SIRT2 Regulates Adipocyte Differentiation through FoxO1 Acetylation/Deacetylation

Armoni, 2006, FOXO1 represses peroxisome proliferator-activated receptor-gamma1 and -gamma2 gene promoters in primary adipocytes. A novel paradigm to increase insulin sensitivity, J. Biol. Chem., 281, 19881, 10.1074/jbc.M600320200 Barthel, 2005, FoxO proteins in insulin action and metabolism, Trends Endocrinol. Metab., 16, 183, 10.1016/j.tem.2005.03.010 Daitoku, 2004, Silent information regulator 2 potentiates Foxo1-mediated transcription through its deacetylase activity, Proc. Natl. Acad. Sci. USA, 101, 10042, 10.1073/pnas.0400593101 Dryden, 2003, Role for human SIRT2 NAD-dependent deacetylase activity in control of mitotic exit in the cell cycle, Mol. Cell. Biol., 23, 3173, 10.1128/MCB.23.9.3173-3185.2003 Emanuelli, 2000, SOCS-3 is an insulin-induced negative regulator of insulin signaling, J. Biol. Chem., 275, 15985, 10.1074/jbc.275.21.15985 Entingh, 2003, Bi-directional regulation of brown fat adipogenesis by the insulin receptor, J. Biol. Chem., 278, 33377, 10.1074/jbc.M303056200 Feng, 2005, Functional analysis of the roles of posttranslational modifications at the p53 C terminus in regulating p53 stability and activity, Mol. Cell. Biol., 25, 5389, 10.1128/MCB.25.13.5389-5395.2005 Ford, 2006, Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription, Genes Dev., 20, 1075, 10.1101/gad.1399706 Frescas, 2005, Nuclear trapping of the forkhead transcription factor FoxO1 via Sirt-dependent deacetylation promotes expression of glucogenetic genes, J. Biol. Chem., 280, 20589, 10.1074/jbc.M412357200 Fulco, 2003, Sir2 regulates skeletal muscle differentiation as a potential sensor of the redox state, Mol. Cell, 12, 51, 10.1016/S1097-2765(03)00226-0 Furukawa-Hibi, 2005, FOXO transcription factors in cell-cycle regulation and the response to oxidative stress, Antioxid. Redox Signal., 7, 752, 10.1089/ars.2005.7.752 Gesta, 2006, Evidence for a role of developmental genes in the origin of obesity and body fat distribution, Proc. Natl. Acad. Sci. USA, 103, 6676, 10.1073/pnas.0601752103 Hallows, 2006, Sirtuins deacetylate and activate mammalian acetyl-CoA synthetases, Proc. Natl. Acad. Sci. USA, 103, 10230, 10.1073/pnas.0604392103 Imai, 2000, Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase, Nature, 403, 795, 10.1038/35001622 Lamming, 2005, HST2 mediates SIR2-independent life-span extension by calorie restriction, Science, 309, 1861, 10.1126/science.1113611 Lane, 1999, Role of the CCAAT enhancer binding proteins (C/EBPs) in adipocyte differentiation, Biochem. Biophys. Res. Commun., 266, 677, 10.1006/bbrc.1999.1885 Liszt, 2005, Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase, J. Biol. Chem., 280, 21313, 10.1074/jbc.M413296200 Luo, 2001, Negative control of p53 by Sir2alpha promotes cell survival under stress, Cell, 107, 137, 10.1016/S0092-8674(01)00524-4 Marcotte, 2004, Fluorescence assay of SIRT protein deacetylases using an acetylated peptide substrate and a secondary trypsin reaction, Anal. Biochem., 332, 90, 10.1016/j.ab.2004.05.039 Matsuzaki, 2005, Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation, Proc. Natl. Acad. Sci. USA, 102, 11278, 10.1073/pnas.0502738102 McIntyre, 2006, Design and cloning strategies for constructing shRNA expression vectors, BMC Biotechnol., 6, 1, 10.1186/1472-6750-6-1 Mostoslavsky, 2006, Genomic instability and aging-like phenotype in the absence of mammalian SIRT6, Cell, 124, 315, 10.1016/j.cell.2005.11.044 Nakae, 2003, The forkhead transcription factor Foxo1 regulates adipocyte differentiation, Dev. Cell, 4, 119, 10.1016/S1534-5807(02)00401-X Nemoto, 2005, SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}, J. Biol. Chem., 280, 16456, 10.1074/jbc.M501485200 North, 2003, The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase, Mol. Cell, 11, 437, 10.1016/S1097-2765(03)00038-8 North, 2004, Sirtuins: Sir2-related NAD-dependent protein deacetylases, Genome Biol., 5, 224, 10.1186/gb-2004-5-5-224 Perrot, 2005, The coactivator p300 directly acetylates the forkhead transcription factor Foxo1 and stimulates Foxo1-induced transcription, Mol. Endocrinol., 19, 2283, 10.1210/me.2004-0292 Picard, 2004, Sirt1 promotes fat mobilization in white adipocytes by repressing PPAR-gamma, Nature, 429, 771, 10.1038/nature02583 Qi, 2000, Peroxisome proliferator-activated receptors, coactivators, and downstream targets, Cell Biochem. Biophys., 32, 187, 10.1385/CBB:32:1-3:187 Rose, 2003, Variability of the SIRT3 gene, human silent information regulator Sir2 homologue, and survivorship in the elderly, Exp. Gerontol., 38, 1065, 10.1016/S0531-5565(03)00209-2 Schwer, 2006, Reversible Lys acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2, Proc. Natl. Acad. Sci. USA, 103, 10224, 10.1073/pnas.0603968103 Tang, 2004, Sequential gene promoter interactions by C/EBPbeta, C/EBPalpha, and PPARgamma during adipogenesis, Biochem. Biophys. Res. Commun., 318, 213, 10.1016/j.bbrc.2004.04.017 Tanner, 2000, Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose, Proc. Natl. Acad. Sci. USA, 97, 14178, 10.1073/pnas.250422697 Tanny, 1999, An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing, Cell, 99, 735, 10.1016/S0092-8674(00)81671-2 Taxman, 2006, Criteria for effective design, construction, and gene knockdown by shRNA vectors, BMC Biotechnol., 6, 7, 10.1186/1472-6750-6-7 van der Heide, 2005, Regulation of FoxO activity by CBP/p300-mediated acetylation, Trends Biochem. Sci., 30, 81, 10.1016/j.tibs.2004.12.002 van der Heide, 2004, The ins and outs of FoxO shuttling: mechanisms of FoxO translocation and transcriptional regulation, Biochem. J., 380, 297, 10.1042/bj20040167 Wang, 2006, Overlapping and distinct functions for a Caenorhabditis elegans SIR2 and DAF-16/FOXO, Mech. Ageing Dev., 127, 48, 10.1016/j.mad.2005.09.005 Wang, 2003, Identification and characterization of a novel p300-mediated p53 acetylation site, Lys 305, J. Biol. Chem., 278, 25568, 10.1074/jbc.M212574200 Wei, 2003, Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts, Mol. Cell. Biol., 23, 2859, 10.1128/MCB.23.8.2859-2870.2003 Yeung, 2004, Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase, EMBO J., 23, 2369, 10.1038/sj.emboj.7600244 Zhang, 2002, Phosphorylation of Ser 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding, J. Biol. Chem., 277, 45276, 10.1074/jbc.M208063200