Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia

Nature - Tập 481 Số 7381 - Trang 380-384 - 2012
Christian M. Metallo1, Paulo A. Gameiro2, Eric L. Bell3, Katherine Mattaini4, Juanjuan Yang5, Karsten Hiller2,6, Christopher M. Jewell4, Zachary R. Johnson4, Darrell J. Irvine7,4, Leonard Guarente3, Joanne K. Kelleher2, Matthew G. Vander Heiden8,4, Othon Iliopoulos5, Gregory Stephanopoulos2
1Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
2Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, USA
3Department of Biology, Massachusetts Institute of Technology, Cambridge, USA
4Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, USA
5Massachusetts General Hospital Center for Cancer Research, Charlestown, USA
6Present addresses: Department of Bioengineering, University of California at San Diego, La Jolla, California 92093, USA (C.M.M.); Luxembourg Centre for Systems Biomedicine, University of Luxembourg, L-1511, Luxembourg (K.H.).,
7Howard Hughes Medical Institute, Chevy Chase, USA
8Dana-Farber Cancer Institute, Boston, USA

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