Transportin-SR2 Imports HIV into the Nucleus
Tài liệu tham khảo
Weinberg, 1991, Productive human immunodeficiency virus type 1 (HIV-1) infection of nonproliferating human monocytes, J. Exp. Med., 174, 1477, 10.1084/jem.174.6.1477
Vodicka, 1998, HIV-1 Vpr interacts with the nuclear transport pathway to promote macrophage infection, Genes Dev., 12, 175, 10.1101/gad.12.2.175
Lewis, 1992, Human immunodeficiency virus infection of cells arrested in the cell cycle, EMBO J., 11, 3053, 10.1002/j.1460-2075.1992.tb05376.x
Suzuki, 2007, The road to chromatin - nuclear entry of retroviruses, Nat. Rev. Microbiol., 5, 187, 10.1038/nrmicro1579
De Rijck, 2007, Lentiviral nuclear import: A complex interplay between virus and host, Bioessays, 29, 441, 10.1002/bies.20561
Gallay, 1997, HIV-1 infection of nondividing cells through the recognition of integrase by the importin/karyopherin pathway, Proc. Natl. Acad. Sci. USA, 94, 9825, 10.1073/pnas.94.18.9825
Armon-Omer, 2004, A synthetic peptide bearing the HIV-1 integrase 161–173 amino acid residues mediates active nuclear import and binding to importin alpha: Characterization of a functional nuclear localization signal, J. Mol. Biol., 336, 1117, 10.1016/j.jmb.2003.11.057
Depienne, 2001, Characterization of the nuclear import pathway for HIV-1 integrase, J. Biol. Chem., 276, 18102, 10.1074/jbc.M009029200
Hearps, 2006, HIV-1 integrase is capable of targeting DNA to the nucleus via an importin alpha/beta-dependent mechanism, Biochem. J., 398, 475, 10.1042/BJ20060466
Fassati, 2003, Nuclear import of HIV-1 intracellular reverse transcription complexes is mediated by importin 7, EMBO J., 22, 3675, 10.1093/emboj/cdg357
Zielske, 2005, Importin 7 may be dispensable for human immunodeficiency virus type 1 and simian immunodeficiency virus infection of primary macrophages, J. Virol., 79, 11541, 10.1128/JVI.79.17.11541-11546.2005
Ao, 2007, Interaction of human immunodeficiency virus type 1 integrase with cellular nuclear import receptor importin 7 and its impact on viral replication, J. Biol. Chem., 282, 13456, 10.1074/jbc.M610546200
Kataoka, 1999, Transportin-SR, a nuclear import receptor for SR proteins, J. Cell Biol., 145, 1145, 10.1083/jcb.145.6.1145
Lai, 2000, A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins, J. Biol. Chem., 275, 7950, 10.1074/jbc.275.11.7950
Lai, 2001, Transportin-SR2 mediates nuclear import of phosphorylated SR proteins, Proc. Natl. Acad. Sci. USA, 98, 10154, 10.1073/pnas.181354098
Yun, 2003, Phosphorylation-dependent and -independent nuclear import of RS domain-containing splicing factors and regulators, J. Biol. Chem., 278, 18050, 10.1074/jbc.M211714200
Lai, 2003, A novel splicing regulator shares a nuclear import pathway with SR proteins, EMBO J., 22, 1359, 10.1093/emboj/cdg126
Legrain P., Rain, J.C., Benarouse, R., Emiliani, S., Berlioz-Torrent, C., and Blot, G. (2003). Protein-protein interactions in human immunodeficiency virus. World Intellectual Property Organization: WO 03/04176 A04172.
