Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching

Bioorganic & Medicinal Chemistry Letters - Tập 13 - Trang 2967-2971 - 2003
Pascal Furet1, Guido Bold1, Francesco Hofmann1, Paul Manley1, Thomas Meyer1, Karl-Heinz Altmann2
1Oncology Research, Novartis Pharma AG, CH-4002 Basel, Switzerland
2Corporate Research, Novartis Pharma AG, CH-4002 Basel, Switzerland

Tài liệu tham khảo

Matter, 2001, Drug Discov. Today, 6, 1005, 10.1016/S1359-6446(01)01939-0 Kerbel, 2000, Carcinogenesis, 21, 505, 10.1093/carcin/21.3.505 Sun, 2000, Drug Discov. Today, 5, 344, 10.1016/S1359-6446(00)01534-8 Manley, P. W.; Furet, P. In Anticancer Agents: Frontiers in Cancer Chemotherapy; Ojima, I., Vite, G., Altmann, K., Eds.; ACS Symposium Series 796; American Chemical Society: Washington, DC, 2001; p 282. Veikkola, 2000, Cancer Res., 60, 203 Boyer, 2002, Curr. Top. Med. Chem., 2, 973, 10.2174/1568026023393273 Adams, 2002, Curr. Opin. Chem. Biol., 6, 486, 10.1016/S1367-5931(02)00357-5 Bold, 2000, J. Med. Chem., 43, 2310, 10.1021/jm9909443 Bold, 2002, Drugs Future, 27, 43, 10.1358/dof.2002.027.01.647609 Manley, 2002, J. Med. Chem., 45, 5687, 10.1021/jm020899q Toledo, 1999, Curr. Med. Chem., 6, 775, 10.2174/092986730609220401150028 Traxler, 1999, Pharmacol. Ther., 82, 195, 10.1016/S0163-7258(98)00044-8 Furet, 2002, Bioorg. Med. Chem. Lett., 12, 221, 10.1016/S0960-894X(01)00715-6 Zhu, 1999, Structure, 7, 651, 10.1016/S0969-2126(99)80086-0 Mohammadi, 1998, EMBO J., 17, 5896, 10.1093/emboj/17.20.5896 Bostrom, 1998, J. Comput.-Aided Mol. Des., 12, 383, 10.1023/A:1008007507641 Rialet, 1991, Anticancer Res., 11, 1581 Meyer, 1989, Int. J. Cancer, 43, 851, 10.1002/ijc.2910430519 Mohamadi, 1990, J. Comput. Chem., 11, 440, 10.1002/jcc.540110405 Bohacek, 1989, J. Mol. Graph, 7, 113, 10.1016/S0263-7855(89)80015-3 (b) Eyraud, V.; Dietrich, A., Novartis Pharma Inc. Unpublished results. Stewart, 1990, J. Comput.-Aided Mol. Des., 1, 1, 10.1007/BF00128336