Biological Versus Chronological Aging

Journal of the American College of Cardiology - Tập 75 - Trang 919-930 - 2020
Magda R. Hamczyk1,2,3, Rosa M. Nevado1,2, Ana Barettino1,2, Valentín Fuster1,4, Vicente Andrés1,2
1Centro Nacional de Investigaciones Cardiovasculares (CNIC), Spain
2Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Spain
3Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología (IUOPA), Universidad de Oviedo, Oviedo, Spain
4The Zena and Michael A. Wiener Cardiovascular Institute/Marie-Josée and Henry R. Kravis Center for Cardiovascular Health, Mount Sinai School of Medicine, New York, New York

Tài liệu tham khảo

Hamczyk, 2018, Aging in the cardiovascular system: lessons from Hutchinson-Gilford progeria syndrome, Annu Rev Physiol, 80, 27, 10.1146/annurev-physiol-021317-121454 Savji, 2013, Association between advanced age and vascular disease in different arterial territories: a population database of over 3.6 million subjects, J Am Coll Cardiol, 61, 1736, 10.1016/j.jacc.2013.01.054 Laurent, 2019, Concept of extremes in vascular aging, Hypertension, 74, 218, 10.1161/HYPERTENSIONAHA.119.12655 Jylhävä, 2017, Biological age predictors, EBioMedicine, 21, 29, 10.1016/j.ebiom.2017.03.046 López-Otín, 2013, The hallmarks of aging, Cell, 153, 1194, 10.1016/j.cell.2013.05.039 Blackburn, 2015, Human telomere biology: a contributory and interactive factor in aging, disease risks, and protection, Science, 350, 1193, 10.1126/science.aab3389 De Meyer, 2018, Telomere length as cardiovascular aging biomarker: JACC review topic of the week, J Am Coll Cardiol, 72, 805, 10.1016/j.jacc.2018.06.014 Bell, 2012, Epigenome-wide scans identify differentially methylated regions for age and age-related phenotypes in a healthy ageing population, PLoS Genet, 8, 10.1371/journal.pgen.1002629 Heyn, 2012, Distinct DNA methylomes of newborns and centenarians, Proc Natl Acad Sci U S A, 109, 10522, 10.1073/pnas.1120658109 Hannum, 2013, Genome-wide methylation profiles reveal quantitative views of human aging rates, Mol Cell, 49, 359, 10.1016/j.molcel.2012.10.016 Horvath, 2013, DNA methylation age of human tissues and cell types, Genome Biol, 14, R115, 10.1186/gb-2013-14-10-r115 Marioni, 2015, DNA methylation age of blood predicts all-cause mortality in later life, Genome Biol, 16, 25, 10.1186/s13059-015-0584-6 Fransquet, 2019, The epigenetic clock as a predictor of disease and mortality risk: a systematic review and meta-analysis, Clin Epigenetics, 11, 62, 10.1186/s13148-019-0656-7 Fuster, 2018, Somatic mutations and clonal hematopoiesis: unexpected potential new drivers of age-related cardiovascular disease, Circ Res, 122, 523, 10.1161/CIRCRESAHA.117.312115 Ferrucci, 2018, Inflammageing: chronic inflammation in ageing, cardiovascular disease, and frailty, Nat Rev Cardiol, 15, 505, 10.1038/s41569-018-0064-2 Vaiserman, 2017, Gut microbiota: a player in aging and a target for anti-aging intervention, Ageing Res Rev, 35, 36, 10.1016/j.arr.2017.01.001 Strazhesko, 2017, Growth hormone, insulin-like growth factor-1, insulin resistance, and leukocyte telomere length as determinants of arterial aging in subjects free of cardiovascular diseases, Front Genet, 8, 198, 10.3389/fgene.2017.00198 Abdullah, 2018, Long-term association of low-density lipoprotein cholesterol with cardiovascular mortality in individuals at low 10-year risk of atherosclerotic cardiovascular disease, Circulation, 138, 2315, 10.1161/CIRCULATIONAHA.118.034273 Bulpitt, 1999, Vascular compliance as a measure of biological age, J Am Geriatr Soc, 47, 657, 10.1111/j.1532-5415.1999.tb01586.x Van Bortel, 2012, Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity, J Hypertens, 30, 445, 10.1097/HJH.0b013e32834fa8b0 Townsend, 2015, Recommendations for improving and standardizing vascular