Convergence of p53 and TGF-beta signaling networks

Shi, 2003, Mechanisms of TGF-beta signaling from cell membrane to the nucleus, Cell, 113, 685, 10.1016/S0092-8674(03)00432-X

Roberts, 2003, The two faces of transforming growth factor beta in carcinogenesis, Proc. Natl Acad. Sci. USA, 100, 8621, 10.1073/pnas.1633291100

Derynck, 2003, Smad-dependent and Smad-independent pathways in TGF-beta family signalling, Nature, 425, 577, 10.1038/nature02006

Dijke Pt, 2004, New insights into TGF-beta-Smad signalling, Trends Biochem. Sci., 29, 265, 10.1016/j.tibs.2004.03.008

Siegel, 2003, Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer, Nat. Rev. Cancer, 3, 807, 10.1038/nrc1208

Massague, 2000, How cells read TGF-beta signals, Nat. Rev. Mol. Cell Biol., 1, 169, 10.1038/35043051

Chen, 1996, A transcriptional partner for MAD proteins in TGF-beta signalling, Nature, 383, 691, 10.1038/383691a0

Chen, 1997, Smad4 and FAST-1 in the assembly of activin-responsive factor, Nature, 389, 85, 10.1038/38008

Yeo, 1999, The role of FAST-1 and Smads in transcriptional regulation by activin during early Xenopus embryogenesis, J. Biol. Chem., 274, 26584, 10.1074/jbc.274.37.26584

Howell, 2002, A novel Xenopus Smad-interacting forkhead transcription factor (XFast-3) cooperates with XFast-1 in regulating gastrulation movements, Development, 129, 2823, 10.1242/dev.129.12.2823

Chen, 2001, Defective repression of c-myc in breast cancer cells: a loss at the core of the transforming growth factor beta growth arrest program, Proc. Natl Acad. Sci. USA, 98, 992, 10.1073/pnas.98.3.992

Verrecchia, 2001, Identification of novel TGF-beta /Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach, J. Biol. Chem., 276, 17058, 10.1074/jbc.M100754200

Zavadil, 2001, Genetic programs of epithelial cell plasticity directed by transforming growth factor-beta, Proc. Natl Acad. Sci. USA, 98, 6686, 10.1073/pnas.111614398

Seoane, 2001, TGFbeta influences Myc, Miz-1 and Smad to control the CDK inhibitor p15INK4b, Nat. Cell Biol., 3, 400

Seoane, 2004, Integration of Smad and forkhead pathways in the control of neuroepithelial and glioblastoma cell proliferation, Cell, 117, 211, 10.1016/S0092-8674(04)00298-3

Kang, 2003, A self-enabling TGFbeta response coupled to stress signaling: Smad engages stress response factor ATF3 for Id1 repression in epithelial cells, Mol. Cell, 11, 915, 10.1016/S1097-2765(03)00109-6

Chen, 2002, E2F4/5 and p107 as Smad cofactors linking the TGFbeta receptor to c-myc repression, Cell, 110, 19, 10.1016/S0092-8674(02)00801-2

Kowanetz, 2004, Id2 and Id3 define the potency of cell proliferation and differentiation responses to transforming growth factor beta and bone morphogenetic protein, Mol. Cell Biol., 24, 4241, 10.1128/MCB.24.10.4241-4254.2004

Derynck, 2001, TGF-beta signaling in tumor suppression and cancer progression, Nat. Genet., 29, 117, 10.1038/ng1001-117

Yang, 2002, Lifetime exposure to a soluble TGF-beta antagonist protects mice against metastasis without adverse side effects, J. Clin. Invest., 109, 1607, 10.1172/JCI200215333

Muraoka, 2002, Blockade of TGF-beta inhibits mammary tumor cell viability, migration, and metastases, J. Clin. Invest., 109, 1551, 10.1172/JCI0215234

Cordenonsi, 2003, Links between tumor suppressors: p53 is required for TGF-beta gene responses by cooperating with Smads, Cell, 113, 301, 10.1016/S0092-8674(03)00308-8

Takebayashi-Suzuki, 2003, Interplay between the tumor suppressor p53 and TGF beta signaling shapes embryonic body axes in Xenopus, Development, 130, 3929, 10.1242/dev.00615

Harland, 1997, Formation and function of Spemann's organizer, Annu. Rev. Cell Dev. Biol., 13, 611, 10.1146/annurev.cellbio.13.1.611

Montes de Oca Luna, 1995, Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53, Nature, 378, 203, 10.1038/378203a0

