A meta-analysis of fibromyalgia treatment interventions
Tóm tắt
Objective: To evaluate and compare the efficacy of pharmacological and nonpharmacological treatments of fibromyalgia syndrome (FMS). Methods: This meta-analysis of 49 fibromyalgia treatment outcome studies assessed the efficacy of pharmacological and nonpharmacological treatment across four types of outcome measures—physical status, self-report of FMS symptoms, psychological status, and daily functioning. Results: After controlling for study design, antidepressants resulted in improvements on physical status and self-report of FMS symptoms. All nonpharmacological treatments were associated with significant improvements in all four categories of outcome measures with the exception that physically-based treatment (primarily exercise) did not significantly improve daily functioning. When compared, nonpharmacological treatment appears to be more efficacious in improving self-report of FMS symptoms than pharmacological treatment alone. A similar trend was suggested for functional measures. Conclusion: The optimal intervention for FMS would include nonpharmacological treatments, specifically exercise and cognitive-behavioral therapy, in addition to appropriate medication management as needed for sleep and pain symptoms.
Tài liệu tham khảo
Wolfe F, Ross K, Anderson J, Russell IJ, Hebert L: The prevalence and characteristics of fibromyalgia in the general population.Arthritis and Rheumatism. 1995,38(1):19–28.
White KP, Harth M: An analytical review of 24 controlled clinical trials for fibromyalgia syndrome (FMS).Pain. 1996,64:211–221.
Baumstark KE, Buckelew SP: Fibromyalgia: Clinical signs, research findings, treatment implications, and future directions.Annals of Behavioral Medicine. 1992,14(4):282–291.
Boissevain MD, McCain GA: Toward an integrated understanding of fibromyalgia syndrome. I. Medical and pathophysiological aspects.Pain. 1991,45:227–238.
Boissevain MD, McCain GA: Toward an integrated understanding of fibromyalgia syndrome. II. Psychological and phenomenological aspects.Pain. 1991,45:239–248.
Burckhardt CS, Bjelle A: Education programmes for fibromyalgia patients: Description and evaluation.Bailliere's. 1994,8:935–954.
Gabriel SE, Bombardier C: Clinical trials in fibrositis: A critical review and future directions.Journal of Rheumatology. 1989,16(Suppl. 19):177–179.
Godfrey RG: A guide to the understanding and use of tricyclic antidepressants in the overall management of fibromyalgia and other chronic pain syndromes.Archives of Internal Medicine. 1996,156:1047–1052.
Goldenberg DL: A review of the role of tricyclic medications in the treatment of fibromyalgia syndrome.Journal of Rheumatology. 1989,16(Suppl. 19):137–139.
Harvey CK, Cadena R, Dunlap L: Fibromyalgia: Part 1. Review of the literature.Journal of the American Podiatric Medical Association. 1993,7:412–415.
McCain GA: Role of physical fitness training in the fibrositis/fibromyalgia syndrome.American Journal of Medicine. 1986,81(3A): 73–77.
Reiffenberger DH, Amundson LH: Fibromyalgia syndrome: A review.American Family Physician. 1996,53(5):1698–1704.
Yunus MB: Diagnosis, etiology, and management of fibromyalgia syndrome: An update [Review].Comprehensive Therapy. 1988,14(4):8–20.
Batra A, Bromer-Breitenbucher A, Kotter I, Dengler W, Bartels M: Psychometric variables before and after behavioral therapy in fibromyalgia.Journal of Musculoskeletal Pain. 1995,3:47.
de Voogd JN, Knipping AA, de Blecourt ACE, van Rijswijk MH: Treatment of fibromyalgia syndrome with psycho-motor therapy and marital counselling [abstract].Scandinavian Journal of Rheumatology. 1992,94(Suppl.):49.
