A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

Oncotarget - Tập 6 Số 29 - Trang 27388-27402 - 2015
Andrew R. Lavik1, Fei Zhong1, Ming-Jin Chang1, Edward F. Greenberg2,1, Yuvraj Choudhary1, Mitchell R. Smith3,4, Karen McColl1, John J. Pink3, Frederic J. Reu3,4, Shigemi Matsuyama3,1, Clark Distelhorst3,1
1Division of Hematology/Oncology, Case Western Reserve University School of Medicine and University Hospitals Case Medical Center, Cleveland, Ohio, USA.
2Department of Medicine, MetroHealth Medical Center and Case Western Reserve University School of Medicine, Cleveland, Ohio, USA
3Case Comprehensive Cancer Center, Cleveland, Ohio, USA
4Department of Translational Hematology and Oncology Research, Taussig Cancer Institute, The Cleveland Clinic Foundation, Cleveland, Ohio, USA.

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