Small-Molecule Inhibitors of HIF-2a Translation Link Its 5′UTR Iron-Responsive Element to Oxygen Sensing

Molecular Cell - Tập 32 Số 6 - Trang 838-848 - 2008
Michael Zimmer1, Benjamin L. Ebert2, Christopher R. Neil1, Keith Brenner1, Ioannis Papaioannou1, Antonia Melas1, Nicola Tolliday3, Justin Lamb2, Kostas Pantopoulos4, Todd R. Golub2, Othon Iliopoulos1
1Department of Medicine, Hematology-Oncology Unit, Massachusetts General Hospital and the Center for Cancer Research, Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
2Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, MA 02142, USA
3Institute of Chemistry and Cell Biology (ICCB) at Harvard Medical School, Boston, MA 02115, USA
4Lady Davis Institute for Medical Research and Department of Medicine, McGill University, Montreal, QC H3T 1E2, Canada.

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