Jones, 1995, Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53, Nature, 378, 206, 10.1038/378206a0

Liberati, 1999, Smads bind directly to the Jun family of AP-1 transcription factors, Proc. Natl Acad. Sci. USA, 96, 4844, 10.1073/pnas.96.9.4844

Labbe, 2000, Association of Smads with lymphoid enhancer binding factor 1/T cell-specific factor mediates cooperative signaling by the transforming growth factor-beta and wnt pathways, Proc. Natl Acad. Sci. USA, 97, 8358, 10.1073/pnas.150152697

Whitman, 2003, p53 and TGF-beta in development: prelude to tumor suppression?, Cell, 113, 275, 10.1016/S0092-8674(03)00317-9

Ahn, 2001, The C-terminus of p53: the more you learn the less you know, Nat. Struct. Biol., 8, 730, 10.1038/nsb0901-730

Hupp, 1995, Small peptides activate the latent sequence-specific DNA binding function of p53, Cell, 83, 237, 10.1016/0092-8674(95)90165-5

Espinosa, 2001, Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment, Mol. Cell, 8, 57, 10.1016/S1097-2765(01)00283-0

Wu, 1997, Activities and response to DNA damage of latent and active sequence-specific DNA binding forms of mouse p53, Proc. Natl Acad. Sci. USA, 94, 8982, 10.1073/pnas.94.17.8982

Chen, 1996, p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells, Genes Dev., 10, 2438, 10.1101/gad.10.19.2438

Almog, 2000, p53-dependent apoptosis is regulated by a C-terminally alternatively spliced form of murine p53, Oncogene, 19, 3395, 10.1038/sj.onc.1203673

Donehower, 1992, Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours, Nature, 356, 215, 10.1038/356215a0

Lu, 2001, Xenopus p63 expression in early ectoderm and neurectoderm, Mech. Dev., 102, 275, 10.1016/S0925-4773(01)00315-X

Rentzsch, 2003, Specific and conserved roles of TAp73 during zebrafish development, Gene, 323, 19, 10.1016/j.gene.2003.10.002

Lee, 2002, A dominant-negative form of p63 is required for epidermal proliferation in zebrafish, Dev. Cell, 2, 607, 10.1016/S1534-5807(02)00166-1

Bakkers, 2002, Zebrafish DeltaNp63 is a direct target of Bmp signaling and encodes a transcriptional repressor blocking neural specification in the ventral ectoderm, Dev. Cell, 2, 617, 10.1016/S1534-5807(02)00163-6

Yang, 2002, On the shoulders of giants: p63, p73 and the rise of p53, Trends Genet., 18, 90, 10.1016/S0168-9525(02)02595-7

Flores, 2002, p63 and p73 are required for p53-dependent apoptosis in response to DNA damage, Nature, 416, 560, 10.1038/416560a

Urist, 2002, p53 leans on its siblings, Cancer Cell, 1, 311, 10.1016/S1535-6108(02)00064-8

Mills, 1999, p63 is a p53 homologue required for limb and epidermal morphogenesis, Nature, 398, 708, 10.1038/19531

Yang, 1999, p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development, Nature, 398, 714

Yang, 2000, p73-deficient mice have neurological, pheromonal and inflammatory defects but lack spontaneous tumors, Nature, 404, 99, 10.1038/35003607

Datto, 1995, Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism, Proc. Natl Acad. Sci. USA, 92, 5545, 10.1073/pnas.92.12.5545

Levrero, 2000, The p53/p63/p73 family of transcription factors: overlapping and distinct functions, J. Cell Sci., 113, 1661, 10.1242/jcs.113.10.1661

Hoh, 2002, The p53MH algorithm and its application in detecting p53-responsive genes, Proc. Natl Acad. Sci. USA, 99, 8467, 10.1073/pnas.132268899

Grunert, 2003, Diverse cellular and molecular mechanisms contribute to epithelial plasticity and metastasis, Nat. Rev. Mol. Cell Biol., 4, 657, 10.1038/nrm1175

Kang, 2003, A multigenic program mediating breast cancer metastasis to bone, Cancer Cell, 3, 537, 10.1016/S1535-6108(03)00132-6

Sablina, 2003, Tumor suppressor p53 and its homologue p73alpha affect cell migration, J. Biol. Chem., 278, 27362, 10.1074/jbc.M300547200

Wang, 2002, p63 expression in normal, hyperplastic and malignant breast tissues, Breast Cancer, 9, 216, 10.1007/BF02967592

