Neutrophil granules and secretory vesicles in inflammation

Bainton, 1966, Origin of granules in polymorphonuclear leukocytes. Two types derived from opposite faces of the Golgi complex in developing granulocytes, J. Cell Biol., 28, 277, 10.1083/jcb.28.2.277 Bainton, 1971, The development of neutrophilic polymorphonuclear leukocytes in human bone marrow, J. Exp. Med., 134, 907, 10.1084/jem.134.4.907 Hartmann, 1995, Regulation of granule size in human and horse eosinophils by number of fusion events among unit granules, J. Physiol., 483, 201, 10.1113/jphysiol.1995.sp020578 Spicer, 1969, Ultrastructure, cytochemistry, and function of neutrophil leukocyte granules, A review, Lab. Invest., 20, 488 Kjeldsen, 1993, Structural and functional heterogeneity among peroxidase-negative granules in human neutrophils: identification of a distinct gelatinase-containing granule subset by combined immunocytochemistry and subcellular fractionation, Blood, 82, 3183, 10.1182/blood.V82.10.3183.bloodjournal82103183 Borregaard, 1995, Biosynthesis of granule proteins in normal human bone marrow cells. Gelatinase is a marker of terminal neutrophil differentiation, Blood, 85, 812, 10.1182/blood.V85.3.812.bloodjournal853812 Borregaard, 1987, Chemoattractant-regulated mobilization of a novel intracellular compartment in human neutrophils, Science, 237, 1204, 10.1126/science.3629236 Cowland, 1999, The individual regulation of granule protein mRNA levels during neutrophil maturation explains the heterogeneity of neutrophil granules, J. Leukocyte Biol., 66, 989, 10.1002/jlb.66.6.989 Borregaard, 1992, Stimulus-dependent secretion of plasma proteins from human neutrophils, J. Clin. Invest., 90, 86, 10.1172/JCI115860 Sorensen, 1997, The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils, Blood, 90, 2796, 10.1182/blood.V90.7.2796 Arnljots, 1998, Timing, targeting and sorting of azurophil granule proteins in human myeloid cells, Leukemia, 12, 1789, 10.1038/sj.leu.2401202 Le Cabec, 1996, Targeting of proteins to granule subsets is determined by timing and not by sorting: the specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells, Proc. Natl. Acad. Sci. USA, 93, 6454, 10.1073/pnas.93.13.6454 Bjerregaard, 2003, The in vivo profile of transcription factors during neutrophil differentiation in human bone marrow, Blood, 13, 4322, 10.1182/blood-2002-03-0835 Borregaard, 1997, Granules of the human neutrophilic polymorphonuclear leukocyte, Blood, 89, 3503, 10.1182/blood.V89.10.3503 Cham, 1994, Granulophysin is located in the membrane of azurophilic granules in human neutrophils and mobilizes to the plasma membrane following cell stimulation, Am. J. Pathol., 144, 1369 Cieutat, 1998, Azurophilic granules of human neutrophilic leukocytes are deficient in lysosome-associated membrane proteins but retain the mannose 6-phosphate recognition marker, Blood, 91, 1044, 10.1182/blood.V91.3.1044 Dahms, 1989, Mannose 6-phosphate receptors and lysosomal enzyme targeting, J. Biol. Chem., 264, 12115, 10.1016/S0021-9258(18)63825-6 Michaelson, 1992, Cationic defensins arise from charge-neutralized propeptides: a mechanism for avoiding leukocyte autocytotoxicity?, J. Leukocyte Biol., 51, 634, 10.1002/jlb.51.6.634 Nauseef, 1992, Roles of heme insertion and the mannose-6-phosphate receptor in processing of the human myeloid lysosomal enzyme, myeloperoxidase, Blood, 80, 2622, 10.1182/blood.V80.10.2622.2622 Saito, 1991, Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes, Am. J. Pathol., 139, 1053 Mirinics, 2002, Identification of the presenilins in hematopoietic cells with localization of presenilin 1 to neutrophil and platelet granules, Blood