Tumor suppressive protein phosphatases in human cancer: Emerging targets for therapeutic intervention and tumor stratification
Tài liệu tham khảo
Abbotts, 2014, Targeting human apurinic/apyrimidinic endonuclease 1 (APE1) in phosphatase and tensin homolog (PTEN) deficient melanoma cells for personalized therapy, Oncotarget, 5, 3273, 10.18632/oncotarget.1926
Abdelsaid, 2012, S-glutathionylation of LMW-PTP regulates VEGF-mediated FAK activation and endothelial cell migration, J. Cell Sci., 125, 4751, 10.1242/jcs.103481
Acun, 2015, PTPRD is homozygously deleted and epigenetically downregulated in human hepatocellular carcinomas, OMICS, 19, 220, 10.1089/omi.2015.0010
Adams, 2005, Positive regulation of Raf1-MEK1/2-ERK1/2 signaling by protein serine/threonine phosphatase 2A holoenzymes, J. Biol. Chem., 280, 42644, 10.1074/jbc.M502464200
Agarwal, 2013, Tumor derived mutations of protein tyrosine phosphatase receptor type k affect its function and alter sensitivity to chemotherapeutics in glioma, PLoS One, 8, e62852, 10.1371/journal.pone.0062852
Agarwal, 2014, Antagonism of SET using OP449 enhances the efficacy of tyrosine kinase inhibitors and overcomes drug resistance in myeloid leukemia, Clin. Cancer Res., 20, 2092, 10.1158/1078-0432.CCR-13-2575
Aguiar, 1999, PTPROt: an alternatively spliced and developmentally regulated B-lymphoid phosphatase that promotes G0/G1 arrest, Blood, 94, 2403, 10.1182/blood.V94.7.2403.419k39_2403_2413
Aguirre-Ghiso, 2003, ERK(MAPK) activity as a determinant of tumor growth and dormancy; regulation by p38(SAPK), Cancer Res., 63, 1684
Al-Shehhi, 2013, Abnormalities of the der(12)t(12;21) in ETV6-RUNX1 acute lymphoblastic leukemia, Genes Chromosomes Cancer, 52, 202, 10.1002/gcc.22021
Alho, 2013, The role of low-molecular-weight protein tyrosine phosphatase (LMW-PTP ACP1) in oncogenesis, Tumour Biol., 34, 1979, 10.1007/s13277-013-0784-1
Alho, 2013, Characterization of low molecular weight protein tyrosine phosphatase isoforms in human breast cancer epithelial cell lines, Anticancer Res., 33, 1983
Alonso, 2016, The extended human PTPome: a growing tyrosine phosphatase family, FEBS J., 283, 1404, 10.1111/febs.13600
Alonso, 2002, Inhibition of T cell antigen receptor signaling by VHR-related MKPX (VHX), a new dual specificity phosphatase related to VH1 related (VHR), J. Biol. Chem., 277, 5524, 10.1074/jbc.M107653200
Alonso, 2003, Tyrosine phosphorylation of VHR phosphatase by ZAP-70, Nat. Immunol., 4, 44, 10.1038/ni856
Alonso, 2004, Protein tyrosine phosphatases in the human genome, Cell, 117, 699, 10.1016/j.cell.2004.05.018
Althubiti, 2014, Characterization of novel markers of senescence and their prognostic potential in cancer, Cell Death Dis., 5, e1528, 10.1038/cddis.2014.489
Amand, 2014, DUSP3/VHR is a pro-angiogenic atypical dual-specificity phosphatase, Mol. Cancer, 13, 108, 10.1186/1476-4598-13-108
Amin, 2007, Decreased expression level of SH2 domain-containing protein tyrosine phosphatase-1 (Shp1) is associated with progression of chronic myeloid leukaemia, J. Pathol., 212, 402, 10.1002/path.2178
Araujo, 2016, Transmembrane prostatic acid phosphatase (TMPAP) delays cells in G1 phase of the cell cycle, Prostate, 76, 151, 10.1002/pros.23105
Ardini, 2000, Expression of protein tyrosine phosphatase alpha (RPTPalpha) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo, Oncogene, 19, 4979, 10.1038/sj.onc.1203869
Armes, 2004, Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers, Oncogene, 23, 5697, 10.1038/sj.onc.1207740
Arnold, 2006, Protein phosphatase 2A regulatory subunit B56alpha associates with c-myc and negatively regulates c-myc accumulation, Mol. Cell. Biol., 26, 2832, 10.1128/MCB.26.7.2832-2844.2006
Arnoldussen, 2008, The mitogen-activated protein kinase phosphatase vaccinia H1-related protein inhibits apoptosis in prostate cancer cells and is overexpressed in prostate cancer, Cancer Res., 68, 9255, 10.1158/0008-5472.CAN-08-1224
Arora, 2011, Protein-tyrosine phosphatase DEP-1 controls receptor tyrosine kinase FLT3 signaling, J. Biol. Chem., 286, 10918, 10.1074/jbc.M110.205021
Arriazu, 2016, Protein phosphatase 2A as a therapeutic target in acute myeloid leukemia, Front. Oncol., 6, 78, 10.3389/fonc.2016.00078
Arroyo-Berdugo, 2014, Involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma, PLoS One, 9, e95522, 10.1371/journal.pone.0095522
Arruga, 2017, Mutations in NOTCH1 PEST domain orchestrate CCL19-driven homing of chronic lymphocytic leukemia cells by modulating the tumor suppressor gene DUSP22, Leukemia, 31, 1882, 10.1038/leu.2016.383
Asbagh, 2014, The tyrosine phosphatase PTPRO sensitizes colon cancer cells to anti-EGFR therapy through activation of SRC-mediated EGFR signaling, Oncotarget, 5, 10070, 10.18632/oncotarget.2458
Assem, 2012, Enhancing diagnosis, prognosis, and therapeutic outcome prediction of gliomas using genomics, OMICS, 16, 113, 10.1089/omi.2011.0031
Astolfi, 2010, A molecular portrait of gastrointestinal stromal tumors: an integrative analysis of gene expression profiling and high-resolution genomic copy number, Lab. Invest., 90, 1285, 10.1038/labinvest.2010.110
Aya-Bonilla, 2013, High-resolution loss of heterozygosity screening implicates PTPRJ as a potential tumor suppressor gene that affects susceptibility to Non-Hodgkin's lymphoma, Genes Chromosomes Cancer, 52, 467, 10.1002/gcc.22044
Baghbani, 2017, Suppression of protein tyrosine phosphatase PTPN22 gene induces apoptosis in T-cell leukemia cell line (Jurkat) through the AKT and ERK pathways, Biomed. Pharmacother., 86, 41, 10.1016/j.biopha.2016.11.124
Baker, 2001, Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation, Mol. Cell. Biol., 21, 2393, 10.1128/MCB.21.7.2393-2403.2001
Balavenkatraman, 2006, DEP-1 protein tyrosine phosphatase inhibits proliferation and migration of colon carcinoma cells and is upregulated by protective nutrients, Oncogene, 25, 6319, 10.1038/sj.onc.1209647
Bang, 1998, Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma, Biochem. Biophys. Res. Commun., 250, 43, 10.1006/bbrc.1998.9256
Barghorn, 2001, Putative tumor suppressor loci at 6q22 and 6q23-q24 are involved in the malignant progression of sporadic endocrine pancreatic tumors, Am. J. Pathol., 158, 1903, 10.1016/S0002-9440(10)64658-5
Barron, 2015, CDKN3 mRNA as a biomarker for survival and therapeutic target in cervical cancer, PLoS One, 10, e0137397, 10.1371/journal.pone.0137397
Bassermann, 2008, The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint, Cell, 134, 256, 10.1016/j.cell.2008.05.043
Basu, 2011, PP2A in the regulation of cell motility and invasion, Curr. Protein Pept. Sci., 12, 3, 10.2174/138920311795659443
Batut, 2008, Two highly related regulatory subunits of PP2A exert opposite effects on TGF-beta/Activin/Nodal signalling, Development, 135, 2927, 10.1242/dev.020842
Beaulieu, 2005, An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior, Cell, 122, 261, 10.1016/j.cell.2005.05.012
Beca, 2015, Altered PPP2R2A and Cyclin D1 expression defines a subgroup of aggressive luminal-like breast cancer, BMC Cancer, 15, 285, 10.1186/s12885-015-1266-1
Becka, 2010, Characterization of the adhesive properties of the type IIb subfamily receptor protein tyrosine phosphatases, Cell Commun. Adhes., 17, 34, 10.3109/15419061.2010.487957
Behjati, 2014, Recurrent PTPRB and PLCG1 mutations in angiosarcoma, Nat. Genet., 46, 376, 10.1038/ng.2921
Belle, 2015, The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking, Sci. Signal., 8, ra18, 10.1126/scisignal.2005547
Benitez, 2017, PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3, Nat. Commun., 8, 15223, 10.1038/ncomms15223
Beothe, 2015, Homozygous losses detected by array comparative genomic hybridization in multiplex urothelial carcinomas of the bladder, Cancer Genet., 208, 434, 10.1016/j.cancergen.2015.05.029
Bernard-Pierrot, 2008, Characterization of the recurrent 8p 11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer, Cancer Res., 68, 7165, 10.1158/0008-5472.CAN-08-1360
Berset, 2015, The C. elegans homolog of the mammalian tumor suppressor Dep-1/Scc1 inhibits EGFR signaling to regulate binary cell fate decisions, Genes Dev., 19, 1328, 10.1101/gad.333505
Besco, 2006, Intracellular substrates of brain-enriched receptor protein tyrosine phosphatase rho (RPTPrho/PTPRT), Brain Res., 1116, 50, 10.1016/j.brainres.2006.07.122
Bi, 2016, miR-1301 promotes prostate cancer proliferation through directly targeting PPP2R2C, Biomed. Pharmacother., 81, 25, 10.1016/j.biopha.2016.03.043
Bian, 2014, Synthetic genetic array screen identifies PP2A as a therapeutic target in Mad2-overexpressing tumors, Proc. Natl. Acad. Sci. U. S. A., 111, 1628, 10.1073/pnas.1315588111
Bianchini, 2007, cDNA microarray study to identify expression changes relevant for apoptosis in K562 cells co-treated with amifostine and imatinib, Cancer Chemother. Pharmacol., 59, 349, 10.1007/s00280-006-0276-8
Bloethner, 2005, Effect of common B-RAF and N-RAS mutations on global gene expression in melanoma cell lines, Carcinogenesis, 26, 1224, 10.1093/carcin/bgi066
Bluemn, 2013, PPP2R2C loss promotes castration-resistance and is associated with increased prostate cancer-specific mortality, Mol. Cancer Res., 11, 568, 10.1158/1541-7786.MCR-12-0710
Bompard, 2002, Protein-tyrosine phosphatase PTPL1/FAP-1 triggers apoptosis in human breast cancer cells, J. Biol. Chem., 277, 47861, 10.1074/jbc.M208950200
Bonilla, 2016, Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma, Nat. Genet., 48, 398, 10.1038/ng.3525
Boulding, 2016, Differential roles for DUSP family members in epithelial-to-mesenchymal transition and cancer stem cell regulation in Breast cancer, PLoS One, 11, e0148065, 10.1371/journal.pone.0148065
Bourgonje, 2016, Comprehensive protein tyrosine phosphatase mRNA profiling identifies new regulators in the progression of glioma, Acta Neuropathol. Commun., 4, 96, 10.1186/s40478-016-0372-x
Boutros, 2007, CDC25 phosphatases in cancer cells: key players? Good targets?, Nat. Rev. Cancer, 7, 495, 10.1038/nrc2169
Boutros, 2008, Mitogen-activated protein (MAP) kinase/MAP kinase phosphatase regulation: roles in cell growth, death, and cancer, Pharmacol. Rev., 60, 261, 10.1124/pr.107.00106
Braggio, 2010, Methylation status of nine tumor suppressor genes in multiple myeloma, Int. J. Hematol., 91, 87, 10.1007/s12185-009-0459-2
Britson, 2009, Deregulation of DUSP activity in EGFR-mutant lung cancer cell lines contributes to sustained ERK1/2 signaling, Biochem. Biophys. Res. Commun., 390, 849, 10.1016/j.bbrc.2009.10.061
Broderick, 2017, Validation of recently proposed colorectal cancer susceptibility gene variants in an analysis of families and patients-a systematic review, Gastroenterology, 152, 75, 10.1053/j.gastro.2016.09.041
Brognard, 2007, PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms, Mol. Cell, 25, 917, 10.1016/j.molcel.2007.02.017
Bruecher-Encke, 2001, Role of the tyrosine phosphatase SHP-1 in K562 cell differentiation, Leukemia, 15, 1424, 10.1038/sj.leu.2402214
Bujko, 2015, Expression changes of cell–cell adhesion-related genes in colorectal tumors, Oncol Lett., 9, 2463, 10.3892/ol.2015.3107
Burgoyne, 2009, PTPmu suppresses glioma cell migration and dispersal, Neuro Oncol., 11, 767, 10.1215/15228517-2009-019
Cai, 2013, miR-205 targets PTEN and PHLPP2 to augment AKT signaling and drive malignant phenotypes in non-small cell lung cancer, Cancer Res., 73, 5402, 10.1158/0008-5472.CAN-13-0297
Cai, 2015, Down-regulation of dual-specificity phosphatase 5 predicts poor prognosis of patients with prostate cancer, Int. J. Clin. Exp. Med., 8, 4186
Calin, 2000, Low frequency of alterations of the alpha (PPP2R1A) and beta (PPP2R1B) isoforms of the subunit A of the serine-threonine phosphatase 2A in human neoplasms, Oncogene, 19, 1191, 10.1038/sj.onc.1203389
Calvisi, 2008, Dual-specificity phosphatase 1 ubiquitination in extracellular signal-regulated kinase-mediated control of growth in human hepatocellular carcinoma, Cancer Res., 68, 4192, 10.1158/0008-5472.CAN-07-6157
Cao, 2012, Tyrosine-protein phosphatase nonreceptor type 12 is a novel prognostic biomarker for esophageal squamous cell carcinoma, Ann. Thorac. Surg., 93, 1674, 10.1016/j.athoracsur.2011.12.056
Cao, 2015, Tyrosine-protein phosphatase non-receptor type 12 expression is a good prognostic factor in resectable non-small cell lung cancer, Oncotarget, 6, 11704, 10.18632/oncotarget.3588
Cardinale, 2014, PTPN3 mutations and HBV may exert synergistic effects in the origin of the intrahepatic cholangiocarcinoma, Gastroenterology, 147, 719, 10.1053/j.gastro.2014.05.046
Carpenter, 1978, Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro, Nature, 276, 409, 10.1038/276409a0
Catlett-Falcone, 1999, Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells, Immunity, 10, 105, 10.1016/S1074-7613(00)80011-4
Cengiz, 2007, Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer, Oral Oncol., 43, 241, 10.1016/j.oraloncology.2006.03.004
Challouf, 2012, Patterns of aberrant DNA hypermethylation in nasopharyngeal carcinoma in Tunisian patients, Clin. Chim. Acta, 413, 795, 10.1016/j.cca.2012.01.018
Chan, 2008, Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells, Carcinogenesis, 29, 1742, 10.1093/carcin/bgn167
Chang, 2014, MicroRNA-331-3p promotes proliferation and metastasis of hepatocellular carcinoma by targeting PH domain and leucine-rich repeat protein phosphatase, Hepatology, 60, 1251, 10.1002/hep.27221
Chang, 2014, High methylation rate of LMX1A, NKX6-1, PAX1, PTPRR, SOX1, and ZNF582 genes in cervical adenocarcinoma, Int. J. Gynecol. Cancer, 24, 201, 10.1097/IGC.0000000000000054
Chao, 2015, Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A, Oncotarget, 6, 2164, 10.18632/oncotarget.2941
Chen, 2004, Identification of specific PP2A complexes involved in human cell transformation, Cancer Cell, 5, 127, 10.1016/S1535-6108(04)00026-1
Chen, 2005, Cancer-associated PP2A Aalpha subunits induce functional haploinsufficiency and tumorigenicity, Cancer Res., 65, 8183, 10.1158/0008-5472.CAN-05-1103
