Longitudinal changes of trabecular bone score after estrogen deprivation: effect of menopause and aromatase inhibition
Tóm tắt
To examine the effects of the menopausal transition and treatment with aromatase inhibitors (AI) on trabecular bone score (TBS, a newly proposed index of bone architecture derived from DXA vertebral scans) and vertebral bone mineral density (BMD). Retrospective cohort study on 29 women who became postmenopausal during a mean follow-up of 2.9 years (MP group) and 34 women treated with AI during a mean follow-up of 2.1 years (AI group). BMD was measured by DXA and TBS with a specific software. TBS decreased after menopause, but the change was significantly lower than that of the lumbar BMD (−4.6 vs. −6.8 %; mean difference: 2.2 %; p = 0.016). An even larger difference was observed in the AI group (−2.1 vs. −5.9 %; mean difference: 3.8 %; p = 0.002). The decrease of TBS induced by menopause or treatment with AI is significantly lower than that of lumbar BMD.
Tài liệu tham khảo
Bousson V, Bergot C, Sutter B et al (2012) Trabecular bone score (TBS): available knowledge, clinical relevance, and future prospects. Osteoporos Int 23:1489–1501. doi:10.1007/s00198-011-1824-6
Silva BC, Leslie WD, Resch H et al (2014) Trabecular bone score: a noninvasive analytical method based upon the DXA image. J Bone Miner Res 29:518–530. doi:10.1002/jbmr.2176
Finkelstein JS, Brockwell SE, Mehta V et al (2008) Bone mineral density changes during the menopause transition in a multiethnic cohort of women. JCEM 93:861–868. doi:10.1210/jc.2007-1876
Lustberg MB, Reinbolt RE, Shapiro CL (2012) Bone health in adult cancer survivorship. J Clin Oncol 30:3665–3674. doi:10.1200/JCO.2012.42.2097
Cauley JA, Danielson ME, Greendale GA (2013) Skeletal changes across menopause. In: Marcus R, Feldman D, Dempster DW et al (eds) Osteoporosis, 4th edn. Academic Press, Waltham, pp 745–756
Simonelli C, Leib E, Mossman N et al (2014) Creation of an age-adjusted, dual-energy X-ray absorptiometry-derived trabecular bone score curve for the lumbar spine in non-hispanic US white women. J Clin Densitom. doi:10.1016/j.jocd.2013.09.002
Dufour R, Winzenrieth R, Heraud A et al (2013) Generation and validation of a normative, age-specific reference curve for lumbar spine trabecular bone score (TBS) in French women. Osteoporos Int 24:2837–2846. doi:10.1007/s00198-013-2384-8
Kalder M, Hans D, Kyvernitakis I et al (2014) Effects of exemestane and tamoxifen treatment on bone texture analysis assessed by TBS in comparison with bone mineral density assessed by DXA in women with breast cancer. J Clin Densitom 17:66–71. doi:10.1016/j.jocd.2013.03.003
Cheung AM, Tile L, Cardew S et al (2012) Bone density and structure in healthy postmenopausal women treated with exemestane for the primary prevention of breast cancer: a nested substudy of the MAP.3 randomised controlled trial. Lancet Oncol 13:275–284. doi:10.1016/S1470-2045(11)70389-8
Cauley JA (2012) Bone loss associated with prevention of breast cancer. Lancet Oncol 13:221–222. doi:10.1016/S1470-2045(12)70030-X