Cells Mol. Dis., 28, 28, 10.1006/bcmd.2002.0486 Feuk-Lagerstedt, 2002, The presence of stomatin in detergent-insoluble domains of neutrophil granule membranes, J. Leukocyte Biol., 72, 970, 10.1189/jlb.72.5.970 Nanda, 1996, Activation of proton pumping in human neutrophils occurs by exocytosis of vesicles bearing vacuolar-type H+-ATPases, J. Biol. Chem., 271, 15963, 10.1074/jbc.271.27.15963 Parmley, 1987, Peroxidase-containing microgranules in human neutrophils: physical, morphological, cytochemical, and secretory properties, Blood, 70, 1630, 10.1182/blood.V70.5.1630.1630 Rice, 1987, Defensin-rich dense granules of human neutrophils, Blood, 70, 757, 10.1182/blood.V70.3.757.757 Egesten, 1994, The heterogeneity of azurophil granules in neutrophil promyelocytes: immunogold localization of myeloperoxidase, cathepsin G, elastase, proteinase 3, and bactericidal/permeability increasing protein, Blood, 83, 2985, 10.1182/blood.V83.10.2985.2985 Sengelov, 1993, Control of exocytosis in early neutrophil activation, J. Immunol., 150, 1535, 10.4049/jimmunol.150.4.1535 Faurschou, 2002, Defensin-rich granules of human neutrophils: characterization of secretory properties, Biochim. Biophys. Acta, 1591, 29, 10.1016/S0167-4889(02)00243-4 Joiner, 1989, The opsonizing ligand on Salmonella typhimurium influences incorporation of specific, but not azurophil, granule constituents into neutrophil phagosomes, J. Cell Biol., 109, 2771, 10.1083/jcb.109.6.2771 Garwicz, 1998, On the role of the proform-conformation for processing and intracellular sorting of human cathepsin G, Blood, 92, 1415, 10.1182/blood.V92.4.1415 Gullberg, 1995, Carboxyl-terminal prodomain-deleted human leukocyte elastase and cathepsin G are efficiently targeted to granules and enzymatically activated in the rat basophilic/mast cell line RBL, J. Biol. Chem., 270, 12912, 10.1074/jbc.270.21.12912 Lindmark, 1999, Characterization of the biosynthesis, processing, and sorting of human HBP/CAP37/azurocidin, J. Leukocyte. Biol., 66, 634, 10.1002/jlb.66.4.634 Liu, 1995, The pro region of human neutrophil defensin contains a motif that is essential for normal subcellular sorting, Blood, 85, 1095, 10.1182/blood.V85.4.1095.bloodjournal8541095 Agner, 1941, Verdoperoxidase. A ferment isolated from leucocytes, Acta Chem. Scand., 2, 1 Klebanoff, 1999, Myeloperoxidase, Proc. Assoc. Am. Physicians, 111, 383, 10.1111/paa.1999.111.5.383 Ganz, 1985, Defensins. Natural peptide antibiotics of human neutrophils, J. Clin. Invest., 76, 1427, 10.1172/JCI112120 Valore, 1992, Posttranslational processing of defensins in immature human myeloid cells, Blood, 79, 1538, 10.1182/blood.V79.6.1538.1538 Daher, 1986, Direct inactivation of viruses by human granulocyte defensins, J. Virol., 60, 1068, 10.1128/jvi.60.3.1068-1074.1986 Lehrer, 1988, Modulation of the in vitro candidacidal activity of human neutrophil defensins by target cell metabolism and divalent cations, J. Clin. Invest., 81, 1829, 10.1172/JCI113527 Wimley, 1994, Interactions between human defensins and lipid bilayers: evidence for formation of multimeric pores, Protein Sci., 3, 1362, 10.1002/pro.5560030902 Territo, 1989, Monocyte-chemotactic activity of defensins from human neutrophils, J. Clin. Invest., 84, 2017, 10.1172/JCI114394 Chertov, 1996, Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils, J. Biol. Chem., 271, 2935, 10.1074/jbc.271.6.2935 Yang, 2000, Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells, J. Leukocyte Biol., 68, 9, 10.1189/jlb.68.1.9 Weiss, 1987, Cellular and subcellular localization of the bactericidal/permeability-increasing protein of neutrophils, Blood, 69, 652, 