Accumulation of oxidative DNA damage in brain mitochondria in mouse model of hereditary ferritinopathy

Neuroscience Letters - Tập 479 - Trang 44-48 - 2010
Xiaoling Deng1, Ruben Vidal2, Ella W. Englander1
1Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, United States
2Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, United States

Tài liệu tham khảo

Baraibar, 2008, Iron-mediated aggregation and a localized structural change characterize ferritin from a mutant light chain polypeptide that causes neurodegeneration, J. Biol. Chem., 283, 31679, 10.1074/jbc.M805532200 Barbeito, 2009, Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene, J. Neurochem., 109, 1067, 10.1111/j.1471-4159.2009.06028.x Berg, 2006, Role of iron in neurodegenerative disorders, Top. Magn. Reson. Imaging, 17, 5, 10.1097/01.rmr.0000245461.90406.ad Bradbury, 1997, Transport of iron in the blood–brain–cerebrospinal fluid system, J. Neurochem., 69, 443, 10.1046/j.1471-4159.1997.69020443.x Chen, 2007, Accumulation of oxidatively generated DNA damage in the brain: a mechanism of neurotoxicity, Free Radic. Biol. Med., 42, 385, 10.1016/j.freeradbiomed.2006.11.009 Chinnery, 2007, Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation, Brain, 130, 110, 10.1093/brain/awl319 Cozzi, 2010, Oxidative stress and cell death in cells expressing l-ferritin variants causing neuroferritinopathy, Neurobiol. Dis., 37, 77, 10.1016/j.nbd.2009.09.009 Cozzi, 2006, Characterization of the l-ferritin variant 460InsA responsible of a hereditary ferritinopathy disorder, Neurobiol. Dis., 23, 644, 10.1016/j.nbd.2006.05.004 Curtis, 2001, Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease, Nat. Genet., 28, 350, 10.1038/ng571 de Souza-Pinto, 2008, Mitochondrial DNA, base excision repair and neurodegeneration, DNA Repair (Amst.), 7, 1098, 10.1016/j.dnarep.2008.03.011 Eaton, 2002, Molecular bases of cellular iron toxicity, Free Radic. Biol. Med., 32, 833, 10.1016/S0891-5849(02)00772-4 Englander, 2008, Brain capacity for repair of oxidatively damaged DNA and preservation of neuronal function, Mech. Ageing Dev., 129, 475, 10.1016/j.mad.2008.02.001 Gaasch, 2007, Brain iron toxicity: differential responses of astrocytes, neurons, and endothelial cells, Neurochem. Res., 32, 1196, 10.1007/s11064-007-9290-4 Gao, 2009, Mitochondrial DNA damage in iron overload, J. Biol. Chem., 284, 4767, 10.1074/jbc.M806235200 Gutteridge, 1992, Iron and oxygen radicals in brain, Ann. Neurol., 32, S16, 10.1002/ana.410320705 Gutteridge, 1992, Antioxidant protection against organic and inorganic oxygen radicals by normal human plasma: the important primary role for iron-binding and iron-oxidising proteins, Biochim. Biophys. Acta, 1159, 248, 10.1016/0167-4838(92)90052-F Halliwell, 2009, The wanderings of a free radical, Free Radic. Biol. Med., 46, 531, 10.1016/j.freeradbiomed.2008.11.008 Kell, 2009, Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases, BMC Med. Genomics, 2, 2, 10.1186/1755-8794-2-2 Koeppen, 2003, A brief history of brain iron research, J. Neurol. Sci., 207, 95, 10.1016/S0022-510X(02)00429-X Kuhn, 2009, How iron controls iron, Cell Metab., 10, 439, 10.1016/j.cmet.2009.11.005 Levenson, 2004, Iron and ageing: an introduction to iron regulatory mechanisms, Ageing Res. Rev., 3, 251, 10.1016/j.arr.2004.03.001 Li, 2009, Elevated metals compromise repair of oxidative DNA damage via the base excision repair pathway: implications of pathologic iron overload in the brain on integrity of neuronal DNA, J. Neurochem., 110, 1774, 10.1111/j.1471-4159.2009.06271.x Liu, 2008, Removal of oxidative DNA damage via FEN1-dependent long-patch base excision repair in human cell mitochondria, Mol. Cell. Biol., 28, 4975, 10.1128/MCB.00457-08 Mancuso, 2005, Hereditary ferritinopathy: a novel mutation, its cellular pathology, and pathogenetic insights, J. Neuropathol. Exp. Neurol., 64, 280, 10.1093/jnen/64.4.280 Mangialasche, 2009, Biomarkers of oxidative and nitrosative damage in Alzheimer's disease and mild cognitive impairment, Ageing Res. Rev., 8, 285, 10.1016/j.arr.2009.04.002 Ory-Magne, 2009, Clinical phenotype and neuroimaging findings in a French family with hereditary ferritinopathy (FTL498–499InsTC), Mov. Disord., 24, 1676, 10.1002/mds.22669 Perry, 2003, Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease, Biometals, 16, 77, 10.1023/A:1020731021276 Petrat, 2002, The chelatable iron pool in living cells: a methodically defined quantity, Biol. Chem., 383, 489, 10.1515/BC.2002.051 Shokolenko, 2009, Oxidative stress induces degradation of mitochondrial DNA, Nucleic Acids Res., 37, 2539, 10.1093/nar/gkp100 Vidal, 2004, Intracellular ferritin accumulation in neural and extraneural tissue characterizes a neurodegenerative disease associated with a mutation in the ferritin light polypeptide gene, J. Neuropathol. Exp. Neurol., 63, 363, 10.1093/jnen/63.4.363 Vidal, 2008, Expression of a mutant form of the ferritin light chain gene induces neurodegeneration and iron overload in transgenic mice, J. Neurosci., 28, 60, 10.1523/JNEUROSCI.3962-07.2008 Wang, 2000, Mitochondrial DNA damage and a hypoxic response are induced by CoCl(2) in rat neuronal PC12 cells, Nucleic Acids Res., 28, 2135, 10.1093/nar/28.10.2135