Chen, 2006, Protein tyrosine phosphatase receptor-type O truncated (PTPROt) regulates SYK phosphorylation, proximal B-cell-receptor signaling, and cellular proliferation, Blood, 108, 3428, 10.1182/blood-2006-03-013821
Chen, 2007, A five-gene signature and clinical outcome in non-small-cell lung cancer, N. Engl. J. Med., 356, 11, 10.1056/NEJMoa060096
Chen, 2014, A critical role of CDKN3 in Bcr-Abl-mediated tumorigenesis, PLoS One, 9, e111611, 10.1371/journal.pone.0111611
Chen, 2015, Low expression of PHLPP1 in sacral chordoma and its association with poor prognosis, Int. J. Clin. Exp. Pathol., 8, 14741
Chen, 2015, Receptor-type tyrosine-protein phosphatase kappa directly targets STAT3 activation for tumor suppression in nasal NK/T-cell lymphoma, Blood, 125, 1589, 10.1182/blood-2014-07-588970
Chen, 2015, The importance of Src signaling in sarcoma, Oncol. Lett., 10, 17, 10.3892/ol.2015.3184
Chen, 2016, Human phosphatase CDC14A is recruited to the cell leading edge to regulate cell migration and adhesion, Proc. Natl. Acad. Sci. U. S. A., 113, 990, 10.1073/pnas.1515605113
Chen, 2017, Human phosphatase CDC14A regulates actin organization through dephosphorylation of epithelial protein lost in neoplasm, Proc. Natl. Acad. Sci. U. S. A., 114, 5201, 10.1073/pnas.1619356114
Chen, 2017, Deficiency in VHR/DUSP3, a suppressor of focal adhesion kinase, reveals its role in regulating cell adhesion and migration, Oncogene, 10.1038/onc.2017.255
Cheng, 2000, Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2C alpha and beta 2 isoforms, J. Biol. Chem., 275, 34744, 10.1074/jbc.M006210200
Cheng, 2011, Evaluation of PPP2R2A as a prostate cancer susceptibility gene: a comprehensive germline and somatic study, Cancer Genet., 204, 375, 10.1016/j.cancergen.2011.05.002
Chiarugi, 1995, PDGF receptor as a specific in vivo target for low M(r) phosphotyrosine protein phosphatase, FEBS Lett., 372, 49, 10.1016/0014-5793(95)00947-8
Chien, 2015, Activation of protein phosphatase 2A tumor suppressor as potential treatment of pancreatic cancer, Mol. Oncol., 9, 889, 10.1016/j.molonc.2015.01.002
Chiesa, 2011, The Cdc14B phosphatase displays oncogenic activity mediated by the Ras-Mek signaling pathway, Cell Cycle, 10, 1607, 10.4161/cc.10.10.15566
Chim, 2004, SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway, Blood, 103, 4630, 10.1182/blood-2003-06-2007
Chim, 2004, Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias, Ann. Hematol., 83, 527, 10.1007/s00277-004-0843-1
Chitale, 2009, An integrated genomic analysis of lung cancer reveals loss of DUSP4 in EGFR-mutant tumors, Oncogene, 28, 2773, 10.1038/onc.2009.135
Chung, 2013, Meta-analysis identifies four new loci associated with testicular germ cell tumor, Nat. Genet., 45, 680, 10.1038/ng.2634
Chung, 2016, Safety, tolerability, and preliminary activity of LB-100, an inhibitor of protein phosphatase 2A, in patients with relapsed solid tumors: an open-label, dose escalation, first-in-human, phase I trial, Clin. Cancer Res., 23, 3277, 10.1158/1078-0432.CCR-16-2299
Ciccone, 2015, From the biology of PP2A to the PADs for therapy of hematologic malignancies, Front. Oncol., 5, 21, 10.3389/fonc.2015.00021
Colella, 2001, Reduced expression of the Aalpha subunit of protein phosphatase 2A in human gliomas in the absence of mutations in the Aalpha and Abeta subunit genes, Int. J. Cancer, 93, 798, 10.1002/ijc.1423
Collett, 1978, Protein kinase activity associated with the avian sarcoma virus src gene product, Proc. Natl. Acad. Sci. U. S. A., 75, 2021, 10.1073/pnas.75.4.2021
Creyghton, 2006, PR130 is a modulator of the Wnt-signaling cascade that counters repression of the antagonist Naked cuticle, Proc. Natl. Acad. Sci. U. S. A., 103, 5397, 10.1073/pnas.0507237103
Cristóbal, 2011, PP2A impaired activity is a common event in acute myeloid leukemia and its activation by forskolin has a potent anti-leukemic effect, Leukemia, 25, 606, 10.1038/leu.2010.294
Cristóbal, 2013, Downregulation of PPP2R5E is a common event in acute myeloid leukemia that affects the oncogenic potential of leukemic cells, Haematologica, 98, e103, 10.3324/haematol.2013.084731
Cristóbal, 2016, Potential anti-tumor effects of FTY720 associated with PP2A activation: a brief review, Curr. Med. Res. Opin., 32, 1137, 10.1185/03007995.2016.1162774
Cristóbal, 2017, Downregulation of microRNA-199b predicts unfavorable prognosis and emerges as a novel therapeutic target which contributes to PP2A inhibition in metastatic colorectal cancer, Oncotarget, 8, 40169, 10.18632/oncotarget.11174
Croonquist, 2003, Gene profiling of a myeloma cell line reveals similarities and unique signatures among IL-6 response, N-ras-activating mutations, and coculture with bone marrow stromal cells, Blood, 102, 2581, 10.1182/blood-2003-04-1227
Csikesz, 2013, Primary cutaneous CD30-positive T-cell lymphoproliferative disorders with biallelic rearrangements of DUSP22, J. Invest. Dermatol., 133, 1680, 10.1038/jid.2013.22
Cui, 1996, TGFbeta1 inhibits the formation of benign skin tumors, but enhances progression to invasive spindle carcinomas in transgenic mice, Cell, 86, 531, 10.1016/S0092-8674(00)80127-0
Cui, 2006, Elevated expression of mitogen-activated protein kinase phosphatase 3 in breast tumors: a mechanism of tamoxifen resistance, Cancer Res., 66, 5950, 10.1158/0008-5472.CAN-05-3243
Cui, 2014, High levels of KAP1 expression are associated with aggressive clinical features in ovarian cancer, Int. J. Mol. Sci., 16, 363, 10.3390/ijms16010363
Cunningham, 2016, Therapeutic relevance of the protein phosphatase 2A in cancer, Oncotarget, 7, 61544, 10.18632/oncotarget.11399
Curtis, 2012, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups, Nature, 486, 346, 10.1038/nature10983
Dai, 2011, PPM1A dephosphorylates RanBP3 to enable efficient nuclear export of Smad2 and Smad3, EMBO Rep., 12, 1175, 10.1038/embor.2011.174
Darnell, 2005, Validating Stat3 in cancer therapy, Nat. Med., 11, 595, 10.1038/nm0605-595
David, 1995, Differential regulation of the alpha/beta interferon-stimulated Jak/Stat pathway by the SH2 domain-containing tyrosine phosphatase SHPTP1, Mol. Cell. Biol., 15, 7050, 10.1128/MCB.15.12.7050
Deichmann, 2001, The protein phosphatase 2A subunit Bgamma gene is identified to be differentially expressed in malignant melanomas by subtractive suppression hybridization, Melanoma Res., 11, 577, 10.1097/00008390-200112000-00004
Deng, 2016, Methylation and expression of PTPN22 in esophageal squamous cell carcinoma, Oncotarget, 7, 64043, 10.18632/oncotarget.11581
Denkert, 2002, Expression of mitogen-activated protein kinase phosphatase-1 (MKP-1) in primary human ovarian carcinoma, Int. J. Cancer, 102, 507, 10.1002/ijc.10746
Derynck, 2001, TGF-beta signaling in tumor suppression and cancer progression, Nat. Genet., 29, 117, 10.1038/ng1001-117
d'Amore, 2012, Up-front autologous stem-cell transplantation in peripheral T-cell lymphoma: NLG-T-01, J. Clin. Oncol., 30, 3093, 10.1200/JCO.2011.40.2719
de Voer, 2016, Identification of novel candidate genes for early-onset colorectal cancer susceptibility, PLoS Genet., 12, e1005880, 10.1371/journal.pgen.1005880
Di Conza, 2017, The mTOR and PP2A pathways regulate PHD2 phosphorylation to fine-tune HIF1α levels and colorectal cancer cell survival under hypoxia, Cell Rep., 18, 1699, 10.1016/j.celrep.2017.01.051
Di Conza, 2017, PHD2 targeting overcomes breast cancer cell death upon glucose starvation in a PP2A/B55α-mediated manner, Cell Rep., 18, 2836, 10.1016/j.celrep.2017.02.081
Dillon, 2014, Therapeutic targeting of cancers with loss of PTEN function, Curr. Drug Targets, 15, 65, 10.2174/1389450114666140106100909
Ding, 2017, MicroRNA-27a contributes to the malignant behavior of gastric cancer cells by directly targeting PH domain and leucine-rich repeat protein phosphatase 2, J. Exp. Clin. Cancer Res., 36, 45, 10.1186/s13046-017-0516-2
Dong, 2017, PTPRO represses ERBB2-driven breast oncogenesis by dephosphorylation and endosomal internalization of ERBB2, Oncogene, 36, 410, 10.1038/onc.2016.213
Dromard, 2007, The putative tumor suppressor gene PTPN13/PTPL1 induces apoptosis through insulin receptor substrate-1 dephosphorylation, Cancer Res., 67, 6806, 10.1158/0008-5472.CAN-07-0513
Du WW, 2013, MicroRNA miR-24 enhances tumor invasion and metastasis by targeting PTPN9 and PTPRF to promote EGF signaling, J. Cell Sci., 126, 1440, 10.1242/jcs.118299
Eckhart, 1979, An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates, Cell, 18, 925, 10.1016/0092-8674(79)90205-8
Eichhorn, 2007, A RNA interference screen identifies the protein phosphatase 2A subunit PR55gamma as a stress-sensitive inhibitor of c-SRC, PLoS Genet., 3, e218, 10.1371/journal.pgen.0030218
Eichhorn, 2009, Protein phosphatase 2A regulatory subunits and cancer, Biochim. Biophys. Acta, 1795, 1
ElShamy, 2004, Identification of BRCA1-IRIS, a BRCA1 locus product, Nat. Cell Biol., 6, 954, 10.1038/ncb1171
Elson, 2017, Stepping out of the shadows: oncogenic and tumor-promoting protein tyrosine phosphatases, Int. J. Biochem. Cell Biol.
Escós, 2016, P38γ and p38δ mitogen activated protein kinases (MAPKs), new stars in the MAPK galaxy, Front. Cell Dev. Biol., 4, 31, 10.3389/fcell.2016.00031
Fan, 2013, Over expression of PPP2R2C inhibits human glioma cells growth through the suppression of mTOR pathway, FEBS Lett., 587, 3892, 10.1016/j.febslet.2013.09.029
Fan, 2014, Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex, Mol. Cell, 53, 534, 10.1016/j.molcel.2013.12.026
Fan, 2014, SHP-1 is a target of regorafenib in colorectal cancer, Oncotarget, 5, 6243, 10.18632/oncotarget.2191
Fan, 2015, Overexpression of major CDKN3 transcripts is associated with poor survival in lung adenocarcinoma, Br. J. Cancer, 113, 1735, 10.1038/bjc.2015.378
Fan, 2016, Phosphatase PPM1A is a novel prognostic marker in pancreatic ductal adenocarcinoma, Hum. Pathol., 55, 151, 10.1016/j.humpath.2016.05.002
Feldman, 2011, Discovery of recurrent t(6;7)(p25.3;q32.3) translocations in ALK-negative anaplastic large cell lymphomas by massively parallel genomic sequencing, Blood, 117, 915, 10.1182/blood-2010-08-303305
Feng, 2017, Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium, Sci. Rep., 7, 825, 10.1038/s41598-017-00850-0
Feurstein, 2014, Haploinsufficiency of ETV6 and CDKN1B in patients with acute myeloid leukemia and complex karyotype, BMC Genomics, 15, 784, 10.1186/1471-2164-15-784
Fiaschi, 2001, Low molecular weight protein-tyrosine phosphatase is involved in growth inhibition during cell differentiation, J. Biol. Chem., 276, 49156, 10.1074/jbc.M107538200
Forsterova, 2010, Advanced rai stage in patients with chronic lymphocytic leukaemia correlates with simultaneous hypermethylation of plural tumour suppressor genes, Folia Biol. (Praha), 56, 158
Forti, 2015, Combined experimental and bioinformatics analysis for the prediction and identification of VHR/DUSP3 nuclear targets related to DNA damage and repair, Integr. Biol. (Camb), 7, 73, 10.1039/C4IB00186A
Fridberg, 2008, Immunohistochemical analyses of phosphatases in childhood B-cell lymphoma: lower expression of PTEN and HePTP and higher number of positive cells for nuclear SHP2 in B-cell lymphoma cases compared to controls, Pediatr. Hematol. Oncol., 25, 528, 10.1080/08880010802237054
Funato, 2011, Tyrosine phosphatase PTPRD suppresses colon cancer cell migration in coordination with CD44, Exp. Ther. Med., 2, 457, 10.3892/etm.2011.231
Furukawa, 2003, Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer, Am. J. Pathol., 162, 1807, 10.1016/S0002-9440(10)64315-5
Furukawa, 2005, Distinct progression pathways involving the dysfunction of DUSP6/MKP-3 in pancreatic intraepithelial neoplasia and intraductal papillary-mucinous neoplasms of the pancreas, Mod. Pathol., 18, 1034, 10.1038/modpathol.3800383
Gaedcke, 2010, Mutated KRAS results in overexpression of DUSP4, a MAP-kinase phosphatase, and SMYD3, a histone methyltransferase, in rectal carcinomas, Genes Chromosomes Cancer, 49, 1024, 10.1002/gcc.20811
Galeano, 2013, ADAR2-editing activity inhibits glioblastoma growth through the modulation of the CDC14B/Skp2/p21/p27 axis, Oncogene, 32, 998, 10.1038/onc.2012.125
Gangula, 2013, WD repeat protein WDR48 in complex with deubiquitinase USP12 suppresses Akt-dependent cell survival signaling by stabilizing PH domain leucine-rich repeat protein phosphatase 1 (PHLPP1), J. Biol. Chem., 288, 34545, 10.1074/jbc.M113.503383
Gao, 2005, PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth, Mol. Cell, 18, 13, 10.1016/j.molcel.2005.03.008
Gao, 2008, The phosphatase PHLPP controls the cellular levels of protein kinase C, J. Biol. Chem., 283, 6300, 10.1074/jbc.M707319200
Gao, 2014, Activating mutations in PTPN3 promote cholangiocarcinoma cell proliferation and migration and are associated with tumor recurrence in patients, Gastroenterology, 146, 1397, 10.1053/j.gastro.2014.01.062
Geng, 2014, Loss of PPM1A expression enhances invasion and the epithelial-to-mesenchymal transition in bladder cancer by activating the TGF-β/Smad signaling pathway, Oncotarget, 5, 5700, 10.18632/oncotarget.2144
Giefing, 2011, High resolution ArrayCGH and expression profiling identifies PTPRD and PCDH17/PCH68 as tumor suppressor gene candidates in laryngeal squamous cell carcinoma, Genes Chromosomes Cancer, 50, 154, 10.1002/gcc.20840
Gilan, 2015, PR55α-containing protein phosphatase 2A complexes promote cancer cell migration and invasion through regulation of AP-1 transcriptional activity, Oncogene, 34, 1333, 10.1038/onc.2014.26
Givant-Horwitz, 2004, The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma, Gynecol. Oncol., 93, 517, 10.1016/j.ygyno.2004.03.009
Glondu-Lassis, 2010, PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase, Cancer Res., 70, 5116, 10.1158/0008-5472.CAN-09-4368
Griswold-Prenner, 1998, Physical and functional interactions between type I transforming growth factor beta receptors and Balpha, a WD-40 repeat subunit of phosphatase 2A, Mol. Cell. Biol., 18, 6595, 10.1128/MCB.18.11.6595