Di Como, 2002, p63 expression profiles in human normal and tumor tissues, Clin. Cancer Res., 8, 494

Hu, 2002, Elevated expression of p63 protein in human esophageal squamous cell carcinomas, Int. J. Cancer, 102, 580, 10.1002/ijc.10739

Massion, 2003, Significance of p63 amplification and overexpression in lung cancer development and prognosis, Cancer Res., 63, 7113

Dohn, 2001, p63alpha and DeltaNp63alpha can induce cell cycle arrest and apoptosis and differentially regulate p53 target genes, Oncogene, 20, 3193, 10.1038/sj.onc.1204427

Ghioni, 2002, Complex transcriptional effects of p63 isoforms: identification of novel activation and repression domains, Mol. Cell Biol., 22, 8659, 10.1128/MCB.22.24.8659-8668.2002

Hibi, 2000, AIS is an oncogene amplified in squamous cell carcinoma, Proc. Natl Acad. Sci. USA, 97, 5462, 10.1073/pnas.97.10.5462

Akhurst, 1999, Genetic events and the role of TGF beta in epithelial tumour progression, J. Pathol., 187, 82, 10.1002/(SICI)1096-9896(199901)187:1<82::AID-PATH248>3.0.CO;2-8

Kemp, 1993, Reduction of p53 gene dosage does not increase initiation or promotion but enhances malignant progression of chemically induced skin tumors, Cell, 74, 813, 10.1016/0092-8674(93)90461-X

Amendt, 1998, Expression of a dominant negative type II TGF-beta receptor in mouse skin results in an increase in carcinoma incidence and an acceleration of carcinoma development, Oncogene, 17, 25, 10.1038/sj.onc.1202161

Burns, 1991, Loss of heterozygosity and mutational alterations of the p53 gene in skin tumours of interspecific hybrid mice, Oncogene, 6, 2363

Ruggeri, 1991, Alterations of the p53 tumor suppressor gene during mouse skin tumor progression, Cancer Res., 51, 6615

Vogelstein, 2000, Surfing the p53 network, Nature, 408, 307, 10.1038/35042675

Reiss, 1993, Mutant p53 tumor suppressor gene causes resistance to transforming growth factor beta 1 in murine keratinocytes, Cancer Res., 53, 899

Bullock, 2001, Rescuing the function of mutant p53, Nat. Rev. Cancer, 1, 68, 10.1038/35094077

Wallingford, 1997, p53 activity is essential for normal development in Xenopus, Curr. Biol., 7, 747, 10.1016/S0960-9822(06)00333-2

Sherr, 2004, Principles of tumor suppression, Cell, 116, 235, 10.1016/S0092-8674(03)01075-4

Halfon, 2000, Ras pathway specificity is determined by the integration of multiple signal-activated and tissue-restricted transcription factors, Cell, 103, 63, 10.1016/S0092-8674(00)00105-7

Yang, 2004, Regulating the p53 system through ubiquitination, Oncogene, 23, 2096, 10.1038/sj.onc.1207411

Marechal, 1997, Conservation of structural domains and biochemical activities of the MDM2 protein from Xenopus laevis, Oncogene, 14, 1427, 10.1038/sj.onc.1200967

Robertson, 1998, The human ARF cell cycle regulatory gene promoter is a CpG island which can be silenced by DNA methylation and down-regulated by wild-type p53, Mol. Cell Biol., 18, 6457, 10.1128/MCB.18.11.6457

Choi, 2002, E2F1 activates the human p53 promoter and overcomes the repressive effect of hepatitis B viral X protein (Hbx) on the p53 promoter, Int. Union Biochem. Mol. Biol. Life, 53, 309, 10.1080/15216540213466

Macleod, 1996, Loss of Rb activates both p53-dependent and independent cell death pathways in the developing mouse nervous system, Eur. Mol. Biol. Org. J., 15, 6178, 10.1002/j.1460-2075.1996.tb01006.x

Kim, 2003, Absence of p16INK4a and truncation of ARF tumor suppressors in chickens, Proc. Natl Acad. Sci. USA, 100, 211, 10.1073/pnas.0135557100

Suzuki, 2000, Xenopus embryonic E2F is required for the formation of ventral and posterior cell fates during early embryogenesis, Mol. Cell, 5, 217, 10.1016/S1097-2765(00)80418-9

Appella, 2001, Post-translational modifications and activation of p53 by genotoxic stresses, Eur. J. Biochem., 268, 2764, 10.1046/j.1432-1327.2001.02225.x