On the importance and mechanisms of burst release in matrix-controlled drug delivery systems

Griffith, 2000, Polymeric biomaterials, Acta Mater., 48, 263, 10.1016/S1359-6454(99)00299-2 Brazel, 1994, Temperature- and pH-sensitive hydrogels for controlled release of antithrombotic agents, Mater. Res. Soc. Symp. Proc., 331, 211, 10.1557/PROC-331-211 Atkins, 1993, Incorporation and release of fluorescein isothiocyanate-linked dextrans from a bead-formed macroporous hydrophilic matrix with potential for sustained release, Biomaterials, 14, 16, 10.1016/0142-9612(93)90016-U Ficek, 1993, Novel preparation of poly(vinyl alcohol) microparticles without crosslinking agent for controlled drug delivery of proteins, J. Control. Release, 27, 259, 10.1016/0168-3659(93)90156-Y Shively, 1995, Physicochemical characterization of polymeric injectable implant delivery system, J. Control. Release, 33, 237, 10.1016/0168-3659(94)00097-E Brazel, 1999, Recent studies and molecular analysis of drug release from swelling-controlled devices, STP Pharma Sci., 9, 473 Pekarek, 1994, Double-walled microspheres for drug delivery, Mater. Res. Soc. Symp. Proc., 331, 97, 10.1557/PROC-331-97 Kishida, 1998, Polymer drugs and polymeric drugs X: slow release of 5-fluorouracil from biodegradable poly(γ-glutamic acid) and its benzyl ester matrices, J. Bioact. Compat. Polym., 13, 270, 10.1177/088391159801300403 Vasudev, 1997, Development of chitosan/polyethylene vinyl acetate co-matrix: controlled release of aspirin-heparin for preventing cardiovascular thrombosis, Biomaterials, 18, 375, 10.1016/S0142-9612(96)00131-7 Patil, 1996, Macroporous poly(sucrose acrylate) hydrogel for controlled release of macromolecules, Biomaterials, 17, 2343, 10.1016/S0142-9612(96)00089-0 Mallapragada, 1997, Crystal dissolution-controlled release systems. II. Metronidazole release from semicrystalline poly(vinyl alcohol) systems, J. Biomed. Mater. Res., 36, 125, 10.1002/(SICI)1097-4636(199707)36:1<125::AID-JBM15>3.0.CO;2-H Baker, 1987 Narasimham, 1997, On the importance of the burst effect during drug release from polymer films, Polym. Mater. Sci. Eng. Proc., 76, 558 Setterstrom, 1984, Development of encapsulated antibiotics for topical administration to wounds, 4 Jeong, 2000, Drug release from biodegradable injectable thermosensitive hydrogel of PEG-PLGA-PEG triblock copolymers, J. Control. Release, 63, 155, 10.1016/S0168-3659(99)00194-7 Zhou, 1997, Finite element analysis of diffusional drug release from complex matrix system. I. Complex geometries and composite structured, J. Control. Release, 49, 277, 10.1016/S0168-3659(97)00103-X Batycky, 1997, A theoretical model of erosion and macromolecular drug release from biodegrading microspheres, J. Pharm. Sci., 86, 1464, 10.1021/js9604117 Brazel, 1999, Mechanisms of solute and drug transport in relaxing, swellable, hydrophilic glassy polymers, Polymer, 40, 3383, 10.1016/S0032-3861(98)00546-1 Lee, 1984, Effect of non-uniform initial drug concentration distribution on the kinetics of drug release from glassy hydrogel matrices, Polymer, 25, 973, 10.1016/0032-3861(84)90082-X Sah, 1994, The influence of biodegradable microcapsule formulations on the controlled release of a protein, J. Control. Release, 30, 201, 10.1016/0168-3659(94)90026-4 Cohen, 1991, Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres, Pharm. Res., 8, 713, 10.1023/A:1015841715384 Roseman, 1970, Release of medroxyprogesterone acetate from a silicone polymer, J. Pharm. Sci., 59, 353, 10.1002/jps.2600590317 Wheatley, 1991, Coated alginate microspheres: factors influencing the controlled delivery of macromolecules, J. Appl. Polym. Sci., 43, 2123, 10.1002/app.1991.070431120 Park, 1992, Controlled protein release from polyethyleneimine-coated poly(l-lactic acid)/pluronic blend matrices, Pharm. Res., 9, 37, 10.1023/A:1018971525301 Park, 1992, Poly(l-lactic acid)/pluronic blends: characterization of phase separation behavior, degradation, and morphology and use as protein-releasing matrices, Macromolecules, 25, 116, 10.1021/ma00027a019 Jalil, 1990, Biodegradable poly(lactic acid) and poly(lactide-co-glycolide) microcapsules: problems associated with preparative techniques and release properties, J. Microencapsulation, 7, 297, 10.3109/02652049009021842 Ahmed, 2000, Reduced burst effect in drug release with solvent-treated microparticles prepared by the solvent evaporation method, Proc. Int. Symp. Control. Release Bioact. Mater., 27, 6112 van de Weert, 2000, Lysozyme distribution and conformation in a biodegradable polymer matrix as determined by FTIR techniques, J. Control. Release, 68, 31, 10.1016/S0168-3659(00)00227-3 Chia, 2000, Effect of preparation temperature on the