research on arterial stiffness: a scientific statement from the American Heart Association, Hypertension, 66, 698, 10.1161/HYP.0000000000000033 Mitchell, 2010, Arterial stiffness and cardiovascular events: the Framingham Heart Study, Circulation, 121, 505, 10.1161/CIRCULATIONAHA.109.886655 Laurent, 2001, Aortic stiffness is an independent predictor of all-cause and cardiovascular mortality in hypertensive patients, Hypertension, 37, 1236, 10.1161/01.HYP.37.5.1236 Humphrey, 2016, Central artery stiffness in hypertension and aging: a problem with cause and consequence, Circ Res, 118, 379, 10.1161/CIRCRESAHA.115.307722 Poulter, 2015, Hypertension, Lancet, 386, 801, 10.1016/S0140-6736(14)61468-9 Thijssen, 2019, Expert consensus and evidence-based recommendations for the assessment of flow-mediated dilation in humans, Eur Heart J, 40, 2534, 10.1093/eurheartj/ehz350 Skaug, 2013, Age and gender differences of endothelial function in 4739 healthy adults: the HUNT3 Fitness Study, Eur J Prev Cardiol, 20, 531, 10.1177/2047487312444234 de Groot, 2004, Measurement of arterial wall thickness as a surrogate marker for atherosclerosis, Circulation, 109, III33 Bauer, 2012, Carotid intima-media thickness as a biomarker of subclinical atherosclerosis, Swiss Med Wkly, 142, w13705 Homma, 2001, Carotid plaque and intima-media thickness assessed by B-mode ultrasonography in subjects ranging from young adults to centenarians, Stroke, 32, 830, 10.1161/01.STR.32.4.830 Lorenz, 2007, Prediction of clinical cardiovascular events with carotid intima-media thickness: a systematic review and meta-analysis, Circulation, 115, 459, 10.1161/CIRCULATIONAHA.106.628875 Inaba, 2012, Carotid plaque, compared with carotid intima-media thickness, more accurately predicts coronary artery disease events: a meta-analysis, Atherosclerosis, 220, 128, 10.1016/j.atherosclerosis.2011.06.044 Naqvi, 2014, Carotid intima-media thickness and plaque in cardiovascular risk assessment, J Am Coll Cardiol Img, 7, 1025, 10.1016/j.jcmg.2013.11.014 Lanzer, 2014, Medial vascular calcification revisited: review and perspectives, Eur Heart J, 35, 1515, 10.1093/eurheartj/ehu163 Kockelkoren, 2017, Computed tomographic distinction of intimal and medial calcification in the intracranial internal carotid artery, PLoS One, 12, 10.1371/journal.pone.0168360 Wang, 2018, Imaging cardiovascular calcification, J Am Heart Assoc, 7 Sangiorgi, 1998, Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology, J Am Coll Cardiol, 31, 126, 10.1016/S0735-1097(97)00443-9 McClelland, 2006, Distribution of coronary artery calcium by race, gender, and age: results from the Multi-Ethnic Study of Atherosclerosis (MESA), Circulation, 113, 30, 10.1161/CIRCULATIONAHA.105.580696 Raggi, 2008, Coronary artery calcium to predict all-cause mortality in elderly men and women, J Am Coll Cardiol, 52, 17, 10.1016/j.jacc.2008.04.004 McClelland, 2009, Arterial age as a function of coronary artery calcium (from the Multi-Ethnic Study of Atherosclerosis [MESA]), Am J Cardiol, 103, 59, 10.1016/j.amjcard.2008.08.031 Handy, 2016, The association of coronary artery calcium with noncardiovascular disease: the Multi-Ethnic Study of Atherosclerosis, J Am Coll Cardiol Img, 9, 568, 10.1016/j.jcmg.2015.09.020 Nilsson Wadström, 2019, A Vascular Aging Index as independent predictor of cardiovascular events and total mortality in an elderly urban population, Angiology, 70, 929, 10.1177/0003319719857270 Kim S, Myers L, Wyckoff J, Cherry KE, Jazwinski SM. The frailty index outperforms DNA methylation age and its derivatives as an indicator of biological age. GeroScience 2017;39:83–92. Jia, 2017, Common methods of biological age estimation, Clin Interv Aging, 12, 759, 10.2147/CIA.S134921 Belsky, 2018, Eleven telomere, epigenetic clock, and biomarker-composite