Cherepanov, 2003, HIV-1 integrase forms stable tetramers and associates with LEDGF/p75 protein in human cells, J. Biol. Chem., 278, 372, 10.1074/jbc.M209278200
Vandekerckhove, 2006, Transient and stable knockdown of the integrase cofactor LEDGF/p75 reveals its role in the replication cycle of human immunodeficiency virus, J. Virol., 80, 1886, 10.1128/JVI.80.4.1886-1896.2006
De Rijck, 2006, Overexpression of the lens epithelium-derived growth factor/p75 integrase binding domain inhibits human immunodeficiency virus replication, J. Virol., 80, 11498, 10.1128/JVI.00801-06
Hombrouck, 2007, Virus evolution reveals an exclusive role for LEDGF/p75 in chromosomal tethering of HIV, PLoS Pathog., 3, e47, 10.1371/journal.ppat.0030047
Llano, 2006, An essential role for LEDGF/p75 in HIV integration, Science, 314, 461, 10.1126/science.1132319
Shun, 2007, LEDGF/p75 functions downstream from preintegration complex formation to effect gene-specific HIV-1 integration, Genes Dev., 21, 1767, 10.1101/gad.1565107
Hombrouck, 2008, Preclinical evaluation of 1H-benzylindole derivatives as novel human immunodeficiency virus integrase strand transfer inhibitors, Antimicrob. Agents Chemother., 52, 2861, 10.1128/AAC.00210-08
Scacheri, 2004, Short interfering RNAs can induce unexpected and divergent changes in the levels of untargeted proteins in mammalian cells, Proc. Natl. Acad. Sci. USA, 101, 1892, 10.1073/pnas.0308698100
Caputi, 2004, A bidirectional SF2/ASF- and SRp40-dependent splicing enhancer regulates human immunodeficiency virus type 1 rev, env, vpu, and nef gene expression, J. Virol., 78, 6517, 10.1128/JVI.78.12.6517-6526.2004
Jacquenet, 2005, Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production, Retrovirology, 2, 33, 10.1186/1742-4690-2-33
Coffin, 1997
Albanese, 2008, HIV-1 pre-integration complexes selectively target decondennsed chromatin in the nuclear periphery, PloS One, 3, e2413, 10.1371/journal.pone.0002413
Wu, 1995, Targeting foreign proteins to human immunodeficiency virus particles via fusion with Vpr and Vpx, J. Virol., 69, 3389, 10.1128/jvi.69.6.3389-3398.1995
Cherepanov, 2004, Identification of an evolutionarily conserved domain in human lens epithelium-derived growth factor/transcriptional co-activator p75 (LEDGF/p75) that binds HIV-1 integrase, J. Biol. Chem., 279, 48883, 10.1074/jbc.M406307200
Cherepanov, 2005, Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator, Proc. Natl. Acad. Sci. USA, 102, 17308, 10.1073/pnas.0506924102
Ciuffi, 2005, A role for LEDGF/p75 in targeting HIV DNA integration, Nat. Med., 11, 1287, 10.1038/nm1329
Emiliani, 2005, Integrase mutants defective for interaction with LEDGF/p75 are impaired in chromosome tethering and HIV-1 replication, J. Biol. Chem., 280, 25517, 10.1074/jbc.M501378200
Llano, 2004, Lens epithelium-derived growth factor/p75 prevents proteasomal degradation of HIV-1 integrase, J. Biol. Chem., 279, 55570, 10.1074/jbc.M408508200
Maertens, 2003, LEDGF/p75 is essential for nuclear and chromosomal targeting of HIV-1 integrase in human cells, J. Biol. Chem., 278, 33528, 10.1074/jbc.M303594200
Zielske, 2006, Modest but reproducible inhibition of human immunodeficiency virus type 1 infection in macrophages following LEDGFp75 silencing, J. Virol., 80, 7275, 10.1128/JVI.02470-05
Engelman, 1992, Identification of conserved amino acid residues critical for human immunodeficiency virus type 1 integrase function in vitro, J. Virol., 66, 6361, 10.1128/jvi.66.11.6361-6369.1992
Liu, 1999, Use of digitonin-permeabilized cells in studies of steroid receptor subnuclear trafficking, Methods, 19, 403, 10.1006/meth.1999.0876
Yamashita, 2005, The cell cycle independence of HIV Infections is not determined by known karyophilic viral elements, PLoS Pathog., 1, e18, 10.1371/journal.ppat.0010018
Yamashita, 2004, Capsid is a dominant determinant of retrovirus infectivity in nondividing cells, J. Virol., 78, 5670, 10.1128/JVI.78.11.5670-5678.2004
Brass, 2008, Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen, Science, 319, 921, 10.1126/science.1152725
Flexner, 2007, HIV drug development: The next 25 years, Nat. Rev. Drug Discov., 6, 959, 10.1038/nrd2336
Busschots, 2005, The interaction of LEDGF/p75 with integrase is lentivirus-specific and promotes DNA binding, J. Biol. Chem., 280, 17841, 10.1074/jbc.M411681200
Novina, 2002, siRNA-directed inhibition of HIV-1 infection, Nat. Med., 8, 681, 10.1038/nm725