Gronblad M, Nykanen J, Konttinen Y, Jarvinen E, Helve T: Effect of zopiclone on sleep quality, morning stiffness, widespread tenderness and pain and general discomfort in primary fibromyalgia patients. A double-blind randomized trial.Clinical Rheumatology. 1993,12:186–191.
Hannonen P, Rahkila P, Kallinen M, Alen M: Effects of prolonged aerobic vs. muscle strength training programs on fibromyalgia [abstract].Journal of Musculoskeletal Pain. 1995,3:34.
Hench PK, Cohen R, Mitler MM: Fibromyalgia: Effects of amitriptyline, temazepam and placebo on pain and sleep [abstract].Arthritis and Rheumatism. 1989,32(Suppl.):S47.
Hoydalsmo O, Johannsen I, Harstad H, Jacobsen S, Kryger P: Effects of a multidisciplinary training programme in fibromyalgia [abstract].Scandinavian Journal of Rheumatology. 1992,94(Suppl.):51.
Isomeri R, Mikkelsson M, Latikka P, Kammonen K: Effects of amitriptyline and cardiovascular fitness training on pain in patients with primary fibromyalgia.Journal of Musculoskeletal Pain. 1993,1:253–260.
Jaeschke R, Adachi J, Guyatt G, Keller J, Wong B: Clinical usefulness of amitriptyline in fibromyalgia: The results of 23 N-of-1 randomized controlled trials.Journal of Rheumatology. 1991,18(3): 447–451.
Hannonen P, Rahkila P, Kallinen MO, Alen M: Reduction in pain perception in fibromyalgia during one-year strength and endurance training [abstract].Journal of Musculoskeletal Pain. 1995,3:162.
Kaplan KH, Goldenberg DL, Galvin-Nadeau M: The impact of a meditation-based stress reduction program on fibromyalgia.Gereral Hospital Psychiatry. 1993,15:284–289.
Kaziyama HHS, Miyazaki M, Imamura M et al: Journal of Musculoskeletal Pain. 1995,3:126.
Kleijnen J, Gerards FM, Kok G: Self management and the treatment of fibromyalgia: A randomized controlled trial [abstract].Arthritis Care and Research. 1992,5:S18.
Kogstad O, Hintringer F, Jonsson YM: Patients with fibromyalgia in pain schools [abstract].Scandinavian Journal of Rheumatology. 1992,94(Suppl.):48.
Maccabruni F, Ghirardini M, Betelemme L, Fatti F: Treatment of primary fibromyalgia with peridural sacral therapy [abstract].Scandinavian Journal of Rheumatology. 1992,94(Suppl.):57.
Nielson WR, Harth M, Bell DA: Outpatient cognitive-behavioural treatment of fibromyalgia: Impact on pain response and health status [abstract].Journal of Musculoskeletal Pain. 1995,3:122.
Norregaard J, Lykkegard J, Mehlsen J, Danneskiold-Samsoe B: Exercise training in treatment of fibromyalgia [abstract].Journal of Musculoskeletal Pain. 1995,3:105.
Pankoff B, Nielson WR: A general conditioning program for patients with fibromyalgia and its impact on function [abstract].Journal of Musculoskeletal Pain. 1995,3:156.
Pestelli G, Rossi RM, Serra A, Maltoni P, Zoli A: Fibromyalgia: What the best for? [abstract].Scandinavian Journal of Rheumatology. 1992,94(Suppl.):40.
Stratz T, Schochat T, Hrycaj P, et al: The blockade of 5-HT-3 receptors in fibromyalgia—A new therapy concept? [abstract].Journal of Musculoskeletal Pain. 1995,3:64.
Weverman I: A functional approach to the treatment of fibromyalgia in a physical therapy and stress management setting [abstract].Journal of Musculoskeletal Pain. 1995,3:31.
Wigers SH, Stiles TC, Vogel PA: Positive effects of aerobic exercise in fibromyalgia. A 4-year follow-up study [abstract].Journal of Musculoskeletal Pain. 1995,3:154.