quantifications of biological aging: do they measure the same thing?, Am J Epidemiol, 187, 1220 Marais, 2018, Sex gap in aging and longevity: can sex chromosomes play a role?, Biol Sex Differ, 9, 33, 10.1186/s13293-018-0181-y Min, 2012, The lifespan of Korean eunuchs, Curr Biol, 22, R792, 10.1016/j.cub.2012.06.036 Gagliano-Jucá, 2019, Testosterone replacement therapy and cardiovascular risk, Nat Rev Cardiol, 16, 555, 10.1038/s41569-019-0211-4 Kolber, 2014, Family history of cardiovascular disease, Can Fam Physician, 60, 1016 Sebastiani, 2013, Meta-analysis of genetic variants associated with human exceptional longevity, Aging (Albany NY), 5, 653, 10.18632/aging.100594 Horvath, 2015, Decreased epigenetic age of PBMCs from Italian semi-supercentenarians and their offspring, Aging (Albany NY), 7, 1159, 10.18632/aging.100861 Goel, 2017, Ethnic difference in proximal aortic stiffness: an observation from the Dallas Heart Study, J Am Coll Cardiol Img, 10, 54, 10.1016/j.jcmg.2016.07.012 Hjelmborg, 2006, Genetic influence on human lifespan and longevity, Hum Genet, 119, 312, 10.1007/s00439-006-0144-y Palinski, 2014, Effect of maternal cardiovascular conditions and risk factors on offspring cardiovascular disease, Circulation, 129, 2066, 10.1161/CIRCULATIONAHA.113.001805 Fleming, 2018, Origins of lifetime health around the time of conception: causes and consequences, Lancet, 391, 1842, 10.1016/S0140-6736(18)30312-X Napoli, 1997, Fatty streak formation occurs in human fetal aortas and is greatly enhanced by maternal hypercholesterolemia. Intimal accumulation of low density lipoprotein and its oxidation precede monocyte recruitment into early atherosclerotic lesions, J Clin Invest, 100, 2680, 10.1172/JCI119813 Milei, 2008, Perinatal and infant early atherosclerotic coronary lesions, Can J Cardiol, 24, 137, 10.1016/S0828-282X(08)70570-1 de Nigris, 2018, Epigenetic hallmarks of fetal early atherosclerotic lesions in humans, JAMA Cardiol, 3, 1184, 10.1001/jamacardio.2018.3546 Lee, 2017, Running as a key lifestyle medicine for longevity, Prog Cardiovasc Dis, 60, 45, 10.1016/j.pcad.2017.03.005 Lee, 2014, Leisure-time running reduces all-cause and cardiovascular mortality risk, J Am Coll Cardiol, 64, 472, 10.1016/j.jacc.2014.04.058 Mozaffarian, 2016, Dietary and policy priorities for cardiovascular disease, diabetes, and obesity: a comprehensive review, Circulation, 133, 187, 10.1161/CIRCULATIONAHA.115.018585 LaRocca, 2017, Nutrition and other lifestyle influences on arterial aging, Ageing Res Rev, 39, 106, 10.1016/j.arr.2016.09.002 Madeo, 2019, Caloric restriction mimetics against age-associated disease: targets, mechanisms, and therapeutic potential, Cell Metab, 29, 592, 10.1016/j.cmet.2019.01.018 Banks, 2019, Tobacco smoking and risk of 36 cardiovascular disease subtypes: fatal and non-fatal outcomes in a large prospective Australian study, BMC Med, 17, 128, 10.1186/s12916-019-1351-4 Havakuk, 2017, The cardiovascular effects of cocaine, J Am Coll Cardiol, 70, 101, 10.1016/j.jacc.2017.05.014 Provost, 2015, Int Panis L, De Boever P, Nawrot TS. Carotid intima-media thickness, a marker of subclinical atherosclerosis, and particulate air pollution exposure: the meta-analytical evidence, PLoS One, 10, 10.1371/journal.pone.0127014 Zhao, 2018, Air pollution and telomere length: a systematic review of 12,058 subjects, Cardiovasc Diagn Ther, 8, 480, 10.21037/cdt.2018.06.05 Domínguez, 2019, Association of sleep duration and quality with subclinical atherosclerosis, J Am Coll Cardiol, 73, 134, 10.1016/j.jacc.2018.10.060 Oliveira, 2016, Systematic review of the association between chronic social stress and telomere length: a life course perspective, Ageing Res Rev, 26, 37, 10.1016/j.arr.2015.12.006 Karimi, 2019, Early-life inequalities and biological