10.1182/blood.V69.2.652.652 Elsbach, 1998, The bactericidal/permeability-increasing protein (BPI) in antibacterial host defense, J. Leukocyte Biol., 64, 14, 10.1002/jlb.64.1.14 Ooi, 1987, A 25-kDa NH2-terminal fragment carries all the antibacterial activities of the human neutrophil 60-kDa bactericidal/permeability-increasing protein, J. Biol. Chem., 262, 14891, 10.1016/S0021-9258(18)48110-0 Iovine, 1997, An opsonic function of the neutrophil bactericidal/permeability-increasing protein depends on both its N- and C-terminal domains, Proc. Natl. Acad. Sci. USA, 94, 10973, 10.1073/pnas.94.20.10973 Campanelli, 1990, Cloning of cDNA for proteinase 3: a serine protease, antibiotic, and autoantigen from human neutrophils, J. Exp. Med., 172, 1709, 10.1084/jem.172.6.1709 Salvesen, 1987, Molecular cloning of human cathepsin G: structural similarity to mast cell and cytotoxic T lymphocyte proteinases, Biochemistry, 26, 2289, 10.1021/bi00382a032 Sinha, 1987, Primary structure of human neutrophil elastase, Proc. Natl. Acad. Sci. USA, 84, 2228, 10.1073/pnas.84.8.2228 Owen, 1999, The cell biology of leukocyte-mediated proteolysis, J. Leukocyte Biol., 65, 137, 10.1002/jlb.65.2.137 Sorensen, 2001, Human cathelicidin, hCAP-18, is processed to the antimicrobial peptide LL-37 by extracellular cleavage with proteinase 3, Blood, 97, 3951, 10.1182/blood.V97.12.3951 Witko-Sarsat, 2000, Neutrophils: molecules, functions and pathophysiological aspects, Lab. Invest., 80, 617, 10.1038/labinvest.3780067 Gabay, 1989, Antibiotic proteins of human polymorphonuclear leukocytes, Proc. Natl. Acad. Sci. USA, 86, 5610, 10.1073/pnas.86.14.5610 Campanelli, 1990, Azurocidin and a homologous serine protease from neutrophils. Differential antimicrobial and proteolytic properties, J. Clin. Invest., 85, 904, 10.1172/JCI114518 Gautam, 2001, Heparin-binding protein (HBP/CAP37): a missing link in neutrophil-evoked alteration of vascular permeability, Nat. Med., 7, 1123, 10.1038/nm1001-1123 Flodgaard, 1991, Covalent structure of two novel neutrophile leucocyte-derived proteins of porcine and human origin. Neutrophile elastase homologues with strong monocyte and fibroblast chemotactic activities, Eur. J. Biochem., 197, 535, 10.1111/j.1432-1033.1991.tb15942.x Kjeldsen, 1992, Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules, Biochem. J., 287, 603, 10.1042/bj2870603 Sengelov, 1995, Mobilization of granules and secretory vesicles during in vivo exudation of human neutrophils, J. Immunol., 154, 4157, 10.4049/jimmunol.154.8.4157 Jesaitis, 1990, Ultrastructural localization of cytochrome b in the membranes of resting and phagocytosing human granulocytes, J. Clin. Invest., 85, 821, 10.1172/JCI114509 Mollinedo, 1997, Major co-localization of the extracellular-matrix degradative enzymes heparanase and gelatinase in tertiary granules of human neutrophils, Biochem. J., 327, 917, 10.1042/bj3270917 Borregaard, 1983, Subcellular localization of the b-cytochrome component of the human neutrophil microbicidal oxidase: translocation during activation, J. Cell Biol., 97, 52, 10.1083/jcb.97.1.52 Masson, 1969, Lactoferrin, an iron-binding protein in neutrophilic leukocytes, J. Exp. Med., 130, 643, 10.1084/jem.130.3.643 Cramer, 1985, Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold, Blood, 65, 423, 10.1182/blood.V65.2.423.423 Oram, 1968, Inhibition of bacteria by lactoferrin and other iron-chelating agents, Biochim. Biophys. Acta, 170, 351, 10.1016/0304-4165(68)90015-9 Chapple, 1998, Structure–function relationship of antibacterial synthetic peptides homologous to a helical surface region on human lactoferrin against Escherichia coli serotype