Wysenbeek AJ, Mor F, Lurie Y, Weinberger A: Imipramine for the treatment of fibrositis: A therapeutic trial.Annals of the Rheumatic Diseases. 1985,44:752–753.
Zizzo A, Zanelli R, Ercolani M, Chattat R: An experience of group psychotherapy body-oriented in fibromyalgic syndrome [abstract].Scandinavian Journal of Rheumatology. 1992,94(Suppl.):57.
Wolfe F, Smythe HA, Yunus MB, et al: The American College of Rheumatology 1990 criteria for the classification of fibromyalgia.Arthritis and Rheumatism. 1990,33(2):160–172.
Hedges LV: Distribution theory for Glass's estimator of effect size and related estimators.Journal of Educational Statistics. 1981,6:107–128.
Hedges LV, Olkin I:Statistical Methods for Meta-Analysis. New York: Academic Press, 1985.
Johnson BT:DSTAT: Software for the Meta-Analytic Review of Research Literatures. Hillsdale, NJ: Lawrence Erlbaum Associates, 1989.
Handbook of Mathematical Functions. Washington, DC: National Bureau of Standards, 1964.
Rosenthal R: Parametric measures of effect size. In Cooper HM, Hedges LV (eds),The Handbook of Research Synthesis. New York: Russell Sage Foundation, 1994.
Glass GV, McGaw B, Smith ML:Meta-Analysis in Social Research. Newbury Park, CA: Sage Publications, Inc., 1981.
Cooper H, Nye B, Charlton K, Lindsay J, Greathouse S: The effects of summer vacation on achievement test scores: A narrative and meta-analytic review.Review of Educational Research. 1996,66:227–268.
Shadish WR, Haddock CK: Combining estimates of effect size. In Cooper HM, Hedges LV (eds),The Handbook of Research Synthesis. New York: Russell Sage Foundation, 1994.
Cooper HM:Integrating Research: A Guide for Literature Reviews (2nd Ed.). Newbury Park, CA: SAGE Publications, Inc., 1989.
Di Benedetto P, Iona LG, Zidarich V: Clinical evaluation of s-adenosyl-1-methionine versus transcutaneous electrical nerve stimulation in primary fibromyalgia.Current Therapeutic Research. 1993,53(2):222–229.
Santandrea S, Montrone F, Sarzi-Puttiniti P, Boccassini L, Caruso I: A double-blind crossover study of two cyclobenzaprine regimens in primary fibromyalgia syndrome.Journal of International Medical Research. 1993,21:74–80.
Tavoni A, Vitali C, Bombardieri S, Pasero G: Evaluation of S-adenosylmethionine in primary fibromyalgia.American Journal of Medicine. 1987,83(5A):107–110.
Grassetto M, Varotto Z: Primary fibromylagia is responsive to s-adenosyl-1-methionine.Current Therapeutic Research. 1994,55(7): 797–806.
Ianniello A, Ostuni PA, Sfriso P, et al: S-adenosyl-1-methionine in Sjogren's Syndrome and fibromyalgia.Current Therapeutic Research. 1994,55(6):699–706.
Jacobsen S, Danneskiold-Samsoe B, Andersen RB: Oral s-adenosylmethionine in primary fibromyalgia. Double-blind clinical evaluation.Scandinavian Journal of Rheumatology. 1991,20:294–302.
Volkmann H, Norregaard J, Jacobsen S, et al: Double-blinded, placebo-controlled cross-over study of intravenous s-adenosyl-1-methionine in patients with fibromyalgia.Scandinavian Journal of Rheumatology. 1997,26:206–211.
Caruso I, Puttini PS, Cazzola M, Azzolini V: Double-blind study of 5-hydroxytryptophan versus placebo in the treatment of primary fibromyalgia syndrome.Journal of International Medical Research. 1990,18:201–209.