ageing: a multisystem Biological Health Score approach in Understanding Society, J Epidemiol Community Health, 73, 693, 10.1136/jech-2018-212010 Jordan, 2015, Joint scientific statement of the European Association for the Study of Obesity and the European Society of Hypertension, J Hypertens, 33, 425, 10.1097/HJH.0000000000000473 Webster, 2017, Chronic kidney disease, Lancet, 389, 1238, 10.1016/S0140-6736(16)32064-5 Frostegård, 2005, Atherosclerosis in patients with autoimmune disorders, Arterioscler Thromb Vasc Biol, 25, 1776, 10.1161/01.ATV.0000174800.78362.ec Fourie, 2017, Early vascular aging in the HIV infected: is arterial stiffness assessment the ideal tool?, Virulence, 8, 1075, 10.1080/21505594.2017.1325984 Castro Cabezas, 2018, Dyslipidemias in clinical practice, Clin Chim Acta, 487, 117, 10.1016/j.cca.2018.09.010 Nitschke, 2017, Inherited arterial calcification syndromes: etiologies and treatment concepts, Curr Osteoporos Rep, 15, 255, 10.1007/s11914-017-0370-3 Oshima, 2017, Werner syndrome: clinical features, pathogenesis and potential therapeutic interventions, Ageing Res Rev, 33, 105, 10.1016/j.arr.2016.03.002 Delaney, 2013, The association between physical activity and both incident coronary artery calcification and ankle brachial index progression: the Multi-Ethnic Study of Atherosclerosis, Atherosclerosis, 230, 278, 10.1016/j.atherosclerosis.2013.07.045 Tucker, 2017, Physical activity and telomere length in U.S. men and women: an NHANES investigation, Prev Med, 100, 145, 10.1016/j.ypmed.2017.04.027 de Cabo, 2014, The search for antiaging interventions: from elixirs to fasting regimens, Cell, 157, 1515, 10.1016/j.cell.2014.05.031 Nowak, 2018, Strategies for achieving healthy vascular aging, Hypertension, 71, 389, 10.1161/HYPERTENSIONAHA.117.10439 Martens, 2016, Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing, J Physiol, 594, 7177, 10.1113/JP272348 Kraus, 2019, 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial, Lancet Diabetes Endocrinol, 7, 673, 10.1016/S2213-8587(19)30151-2 Belsky, 2018, Change in the rate of biological aging in response to caloric restriction: CALERIE biobank analysis, J Gerontol A Biol Sci Med Sci, 73, 4, 10.1093/gerona/glx096 Fontana, 2010, Extending healthy life span—from yeast to humans, Science, 328, 321, 10.1126/science.1172539 Barzilai, 2016, Metformin as a tool to target aging, Cell Metab, 23, 1060, 10.1016/j.cmet.2016.05.011 Johnson, 2001, Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure, Transplantation, 72, 777, 10.1097/00007890-200109150-00007 Joannidès, 2011, Immunosuppressant regimen based on sirolimus decreases aortic stiffness in renal transplant recipients in comparison to cyclosporine, Am J Transplant, 11, 2414, 10.1111/j.1600-6143.2011.03697.x Silva, 2018, Effect of sirolimus on carotid atherosclerosis in kidney transplant recipients: data derived from a prospective randomized controlled trial, Clin Kidney J, 11, 846 Kurdi, 2016, Potential therapeutic effects of mTOR inhibition in atherosclerosis, Br J Clin Pharmacol, 82, 1267, 10.1111/bcp.12820 Chih, 2016, Allograft vasculopathy: the Achilles’ heel of heart transplantation, J Am Coll Cardiol, 68, 80, 10.1016/j.jacc.2016.04.033 Salmon, 2015, About-face on the metabolic side effects of rapamycin, Oncotarget, 6, 2585, 10.18632/oncotarget.3354 Mannick, 2018, TORC1 inhibition enhances immune function and reduces infections in the elderly, Sci Transl Med, 10, 10.1126/scitranslmed.aaq1564 Agarwal, 2010, Metformin reduces arterial stiffness and improves endothelial function in young women with polycystic ovary syndrome: a randomized, placebo-controlled, crossover trial, J Clin Endocrinol Metab, 95, 722, 10.1210/jc.2009-1985 Bannister, 2014, Can people with type 2 diabetes live longer than those without? A comparison