characteristics and release profiles of PLGA microspheres fabricated by double-emulsion solvent extraction/evaporation method, Proc. Int. Symp. Control. Release Bioact. Mater., 27, 8137 Wang, 1991, Influence of formulation methods on the in vitro controlled release of protein from poly(ester) microspheres, J. Control. Release, 17, 23, 10.1016/0168-3659(91)90127-Y Tzafriri, 2000, Mathematical modeling of diffusion-mediated release from bulk degrading matrices, J. Control. Release, 63, 69, 10.1016/S0168-3659(99)00174-1 Mukae, 1990, A thermo-sensitive hydrogel: poly(ethylene oxide-dimethyl siloxane-ethylene oxide)/poly(N-isopropylacrylamide) interpenetrating polymer networks. II. On-off regulation of solute release from thermo-sensitive hydrogel, Polym. J., 22, 250, 10.1295/polymj.22.250 Gutowska, 1995, Heparin release from thermosensitive polymer coatings: In vivo studies, J. Biomed. Mater. Res., 29, 811, 10.1002/jbm.820290705 Lee, 1985, Kinetics of drug release from hydrogel matrices, J. Control. Release, 2, 277, 10.1016/0168-3659(85)90051-3 Conte, 1988, Swelling-activated drug delivery systems, Biomaterials, 9, 489, 10.1016/0142-9612(88)90043-9 Harland, 1988, Drug/polymer matrix swelling and dissolution, Pharm. Res., 5, 488, 10.1023/A:1015913207052 Colombo, 1995, Drug diffusion front movement is important in drug release control from swellable matrix tablets, J. Pharm. Sci., 84, 991, 10.1002/jps.2600840816 Colombo, 1996, Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport, J. Control. Release, 39, 231, 10.1016/0168-3659(95)00158-1 Baveja, 1987, Zero-order release hydrophilic matrix tablets of β-adrenergic blockers, Int. J. Pharm., 39, 39, 10.1016/0378-5173(87)90196-7 Colombo, 2000, Drug release from swelling-controlled systems, 183 Narasimhan, 1997, Zero-order release of micro- and macromolecules from polymeric devices: the role of the burst effect, J. Control. Release, 47, 13, 10.1016/S0168-3659(96)01611-2 Gutowska, 1992, Heparin release from thermosensitive hydrogels, J. Control. Release, 22, 95, 10.1016/0168-3659(92)90194-V Colombo, 1992, Swelling characteristics of hydrophilic matrices for controlled release: new dimensionless number to describe the swelling and release behavior, Int. J. Pharm., 88, 99, 10.1016/0378-5173(92)90307-N Colombo, 1993, Swelling-controlled release in hydrogel matrices for oral route, Adv. Drug Deliv. Rev., 11, 37, 10.1016/0169-409X(93)90026-Z Colombo, 1990, Drug release modulation by physical restrictions of matrix swelling, Int. J. Pharm., 63, 43, 10.1016/0378-5173(90)90099-P Lu, 1998, Modeling and optimization of drug release from laminated polymer matrix devices, AIChE J., 44, 1689, 10.1002/aic.690440720 Catellani, 1988, Modified release tablet formulation, Polym. Med., 3, 169 1989 Langer, 1980, Polymeric delivery systems for controlled drug release, Chem. Eng. Commun., 6, 1, 10.1080/00986448008912519 Crank, 1956 Higuchi, 1961, Rate of release of medicaments from ointment bases containing drugs in suspension, J. Pharm. Sci., 50, 874, 10.1002/jps.2600501018 Higuchi, 1963, Mechanism of sustained-action medication, J. Pharm. Sci., 52, 1145, 10.1002/jps.2600521210 Peppas, 1997, Analysis of drug release behavior from swellable polymer carriers using the dimensionality index, J. Control. Release, 45, 35, 10.1016/S0168-3659(96)01542-8 Peppas, 1983, The swelling interface number as a criterion for prediction of diffusional solute release mechanisms in swellable polymers, J. Polym. Sci., 21, 983 Klier, 1988, Solute and penetrant diffusion in swellable polymers. VIII. Influence of the swelling interface number on solute concentration profiles and release, J. Control. Release, 7, 61, 10.1016/0168-3659(88)90081-8 Brazel, 1999, Modeling of drug release from swellable polymers, Eur. J. Pharm. Biopharm., 48, 1 Morimoto, 1989, Design of poly(vinyl alcohol) hydrogel as a controlled-release vehicle for rectal administration of d,l-propranolol-HCl and atenolol, Chem. Pharm. Bull., 37, 2491, 10.1248/cpb.37.2491 Korsmeyer, 1986, Solute and penetrant diffusion in swellable polymers. I. Mathematical modeling, J. Polym. Sci. Part B: Polym. Phys., 24, 395, 10.1002/polb.1986.090240214 Lustig, 1987, Solute and penetrant diffusion in swellable polymers, VII. A free volume-based model with mechanical relaxation. J. Appl. Polym. Sci., 33, 533 Iordanskii, 2000, Modeling of the drug delivery from a hydrophilic transdermal therapeutic system across polymer membrane, Eur. J. Pharm. Biopharm., 49, 287, 10.1016/S0939-6411(00)00063-1 Petropoulos, 1992, A general model for the release of active agents incorporated in swellable polymeric matrices, J. Polym. Sci. B Polym. Phys., 30, 717, 10.1002/polb.1992.090300709