Predictors of mortality in patients infected with carbapenem-resistant Acinetobacter baumannii: A systematic review and meta-analysis

Potron, 2015, Emerging broad-spectrum resistance in Pseudomonas aeruginosa and Acinetobacter baumannii: mechanisms and epidemiology, Int J Antimicrob Agents, 45, 568, 10.1016/j.ijantimicag.2015.03.001 Weinstein, 2005, Overview of nosocomial infections caused by gram-negative bacilli, Clin Infect Dis, 41, 848, 10.1086/432803 Codjoe, 2017, Carbapenem resistance: a review, Med Sci (Basel), 6, 1 Mahamat, 2016, Clinical epidemiology and resistance mechanisms of carbapenem-resistant Acinetobacter baumannii, French Guiana, 2008-2014, Int J Antimicrob Agents, 48, 51, 10.1016/j.ijantimicag.2016.03.006 Munoz-Price, 2008, Acinetobacter infection, N Engl J Med, 358, 1271, 10.1056/NEJMra070741 Abbott, 2013, Carbapenem resistance in Acinetobacter baumannii: laboratory challenges, mechanistic insights and therapeutic strategies, Expert Rev Anti Infect Ther, 11, 395, 10.1586/eri.13.21 Kuo, 2012, Emergence of extensively drug-resistant Acinetobacter baumannii complex over 10 years: nationwide data from the Taiwan Surveillance of Antimicrobial Resistance (TSAR) program, BMC Infect Dis, 12, 200, 10.1186/1471-2334-12-200 Willyard, 2017, The drug-resistant bacteria that pose the greatest health threats, Nature, 543, 15, 10.1038/nature.2017.21550 Choi, 2016, Trends in the distribution and antimicrobial susceptibility of causative pathogens of device-associated infection in Korean intensive care units from 2006 to 2013: results from the Korean Nosocomial Infections Surveillance System (KONIS), J Hosp Infect, 92, 363, 10.1016/j.jhin.2015.12.012 Lemos, 2014, Carbapenem resistance and mortality in patients with Acinetobacter baumannii infection: systematic review and meta-analysis, Clin Microbiol Infect, 20, 416, 10.1111/1469-0691.12363 Shields, 2012, Epidemiology, clinical characteristics and outcomes of extensively drug-resistant Acinetobacter baumannii infections among solid organ transplant recipients, PLoS One, 7, e52349, 10.1371/journal.pone.0052349 Park, 2018, Early administration of appropriate antimicrobial agents to improve the outcome of carbapenem-resistant Acinetobacter baumannii complex bacteraemic pneumonia, Int J Antimicrob Agents, 51, 407, 10.1016/j.ijantimicag.2017.10.018 Papadimitriou-Olivgeris, 2017, Risk factors and predictors of carbapenem-resistant Pseudomonas aeruginosa and Acinetobacter baumannii mortality in critically ill bacteraemic patients over a 6-year period (2010-15): antibiotics do matter, J Med Microbiol, 66, 1092, 10.1099/jmm.0.000538 Moher, 2009, Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement, BMJ, 339, b2535, 10.1136/bmj.b2535 Playford, 2007, Carbapenem-resistant Acinetobacter baumannii in intensive care unit patients: risk factors for acquisition, infection and their consequences, J Hosp Infect, 65, 204, 10.1016/j.jhin.2006.11.010 Prata-Rocha, 2012, Factors influencing survival in patients with multidrug-resistant Acinetobacter baumannii infection, Braz J Infect Dis, 16, 237 Retamar, 2012, Impact of inadequate empirical therapy on the mortality of patients with bloodstream infections: a propensity score-based analysis, Antimicrob Agents Chemother, 56, 472, 10.1128/AAC.00462-11 Stang, 2010, Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses, Eur J Epidemiol, 25, 603, 10.1007/s10654-010-9491-z Aydemir, 2012, Mortality attributable to carbapenem-resistant nosocomial Acinetobacter baumannii infections in a Turkish university hospital, Jpn J Infect Dis, 65, 66, 10.7883/yoken.65.66 Kim, 2012, Risk factors for occurrence and 30-day mortality for carbapenem-resistant Acinetobacter baumannii bacteremia in an intensive care unit, J Korean Med Sci, 27, 939, 10.3346/jkms.2012.27.8.939 Luo, 2018, Optimally estimating the sample mean from the sample size, median, mid-range, and/or