Puttini PS, Caruso I: Primary fibromyalgia syndrome and 5-hydroxy-L-tryptophan: A 90-day open study.Journal of International Medical Research. 1992,20(2):182–189.
Fossaluzza V, De Vita S: Combined therapy with cyclobenzaprine and ibuprofen in primary fibromyalgia syndrome.International Journal of Clinical Pharmacological Research. 1992,12(2):99–102.
Goldenberg DL, Felson DT, Dinerman H: A randomized, controlled trial of amitriptyline and naproxen in the treatment of patients with fibromyalgia.Arthritis and Rheumatism. 1986,29(11):1371–1377.
Russell IJ, Fletcher EM, Michalek JE, McBroom PC, Hester GG: Treatment of primary fibrositis/fibromyalgia syndrome with ibuprofen and alprazolam.Arthritis and Rheumatism. 1991,34(5):552–560.
McCarty DJ, Csuka M, McCarthy G, Trotter D: Treatment of pain due to fibromyalgia with topical capsaicin: A pilot study.Seminars in Arthritis and Rheumatism. 1994,23(6):41–47.
Russell IJ, Michalek JE, Flechas JD, Abraham GE: Treatment of fibromyalgia syndrome with super malicR. A randomized, double blind, placebo controlled, crossover pilot study.Journal of Rheumatology. 1995,22(5):953–958.
Simms RW: Controlled trials of therapy in fibromyalgia syndrome.Bailliere's. 1994,8(4):917–934.
Deluze C, Bosia L, Zirbs A, Chantraine A, Vischer TL: Electroacu-puncture in fibromyalgia: Results of a controlled trial.British Medical Journal. 1992,305:1249–1252.
Ferraccioli G, Ghirelli L, Scita F, et al: EMG-biofeedback training in fibromyalgia syndrome.Journal of Rheumatology. 1987,14(4):820–825.
Buckelew SP, Conway R, Parker J, et al: Biofeedback/relaxation training and exercise interventions for fibromyalgia: A prospective trial.Arthritis Care and Research. 1998,11:196–209.
Haanen HCM, Hoenderdos HTW, van Romunde LKJ, et al: Controlled trial of hypnotherapy in the treatment of refractory fibromyalgia.Journal of Rheumatology. 1991,18(1):72–75.
McCain GA, Bell DA, Mai FM, Halliday PD: A controlled study of the effects of a supervised cardiovascular fitness training program on the manifestations of primary fibromyalgia.Arthritis and Rheumatism. 1988,31(9):1135–1141.
Martin L, Nutting A, Macintosh BR, et al: An exercise program in the treatment of fibromyalgia.Journal of Rheumatology. 1996,23(6):1050–1053.
Burckhardt CS, Mannerkorpi K, Hedenberb L, Bjelle A: A randomized, controlled clinical trial of education and physical training for women with fibromyalgia.Journal of Rheumatology. 1994,21:714–720.
Goldenberg DL, Kaplan KH, Nadeau MG, et al: A controlled study of a stress-reduction, cognitive-behavioral treatment program in fibromyalgia.Journal of Musculoskeletal Pain. 1994,2(2):53–65.
Wigers SH, Stiles TC, Vogel PA: Effects of aerobic exercise versus stress management treatment in fibromyalgia. A 4.5-year follow-up study.Scandinavian Journal of Rheumatology. 1996,25:77–86.
Nichols DS, Glenn TM: Effects of aerobic exercise on pain perception, affect, and level of disability in individuals with fibromyalgia.Physical Therapy. 1994,74(4):327–332.
Mengshoel AM, Komnaes HB, Forre O: The effects of 20 weeks of physical fitness training in female patients with fibromyalgia.Clinical and Experimental Rheumatology. 1992,10:345–349.
Yunus MB, Masi AT, Aldag JC: Short-term effects of ibuprofen in primary fibromyalgia syndrome: A double blind, placebo controlled trial.Journal of Rheumatology. 1989,16(4):527–532.