O111, Infect. Immun., 66, 2434, 10.1128/IAI.66.6.2434-2440.1998 Yamauchi, 1993, Antibacterial activity of lactoferrin and a pepsin-derived lactoferrin peptide fragment, Infect. Immun., 61, 719, 10.1128/iai.61.2.719-728.1993 Bullen, 1972, Iron-binding proteins in milk and resistance to Escherichia coli infection in infants, Br. Med. J., 1, 69, 10.1136/bmj.1.5792.69 Agerberth, 1995, FALL-39, a putative human peptide antibiotic, is cysteine-free and expressed in bone marrow and testis, Proc. Natl. Acad. Sci. USA, 92, 195, 10.1073/pnas.92.1.195 Cowland, 1995, hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules, FEBS Lett., 368, 173, 10.1016/0014-5793(95)00634-L Larrick, 1995, Human CAP18: a novel antimicrobial lipopolysaccharide-binding protein, Infect. Immun., 63, 1291, 10.1128/iai.63.4.1291-1297.1995 Turner, 1998, Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils, Antimicrob. Agents Chemother., 42, 2206, 10.1128/AAC.42.9.2206 Yang, 2000, LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells, J. Exp. Med., 192, 1069, 10.1084/jem.192.7.1069 Frohm, 1997, The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders, J. Biol. Chem., 272, 15258, 10.1074/jbc.272.24.15258 Agerberth, 2000, The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations, Blood, 96, 3086, 10.1182/blood.V96.9.3086 Frohm, 1999, The human cationic antimicrobial protein (hCAP18), a peptide antibiotic, is widely expressed in human squamous epithelia and colocalizes with interleukin-6, Infect. Immun., 67, 2561, 10.1128/IAI.67.5.2561-2566.1999 Malm, 2000, The human cationic antimicrobial protein (hCAP-18) is expressed in the epithelium of human epididymis, is present in seminal plasma at high concentrations, and is attached to spermatozoa, Infect. Immun., 68, 4297, 10.1128/IAI.68.7.4297-4302.2000 Kjeldsen, 1993, Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase, J. Biol. Chem., 268, 10425, 10.1016/S0021-9258(18)82217-7 Triebel, 1992, A 25 kDa alpha 2-microglobulin-related protein is a component of the 125 kDa form of human gelatinase, FEBS Lett., 314, 386, 10.1016/0014-5793(92)81511-J Kjeldsen, 1994, Identification of neutrophil gelatinase-associated lipocalin as a novel matrix protein of specific granules in human neutrophils, Blood, 83, 799, 10.1182/blood.V83.3.799.799 Goetz, 2002, The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition, Mol. Cell, 10, 1033, 10.1016/S1097-2765(02)00708-6 Nielsen, 1996, Induction of NGAL synthesis in epithelial cells of human colorectal neoplasia and inflammatory bowel diseases, Gut, 38, 414, 10.1136/gut.38.3.414 Friedl, 1999, Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression, Histochem. J., 31, 433, 10.1023/A:1003708808934 Fleming, 1922, On a remarkable bacteriolytic element found in tissues and excretions, Proc. R. Soc., 93, 306 Lollike, 1995, Lysozyme in human neutrophils and plasma. A parameter of myelopoietic activity, Leukemia, 9, 159 Selsted, 1978, Lysozyme: primary bactericidin in human plasma serum active against Bacillus subtilis, Infect. Immun., 20, 782, 10.1128/iai.20.3.782-791.1978 Tanida, 1992, Modification of immunopharmacological activities of synthetic monosaccharide lipid A analogue, GLA60, by lysozyme, J. Biochem. (Tokyo), 112, 616, 10.1093/oxfordjournals.jbchem.a123949 Takada, 1994, Binding of lysozyme to lipopolysaccharide suppresses tumor necrosis factor production in vivo, Infect. Immun., 62, 1171, 10.1128/iai.62.4.1171-1175.1994 Ganz, 2003, Increased inflammation in lysozyme M-deficient mice in response to Micrococcus luteus and its peptidoglycan, Blood, 101, 2388, 10.1182/blood-2002-07-2319 Vidal, 