mid-quartile range, Stat Methods Med Res, 27, 1785, 10.1177/0962280216669183 Wan, 2014, Estimating the sample mean and standard deviation from the sample size, median, range and/or interquartile range, BMC Med Res Methodol, 14, 135, 10.1186/1471-2288-14-135 del Mar Tomas, 2005, Hospital outbreak caused by a carbapenem-resistant strain of Acinetobacter baumannii: patient prognosis and risk-factors for colonisation and infection, Clin Microbiol Infect, 11, 540, 10.1111/j.1469-0691.2005.01184.x Kwon, 2007, Impact of imipenem resistance on mortality in patients with Acinetobacter bacteraemia, J Antimicrob Chemother, 59, 525, 10.1093/jac/dkl499 Tseng, 2007, Prognosis of adult patients with bacteremia caused by extensively resistant Acinetobacter baumannii, Diagn Microbiol Infect Dis, 59, 181, 10.1016/j.diagmicrobio.2007.04.024 Munoz-Price, 2010, Clinical outcomes of carbapenem-resistant Acinetobacter baumannii bloodstream infections: study of a 2-state monoclonal outbreak, Infect Control Hosp Epidemiol, 31, 1057, 10.1086/656247 Prates, 2011, Risk factors for 30-day mortality in patients with carbapenem-resistant Acinetobacter baumannii during an outbreak in an intensive care unit, Epidemiol Infect, 139, 411, 10.1017/S0950268810001238 Song, 2011, Clinical and microbiological characterization of carbapenem-resistant Acinetobacter baumannii bloodstream infections, J Med Microbiol, 60, 605, 10.1099/jmm.0.029439-0 Hernandez-Torres, 2012, Multidrug and carbapenem-resistant Acinetobacter baumannii infections: factors associated with mortality, Med Clin (Barc), 138, 650, 10.1016/j.medcli.2011.06.024 Moon, 2013, Implications of postneurosurgical meningitis caused by carbapenem-resistant Acinetobacter baumannii, J Infect Chemother, 19, 916, 10.1007/s10156-013-0608-7 Nutman, 2014, A case-control study to identify predictors of 14-day mortality following carbapenem-resistant Acinetobacter baumannii bacteraemia, Clin Microbiol Infect, 20, 1028, 10.1111/1469-0691.12716 Lee, 2015, Emergence in Taiwan of novel imipenem-resistant Acinetobacter baumannii ST455 causing bloodstream infection in critical patients, J Microbiol Immunol Infect, 48, 588 Alvarez-Marin, 2016, Colistin dosage without loading dose is efficacious when treating carbapenem-resistant Acinetobacter baumannii ventilator-associated pneumonia caused by strains with high susceptibility to colistin, PLoS One, 11, 10.1371/journal.pone.0168468 Freire, 2016, Bloodstream infection caused by extensively drug-resistant Acinetobacter baumannii in cancer patients: high mortality associated with delayed treatment rather than with the degree of neutropenia, Clin Microbiol Infect, 22, 352, 10.1016/j.cmi.2015.12.010 Liu, 2016, Risk factors of mortality in patients with carbapenem-resistant Acinetobacter baumannii bacteremia, J Microbiol Immunol Infect, 49, 934, 10.1016/j.jmii.2014.10.006 Liang, 2018, Antibiotic strategies and clinical outcomes in critically ill patients with pneumonia caused by carbapenem-resistant Acinetobacter baumannii, Clin Microbiol Infect, 24, 10.1016/j.cmi.2017.10.033 Peleg, 2008, Acinetobacter baumannii: emergence of a successful pathogen, Clin Microbiol Rev, 21, 538, 10.1128/CMR.00058-07 Santajit, 2016, Mechanisms of antimicrobial resistance in ESKAPE pathogens, Biomed Res Int, 2016, 10.1155/2016/2475067 Erbay, 2009, Impact of early appropriate antimicrobial therapy on survival in Acinetobacter baumannii bloodstream infections, Int J Antimicrob Agents, 34, 575, 10.1016/j.ijantimicag.2009.07.006 Yu, 2003, An international prospective study of pneumococcal bacteremia: correlation with in vitro resistance, antibiotics administered, and clinical outcome, Clin Infect Dis, 37, 230, 10.1086/377534 Hill, 2001, Prospective study of 424 cases of Staphylococcus aureus bacteraemia: determination of factors affecting incidence and mortality, Intern Med J, 31, 97, 10.1111/j.1444-0903.2001.00029.x