide) microspheres, J. Control. Release, 17, 61, 10.1016/0168-3659(91)90131-V

Li, 1990, Structure-property relationships in the case of the degradation of massive poly ( α-hydroxyacid) in aqueous media, J. Mater. Sci. Med., 1, 131, 10.1007/BF00700872

Park, 1994, Degradation of poly (d,l-lactic acid) microspheres: effect of molecular weight, J. Control. Release, 30, 161, 10.1016/0168-3659(94)90263-1

Manning, 1989, Stability of protein pharmaceuticals, Pharm. Res., 6, 903, 10.1023/A:1015929109894

Cleland, 1990, Refolding and aggregation of bovine carbonic anhydrase B: quasi-elastic light scattering analysis, Biochemistry, 29, 11072, 10.1021/bi00502a009

Liu, 1991, Moisture-induced aggregation of lyophilized proteins in the solid state, Biotech. Bioeng., 37, 845, 10.1002/bit.260370210

Makino, 1985, Preparation and in vitro degradation properties of polylactide microcapsules, Chem. Pharm. Bull., 33, 1195, 10.1248/cpb.33.1195

Makino, 1987, Effects of plasma proteins on degradation properties of poly(l-lactide) microcapsules, Pharm. Res., 4, 62, 10.1023/A:1016438129284

Kenley, 1987, Poly (lactide-co-glycolide) decomposition kinetics in vivo and in vitro, Macromolecules, 20, 2398, 10.1021/ma00176a012

Therin, 1992, In vivo degradation of massive poly( α-hydroxy acid): validation of in vitro findings, Biomaterials, 13, 594, 10.1016/0142-9612(92)90027-L