Grzechnik, 2016, PHLPPing through history: a decade in the life of PHLPP phosphatases, Biochem. Soc. Trans., 44, 1675, 10.1042/BST20160170
Gu, 2015, MicroRNA-145 inhibits human papillary cancer TPC1 cell proliferation by targeting DUSP6, Int. J. Clin. Exp. Med., 8, 8590
Gutierrez, 2014, Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia, J. Clin. Invest., 124, 644, 10.1172/JCI65093
Gutteridge, 2017, Targeted knockdown of polo-like kinase 1 alters metabolic regulation in melanoma, Cancer Lett., 394, 13, 10.1016/j.canlet.2017.02.013
Haag, 2016, The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms, BMC Cancer, 16, 49, 10.1186/s12885-016-2087-6
Hachana, 2009, Evidence for a role of the Simian Virus 40 in human breast carcinomas, Breast Cancer Res. Treat., 113, 43, 10.1007/s10549-008-9901-z
Haesen, 2016, Recurrent PPP2R1A mutations in uterine cancer act through a dominant-negative mechanism to promote malignant cell growth, Cancer Res., 76, 5719, 10.1158/0008-5472.CAN-15-3342
Hahn, 2002, Rules for making human tumor cells, N. Engl. J. Med., 347, 1593, 10.1056/NEJMra021902
Hahn, 1999, Creation of human tumour cells with defined genetic elements, Nature, 400, 464, 10.1038/22780
Hahn, 2002, Enumeration of the simian virus 40 early region elements necessary for human cell transformation, Mol. Cell. Biol., 22, 2111, 10.1128/MCB.22.7.2111-2123.2002
Hahn, 2010, PP2A regulatory subunit PP2A-B' counteracts S6K phosphorylation, Cell Metab., 11, 438, 10.1016/j.cmet.2010.03.015
Han, 2013, The role of PTPN13 in invasion and metastasis of lung squamous cell carcinoma, Exp. Mol. Pathol., 95, 270, 10.1016/j.yexmp.2013.07.008
Han, 2013, Stat3 inhibits PTPN13 expression in squamous cell lung carcinoma through recruitment of HDAC5, Biomed. Res. Int., 468963
Hanada, 1998, Selective suppression of stress-activated protein kinase pathway by protein phosphatase 2C in mammalian cells, FEBS Lett., 437, 172, 10.1016/S0014-5793(98)01229-0
Hanada, 2001, Regulation of the TAK1 signaling pathway by protein phosphatase 2C, J. Biol. Chem., 276, 5753, 10.1074/jbc.M007773200
Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013
Hannon, 1994, KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases, Proc. Natl. Acad. Sci. U. S. A., 91, 1731, 10.1073/pnas.91.5.1731
Hao, 2007, BRCA1-IRIS activates cyclin D1 expression in breast cancer cells by downregulating the JNK phosphatase DUSP3/VHR, Int. J. Cancer, 121, 39, 10.1002/ijc.22597
Hao, 2015, Disruption of a regulatory loop between DUSP1 and p53 contributes to hepatocellular carcinoma development and progression, J. Hepatol., 62, 1278, 10.1016/j.jhep.2014.12.033
Hassan, 2010, Structural and functional analysis of human prostatic acid phosphatase, Expert Rev. Anticancer Ther., 10, 1055, 10.1586/era.10.46
Hausmann, 2015, ILKAP, ILK and PINCH1 control cell survival of p53-wildtype glioblastoma cells after irradiation, Oncotarget, 6, 34592, 10.18632/oncotarget.5423
Hein, 2016, PR55α subunit of protein phosphatase 2A supports the tumorigenic and metastatic potential of pancreatic cancer cells by sustaining hyperactive oncogenic signaling, Cancer Res., 76, 2243, 10.1158/0008-5472.CAN-15-2119
Hellberg, 2002, Expression of the receptor protein-tyrosine phosphatase, PTPmu, restores E-cadherin-dependent adhesion in human prostate carcinoma cells, J. Biol. Chem., 277, 11165, 10.1074/jbc.M112157200
Henkens, 2008, Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR, BMC Cancer, 8, 147, 10.1186/1471-2407-8-147
Hijiya, 2016, Genomic loss of DUSP4 contributes to the progression of intraepithelial neoplasm of pancreas to invasive carcinoma, Cancer Res., 76, 2612, 10.1158/0008-5472.CAN-15-1846
Hiscox, 1999, Association of the HGF/SF receptor, c-met, with the cell-surface adhesion molecule, E-cadherin, and catenins in human tumor cells, Biochem. Biophys. Res. Commun., 261, 406, 10.1006/bbrc.1999.1002
Holness, 2003, Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation, Biochem. Soc. Trans., 31, 1143, 10.1042/bst0311143
Hong, 2015, LB100, a small molecule inhibitor of PP2A with potent chemo- and radio-sensitizing potential, Cancer Biol. Ther., 16, 821, 10.1080/15384047.2015.1040961
Hong, 2016, miR-96 promotes cell proliferation, migration and invasion by targeting PTPN9 in breast cancer, Sci. Rep., 6, 37421, 10.1038/srep37421
Hoornaert, 2003, MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p 12–13, reduces BCR-ABL-induced transformation, Oncogene, 22, 7728, 10.1038/sj.onc.1207089
Hoover, 2009, Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway, Oncogene, 28, 3960, 10.1038/onc.2009.251
Horita, 2008, Suppression of the invasive capacity of rat ascites hepatoma cells by knockdown of Slingshot or LIM kinase, J. Biol. Chem., 283, 6013, 10.1074/jbc.M706538200
Hou, 2012, FKBP5 as a selection biomarker for gemcitabine and Akt inhibitors in treatment of pancreatic cancer, PLoS One, 7, e36252, 10.1371/journal.pone.0036252
Hou, 2010, PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction, Cancer Res., 70, 2901, 10.1158/0008-5472.CAN-09-3229
Hou, 2013, Estrogen-sensitive PTPRO expression represses hepatocellular carcinoma progression by control of STAT3, Hepatology, 57, 678, 10.1002/hep.25980
Houge, 2015, B56δ-related protein phosphatase 2A dysfunction identified in patients with intellectual disability, J. Clin. Invest., 125, 3051, 10.1172/JCI79860
Hoyt, 2007, Cutting edge: selective tyrosine dephosphorylation of interferon-activated nuclear STAT5 by the VHR phosphatase, J. Immunol., 179, 3402, 10.4049/jimmunol.179.6.3402
Hsu, 2013, Methylation of the PTPRO gene in human hepatocellular carcinoma and identification of VCP as its substrate, J. Cell. Biochem., 114, 1810, 10.1002/jcb.24525
Hu, 2006, Association and regulation of heat shock transcription factor 4b with both extracellular signal-regulated kinase mitogen-activated protein kinase and dual-specificity tyrosine phosphatase DUSP26, Mol. Cell. Biol., 26, 3282, 10.1128/MCB.26.8.3282-3294.2006
Hu, 2015, Inhibition of pten deficient castration resistant prostate cancer by targeting of the SET - PP2A signaling axis, Sci. Rep., 5, 15182, 10.1038/srep15182
Hu, 2016, Downregulated expression of PTPN9 contributes to human hepatocellular carcinoma growth and progression, Pathol. Oncol. Res., 22, 555, 10.1007/s12253-015-0038-1
Hua, 2014, The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis, Mol. Cancer, 13, 189, 10.1186/1476-4598-13-189
Huang, 1998, Isoenzymes of pyruvate dehydrogenase phosphatase DNA-derived amino acid sequences, expression, and regulation, J. Biol. Chem., 273, 17680, 10.1074/jbc.273.28.17680
Huang, 2013, PTPRO promoter methylation is predictive of poorer outcome for HER2-positive breast cancer: indication for personalized therapy, J. Transl. Med., 11, 245, 10.1186/1479-5876-11-245
Huang, 2013, Fas-associated phosphatase 1 mediates Fas resistance in myeloid progenitor cells expressing the Bcr-abl oncogene, Leuk. Lymphoma, 54, 619, 10.3109/10428194.2012.720979
Hung, 2016, SET antagonist enhances the chemosensitivity of non-small cell lung cancer cells by reactivating protein phosphatase 2A, Oncotarget, 7, 638, 10.18632/oncotarget.6313
Hunt, 2013, On the regulation of protein phosphatase 2A and its role in controlling entry into and exit from mitosis, Adv. Biol. Regul., 53, 173, 10.1016/j.jbior.2013.04.001
Hunter, 2000, Signaling–2000 and beyond, Cell, 100, 113, 10.1016/S0092-8674(00)81688-8
Iervolino, 2006, The receptor-type protein tyrosine phosphatase J antagonizes the biochemical and biological effects of RET-derived oncoproteins, Cancer Res., 66, 6280, 10.1158/0008-5472.CAN-06-0228
Igawa, 2003, Suppression of LNCaP prostate cancer xenograft tumors by a prostate-specific protein tyrosine phosphatase, prostatic acid phosphatase, Prostate, 55, 247, 10.1002/pros.10240
Inazawa, 1996, PTPN13, a fas-associated protein tyrosine phosphatase, is located on the long arm of chromosome 4 at band q21.3, Genomics, 31, 240, 10.1006/geno.1996.0039
Ishibashi, 1992, Expression cloning of a human dual-specificity phosphatase, Proc. Natl. Acad. Sci. U. S. A., 89, 12170, 10.1073/pnas.89.24.12170
Ito, 2000, A truncated isoform of the PP2A B56 subunit promotes cell motility through paxillin phosphorylation, EMBO J., 19, 562, 10.1093/emboj/19.4.562
Ito, 2016, Activation of ERK/IER3/PP2A-B56γ-positive feedback loop in lung adenocarcinoma by allelic deletion of B56γ gene, Oncol. Rep., 35, 2635, 10.3892/or.2016.4677
Iuliano, 2004, The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis, Oncogene, 23, 8432, 10.1038/sj.onc.1207766
Janssens, 2001, Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling, Biochem. J, 353, 417, 10.1042/bj3530417
Janssens, 2012, The role and therapeutic potential of Ser/Thr phosphatase PP2A in apoptotic signalling networks in human cancer cells, Curr. Mol. Med., 12, 268, 10.2174/156652412799218930
Janssens, 2016, PP2A binds to the LIM domains of lipoma-preferred partner through its PR130/B′′ subunit to regulate cell adhesion and migration, J. Cell Sci., 129, 1605, 10.1242/jcs.175778
Jardin, 2012, Identification of the structural features that mediate binding specificity in the recognition of STAT proteins by dual-specificity phosphatases, J. Biomol. Struct. Dyn., 29, 777, 10.1080/07391102.2012.10507413
Jeong, 2016, Patient derived mutation W257G of PPP2R1A enhances cancer cell migration through SRC-JNK-c-Jun pathway, Sci. Rep., 6, 27391, 10.1038/srep27391
Jiang, 2014, Survival and inflammation promotion effect of PTPRO in fulminant hepatitis is associated with NF-kappaB activation, J. Immunol., 193, 5161, 10.4049/jimmunol.1303354
Jiang, 2015, MicroRNA-3127 promotes cell proliferation and tumorigenicity in hepatocellular carcinoma by disrupting of PI3K/AKT negative regulation, Oncotarget, 6, 6359, 10.18632/oncotarget.3438
Jiang, 2015, miR-93 promotes cell proliferation in gliomas through activation of PI3K/Akt signaling pathway, Oncotarget, 6, 8286, 10.18632/oncotarget.3221
Jin, 2010, PP2A:B56{epsilon}, a substrate of caspase-3, regulates p53-dependent and p53-independent apoptosis during development, J. Biol. Chem., 285, 34493, 10.1074/jbc.M110.169581
Ju, 2016, Scaffold role of DUSP22 in ASK1-MKK7-JNK signaling pathway, PLoS One, 11, e0164259, 10.1371/journal.pone.0164259
Julien, 2011, Inside the human cancer tyrosine phosphatome, Nat. Rev. Cancer, 11, 35, 10.1038/nrc2980
Jung, 2012, Discovery of ALK-PTPN3 gene fusion from human non-small cell lung carcinoma cell line using next generation RNA sequencing, Genes Chromosomes Cancer, 51, 590, 10.1002/gcc.21945
Junttila, 2007, CIP2A inhibits PP2A in human malignancies, Cell, 130, 51, 10.1016/j.cell.2007.04.044
Juszczynski, 2009, BCL6 modulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt, Blood, 114, 5315, 10.1182/blood-2009-02-204362
Kalev, 2012, Loss of PPP2R2A inhibits homologous recombination DNA repair and predicts tumor sensitivity to PARP inhibition, Cancer Res., 72, 6414, 10.1158/0008-5472.CAN-12-1667
Kaplon, 2013, A key role for mitochondrial gatekeeper pyruvate dehydrogenase in oncogene-induced senescence, Nature, 498, 109, 10.1038/nature12154
Karai, 2013, Chromosomal rearrangements of 6p25.3 define a new subtype of lymphomatoid papulosis, Am. J. Surg. Pathol., 37, 1173, 10.1097/PAS.0b013e318282d01e
Karlsson, 2015, Loss of protein tyrosine phosphatase, non-receptor type 2 is associated with activation of AKT and tamoxifen resistance in breast cancer, Breast Cancer Res. Treat., 153, 31, 10.1007/s10549-015-3516-y
Kaur, 2016, Regulation of protein phosphatase 2A (PP2A) tumor suppressor function by PME-1, Biochem. Soc. Trans., 44, 1683, 10.1042/BST20160161
Kaur, 2015, Protein phosphatase methylesterase-1 (PME-1) expression predicts a favorable clinical outcome in colorectal cancer, Cancer Med., 4, 1798, 10.1002/cam4.541
Kaur, 2016, PP2A inhibitor PME-1 drives kinase inhibitor resistance in glioma cells, Cancer Res., 76, 7001, 10.1158/0008-5472.CAN-16-1134
Kawahara, 2013, Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration, PLoS One, 8, e63729, 10.1371/journal.pone.0063729
Keane, 1996, The protein tyrosine phosphatase DEP-1 is induced during differentiation and inhibits growth of breast cancer cells, Cancer Res., 56, 4236
Khanna, 2016, Clinical significance of cancerous inhibitor of protein phosphatase 2A in human cancers, Int. J. Cancer, 138, 525, 10.1002/ijc.29431
Khanna, 2013, Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells, Cancer Res., 73, 6757, 10.1158/0008-5472.CAN-13-1002
Khor, 2013, DNA methylation profiling revealed promoter hypermethylation-induced silencing of p16, DDAH2 and DUSP1 in primary oral squamous cell carcinoma, Int. J. Med. Sci., 10, 1727, 10.7150/ijms.6884
Kibel, 2004, Expression mapping at 12p 12-13 in advanced prostate carcinoma, Int. J. Cancer, 109, 668, 10.1002/ijc.20060
Kidger, 2017, Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling, Proc. Natl. Acad. Sci. U. S. A., 114, E317, 10.1073/pnas.1614684114
Kim, 1999, Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1, Blood, 93, 3893, 10.1182/blood.V93.11.3893
Kim, 2002, Gastrin-releasing peptide is a growth factor for human neuroblastomas, Ann. Surg., 235, 621, 10.1097/00000658-200205000-00003
Kim, 2014, The DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth, Nat. Commun., 5, 3351, 10.1038/ncomms4351
Kim, 2014, Loss of CDC14B expression in clear cell renal cell carcinoma: meta-analysis of microarray data sets, Am. J. Clin. Pathol., 141, 551, 10.1309/AJCP4PE4JPSRGBQS
King, 2016, Morphologic features of ALK-negative anaplastic large cell lymphomas with DUSP22 rearrangements, Am. J. Surg. Pathol., 40, 36, 10.1097/PAS.0000000000000500
Kleppe, 2010, Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia, Nat. Genet., 42, 530, 10.1038/ng.587
Kleppe, 2011, Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin's lymphoma and T-cell non-Hodgkin's lymphoma, Haematologica, 96, 1723, 10.3324/haematol.2011.041921