of mortality in people initiated with metformin or sulphonylurea monotherapy and matched, non-diabetic controls, Diabetes Obes Metab, 16, 1165, 10.1111/dom.12354 Springer, 2019, Resveratrol and its human metabolites—effects on metabolic health and obesity, Nutrients, 11, 143, 10.3390/nu11010143 Breuss, 2019, Resveratrol and its effects on the vascular system, Int J Mol Sci, 20, 1523, 10.3390/ijms20071523 de Picciotto, 2016, Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice, Aging Cell, 15, 522, 10.1111/acel.12461 Martens, 2018, Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults, Nat Commun, 9, 1286, 10.1038/s41467-018-03421-7 Angel, 2012, Effect of 1-year anti-TNF-α therapy on aortic stiffness, carotid atherosclerosis, and calprotectin in inflammatory arthropathies: a controlled study, Am J Hypertens, 25, 644, 10.1038/ajh.2012.12 Shetty, 2018, Emerging anti-aging strategies - scientific basis and efficacy, Aging Dis, 9, 1165, 10.14336/AD.2018.1026 Rossman, 2018, Healthy lifestyle-based approaches for successful vascular aging, J Appl Physiol (1985), 125, 1888, 10.1152/japplphysiol.00521.2018 Zheng, 2019, Effect of aerobic exercise on inflammatory markers in healthy middle-aged and older adults: a systematic review and meta-analysis of randomized controlled trials, Front Aging Neurosci, 11, 98, 10.3389/fnagi.2019.00098 Brandhorst, 2015, A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan, Cell Metab, 22, 86, 10.1016/j.cmet.2015.05.012 Wei, 2017, Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease, Sci Transl Med, 9, 10.1126/scitranslmed.aai8700 Longo, 2016, Fasting, circadian rhythms, and time-restricted feeding in healthy lifespan, Cell Metab, 23, 1048, 10.1016/j.cmet.2016.06.001 Mattson, 2017, Impact of intermittent fasting on health and disease processes, Ageing Res Rev, 39, 46, 10.1016/j.arr.2016.10.005 Accardi, 2016, Mediterranean nutraceutical foods: strategy to improve vascular ageing, Mech Ageing Dev, 159, 63, 10.1016/j.mad.2016.02.007 Calder, 2017, Health relevance of the modification of low grade inflammation in ageing (inflammageing) and the role of nutrition, Ageing Res Rev, 40, 95, 10.1016/j.arr.2017.09.001 Garofalo, 2018, Dietary salt restriction in chronic kidney disease: a meta-analysis of randomized clinical trials, Nutrients, 10, 732, 10.3390/nu10060732 DiNicolantonio, 2018, Salt and hypertension: what do we know?, Curr Opin Cardiol, 33, 377, 10.1097/HCO.0000000000000525 Soefje, 2011, Common toxicities of mammalian target of rapamycin inhibitors, Target Oncol, 6, 125, 10.1007/s11523-011-0174-9 Piskovatska, 2019, Health benefits of anti-aging drugs, Subcell Biochem, 91, 339, 10.1007/978-981-13-3681-2_13 Rodriguez, 2006, Oral rapamycin after coronary bare-metal stent implantation to prevent restenosis: the prospective, randomized Oral Rapamycin in Argentina (ORAR II) study, J Am Coll Cardiol, 47, 1522, 10.1016/j.jacc.2005.12.052 Bjornstad, 2018, Metformin improves insulin sensitivity and vascular health in youth with type 1 diabetes mellitus: randomized controlled trial, Circulation, 138, 2895, 10.1161/CIRCULATIONAHA.118.035525 Adak, 2018, A reappraisal on metformin, Regul Toxicol Pharmacol, 92, 324, 10.1016/j.yrtph.2017.12.023 Gliemann, 2013, Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men, J Physiol, 591, 5047, 10.1113/jphysiol.2013.258061 Sahebkar, 2015, Lack of efficacy of resveratrol on C-reactive protein and selected cardiovascular risk factors—results from a systematic review and meta-analysis of randomized controlled trials, Int J Cardiol, 189, 47, 10.1016/j.ijcard.2015.04.008 Bogan, 2008, Nicotinic acid, nicotinamide, and nicotinamide riboside: a molecular evaluation of NAD + precursor vitamins in human nutrition, Annu Rev Nutr, 28, 115, 10.1146/annurev.nutr.28.061807.155443