1993, Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg, Cell, 73, 469, 10.1016/0092-8674(93)90135-D Canonne-Hergaux, 2002, Expression and subcellular localization of NRAMP1 in human neutrophil granules, Blood, 100, 268, 10.1182/blood.V100.1.268 Jabado, 2000, Natural resistance to intracellular infections: natural resistance-associated macrophage protein 1 (Nramp1) functions as a pH-dependent manganese transporter at the phagosomal membrane, J. Exp. Med., 192, 1237, 10.1084/jem.192.9.1237 Lazarus, 1968, Human granulocyte collagenase, Science, 159, 1483, 10.1126/science.159.3822.1483 Murphy, 1977, Collagenase is a component of the specific granules of human neutrophil leucocytes, Biochem. J., 162, 195, 10.1042/bj1620195 Wilhelm, 1989, SV40-transformed human lung fibroblasts secrete a 92-kDa type IV collagenase which is identical to that secreted by normal human macrophages, J. Biol. Chem., 264, 17213, 10.1016/S0021-9258(18)71480-4 Pei, 1999, Leukolysin/MMP25/MT6-MMP: a novel matrix metalloproteinase specifically expressed in the leukocyte lineage, Cell Res., 9, 291, 10.1038/sj.cr.7290028 Kang, 2001, Subcellular distribution and cytokine- and chemokine-regulated secretion of leukolysin/MT6-MMP/MMP-25 in neutrophils, J. Biol. Chem., 276, 21960, 10.1074/jbc.M007997200 Cederqvist, 2001, Matrix metalloproteinases-2, -8, and -9 and TIMP-2 in tracheal aspirates from preterm infants with respiratory distress, Pediatrics, 108, 686, 10.1542/peds.108.3.686 Sengelov, 1993, Subcellular localization and dynamics of Mac-1 (alpha m beta 2) in human neutrophils, J. Clin. Invest., 92, 1467, 10.1172/JCI116724 Sengelov, 1994, Secretory vesicles are the intracellular reservoir of complement receptor 1 in human neutrophils, J. Immunol., 153, 804, 10.4049/jimmunol.153.2.804 Sengelov, 1994, Subcellular localization and translocation of the receptor for N-formylmethionyl-leucyl-phenylalanine in human neutrophils, Biochem. J., 299, 473, 10.1042/bj2990473 Detmers, 1995, Endotoxin receptors (CD14) are found with CD16 (Fc gamma RIII) in an intracellular compartment of neutrophils that contains alkaline phosphatase, J. Immunol., 155, 2085, 10.4049/jimmunol.155.4.2085 Borregaard, 1994, Changes in subcellular localization and surface expression of L-selectin, alkaline phosphatase, and Mac-1 in human neutrophils during stimulation with inflammatory mediators, J. Leukocyte Biol., 56, 80, 10.1002/jlb.56.1.80 Sengelov, 1993, Subcellular localization and dynamics of Mac-1 (alpha and beta 2) in human neutrophils, J. Clin. Invest., 92, 1467, 10.1172/JCI116724 Laudanna, 1994, Sulfatides trigger increase of cytosolic free calcium and enhanced expression of tumor necrosis factor-alpha and interleukin-8 mRNA in human neutrophils. Evidence for a role of L-selectin as a signaling molecule, J. Biol. Chem., 269, 4021, 10.1016/S0021-9258(17)41736-4 Ng-Sikorski, 1991, Calcium signaling capacity of the CD11b/CD18 integrin on human neutrophils, Exp. Cell Res., 195, 504, 10.1016/0014-4827(91)90402-G Berton, 1994, Beta 2 integrin-dependent protein tyrosine phosphorylation and activation of the FGR protein tyrosine kinase in human neutrophils, J. Cell Biol., 126, 1111, 10.1083/jcb.126.4.1111 Fuortes, 1993, Adhesion-dependent protein tyrosine phosphorylation in neutrophils treated with tumor necrosis factor, J. Cell Biol., 120, 777, 10.1083/jcb.120.3.777 Fallman, 1992, Complement receptor-mediated phagocytosis is associated with accumulation of phosphatidylcholine-derived diglyceride in human neutrophils. Involvement of phospholipase D and direct evidence for a positive feedback signal of protein kinase, J. Biol. Chem., 267, 2656, 10.1016/S0021-9258(18)45931-5 Hellberg, 