Kleppe, 2011, PTPN2 negatively regulates oncogenic JAK1 in T-cell acute lymphoblastic leukemia, Blood, 117, 7090, 10.1182/blood-2010-10-314286
Klingler-Hoffmann, 2001, The protein tyrosine phosphatase TCPTP suppresses the tumorigenicity of glioblastoma cells expressing a mutant epidermal growth factor receptor, J. Biol. Chem., 276, 46313, 10.1074/jbc.M106571200
Klingmüller, 1995, Specific recruitment of SH-PTP1 to the erythropoietin receptor causes inactivation of JAK2 and termination of proliferative signals, Cell, 80, 729, 10.1016/0092-8674(95)90351-8
Klumpp, 2003, Protein phosphatase type 2C dephosphorylates BAD, Neurochem. Int., 42, 555, 10.1016/S0197-0186(02)00174-2
Kodama, 2016, Transposon mutagenesis identifies genes and cellular processes driving epithelial-mesenchymal transition in hepatocellular carcinoma, Proc. Natl. Acad. Sci. U. S. A., 113, E3384, 10.1073/pnas.1606876113
Koh, 2002, The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family, Curr. Biol., 12, 317, 10.1016/S0960-9822(02)00652-8
Kolupaeva, 2013, PP1 and PP2A phosphatases–cooperating partners in modulating retinoblastoma protein activation, FEBS J., 280, 627, 10.1111/j.1742-4658.2012.08511.x
Kolupaeva, 2013, The B55α regulatory subunit of protein phosphatase 2A mediates fibroblast growth factor-induced p107 dephosphorylation and growth arrest in chondrocytes, Mol. Cell. Biol., 33, 2865, 10.1128/MCB.01730-12
Kontturi, 1991, Is acid phosphatase (PAP) still justified in the management of prostatic cancer?, Acta Oncol., 30, 169, 10.3109/02841869109092343
Kovalenko, 2000, Site-selective dephosphorylation of the platelet-derived growth factor beta-receptor by the receptor-like protein-tyrosine phosphatase DEP-1, J. Biol. Chem., 275, 16219, 10.1074/jbc.275.21.16219
Kucharska, 2009, Regulation of the inducible nuclear dual-specificity phosphatase DUSP5 by ERK MAPK, Cell. Signal., 21, 1794, 10.1016/j.cellsig.2009.07.015
Kumar, 2004, ILKAP regulates ILK signaling and inhibits anchorage-independent growth, Oncogene, 23, 3454, 10.1038/sj.onc.1207473
Kuo, 2008, Regulation of phosphorylation of Thr-308 of Akt, cell proliferation, and survival by the B55alpha regulatory subunit targeting of the protein phosphatase 2A holoenzyme to Akt, J. Biol. Chem., 283, 1882, 10.1074/jbc.M709585200
Kurimchak, 2013, Activation of p107 by fibroblast growth factor, which is essential for chondrocyte cell cycle exit, is mediated by the protein phosphatase 2A/B55α holoenzyme, Mol. Cell. Biol., 33, 3330, 10.1128/MCB.00082-13
Labes, 1998, A novel phosphatase regulating neurite extension on CNS inhibitors, Mol. Cell. Neurosci., 12, 29, 10.1006/mcne.1998.0692
Laczmanska, 2011, Tyrosine phosphatases as a superfamily of tumor suppressors in colorectal cancer, Acta Biochim. Pol., 58, 467, 10.18388/abp.2011_2212
Laczmanska, 2013, Protein tyrosine phosphatase receptor-like genes are frequently hypermethylated in sporadic colorectal cancer, J. Hum. Genet., 58, 11, 10.1038/jhg.2012.119
Lai, 2012, Overexpression of cyclin-dependent kinase-associated protein phosphatase enhances cell proliferation in renal cancer cells, Urol. Oncol., 30, 871, 10.1016/j.urolonc.2010.09.010
Lai, 2016, The B56γ3 regulatory subunit-containing protein phosphatase 2A outcompetes Akt to regulate p27KIP1 subcellular localization by selectively dephosphorylating phospho-Thr157 of p27KIP1, Oncotarget, 7, 4542, 10.18632/oncotarget.6609
Laine, 2014, Molecular pathways: harnessing E2F1 regulation for prosenescence therapy in p53-defective cancer cells, Clin. Cancer Res., 20, 3644, 10.1158/1078-0432.CCR-13-1942
Lambrecht, 2013, Structure, regulation, and pharmacological modulation of PP2A phosphatases, Methods Mol. Biol., 1053, 283, 10.1007/978-1-62703-562-0_17
Lambrecht, 2017, Loss of protein phosphatase 2A regulatory subunit B56δ promotes spontaneous tumorigenesis in vivo, Oncogene
Lammers, 2007, Role of type 2C protein phosphatases in growth regulation and in cellular stress signaling, Crit. Rev. Biochem. Mol. Biol., 42, 437, 10.1080/10409230701693342
Lammers, 2007, Role of PP2Calpha in cell growth, in radio- and chemosensitivity, and in tumorigenicity, Mol. Cancer, 6, 65, 10.1186/1476-4598-6-65
Lee, 2009, Genomic-wide analysis of lymphatic metastasis-associated genes in human hepatocellular carcinoma, World J. Gastroenterol., 15, 356, 10.3748/wjg.15.356
Lee, 2010, DUSP16 is an epigenetically regulated determinant of JNK signalling in Burkitt's lymphoma, Br. J. Cancer, 103, 265, 10.1038/sj.bjc.6605711
Lee, 2017, Targeted disruption of TC-PTP in the proliferative compartment augments STAT3 and AKT signaling and skin tumor development, Sci. Rep., 7, 45077, 10.1038/srep45077
Lee-Hoeflich, 2011, PPM1H is a p27 phosphatase implicated in trastuzumab resistance, Cancer Discov., 1, 326, 10.1158/2159-8290.CD-11-0062
Lessard, 2010, The two faces of PTP1B in cancer, Biochim. Biophys. Acta, 1804, 613, 10.1016/j.bbapap.2009.09.018
Lesueur, 2005, Allelic association of the human homologue of the mouse modifier Ptprj with breast cancer, Hum. Mol. Genet., 14, 2349, 10.1093/hmg/ddi237
Letourneux, 2006, B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK, EMBO J., 25, 727, 10.1038/sj.emboj.7600980
Leung-Hagesteijn, 2001, Modulation of integrin signal transduction by ILKAP, a protein phosphatase 2C associating with the integrin-linked kinase, ILK1, EMBO J., 20, 2160, 10.1093/emboj/20.9.2160
Levea, 2000, PTP LAR. expression compared to prognostic indices in metastatic and non-metastatic breast cancer, Breast Cancer Res. Treat., 64, 221, 10.1023/A:1006410509740
Levinson, 1978, Evidence that the transforming gene of avian sarcoma virus encodes a protein kinase associated with a phosphoprotein, Cell, 15, 561, 10.1016/0092-8674(78)90024-7
Li, 1996, The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A, J. Biol. Chem., 271, 11059, 10.1074/jbc.271.19.11059
Li, 2000, Negative regulation of Fas-mediated apoptosis by FAP-1 in human cancer cells, Int. J. Cancer, 87, 473, 10.1002/1097-0215(20000815)87:4<473::AID-IJC3>3.0.CO;2-1
Li, 2010, JNK pathway-associated phosphatase dephosphorylates focal adhesion kinase and suppresses cell migration, J. Biol. Chem., 285, 5472, 10.1074/jbc.M109.060186
Li, 2013, Metal-dependent protein phosphatase 1A functions as an extracellular signal-regulated kinase phosphatase, FEBS J., 280, 2700, 10.1111/febs.12275
Li, 2013, The deubiquitination enzyme USP46 functions as a tumor suppressor by controlling PHLPP-dependent attenuation of Akt signaling in colon cancer, Oncogene, 32, 471, 10.1038/onc.2012.66
Li, 2014, PHLPP is a negative regulator of RAF1, which reduces colorectal cancer cell motility and prevents tumor progression in mice, Gastroenterology, 146, 1301, 10.1053/j.gastro.2014.02.003
Li, 2014, Methylation and decreased expression of SHP-1 are related to disease progression in chronic myelogenous leukemia, Oncol. Rep., 31, 2438, 10.3892/or.2014.3098
Li, 2014, CDKN3 is an independent prognostic factor and promotes ovarian carcinoma cell proliferation in ovarian cancer, Oncol. Rep., 31, 1825, 10.3892/or.2014.3045
Li, 2014, Aberrant PTPRO methylation in tumor tissues as a potential biomarker that predicts clinical outcomes in breast cancer patients, BMC Genet., 15, 67, 10.1186/1471-2156-15-67
Li, 2015, The association between Salt-inducible kinase 2 (SIK2) and gamma isoform of the regulatory subunit B55 of PP2A (B55gamma) contributes to the survival of glioma cells under glucose depletion through inhibiting the phosphorylation of S6K, Cancer Cell Int., 15, 21, 10.1186/s12935-015-0164-6
Li, 2015, Protein tyrosine phosphatase PTPN3 inhibits lung cancer cell proliferation and migration by promoting EGFR endocytic degradation, Oncogene, 34, 3791, 10.1038/onc.2014.312
Li, 2015, Loss of PTPN12 stimulates progression of erbB2-dependent breast cancer by enhancing cell survival, migration, and epithelial-to-mesenchymal transition, Mol. Cell. Biol., 35, 4069, 10.1128/MCB.00741-15
Li, 2015, KAP regulates ROCK2 and Cdk2 in an RNA-activated glioblastoma invasion pathway, Oncogene, 34, 1432, 10.1038/onc.2014.49
Li, 2015, Methylation profiling of 48 candidate genes in tumor and matched normal tissues from breast cancer patients, Breast Cancer Res. Treat., 149, 767, 10.1007/s10549-015-3276-8
Li, 2016, Methylation analysis of plasma cell-free DNA for breast cancer early detection using bisulfite next-generation sequencing, Tumour Biol., 37, 13111, 10.1007/s13277-016-5190-z
Li, 2017, Knockdown of cyclin-dependent kinase inhibitor-3 inhibits proliferation and invasion in human gastric cancer cells, Oncol. Res., 25, 721, 10.3727/096504016X14772375848616
Liao, 2003, Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells, Gastroenterology, 124, 1830, 10.1016/S0016-5085(03)00398-6
Lin, 1996, Tyrosine phosphorylation of a 185kDa phosphoprotein (pp185) inversely correlates with the cellular activity of human prostatic acid phosphatase, Biochem. Biophys. Res. Commun., 226, 206, 10.1006/bbrc.1996.1334
Lin, 2001, Decreased expression of cellular prostatic acid phosphatase increases tumorigenicity of human prostate cancer cells, J. Urol., 166, 1943, 10.1016/S0022-5347(05)65725-4
Lin, 2006, PPM1A functions as a Smad phosphatase to terminate TGFbeta signaling, Cell, 125, 915, 10.1016/j.cell.2006.03.044
Lin, 2011, Suppression of dual-specificity phosphatase-2 by hypoxia increases chemoresistance and malignancy in human cancer cells, J. Clin. Invest., 121, 1905, 10.1172/JCI44362
Liu, 2012, Regulation of c-Myc protein abundance by a protein phosphatase 2A-glycogen synthase kinase 3β-negative feedback pathway, Genes Cancer, 3, 23, 10.1177/1947601912448067
Liu, 2007, Microtubule disruption and tumor suppression by mitogen-activated protein kinase phosphatase 4, Cancer Res., 67, 10711, 10.1158/0008-5472.CAN-07-1968
Liu, 2008, Homozygous deletions and recurrent amplifications implicate new genes involved in prostate cancer, Neoplasia, 10, 897, 10.1593/neo.08428
Liu, 2009, Loss of PHLPP expression in colon cancer: role in proliferation and tumorigenesis, Oncogene, 28, 994, 10.1038/onc.2008.450
Liu, 2010, Identifying mRNA targets of microRNA dysregulated in cancer: with application to clear cell Renal Cell Carcinoma, BMC Syst. Biol., 4, 51, 10.1186/1752-0509-4-51
Liu, 2011, PHLPP-mediated dephosphorylation of S6K1 inhibits protein translation and cell growth, Mol. Cell. Biol., 31, 4917, 10.1128/MCB.05799-11
Liu, 2013, PTPN14 interacts with and negatively regulates the oncogenic function of YAP, Oncogene, 32, 1266, 10.1038/onc.2012.147
Liu, 2013, Novel sorafenib analogues induce apoptosis through SHP-1 dependent STAT3 inactivation in human breast cancer cells, Breast Cancer Res., 15, R63, 10.1186/bcr3457
Liu, 2015, Protein tyrosine phosphatase receptor type O expression in the tumor niche correlates with reduced tumor growth, angiogenesis, circulating tumor cells and metastasis of breast cancer, Oncol. Rep., 33, 1908, 10.3892/or.2015.3772
Liu, 2015, Overexpression of PP2A inhibitor SET oncoprotein is associated with tumor progression and poor prognosis in human non-small cell lung cancer, Oncotarget, 6, 14913, 10.18632/oncotarget.3818
Liu, 2016, Hepatitis B virus X protein amplifies TGF-βpromotion on HCC motility through down-regulating PPM1a, Oncotarget, 7, 33125, 10.18632/oncotarget.8884
Liu, 2016, HEATR1 negatively regulates Akt to help sensitize pancreatic cancer cells to chemotherapy, Cancer Res., 76, 572, 10.1158/0008-5472.CAN-15-0671
Liu, 2017, Promoter methylation attenuates SHP1 expression and function in patients with primary central nervous system lymphoma, Oncol. Rep., 37, 887, 10.3892/or.2016.5308
Liu, 2017, Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells, J. Mol. Med. (Berl)
Liu, 2017, Sorafenib analogue SC-60 induces apoptosis through the SHP-1/STAT3 pathway and enhances docetaxel cytotoxicity in triple-negative breast cancer cells, Mol. Oncol., 11, 266, 10.1002/1878-0261.12033
Loda, 1996, Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis, Am. J. Pathol., 149, 1553
Loor, 1981, Expression of prostatic acid phosphatase in human prostate cancer, Cancer Lett., 14, 63, 10.1016/0304-3835(81)90010-0
Lorenzato, 2016, The integrin-linked kinase-associated phosphatase (ILKAP) is a regulatory hub of ovarian cancer cell susceptibility to platinum drugs, Eur. J. Cancer, 60, 59, 10.1016/j.ejca.2016.02.022
Lorsbach, 2001, The role of the AML1 transcription factor in leukemogenesis, Int. J. Hematol., 74, 258, 10.1007/BF02982058
Lu, 2008, Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family, Clin. Exp. Pharmacol. Physiol., 35, 107, 10.1111/j.1440-1681.2007.04843.x
Lu, 2007, T-cell protein tyrosine phosphatase, distinctively expressed in activated-B-cell-like diffuse large B-cell lymphomas, is the nuclear phosphatase of STAT6, Mol. Cell. Biol., 27, 2166, 10.1128/MCB.01234-06
Lu, 2014, PPM1A is a RelA phosphatase with tumor suppressor-like activity, Oncogene, 33, 2918, 10.1038/onc.2013.246
Lucci, 2010, Expression profile of tyrosine phosphatases in HER2 breast cancer cells and tumors, Cell. Oncol., 32, 361
Luechapanichkul, 2013, Specificity profiling of dual specificity phosphatase vaccinia VH1-related (VHR) reveals two distinct substrate binding modes, J. Biol. Chem., 288, 6498, 10.1074/jbc.M112.449611
Lui, 2014, Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer, Proc. Natl. Acad. Sci. U. S. A., 111, 1114, 10.1073/pnas.1319551111
Luo, 2014, Decreased expression of PTPN12 correlates with tumor recurrence and poor survival of patients with hepatocellular carcinoma, PLoS One, 9, e85592, 10.1371/journal.pone.0085592
Luo, 2015, MicroRNA-328 enhances cellular motility through posttranscriptional regulation of PTPRJ in human hepatocellular carcinoma, Onco Targets Ther., 8, 3159
Lv, 2015, High PHLPP expression is associated with better prognosis in patients with resected lung adenocarcinoma, BMC Cancer, 15, 687, 10.1186/s12885-015-1711-1
