Engineering Plant Disease Resistance Based on TAL Effectors

Annual Review of Phytopathology - Tập 51 Số 1 - Trang 383-406 - 2013
Sebastián Schornack1, Matthew Moscou2, E. R. Ward3,4, Diána Horváth5
1Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, United Kingdom;
2Sainsbury Laboratory, Norwich Research Park, Norwich NR4 7UH, United Kingdom
3Current address: AgBiome, Research Triangle Park, North Carolina 27709
4Current address: AgBiome, Research Triangle Park, North Carolina 27709; Two Blades Foundation, Evanston, Illinois 60201;
5Two Blades Foundation, Evanston, Illinois 60201;

Tóm tắt

Transcription activator-like (TAL) effectors are encoded by plant-pathogenic bacteria and induce expression of plant host genes. TAL effectors bind DNA on the basis of a unique code that specifies binding of amino acid residues in repeat units to particular DNA bases in a one-to-one correspondence. This code can be used to predict binding sites of natural TAL effectors and to design novel synthetic DNA-binding domains for targeted genome manipulation. Natural mechanisms of resistance in plants against TAL effector–containing pathogens have given insights into new strategies for disease control.

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