1996, Ca2+ signalling mechanisms of the beta 2 integrin on neutrophils: involvement of phospholipase C gamma 2 and Ins(1,4,5)P3, Biochem. J., 317, 403, 10.1042/bj3170403 Agwu, 1989, Choline-linked phosphoglycerides. A source of phosphatidic acid and diglycerides in stimulated neutrophils, J. Biol. Chem., 264, 1405, 10.1016/S0021-9258(18)94202-X Suchard, 1994, Phospholipase D-mediated diradylglycerol formation coincides with H2O2 and lactoferrin release in adherent human neutrophils, J. Biol. Chem., 269, 8063, 10.1016/S0021-9258(17)37160-0 Berton, 1999, Integrin signalling in neutrophils and macrophages, Cell Signal., 11, 621, 10.1016/S0898-6568(99)00003-0 Bradford, 1986, Quantitative changes in inositol 1,4,5-trisphosphate in chemoattractant-stimulated neutrophils, J. Biol. Chem., 261, 15644, 10.1016/S0021-9258(18)66764-X Blackwood, 1990, Characterization of Ca2(+)-dependent phospholipid binding, vesicle aggregation and membrane fusion by annexins, Biochem. J., 266, 195, 10.1042/bj2660195 Francis, 1992, Human neutrophil annexin I promotes granule aggregation and modulates Ca(2+)-dependent membrane fusion, J. Clin. Invest., 90, 537, 10.1172/JCI115892 Sjolin, 1997, Translocation of annexin XI to neutrophil subcellular organelles, Biochim. Biophys. Acta, 1326, 149, 10.1016/S0005-2736(97)00018-7 Ernst, 1990, Purification and characterization of an abundant cytosolic protein from human neutrophils that promotes Ca2(+)-dependent aggregation of isolated specific granules, J. Clin. Invest., 85, 1065, 10.1172/JCI114537 Lollike, 2001, Biochemical characterization of the penta-EF-hand protein grancalcin and identification of L-plastin as a binding partner, J. Biol. Chem., 276, 17762, 10.1074/jbc.M100965200 Rothman, 1996, The protein machinery of vesicle budding and fusion, Protein Sci., 5, 185, 10.1002/pro.5560050201 Brumell, 1995, Subcellular distribution of docking/fusion proteins in neutrophils, secretory cells with multiple exocytic compartments, J. Immunol., 155, 5750, 10.4049/jimmunol.155.12.5750 Martin-Martin, 2000, Involvement of SNAP-23 and syntaxin 6 in human neutrophil exocytosis, Blood, 96, 2574, 10.1182/blood.V96.7.2574 Nabokina, 1997, Intracellular location of SNAP-25 in human neutrophils, Biochem. Biophys. Res. Commun., 239, 592, 10.1006/bbrc.1997.7515 Geng, 1990, Rapid neutrophil adhesion to activated endothelium mediated by GMP-140, Nature, 343, 757, 10.1038/343757a0 Norman, 1995, Leukocyte rolling in vivo is mediated by P-selectin glycoprotein ligand-1, Blood, 86, 4417, 10.1182/blood.V86.12.4417.bloodjournal86124417 Bevilacqua, 1989, Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins, Science, 243, 1160, 10.1126/science.2466335 Tu, 1999, The cutaneous lymphocyte antigen is an essential component of the L-selectin ligand induced on human vascular endothelial cells, J. Exp. Med., 189, 241, 10.1084/jem.189.2.241 Zimmerman, 1990, Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion, J. Cell Biol., 110, 529, 10.1083/jcb.110.2.529 Huber, 1991, Regulation of transendothelial neutrophil migration by endogenous interleukin-8, Science, 254, 99, 10.1126/science.1718038 Carlos, 1994, Leukocyte–endothelial adhesion molecules, Blood, 84, 2068, 10.1182/blood.V84.7.2068.2068 Delclaux, 1996, Role of gelatinase B and elastase in human polymorphonuclear neutrophil migration across basement membrane, Am. J. Respir. Cell Mol. Biol., 14, 288, 10.1165/ajrcmb.14.3.8845180 Singer, 1989, Adhesomes: specific granules containing receptors for laminin, C3bi/fibrinogen, fibronectin, and vitronectin in human polymorphonuclear leukocytes and monocytes, J. Cell Biol., 109, 3169, 10.1083/jcb.109.6.3169