Mélard, 2016, Molecular alterations and tumor suppressive function of the DUSP22 (Dual Specificity Phosphatase 22) gene in peripheral T-cell lymphoma subtypes, Oncotarget, 7, 68734, 10.18632/oncotarget.11930
Magi-Galluzzi, 1997, Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis, Lab. Invest., 76, 37
Malentacchi, 2005, Up-regulated expression of low molecular weight protein tyrosine phosphatases in different human cancers, Biochem. Biophys. Res. Commun., 334, 875, 10.1016/j.bbrc.2005.06.176
Manchado, 2010, Targeting mitotic exit leads to tumor regression in vivo: modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase, Cancer Cell, 18, 641, 10.1016/j.ccr.2010.10.028
Mandl, 2005, Specific inactivation and nuclear anchoring of extracellular signal-regulated kinase 2 by the inducible dual-specificity protein phosphatase DUSP5, Mol. Cell. Biol., 25, 1830, 10.1128/MCB.25.5.1830-1845.2005
Mannava, 2012, PP2A-B56α controls oncogene-induced senescence in normal and tumor human melanocytic cells, Oncogene, 31, 1484, 10.1038/onc.2011.339
Manzano, 2002, CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential, Oncogene, 21, 4435, 10.1038/sj.onc.1205542
Marchetti, 2004, Inducible expression of a MAP kinase phosphatase-3-GFP chimera specifically blunts fibroblast growth and ras-dependent tumor formation in nude mice, J. Cell. Physiol., 199, 441, 10.1002/jcp.10465
Martin, 2011, Identification of PTPsigma as an autophagic phosphatase, J. Cell Sci., 124, 812, 10.1242/jcs.080341
Martin, 2013, PP2A regulatory subunit Bα controls endothelial contractility and vessel lumen integrity via regulation of HDAC7, EMBO J., 32, 2491, 10.1038/emboj.2013.187
Mason, 2014, Functional characterization of CFI-400945, a Polo-like kinase 4 inhibitor, as a potential anticancer agent, Cancer Cell, 26, 163, 10.1016/j.ccr.2014.05.006
Mattila, 2008, The protein tyrosine phosphatase TCPTP controls VEGFR2 signalling, J. Cell Sci., 121, 3570, 10.1242/jcs.031898
Mattila, 2010, Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase, BMC Cancer, 10, 7, 10.1186/1471-2407-10-7
Mazumdar, 2016, Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion, Breast Cancer Res. Treat., 158, 441, 10.1007/s10549-016-3892-y
McArdle, 2001, Protein tyrosine phosphatase genes downregulated in melanoma, J. Invest. Dermatol., 117, 1255, 10.1046/j.0022-202x.2001.01534.x
McCabe, 2015, Mechanistic rationale to target PTEN-deficient tumor cells with inhibitors of the DNA damage response kinase ATM, Cancer Res., 75, 2159, 10.1158/0008-5472.CAN-14-3502
McConechy, 2011, Subtype-specific mutation of PPP2R1A in endometrial and ovarian carcinomas, J. Pathol., 223, 567, 10.1002/path.2848
McCorkle, 2014, The metastasis suppressor NME1 regulates expression of genes linked to metastasis and patient outcome in melanoma and breast carcinoma, Cancer Genomics Proteomics, 11, 175
Meehan, 2012, Protein tyrosine phosphatase receptor delta acts as a neuroblastoma tumor suppressor by destabilizing the aurora kinase A oncogene, Mol. Cancer, 11, 6, 10.1186/1476-4598-11-6
Mendes-Pereira, 2009, Synthetic lethal targeting of PTEN mutant cells with PARP inhibitors, EMBO Mol. Med., 1, 315, 10.1002/emmm.200900041
Mendes-Pereira, 2012, NLK is a novel therapeutic target for PTEN deficient tumour cells, PLoS One, 7, e47249, 10.1371/journal.pone.0047249
Meng, 1998, Tyrosine phosphorylation of c-ErbB-2 is regulated by the cellular form of prostatic acid phosphatase in human prostate cancer cells, J. Biol. Chem., 273, 22096, 10.1074/jbc.273.34.22096
Menigatti, 2009, The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis, Mol. Cancer, 8, 124, 10.1186/1476-4598-8-124
Mereniuk, 2013, Synthetic lethal targeting of PTEN-deficient cancer cells using selective disruption of polynucleotide kinase/phosphatase, Mol. Cancer Ther., 12, 2135, 10.1158/1535-7163.MCT-12-1093
Mereniuk, 2012, Genetic screening for synthetic lethal partners of polynucleotide kinase/phosphatase: potential for targeting SHP-1-depleted cancers, Cancer Res., 72, 5934, 10.1158/0008-5472.CAN-12-0939
Meyer, 2014, Tyrosine phosphatase PTPalpha contributes to HER2-evoked breast tumor initiation and maintenance, Oncogene, 33, 398, 10.1038/onc.2012.585
Michaloglou, 2013, The tyrosine phosphatase PTPN14 is a negative regulator of YAP activity, PLoS One, 8, e61916, 10.1371/journal.pone.0061916
Mita, 2010, Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers, J. Cancer Res. Clin. Oncol., 136, 249, 10.1007/s00432-009-0656-7
Molina, 2012, PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma, Oncogene, 31, 1264, 10.1038/onc.2011.324
Moncho-Amor, 2011, DUSP1/MKP1 promotes angiogenesis, invasion and metastasis in non-small-cell lung cancer, Oncogene, 30, 668, 10.1038/onc.2010.449
Moore, 1991, Evidence that AMP triggers phosphorylation as well as direct allosteric activation of rat liver AMP-activated protein kinase. A sensitive mechanism to protect the cell against ATP depletion, Eur. J. Biochem., 199, 691, 10.1111/j.1432-1033.1991.tb16172.x
Mori, 2004, Identification of genes uniquely involved in frequent microsatellite instability colon carcinogenesis by expression profiling combined with epigenetic scanning, Cancer Res., 64, 2434, 10.1158/0008-5472.CAN-03-3508
Morris, 2011, Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers, Proc. Natl. Acad. Sci. U. S. A., 108, 19024, 10.1073/pnas.1111963108
Mosca, 2013, Genome-wide analysis of primary plasma cell leukemia identifies recurrent imbalances associated with changes in transcriptional profiles, Am. J. Hematol., 88, 16, 10.1002/ajh.23339
Mosinger, 1992, Cloning and characterization of a mouse cDNA encoding a cytoplasmic protein-tyrosine-phosphatase, Proc. Natl. Acad. Sci. U. S. A., 89, 499, 10.1073/pnas.89.2.499
Motiwala, 2003, Suppression of the protein tyrosine phosphatase receptor type O gene (PTPRO) by methylation in hepatocellular carcinomas, Oncogene, 22, 6319, 10.1038/sj.onc.1206750
Motiwala, 2004, Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer, Proc. Natl. Acad. Sci. U. S. A., 101, 13844, 10.1073/pnas.0405451101
Motiwala, 2007, Methylation and silencing of protein tyrosine phosphatase receptor type O in chronic lymphocytic leukemia, Clin. Cancer Res., 13, 3174, 10.1158/1078-0432.CCR-06-1720
Motiwala, 2009, PTPROt inactivates the oncogenic fusion protein BCR/ABL and suppresses transformation of K562 cells, J. Biol. Chem., 284, 455, 10.1074/jbc.M802840200
Motiwala, 2015, PTPROt-mediated regulation of p53/Foxm1 suppresses leukemic phenotype in a CLL mouse model, Leukemia, 29, 1350, 10.1038/leu.2014.341
Mourton, 2001, The PTPmu protein-tyrosine phosphatase binds and recruits the scaffolding protein RACK1 to cell-cell contacts, J. Biol. Chem., 276, 14896, 10.1074/jbc.M010823200
Muda, 1997, Molecular cloning and functional characterization of a novel mitogen-activated protein kinase phosphatase, MKP-4, J. Biol. Chem., 272, 5141, 10.1074/jbc.272.8.5141
Muggerud, 2010, Frequent aberrant DNA methylation of ABCB1, FOXC1, PPP2R2B and PTEN in ductal carcinoma in situ and early invasive breast cancer, Breast Cancer Res., 12, R3, 10.1186/bcr2466
Munkley, 2015, Androgen-regulation of the protein tyrosine phosphatase PTPRR activates ERK1/2 signalling in prostate cancer cells, BMC Cancer, 15, 9, 10.1186/s12885-015-1012-8
Nagao, 1989, Role of protein phosphatases in malignant transformation, Princess Takamatsu Symp., 20, 177
Nagendra, 2012, PPP2R1A mutations are common in the serous type of endometrial cancer, Mol. Carcinog., 51, 826, 10.1002/mc.20850
Nakamura, 2002, A novel low-molecular-mass dual-specificity phosphatase, LDP-2, with a naturally occurring substitution that affects substrate specificity, J. Biochem., 132, 463, 10.1093/oxfordjournals.jbchem.a003244
Nakamura, 2003, Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas, Cancer Res., 63, 737
Nalepa, 2013, The tumor suppressor CDKN3 controls mitosis, J. Cell Biol., 201, 997, 10.1083/jcb.201205125
Nassar, 2015, Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma, Nat. Med., 21, 946, 10.1038/nm.3878
Negro, 2012, Overexpression of the autoimmunity-associated phosphatase PTPN22 promotes survival of antigen-stimulated CLL cells by selectively activating AKT, Blood, 119, 6278, 10.1182/blood-2012-01-403162
Niedergethmann, 2007, Gene expression profiling of liver metastases and tumour invasion in pancreatic cancer using an orthotopic SCID mouse model, Br. J. Cancer, 97, 1432, 10.1038/sj.bjc.6604031
Nikitina, 2017, Novel RNA biomarkers of prostate cancer revealed by RNA-seq analysis of formalin-fixed samples obtained from Russian patients, Oncotarget, 8, 32990, 10.18632/oncotarget.16518
Nitsche, 2012, The phosphatase PHLPP1 regulates Akt2, promotes pancreatic cancer cell death, and inhibits tumor formation, Gastroenterology, 142, 377, 10.1053/j.gastro.2011.10.026
Niu, 2009, Genetic polymorphisms in the PTPN13 gene and risk of squamous cell carcinoma of head and neck, Carcinogenesis, 30, 2053, 10.1093/carcin/bgp265
Nobumori, 2013, B56γ tumor-associated mutations provide new mechanisms for B56γ-PP2A tumor suppressor activity, Mol. Cancer Res., 11, 995, 10.1158/1541-7786.MCR-12-0633
Novellino, 2008, PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells, Cell. Signal., 20, 872, 10.1016/j.cellsig.2007.12.024
Nunes-Xavier, 2011, Dual-specificity MAP kinase phosphatases as targets of cancer treatment, Anticancer Agents Med. Chem., 11, 109, 10.2174/187152011794941190
Oczko-Wojciechowska, 2017, Differences in the transcriptome of medullary thyroid cancer regarding the status and type of RET gene mutations, Sci. Rep., 7, 42074, 10.1038/srep42074
Ofek, 2003, Cell cycle regulation and p53 activation by protein phosphatase 2C alpha, J. Biol. Chem., 278, 14299, 10.1074/jbc.M211699200
Ohtaka, 2017, Low-molecular-weight protein tyrosine phosphatase expression as a prognostic factor for men with metastatic hormone-naïve prostate cancer, Urol. Oncol., 10.1016/j.urolonc.2017.05.019
Oka, 2001, Reduction of hematopoietic cell-specific tyrosine phosphatase SHP-1 gene expression in natural killer cell lymphoma and various types of lymphomas/leukemias: combination analysis with cDNA expression array and tissue microarray, Am. J. Pathol., 159, 1495, 10.1016/S0002-9440(10)62535-7
Oka, 2002, Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas, Cancer Res., 62, 6390
Okudela, 2009, Down-regulation of DUSP6 expression in lung cancer: its mechanism and potential role in carcinogenesis, Am. J. Pathol., 175, 867, 10.2353/ajpath.2009.080489
Omerovic, 2010, Phosphatome profiling reveals PTPN2, PTPRJ and PTEN as potent negative regulators of PKB/Akt activation in Ras-mutated cancer cells, Biochem. J., 426, 65, 10.1042/BJ20091413
Ortega-Paino, 2008, Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference, Blood, 111, 1617, 10.1182/blood-2007-02-068791
Ortiz, 2014, Loss of the tyrosine phosphatase PTPRD leads to aberrant STAT3 activation and promotes gliomagenesis, Proc. Natl. Acad. Sci. U. S. A., 111, 8149, 10.1073/pnas.1401952111
Ortuso, 2013, Discovery of PTPRJ agonist peptides that effectively inhibit in vitro cancer cell proliferation and tube formation, ACS Chem. Biol., 8, 1497, 10.1021/cb3007192
Ory, 2003, Protein phosphatase 2A positively regulates Ras signaling by dephosphorylating KSR1 and Raf-1 on critical 14-3-3 binding sites, Curr. Biol., 13, 1356, 10.1016/S0960-9822(03)00535-9
Ouillette, 2008, Integrated genomic profiling of chronic lymphocytic leukemia identifies subtypes of deletion 13q14, Cancer Res., 68, 1012, 10.1158/0008-5472.CAN-07-3105
Paduano, 2012, Isolation and functional characterization of peptide agonists of PTPRJ, a tyrosine phosphatase receptor endowed with tumor suppressor activity, ACS Chem. Biol., 7, 1666, 10.1021/cb300281t
Paduano, 2013, Protein tyrosine phosphatase PTPRJ is negatively regulated by microRNA-328, FEBS J., 280, 401, 10.1111/j.1742-4658.2012.08624.x
Palka, 2003, Hepatocyte growth factor receptor tyrosine kinase met is a substrate of the receptor protein-tyrosine phosphatase DEP-1, J. Biol. Chem., 278, 5728, 10.1074/jbc.M210656200
Pallas, 1990, Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A, Cell, 60, 167, 10.1016/0092-8674(90)90726-U
Parrilla Castellar, 2014, ALK-negative anaplastic large cell lymphoma is a genetically heterogeneous disease with widely disparate clinical outcomes, Blood, 124, 1473, 10.1182/blood-2014-04-571091
Pasquo, 2012, Structural stability of human protein tyrosine phosphatase ρ catalytic domain: effect of point mutations, PLoS One, 7, e32555, 10.1371/journal.pone.0032555
Patterson, 2009, Dual-specificity phosphatases: critical regulators with diverse cellular targets, Biochem. J., 418, 475, 10.1042/BJ20082234
Patterson, 2010, DUSP26 negatively affects the proliferation of epithelial cells, an effect not mediated by dephosphorylation of MAPKs, Biochim. Biophys. Acta, 1803, 1003, 10.1016/j.bbamcr.2010.03.014
Pavic, 2015, VHR/DUSP3 phosphatase: structure, function and regulation, FEBS J., 282, 1871, 10.1111/febs.13263
Pedersen, 2017, DUSP22 and TP63 rearrangements predict outcome of ALK-negative anaplastic large cell lymphoma: a Danish cohort study, Blood, 130, 554, 10.1182/blood-2016-12-755496
Pei, 2009, FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt, Cancer Cell, 16, 259, 10.1016/j.ccr.2009.07.016
Perander, 2017, Regulation of atypical MAP kinases ERK3 and ERK4 by the phosphatase DUSP2, Sci. Rep., 7, 43471, 10.1038/srep43471
Perrotti, 2013, Protein phosphatase 2A: a target for anticancer therapy, Lancet Oncol., 14, e229, 10.1016/S1470-2045(12)70558-2
Persson, 2004, Site-selective regulation of platelet-derived growth factor beta receptor tyrosine phosphorylation by T-cell protein tyrosine phosphatase, Mol. Cell. Biol., 24, 2190, 10.1128/MCB.24.5.2190-2201.2004
Petermann, 2011, Loss of the protein-tyrosine phosphatase DEP-1/PTPRJ drives meningioma cell motility, Brain Pathol., 21, 405, 10.1111/j.1750-3639.2010.00464.x
Petritsch, 2000, TGF-beta inhibits p70 S6 kinase via protein phosphatase 2A to induce G(1) arrest, Genes Dev., 14, 3093, 10.1101/gad.854200
Peyser, 2015, Loss-of-function PTPRD mutations lead to increased STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer, PLoS One, 10, e0135750, 10.1371/journal.pone.0135750
Peyser, 2016, Frequent promoter hypermethylation of PTPRT increases STAT3 activation and sensitivity to STAT3 inhibition in head and neck cancer, Oncogene, 35, 1163, 10.1038/onc.2015.171
Phillips-Mason, 2008, BCCIP associates with the receptor protein tyrosine phosphatase PTPmu, J. Cell. Biochem., 105, 1059, 10.1002/jcb.21907
Phillips-Mason, 2011, Identification of phospholipase C gamma1 as a protein tyrosine phosphatase mu substrate that regulates cell migration, J. Cell. Biochem., 112, 39, 10.1002/jcb.22710
Plutzky, 1992, Chromosomal localization of an SH2-containing tyrosine phosphatase (PTPN6), Genomics, 13, 869, 10.1016/0888-7543(92)90172-O
Poon, 1995, Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin, Science, 270, 90, 10.1126/science.270.5233.90
Prabhu, 2015, Ras-mediated modulation of pyruvate dehydrogenase activity regulates mitochondrial reserve capacity and contributes to glioblastoma tumorigenesis, Neuro Oncol., 17, 1220, 10.1093/neuonc/nou369
Prajapati, 2004, Protein phosphatase 2Cbeta association with the IkappaB kinase complex is involved in regulating NF-kappaB activity, J. Biol. Chem., 279, 1739, 10.1074/jbc.M306273200
Purdie, 2007, Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis, Genes Chromosomes Cancer, 46, 661, 10.1002/gcc.20447
Puustinen, 2009, PME-1 protects extracellular signal-regulated kinase pathway activity from protein phosphatase 2A-mediated inactivation in human malignant glioma, Cancer Res., 69, 2870, 10.1158/0008-5472.CAN-08-2760
Qi, 2016, Protein tyrosine phosphatase PTPRB regulates Src phosphorylation and tumour progression in NSCLC, Clin. Exp. Pharmacol. Physiol., 43, 1004, 10.1111/1440-1681.12610
Qiao, 2010, Mst1 is an interacting protein that mediates PHLPPs' induced apoptosis, Mol. Cell, 38, 512, 10.1016/j.molcel.2010.03.017
Qiao, 2016, Loss of protein tyrosine phosphatase receptor J expression predicts an aggressive clinical course in patients with esophageal squamous cell carcinoma, Pathol. Oncol. Res., 22, 541, 10.1007/s12253-015-0036-3
Qin, 2017, SNORA74B gene silencing inhibits gallbladder cancer cells by inducing PHLPP and suppressing Akt/mTOR signaling, Oncotarget, 8, 19980, 10.18632/oncotarget.15301
Qiu, 2015, Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer, Oncotarget, 6, 19148, 10.18632/oncotarget.3721
Quintero, 2007, Prostatic acid phosphatase is not a prostate specific target, Cancer Res., 67, 6549, 10.1158/0008-5472.CAN-07-1651
Quintero, 2013, Transmembrane prostatic acid phosphatase (TMPAP) interacts with snapin and deficient mice develop prostate adenocarcinoma, PLoS One, 8, e73072, 10.1371/journal.pone.0073072
Révillion, 2009, Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer, Int. J. Cancer, 124, 638, 10.1002/ijc.23989
Rahman, 2013, PPP2R1A mutation is a rare event in ovarian carcinoma across histological subtypes, Anticancer Res., 33, 113
Rahmouni, 2006, Loss of the VHR dual-specific phosphatase causes cell-cycle arrest and senescence, Nat. Cell Biol., 8, 524, 10.1038/ncb1398
Ramaswamy, 2009, Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity, Mol. Endocrinol., 23, 176, 10.1210/me.2008-0211
Ramesh, 2015, A novel phosphatidic acid-protein-tyrosine phosphatase D2 axis is essential for ERBB2 signaling in mammary epithelial cells, J. Biol. Chem., 290, 9646, 10.1074/jbc.M114.627968
Ramnarain, 2006, Differential gene expression analysis reveals generation of an autocrine loop by a mutant epidermal growth factor receptor in glioma cells, Cancer Res., 66, 867, 10.1158/0008-5472.CAN-05-2753
Rauhala, 2005, Dual-specificity phosphatase 1 and serum/glucocorticoid-regulated kinase are downregulated in prostate cancer, Int. J. Cancer, 117, 738, 10.1002/ijc.21270
Rebay, 2015, Multiple functions of the eya phosphotyrosine phosphatase, Mol. Cell. Biol., 36, 668, 10.1128/MCB.00976-15
Reid, 2013, The B55α subunit of PP2A drives a p53-dependent metabolic adaptation to glutamine deprivation, Mol. Cell, 50, 200, 10.1016/j.molcel.2013.02.008
Reif, 1973, Acid phosphatase isozymes in cancer of the prostate, Cancer, 31, 689, 10.1002/1097-0142(197303)31:3<689::AID-CNCR2820310331>3.0.CO;2-F
Rellinger, 2015, Silencing gastrin-releasing peptide receptor suppresses key regulators of aerobic glycolysis in neuroblastoma cells, Pediatr. Blood Cancer, 62, 581, 10.1002/pbc.25348
Reyes, 2014, Pleckstrin homology domain leucine-rich repeat protein phosphatases set the amplitude of receptor tyrosine kinase output, Proc. Natl. Acad. Sci. U. S. A., 111, E3957, 10.1073/pnas.1404221111
Richard, 2016, Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia, Oncotarget, 7, 84214, 10.18632/oncotarget.12394
Rigacci, 2002, Low Mr phosphotyrosine protein phosphatase associates and dephosphorylates p125 focal adhesion kinase, interfering with cell motility and spreading, J. Biol. Chem., 277, 41631, 10.1074/jbc.M201709200
Rigacci, 2003, LMW-PTP associates and dephosphorylates STAT5 interacting with its C-terminal domain, Biochem. Biophys. Res. Commun., 312, 360, 10.1016/j.bbrc.2003.10.126
Rigacci, 2008, Modulation of STAT5 interaction with LMW-PTP during early megakaryocyte differentiation, Biochemistry, 47, 1482, 10.1021/bi701131e
Roberts, 2010, Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers, Cancer Res., 70, 5438, 10.1158/0008-5472.CAN-09-2544
Rocher, 2007, Inhibition of B56-containing protein phosphatase 2As by the early response gene IEX-1 leads to control of Akt activity, J. Biol. Chem., 282, 5468, 10.1074/jbc.M609712200
Rojo, 2009, Mitogen-activated protein kinase phosphatase-1 in human breast cancer independently predicts prognosis and is repressed by doxorubicin, Clin. Cancer Res., 15, 3530, 10.1158/1078-0432.CCR-08-2070
Rothschild, 2010, Src inhibitors in lung cancer: current status and future directions, Clin. Lung Cancer, 11, 238, 10.3816/CLC.2010.n.030
Ruediger, 2001, Disruption of protein phosphatase 2A subunit interaction in human cancers with mutations in the A alpha subunit gene, Oncogene, 20, 10, 10.1038/sj.onc.1204059
Ruediger, 2001, Alterations in protein phosphatase 2A subunit interaction in human carcinomas of the lung and colon with mutations in the A beta subunit gene, Oncogene, 20, 1892, 10.1038/sj.onc.1204279
Ruediger, 2011, Human cancer-associated mutations in the Aα subunit of protein phosphatase 2A increase lung cancer incidence in Aα knock-in and knockout mice, Mol. Cell. Biol., 31, 3832, 10.1128/MCB.05744-11
Ruivenkamp, 2003, LOH of PTPRJ occurs early in colorectal cancer and is associated with chromosomal loss of 18q12-21, Oncogene, 22, 3472, 10.1038/sj.onc.1206246
Rushworth, 2014, Dual-specificity phosphatase 5 regulates nuclear ERK activity and suppresses skin cancer by inhibiting mutant Harvey-Ras (HRasQ61L)-driven SerpinB2 expression, Proc. Natl. Acad. Sci. U. S. A., 111, 18267, 10.1073/pnas.1420159112
Ruvolo, 2008, PKR regulates B56(alpha)-mediated BCL2 phosphatase activity in acute lymphoblastic leukemia-derived REH cells, J. Biol. Chem., 283, 35474, 10.1074/jbc.M800951200
Ruvolo, 2011, Low expression of PP2A regulatory subunit B55αα is associated with T308 phosphorylation of AKT and shorter complete remission duration in acute myeloid leukemia patients, Leukemia, 25, 1711, 10.1038/leu.2011.146
Ruvolo, 2014, The protein phosphatase 2A regulatory subunit B55α is a modulator of signaling and microRNA expression in acute myeloid leukemia cells, Biochim. Biophys. Acta, 1843, 1969, 10.1016/j.bbamcr.2014.05.006
Ruvolo, 2015, The interplay between PP2A and microRNAs in leukemia, Front. Oncol., 5, 43, 10.3389/fonc.2015.00043
Sablina, 2007, The tumor suppressor PP2A Abeta regulates the RalA GTPase, Cell, 129, 969, 10.1016/j.cell.2007.03.047
Sablina, 2010, Identification of PP2A complexes and pathways involved in cell transformation, Cancer Res., 70, 10474, 10.1158/0008-5472.CAN-10-2855
Sacco, 2009, Tumor suppressor density-enhanced phosphatase-1 (DEP-1) inhibits the RAS pathway by direct dephosphorylation of ERK1/2 kinases, J. Biol. Chem., 284, 22048, 10.1074/jbc.M109.002758
Sacristan, 2011, Human Cdc14A becomes a cell cycle gene in controlling Cdk1 activity at the G(2)/M transition, Cell Cycle, 10, 387, 10.4161/cc.10.3.14643
Saidak, 2017, Mathematical modelling unveils the essential role of cellular phosphatases in the inhibition of RAF-MEK-ERK signalling by sorafenib in hepatocellular carcinoma cells, Cancer Lett., 392, 1, 10.1016/j.canlet.2017.01.038
Sallman, 2014, PP2A, The achilles heal in MDS with 5q deletion, Front. Oncol., 4, 264, 10.3389/fonc.2014.00264
Samols, 2014, Intralymphatic cutaneous anaplastic large cell lymphoma/lymphomatoid papulosis: expanding the spectrum of CD30-positive lymphoproliferative disorders, Am. J. Surg. Pathol., 38, 1203, 10.1097/PAS.0000000000000217
Sangodkar, 2016, All roads lead to PP2A: exploiting the therapeutic potential of this phosphatase, FEBS J., 283, 1004, 10.1111/febs.13573
Sangodkar, 2017, Activation of tumor suppressor protein PP2A inhibits KRAS-driven tumor growth, J. Clin. Invest., 127, 2081, 10.1172/JCI89548
Sangwan, 2008, Regulation of the Met receptor-tyrosine kinase by the protein-tyrosine phosphatase 1B and T-cell phosphatase, J. Biol. Chem., 283, 34374, 10.1074/jbc.M805916200
Sap, 1994, Receptor tyrosine phosphatase R-PTP-kappa mediates homophilic binding, Mol. Cell. Biol., 14, 1, 10.1128/MCB.14.1.1
Sarhan, 2016, LAR protein tyrosine phosphatase regulates focal adhesions through CDK1, J. Cell Sci., 129, 2962, 10.1242/jcs.191379
Sato, 2010, Multi-step aberrant CpG island hyper-methylation is associated with the progression of adult T-cell leukemia/lymphoma, Am. J. Pathol., 176, 402, 10.2353/ajpath.2010.090236
Schmid, 2015, DUSP4 deficiency caused by promoter hypermethylation drives JNK signaling and tumor cell survival in diffuse large B cell lymphoma, J. Exp. Med., 212, 775, 10.1084/jem.20141957
Schmitz, 2010, Live-cell imaging RNAi screen identifies PP2A-B55alpha and importin-beta1 as key mitotic exit regulators in human cells, Nat. Cell Biol., 12, 886, 10.1038/ncb2092
Schramm, 2015, Mutational dynamics between primary and relapse neuroblastomas, Nat. Genet., 47, 872, 10.1038/ng.3349
Schubbert, 2007, Hyperactive Ras in developmental disorders and cancer, Nat. Rev. Cancer, 7, 295, 10.1038/nrc2109
Schumacher, 2002, Structural basis for the recognition of a bisphosphorylated MAP kinase peptide by human VHR protein Phosphatase, Biochemistry, 41, 3009, 10.1021/bi015799l
Schumacher, 2017, Somatic copy number alterations in gastric adenocarcinomas among Asian and Western patients, PLoS One, 12, e0176045, 10.1371/journal.pone.0176045
Schwertassek, 2010, Myristoylation of the dual-specificity phosphatase c-JUN N-terminal kinase (JNK) stimulatory phosphatase 1 is necessary for its activation of JNK signaling and apoptosis, FEBS J., 277, 2463, 10.1111/j.1742-4658.2010.07661.x
Sciallis, 2012, Mucosal CD30-positive T-cell lymphoproliferations of the head and neck show a clinicopathologic spectrum similar to cutaneous CD30-positive T-cell lymphoproliferative disorders, Mod. Pathol., 25, 983, 10.1038/modpathol.2012.38
Scrima, 2012, The nonreceptor-type tyrosine phosphatase PTPN13 is a tumor suppressor gene in non-small cell lung cancer, Am. J. Pathol., 180, 1202, 10.1016/j.ajpath.2011.11.038
Sekine, 2006, Regulation of STAT3-mediated signaling by LMW-DSP2, Oncogene, 25, 5801, 10.1038/sj.onc.1209578
Sekine, 2007, DUSP22/LMW-DSP2 regulates estrogen receptor-alpha-mediated signaling through dephosphorylation of Ser-118, Oncogene, 26, 6038, 10.1038/sj.onc.1210426
Sents, 2017, PP2A inactivation mediated by PPP2R4 haploinsufficiency promotes cancer development, Cancer Res., 10.1158/0008-5472.CAN-16-2911
Shan, 2014, Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth, J. Biol. Chem., 289, 21413, 10.1074/jbc.M114.581124
Shang, 2010, Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma, Oncogene, 29, 4938, 10.1038/onc.2010.244
Shen, 2001, Activation of the Jnk signaling pathway by a dual-specificity phosphatase, JSP-1, Proc. Natl. Acad. Sci. U. S. A., 98, 13613, 10.1073/pnas.231499098
Shen, 2014, Upregulation of miR-136 in human non-small cell lung cancer cells promotes Erk1/2 activation by targeting PPP2R2A, Tumour Biol., 35, 631, 10.1007/s13277-013-1087-2
Shen, 2014, Specific control of BMP signaling and mesenchymal differentiation by cytoplasmic phosphatase PPM1H, Cell Res., 24, 727, 10.1038/cr.2014.48
Shen, 2017, DUSP1 inhibits cell proliferation, metastasis and invasion and angiogenesis in gallbladder cancer, Oncotarget, 8, 12133, 10.18632/oncotarget.14815
Shi, 2009, Serine/threonine phosphatases: mechanism through structure, Cell, 139, 468, 10.1016/j.cell.2009.10.006
Shields, 2013, TCPTP regulates SFK and STAT3 signaling and is lost in triple-negative breast cancers, Mol. Cell. Biol., 33, 557, 10.1128/MCB.01016-12
Shih, 2011, Mutation of PPP2R1A: a new clue in unveiling the pathogenesis of uterine serous carcinoma, J. Pathol., 224, 1, 10.1002/path.2884
Shih, 2011, Somatic mutations of PPP2R1A in ovarian and uterine carcinomas, Am. J. Pathol., 178, 1442, 10.1016/j.ajpath.2011.01.009
Shimozato, 2015, Receptor-type protein tyrosine phosphatase kappa directly dephosphorylates CD133 and regulates downstream AKT activation, Oncogene, 34, 1949, 10.1038/onc.2014.141
Shojaee, 2015, Erk negative feedback control enables pre-B cell transformation and represents a therapeutic target in acute lymphoblastic leukemia, Cancer Cell, 28, 114, 10.1016/j.ccell.2015.05.008
Shouse, 2010, A B56gamma mutation in lung cancer disrupts the p53-dependent tumor-suppressor function of protein phosphatase 2A, Oncogene, 29, 3933, 10.1038/onc.2010.161
Shouse, 2016, Novel B55α-PP2A mutations in AML promote AKT T308 phosphorylation and sensitivity to AKT inhibitor-induced growth arrest, Oncotarget, 7, 61081, 10.18632/oncotarget.11209
Shuai, 2003, Regulation of JAK-STAT signalling in the immune system, Nat. Rev. Immunol., 3, 900, 10.1038/nri1226
Sieben, 2005, Differential gene expression in ovarian tumors reveals Dusp 4 and Serpina 5 as key regulators for benign behavior of serous borderline tumors, J. Clin. Oncol., 23, 7257, 10.1200/JCO.2005.02.2541
Sim, 2015, Immunohistochemical expression of dual-specificity protein phosphatase 4 in patients with colorectal adenocarcinoma, Gastroenterol. Res. Pract., 2015, 283764, 10.1155/2015/283764
Simoncic, 2002, The T cell protein tyrosine phosphatase is a negative regulator of janus family kinases 1 and 3, Curr. Biol., 12, 446, 10.1016/S0960-9822(02)00697-8
Singchat, 2016, Genomic alteration in head and neck squamous cell carcinoma (HNSCC) cell lines inferred from karyotyping, molecular cytogenetics, and array comparative genomic hybridization, PLoS One, 11, e0160901, 10.1371/journal.pone.0160901
Singh, 2008, Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells, Cancer Lett., 259, 28, 10.1016/j.canlet.2007.09.018
Sjöblom, 2006, The consensus coding sequences of human breast and colorectal cancers, Science, 314, 268, 10.1126/science.1133427
Smith, 2016, PHLPP negatively regulates cell motility through inhibition of Akt activity and integrin expression in pancreatic cancer cells, Oncotarget, 7, 7801, 10.18632/oncotarget.6848
Smith, 2016, Activation of protein phosphatase 2A in FLT3+ acute myeloid leukemia cells enhances the cytotoxicity of FLT3 tyrosine kinase inhibitors, Oncotarget, 7, 47465, 10.18632/oncotarget.10167
Sobral, 2014, Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models, Mol. Cancer, 13, 32, 10.1186/1476-4598-13-32
Solomon, 2008, Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma, Cancer Res., 68, 10300, 10.1158/0008-5472.CAN-08-3272
Song, 2012, The functions and regulation of the PTEN tumour suppressor, Nat. Rev. Mol. Cell Biol., 13, 283, 10.1038/nrm3330
Song, 2015, Silencing of DUSP6 gene by RNAi-mediation inhibits proliferation and growth in MDA-MB-231 breast cancer cells: an in vitro study, Int. J. Clin. Exp. Med., 8, 10481
Song, 2016, Protein tyrosine phosphatases receptor type D is a potential tumour suppressor gene inactivated by deoxyribonucleic acid methylation in paediatric acute myeloid leukaemia, Acta Paediatr., 105, e132, 10.1111/apa.13284
Sooman, 2014, PTPN6 expression is epigenetically regulated and influences survival and response to chemotherapy in high-grade gliomas, Tumour Biol., 35, 4479, 10.1007/s13277-013-1590-5
Spina, 2016, The genetics of nodal marginal zone lymphoma, Blood, 128, 1362, 10.1182/blood-2016-02-696757
Spring, 2015, The protein tyrosine phosphatase DEP-1/PTPRJ promotes breast cancer cell invasion and metastasis, Oncogene, 34, 5536, 10.1038/onc.2015.9
Stevenson, 2014, DNA methylation of membrane-bound tyrosine phosphatase genes in acute lymphoblastic leukaemia, Leukemia, 28, 787, 10.1038/leu.2013.270
Stokoe, 2001, PTEN, Curr. Biol., 11, R502, 10.1016/S0960-9822(01)00303-7
Su, 2013, Epigenetic silencing of PTPRR activates MAPK signaling, promotes metastasis and serves as a biomarker of invasive cervical cancer, Oncogene, 32, 15, 10.1038/onc.2012.29
Su, 2013, PTPN12 inhibits oral squamous epithelial carcinoma cell proliferation and invasion and can be used as a prognostic marker, Med. Oncol., 30, 618, 10.1007/s12032-013-0618-4
Su, 2016, Disrupting VEGF-A paracrine and autocrine loops by targeting SHP-1 suppresses triple negative breast cancer metastasis, Sci. Rep., 6, 28888, 10.1038/srep28888
Suarez Pestana, 1999, The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal growth factor receptor in A431 cells, Oncogene, 18, 4069, 10.1038/sj.onc.1202794
Sudhir, 2015, Loss of PTPRM associates with the pathogenic development of colorectal adenoma-carcinoma sequence, Sci. Rep., 5, 9633, 10.1038/srep09633
Suganuma, 1988, Okadaic acid: an additional non-phorbol-12-tetradecanoate-13-acetate-type tumor promoter, Proc. Natl. Acad. Sci. U. S. A., 85, 1768, 10.1073/pnas.85.6.1768
Sugiura, 2008, Protein phosphatase 1H, overexpressed in colon adenocarcinoma, is associated with CSE1L, Cancer Biol. Ther., 7, 285, 10.4161/cbt.7.2.5302
Sun, 2008, Quantitative proteomic signature of liver cancer cells: tissue transglutaminase 2 could be a novel protein candidate of human hepatocellular carcinoma, J. Proteome Res., 7, 3847, 10.1021/pr800153s
Sun, 2009, PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation, Cell. Signal., 21, 95, 10.1016/j.cellsig.2008.09.012
Sun, 2011, Activation of multiple proto-oncogenic tyrosine kinases in breast cancer via loss of the PTPN12 phosphatase, Cell, 144, 703, 10.1016/j.cell.2011.02.003
Sun, 2012, Protein tyrosine phosphatase μ (PTP μ or PTPRM), a negative regulator of proliferation and invasion of breast cancer cells, is associated with disease prognosis, PLoS One, 7, e50183, 10.1371/journal.pone.0050183
Sun, 2013, Protein tyrosine phosphatase kappa (PTPRK) is a negative regulator of adhesion and invasion of breast cancer cells, and associates with poor prognosis of breast cancer, J. Cancer Res. Clin. Oncol., 139, 1129, 10.1007/s00432-013-1421-5
Sun, 2013, Receptor-like protein tyrosine phosphatase κ negatively regulates the apoptosis of prostate cancer cells via the JNK pathway, Int. J. Oncol., 43, 1560, 10.3892/ijo.2013.2082
Sun, 2017, Dual roles of protein tyrosine phosphatase kappa in coordinating angiogenesis induced by pro-angiogenic factors, Int. J. Oncol., 50, 1127, 10.3892/ijo.2017.3884
Szaumkessel, 2017, Recurrent epigenetic silencing of the PTPRD tumor suppressor in laryngeal squamous cell carcinoma, Tumour Biol., 39, 10.1177/1010428317691427
Tai, 2010, The investigation of mitogen-activated protein kinase phosphatase-1 as a potential pharmacological target in non-small cell lung carcinomas, assisted by non-invasive molecular imaging, BMC Cancer, 10, 95, 10.1186/1471-2407-10-95
Tai, 2014, Discovery of novel Src homology region 2 domain-containing phosphatase 1 agonists from sorafenib for the treatment of hepatocellular carcinoma, Hepatology, 59, 190, 10.1002/hep.26640
Takagi, 2000, Alterations of the PPP2R1B gene located at 11q23 in human colorectal cancers, Gut, 47, 268, 10.1136/gut.47.2.268
Takahashi, 2006, A monoclonal antibody against CD148, a receptor-like tyrosine phosphatase, inhibits endothelial-cell growth and angiogenesis, Blood, 108, 1234, 10.1182/blood-2005-10-4296
Takahashi, 2012, DNA damage signaling triggers degradation of histone methyltransferases through APC/C(Cdh1) in senescent cells, Mol. Cell, 45, 123, 10.1016/j.molcel.2011.10.018
Tamaki, 2004, PPP2R1B gene alterations inhibit interaction of PP2A-Abeta and PP2A-C proteins in colorectal cancers, Oncol. Rep., 11, 655
Tan, 2010, B55β-associated PP2A complex controls PDK1-directed myc signaling and modulates rapamycin sensitivity in colorectal cancer, Cancer Cell, 18, 459, 10.1016/j.ccr.2010.10.021
Tanuma, 2009, Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell-cell adhesion, Oncogene, 28, 752, 10.1038/onc.2008.431
Tarcic, 2009, An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis, Curr. Biol., 19, 1788, 10.1016/j.cub.2009.09.048
ten Hoeve, 2002, Identification of a nuclear Stat1 protein tyrosine phosphatase, Mol. Cell. Biol., 22, 5662, 10.1128/MCB.22.16.5662-5668.2002
Teng, 2016, Role of PHLPP1 in inflammation response: its loss contributes to gliomas development and progression, Int. Immunopharmacol., 34, 229, 10.1016/j.intimp.2016.02.034
Tiganis, 1998, Epidermal growth factor receptor and the adaptor protein p52Shc are specific substrates of T-cell protein tyrosine phosphatase, Mol. Cell. Biol., 18, 1622, 10.1128/MCB.18.3.1622
Toda-Ishii, 2016, Clinicopathological effects of protein phosphatase 2, regulatory subunit A, alpha mutations in gastrointestinal stromal tumors, Mod. Pathol., 29, 1424, 10.1038/modpathol.2016.138
Todd, 1999, Extracellular regulated kinases (ERK) 1 and ERK2 are authentic substrates for the dual-specificity protein-tyrosine phosphatase VHR. A novel role in down-regulating the ERK pathway, J. Biol. Chem., 274, 13271, 10.1074/jbc.274.19.13271
Todd, 2002, Dual-specificity protein tyrosine phosphatase VHR down-regulates c-Jun N-terminal kinase (JNK), Oncogene, 21, 2573, 10.1038/sj.onc.1205344
Tonks, 2013, Protein tyrosine phosphatases–from housekeeping enzymes to master regulators of signal transduction, FEBS J., 280, 346, 10.1111/febs.12077
Torres, 2017, Loss of DUSP3 activity radiosensitizes human tumor cell lines via attenuation of DNA repair pathways, Biochim. Biophys. Acta, 1861, 1879, 10.1016/j.bbagen.2017.04.004
Trapasso, 2000, Rat protein tyrosine phosphatase eta suppresses the neoplastic phenotype of retrovirally transformed thyroid cells through the stabilization of p27(Kip1), Mol. Cell. Biol., 20, 9236, 10.1128/MCB.20.24.9236-9246.2000
Trapasso, 2004, Restoration of receptor-type protein tyrosine phosphatase eta function inhibits human pancreatic carcinoma cell growth in vitro and in vivo, Carcinogenesis, 25, 2107, 10.1093/carcin/bgh224
Trojan, 2005, Identification of metastasis-associated genes in prostate cancer by genetic profiling of human prostate cancer cell lines, Anticancer Res., 25, 183
Tsuboi, 2008, The tyrosine phosphatase CD148 interacts with the p85 regulatory subunit of phosphoinositide 3-kinase, Biochem. J., 413, 193, 10.1042/BJ20071317
Tumurbaatar, 2011, Human Cdc14B promotes progression through mitosis by dephosphorylating Cdc25 and regulating Cdk1/cyclin B activity, PLoS One, 6, e14711, 10.1371/journal.pone.0014711
Ueda, 2003, Dual-specificity phosphatase 5 (DUSP5) as a direct transcriptional target of tumor suppressor p53, Oncogene, 22, 5586, 10.1038/sj.onc.1206845
Uhm, 2009, Differential methylation pattern of ID4, SFRP1, and SHP1 between acute myeloid leukemia and chronic myeloid leukemia, J. Korean Med. Sci., 24, 493, 10.3346/jkms.2009.24.3.493
Van Renne, 2017, miR -135a-5p-mediated downregulation of protein tyrosine phosphatase receptor delta is a candidate driver of HCV-associated hepatocarcinogenesis, Gut
Vasudevan, 2005, MKP-8, a novel MAPK phosphatase that inhibits p38 kinase, Biochem. Biophys. Res. Commun., 330, 511, 10.1016/j.bbrc.2005.03.028
Vazquez-Novelle, 2010, Human Cdc14A phosphatase modulates the G2/M transition through Cdc25A and Cdc25B, J. Biol. Chem., 285, 40544, 10.1074/jbc.M110.133009
Veeramani, 2005, Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer, Endocr. Relat. Cancer, 12, 805, 10.1677/erc.1.00950
Veeramani, 2009, Revisiting histidine-dependent acid phosphatases: a distinct group of tyrosine phosphatases, Trends Biochem. Sci., 34, 273, 10.1016/j.tibs.2009.03.002
Veeriah, 2009, The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers, Proc. Natl. Acad. Sci. U. S. A., 106, 9435, 10.1073/pnas.0900571106
Venkatachalam, 2010, Germline epigenetic silencing of the tumor suppressor gene PTPRJ in early-onset familial colorectal cancer, Gastroenterology, 139, 2221, 10.1053/j.gastro.2010.08.063
Venter, 2005, Complex CGH alterations on chromosome arm 8p at candidate tumor suppressor gene loci in breast cancer cell lines, Cancer Genet. Cytogenet., 160, 134, 10.1016/j.cancergencyto.2004.12.007
Vermeer, 2012, ErbB2, EphrinB1, Src kinase and PTPN13 signaling complex regulates MAP kinase signaling in human cancers, PLoS One, 7, e30447, 10.1371/journal.pone.0030447
Vezzalini, 2007, Expression of transmembrane protein tyrosine phosphatase gamma (PTPgamma) in normal and neoplastic human tissues, Histopathology, 50, 615, 10.1111/j.1365-2559.2007.02661.x
Vicent, 2004, Mitogen-activated protein kinase phosphatase-1 is overexpressed in non-small cell lung cancer and is an independent predictor of outcome in patients, Clin. Cancer Res., 10, 3639, 10.1158/1078-0432.CCR-03-0771
Voss, 2011, Ppm1E is an in cellulo AMP-activated protein kinase phosphatase, Cell. Signal., 23, 114, 10.1016/j.cellsig.2010.08.010
Wadham, 2003, The protein tyrosine phosphatase Pez is a major phosphatase of adherens junctions and dephosphorylates beta-catenin, Mol. Biol. Cell, 14, 2520, 10.1091/mbc.e02-09-0577
Wagner, 2009, Signal integration by JNK and p38 MAPK pathways in cancer development, Nat. Rev. Cancer, 9, 537, 10.1038/nrc2694
Wagner, 2013, KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling, J. Clin. Invest., 123, 5231, 10.1172/JCI68642
Waha, 2010, Epigenetic downregulation of mitogen-activated protein kinase phosphatase MKP-2 relieves its growth suppressive activity in glioma cells, Cancer Res., 70, 1689, 10.1158/0008-5472.CAN-09-3218
Walia, 2014, Mutational and functional analysis of the tumor-suppressor PTPRD in human melanoma, Hum. Mutat., 35, 1301
Walter, 1990, Association of protein phosphatase 2A with polyoma virus medium tumor antigen, Proc. Natl. Acad. Sci. U. S. A., 87, 2521, 10.1073/pnas.87.7.2521
Wang, 1998, Alterations of the PPP2R1B gene in human lung and colon cancer, Science, 282, 284, 10.1126/science.282.5387.284
Wang, 2003, Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer, Cancer Lett., 191, 229, 10.1016/S0304-3835(02)00612-2
Wang, 2004, Mutational analysis of the tyrosine phosphatome in colorectal cancers, Science, 304, 1164, 10.1126/science.1096096
Wang, 2006, Biochemical and biological characterization of a neuroendocrine-associated phosphatase, J. Neurochem., 98, 89, 10.1111/j.1471-4159.2006.03852.x
Wang, 2007, The tumor suppressor DAPK is reciprocally regulated by tyrosine kinase Src and phosphatase LAR, Mol. Cell, 27, 701, 10.1016/j.molcel.2007.06.037
Wang, 2008, NEAP causes down-regulation of EGFR, subsequently induces the suppression of NGF-induced differentiation in PC12 cells, J. Neurochem., 107, 1544, 10.1111/j.1471-4159.2008.05714.x
Wang, 2010, Activation of protein serine/threonine phosphatase PP2Cα efficiently prevents liver fibrosis, PLoS One, 5, e14230, 10.1371/journal.pone.0014230
Wang, 2011, Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer, J. Biol. Chem., 286, 10177, 10.1074/jbc.M110.163295
Wang, 2012, PTPN14 is required for the density-dependent control of YAP1, Genes Dev., 26, 1959, 10.1101/gad.192955.112
Wang, 2014, Reduced expression of PTPRD correlates with poor prognosis in gastric adenocarcinoma, PLoS One, 9, e113754, 10.1371/journal.pone.0113754
Wang, 2014, High-resolution genomic copy number profiling of primary intraocular lymphoma by single nucleotide polymorphism microarrays, Cancer Sci., 105, 592, 10.1111/cas.12388
Wang, 2014, CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation, Lung Cancer, 85, 152, 10.1016/j.lungcan.2014.05.024
Wang, 2015, Protein tyrosine phosphatase receptor S acts as a metastatic suppressor in hepatocellular carcinoma by control of epithermal growth factor receptor-induced epithelial-mesenchymal transition, Hepatology, 62, 1201, 10.1002/hep.27911
Wang, 2015, MiR-21 promotes intrahepatic cholangiocarcinoma proliferation and growth in vitro and in vivo by targeting PTPN14 and PTEN, Oncotarget, 6, 5932, 10.18632/oncotarget.3465
Wang, 2015, Expression and clinical significance of PTPN14 in cholangiocarcinoma, Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi., 31, 1251
Wang, 2015, Cofilin-phosphatase slingshot-1L (SSH1L) is over-expressed in pancreatic cancer (PC) and contributes to tumor cell migration, Cancer Lett., 360, 171, 10.1016/j.canlet.2015.02.015
Wang, 2016, DCAF4L2 promotes colorectal cancer invasion and metastasis via mediating degradation of NFκb negative regulator PPM1B, Am. J. Transl. Res., 8, 405
Wang, 2016, Role for DUSP1 (dual-specificity protein phosphatase 1) in the regulation of autophagy, Autophagy, 10, 1791, 10.1080/15548627.2016.1203483
Warabi, 2000, Expression of protein tyrosine phosphatases and its significance in esophageal cancer, Exp. Mol. Pathol., 68, 187, 10.1006/exmp.2000.2303
Warfel, 2011, Mislocalization of the E3 ligase, β-transducin repeat-containing protein 1 (β-TrCP1), in glioblastoma uncouples negative feedback between the pleckstrin homology domain leucine-rich repeat protein phosphatase 1 (PHLPP1) and Akt, J. Biol. Chem., 286, 19777, 10.1074/jbc.M111.237081
Warmka, 2004, Mitogen-activated protein kinase phosphatase-3 is a tumor promoter target in initiated cells that express oncogenic Ras, J. Biol. Chem., 279, 33085, 10.1074/jbc.M403120200
Watt, 2017, Functional importance of PP2A regulatory subunit loss in breast cancer, Breast Cancer Res. Treat., 10.1007/s10549-017-4403-5
Weir, 2007, Characterizing the cancer genome in lung adenocarcinoma, Nature, 450, 893, 10.1038/nature06358
Wen, 2013, Downregulation of PHLPP expression contributes to hypoxia-induced resistance to chemotherapy in colon cancer cells, Mol. Cell. Biol., 33, 4594, 10.1128/MCB.00695-13
Wittig-Blaich, 2017, Systematic screening of isogenic cancer cells identifies DUSP6 as context-specific synthetic lethal target in melanoma, Oncotarget, 8, 23760, 10.18632/oncotarget.15863
Wlodarchak, 2016, PP2A as a master regulator of the cell cycle, Crit. Rev. Biochem. Mol. Biol., 51, 162, 10.3109/10409238.2016.1143913
Wong, 2015, Regulation of autophagy by coordinated action of mTORC1 and protein phosphatase 2A, Nat. Commun., 6, 8048, 10.1038/ncomms9048
Woodward, 2017, Genomic complexity and targeted genes in anaplastic thyroid cancer cell lines, Endocr. Relat. Cancer, 24, 209, 10.1530/ERC-16-0522
Wu, 2003, The function of the protein tyrosine phosphatase SHP-1 in cancer, Gene, 306, 1, 10.1016/S0378-1119(03)00400-1
Wu, 2006, PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma, Anticancer Res., 26, 1643
Wu, 2010, Identification of tyrosine-phosphorylated proteins associated with lung cancer metastasis using label-free quantitative analyses, J. Proteome Res., 9, 4102, 10.1021/pr1006153
Wu, 2011, Decreased expression of dual-specificity phosphatase 9 is associated with poor prognosis in clear cell renal cell carcinoma, BMC Cancer, 11, 413, 10.1186/1471-2407-11-413
Wu, 2013, Low expression of tyrosine-protein phosphatase nonreceptor type 12 is associated with lymph node metastasis and poor prognosis in operable triple-negative breast cancer, Asian Pac. J. Cancer Prev., 14, 287, 10.7314/APJCP.2013.14.1.287
Wu, 2015, Epigenetic silencing of DUSP9 induces the proliferation of human gastric cancer by activating JNK signaling, Oncol. Rep., 34, 121, 10.3892/or.2015.3998
Xing, 2015, Anaplastic large cell lymphomas: ALK positive, ALK negative, and primary cutaneous, Adv. Anat. Pathol., 22, 29, 10.1097/PAP.0000000000000047
Xiong, 2017, PHLPP regulates hexokinase 2-dependent glucose metabolism in colon cancer cells, Cell Death Discov., 3, 16103, 10.1038/cddiscovery.2016.103
Xu, 2005, Receptor-type protein-tyrosine phosphatase-kappa regulates epidermal growth factor receptor function, J. Biol. Chem., 280, 42694, 10.1074/jbc.M507722200
Xu, 2005, Abrogation of DUSP6 by hypermethylation in human pancreatic cancer, J. Hum. Genet., 50, 159, 10.1007/s10038-005-0235-y
Xu, 2014, Interaction of PTPRO and TLR4 signaling in hepatocellular carcinoma, Tumour Biol., 35, 10267, 10.1007/s13277-014-2302-5
Xu, 2016, miR-26a desensitizes non-small cell lung cancer cells to tyrosine kinase inhibitors by targeting PTPN13, Oncotarget, 7, 45687, 10.18632/oncotarget.9920
Xu, 2017, Genomic characteristics of pancreatic squamous cell carcinoma, an investigation by using high throughput sequencing after in-solution hybrid capture, Oncotarget, 8, 14620, 10.18632/oncotarget.14678
Xunyi, 2012, Clinicopathological significance of PTPN12 expression in human breast cancer, Braz. J. Med. Biol. Res., 45, 1334, 10.1590/S0100-879X2012007500163
Yan, 2002, Physical and functional interaction between receptor-like protein tyrosine phosphatase PCP-2 and beta-catenin, Biochemistry, 41, 15854, 10.1021/bi026095u
Yan, 2006, Protein-tyrosine phosphatase PCP-2 inhibits beta-catenin signaling and increases E-cadherin-dependent cell adhesion, J. Biol. Chem., 281, 15423, 10.1074/jbc.M602607200
Yan, 2010, PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR, Mol. Cell, 37, 633, 10.1016/j.molcel.2010.01.031
Yan, 2015, Blockage of PTPRJ promotes cell growth and resistance to 5-FU through activation of JAK1/STAT3 in the cervical carcinoma cell line C33A, Oncol. Rep., 33, 1737, 10.3892/or.2015.3769
Yan, 2016, Dual specificity phosphatase 5 is a novel prognostic indicator for patients with advanced colorectal cancer, Am. J. Cancer Res., 6, 2323
Yang, 2015, Methylated alteration of SHP1 complements mutation of JAK2 tyrosine kinase in patients with myeloproliferative neoplasm, Asian Pac. J. Cancer Prev., 16, 2219, 10.7314/APJCP.2015.16.6.2219
Yang, 2016, Wang B: miR-186 downregulates protein phosphatase PPM1B in bladder cancer and mediates G1-S phase transition, Tumour Biol., 37, 4331, 10.1007/s13277-015-4117-4
Yeh, 2006, Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma, Clin. Cancer Res., 12, 1097, 10.1158/1078-0432.CCR-05-1383
Yin, 2003, PAC1 phosphatase is a transcription target of p53 in signalling apoptosis and growth suppression, Nature, 422, 527, 10.1038/nature01519
Yip-Schneider, 2001, Pancreatic tumor cells with mutant K-ras suppress ERK activity by MEK-dependent induction of MAP kinase phosphatase-2, Biochem. Biophys. Res. Commun., 280, 992, 10.1006/bbrc.2001.4243
Yokoyama, 1997, The characteristic gene expressions of MAPK phosphatases 1 and 2 in hepatocarcinogenesis, rat ascites hepatoma cells, and regenerating rat liver, Biochem. Biophys. Res. Commun., 239, 746, 10.1006/bbrc.1997.7547
Young, 2009, TC-PTP is required for the maintenance of MYC-driven B-cell lymphomas, Blood, 114, 5016, 10.1182/blood-2008-12-196709
Yu, 2007, Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma, Cancer Res., 67, 130, 10.1158/0008-5472.CAN-06-2478
Yu, 2007, A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity, Oncogene, 26, 1178, 10.1038/sj.onc.1209899
Yu, 2012, Expression profiling during mammary epithelial cell three-dimensional morphogenesis identifies PTPRO as a novel regulator of morphogenesis and ErbB2-mediated transformation, Mol. Cell. Biol., 32, 3913, 10.1128/MCB.00068-12
Yu, 2013, Inhibition of CIP2A determines erlotinib-induced apoptosis in hepatocellular carcinoma, Biochem. Pharmacol., 85, 356, 10.1016/j.bcp.2012.11.009
Yu, 2015, Decreased expression of dual specificity phosphatase 22 in colorectal cancer and its potential prognostic relevance for stage IV CRC patients, Tumour Biol., 36, 8531, 10.1007/s13277-015-3588-7
Yuan, 2010, Protein-tyrosine phosphatase PTPN9 negatively regulates ErbB2 and epidermal growth factor receptor signaling in breast cancer cells, J. Biol. Chem., 285, 14861, 10.1074/jbc.M109.099879
Yuwanita, 2015, Increased metastasis with loss of E2F2 in Myc-driven tumors, Oncotarget, 6, 38210, 10.18632/oncotarget.5690
Zaidi, 2009, Altered Runx1 subnuclear targeting enhances myeloid cell proliferation and blocks differentiation by activating a miR-24/MKP-7/MAPK network, Cancer Res., 69, 8249, 10.1158/0008-5472.CAN-09-1567
Zang, 2015, Identifying CDKN3 gene expression as a prognostic biomarker in lung adenocarcinoma via meta-analysis, Cancer Inform., 14, 183
Zanke, 1992, Cloning and expression of an inducible lymphoid-specific, protein tyrosine phosphatase (HePTPase), Eur. J. Immunol., 22, 235, 10.1002/eji.1830220134
Zanke, 1994, A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1, Leukemia, 8, 236
Zhan, 2016, Tumour-suppressive role of PTPN13 in hepatocellular carcinoma and its clinical significance, Tumour Biol., 37, 9691, 10.1007/s13277-016-4843-2
Zhang, 2005, STAT3- and DNA methyltransferase 1-mediated epigenetic silencing of SHP-1 tyrosine phosphatase tumor suppressor gene in malignant T lymphocytes, Proc. Natl. Acad. Sci. U. S. A., 102, 6948, 10.1073/pnas.0501959102
Zhang, 2007, Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T, Proc. Natl. Acad. Sci. U. S. A., 104, 4060, 10.1073/pnas.0611665104
Zhang, 2009, PR55 alpha, a regulatory subunit of PP2A, specifically regulates PP2A-mediated beta-catenin dephosphorylation, J. Biol. Chem., 284, 22649, 10.1074/jbc.M109.013698
Zhang, 2009, Cancer-derived mutations in the fibronectin III repeats of PTPRT/PTPrho inhibit cell-cell aggregation, Cell Commun. Adhes., 16, 146
Zhang, 2013, Identification and functional characterization of p130Cas as a substrate of protein tyrosine phosphatase nonreceptor 14, Oncogene, 32, 2087, 10.1038/onc.2012.220
Zhang, 2014, Incidence and prognostic value of multiple gene promoter methylations in gliomas, J. Neurooncol., 116, 349, 10.1007/s11060-013-1301-5
Zhang, 2014, DUSP1 phosphatase regulates the proinflammatory milieu in head and neck squamous cell carcinoma, Cancer Res., 74, 7191, 10.1158/0008-5472.CAN-14-1379
Zhang, 2015, CDKN3 knockdown reduces cell proliferation, invasion and promotes apoptosis in human ovarian cancer, Int. J. Clin. Exp. Pathol., 8, 4535
Zhang, 2015, DUSP16 ablation arrests the cell cycle and induces cellular senescence, FEBS J., 282, 4580, 10.1111/febs.13518
Zhang, 2016, Genetic variations in the Hippo signaling pathway and breast cancer risk in African American women in the AMBER Consortium, Carcinogenesis, 37, 951, 10.1093/carcin/bgw077
Zhang, 2016, MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer, Cell Death Dis., 7, e2525, 10.1038/cddis.2016.450
Zhang, 2017, Tumor suppressor PTPRJ is a target of miR-155 in colorectal cancer, J. Cell. Biochem., 118, 3391, 10.1002/jcb.25995
Zhao, 2017, Synthetic essentiality: targeting tumor suppressor deficiencies in cancer, Bioessays, 39, 10.1002/bies.201700076
Zhao, 2010, Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T, Proc. Natl. Acad. Sci. U. S. A., 107, 2592, 10.1073/pnas.0914884107
Zhao, 2017, Regulation of paxillin-p130-PI3K-AKT signaling axis by Src and PTPRT impacts colon tumorigenesis, Oncotarget, 8, 48782, 10.18632/oncotarget.10654
Zhao, 2017, Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer, Nature, 542, 484, 10.1038/nature21357
Zheng, 2013, Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST), Chin. J. Cancer, 32, 75, 10.5732/cjc.012.10084
Zheng, 2008, Apoptosis of estrogen-receptor negative breast cancer and colon cancer cell lines by PTP alpha and src RNAi, Int. J. Cancer, 122, 1999, 10.1002/ijc.23321
Zhi, 2011, PTPH1 cooperates with vitamin D receptor to stimulate breast cancer growth through their mutual stabilization, Oncogene, 30, 1706, 10.1038/onc.2010.543
Zhou, 2013, Characterization of nuclear localization signal in the N terminus of integrin-linked kinase-associated phosphatase (ILKAP) and its essential role in the down-regulation of RSK2 protein signaling, J. Biol. Chem., 288, 6259, 10.1074/jbc.M112.432195
Zhou, 2015, Aberrant expression of PHLPP1 and PHLPP2 correlates with poor prognosis in patients with hypopharyngeal squamous cell carcinoma, PLoS One, 10, e0119405, 10.1371/journal.pone.0119405
Zhou, 2015, MiR-34c-3p suppresses the proliferation and invasion of non-small cell lung cancer (NSCLC) by inhibiting PAC1/MAPK pathway, Int. J. Clin. Exp. Pathol., 8, 6312
Zhou, 2017, Hepatitis C virus NS3 protein enhances hepatocellular carcinoma cell invasion by promoting PPM1A ubiquitination and degradation, J. Exp. Clin. Cancer Res., 36, 42, 10.1186/s13046-017-0510-8
Zhu, 2008, Protein tyrosine phosphatase PTPN13 negatively regulates Her2/ErbB2 malignant signaling, Oncogene, 27, 2525, 10.1038/sj.onc.1210922
Zhu, 2016, Effect of PPM1H on malignant phenotype of human pancreatic cancer cells, Oncol. Rep., 36, 2926, 10.3892/or.2016.5065
Zhuang, 2016, Protein phosphatase 2A-B55δ enhances chemotherapy sensitivity of human hepatocellular carcinoma under the regulation of microRNA-133b, J. Exp. Clin. Cancer Res., 35, 67, 10.1186/s13046-016-0341-z
Zwaenepoel, 2010, Protein phosphatase 2A PR130/B′′alpha1 subunit binds to the SH2 domain-containing inositol polyphosphate 5-phosphatase 2 and prevents epidermal growth factor (EGF)-induced EGF receptor degradation sustaining EGF-mediated signaling, FASEB J., 24, 538, 10.1096/fj.09-140228