Nielson WR, Walker C, McCain GA: Cognitive-behavioral treatment of fibromyalgia syndrome: Preliminary findings.Journal of Rheumatology. 1992,19(1):98–103.
Ostuni PA, Cassisi GA, Ianniello A, et al: Acupuncture vs. low-dose myanserine in primary fibromyalgia [abstract].Journal of Musculoskeletal Pain. 1995,3:88.
Carette S, Bell MJ, Reynolds WJ, et al: Comparison of amitriptyline, cyclobenzaprine, and placebo in the treatment of fibromyalgia. A randomized, double-blind clinical trial.Arthritis and Rheumatism. 1994,37:32–40.
Goldenberg DL, Mayskiy M, Mossey C, Ruthazer R, Schmid C: A randomized, double-blind crossover trial of fluoxetine and amitriptyline in the treatment of fibromyalgia.Arthritis and Rheumatism. 1996,39(11):1852–1859.
Wolfe F, Cathey MA, Hawley DJ: A double-blind placebo controlled trial of fluoxetine in fibromyalgia.Scandinavian Journal of Rheumatology. 1994,23:255–259.
Carette S, McCain GA, Bell DA, Fam AG: Evaluation of amitriptyline in primary fibrositis. A double-blind, placebo-controlled study.Arthritis and Rheumatism. 1986,29(5):655–659.
Pioro-Boisset M, Esdaile JM, Fitzcharles M: Alternative medicine use in fibromyalgia syndrome.Arthritis Care and Research. 1996,9:13–17.
Nicassio PM, Schuman C, Kim J, Cordova A, Weisman MH: Psychosocial factors associated with complementary treatment use in fibromyalgia.Journal of Rheumatology. 1994,24:2008–2013.
Eisenberg DM, Lessler RC, Foster C, et al: Unconventional medicine in the United States.New England Journal of Medicine. 1993,328:246–252.
Bennett RM, Burckhardt CS, Clark SR, et al: Group treatment of fibromyalgia: A 6-month outpatient program.Journal of Rheumatology. 1996,23(3):521–528.
Vlaeyen JWS, Teeken-Gruben NJG, Goossens MEJB, et al: Cognitive-educational treatment of fibromyalgia: A randomized clinical trial. I. Clinical effects.Journal of Rheumatology. 1996,23:1237–1245.
White KP, Nielson WR: Cognitive-behavioral treatment of fibromyalgia syndrome: A follow-up assessment.Journal of Rheumatology. 1995,22:717–721.
Mengshoel AM, Forseth KO, Haugen M, Walle-Hansen R, Forre O: Multidisciplinary approach to fibromyalgia: A pilot study.Clinical Rheumatology. 1995,14(2):165–170.
Nicassio PM, Radojevic V, Weisman MH, et al: A comparison of behavioral and educational interventions for fibromyalgia.Journal of Rheumatology. 1997,24:2000–2007.
Aaron LA, Bradley LA, Alarcon GS, et al: Psychiatric diagnosis in patients with fibromyalgia are related to health care-seeking behavior rather than to illness.Arthritis and Rheumatism. 1996,39(3):436–445.
Ahles TA, Yunus MB, Riley SD, Bradley JM, Masi AT: Psychological factors associated with primary fibromyalgia syndrome.Arthritis and Rheumatism. 1984,27(10):1101–1106.
Goldenberg DL: Psychologic studies in fibrositis.American Journal of Medicine. 1986,81(3A):67–70.
Hudson JI, Goldenberg DL, Pope HG, Keck PE, Schlesinger L: Comorbidity of fibromyalgia with medical and psychiatric disorders.American Journal of Medicine. 1992,92:363–367.
Wolfe F, Cathey MA, Kleinheksel SM, et al: Psychological status in primary fibrositis and fibrositis associated with rheumatoid arthritis.Journal of Rheumatology. 1984,11(4):500–506.
Potts MK, Silverman SL: The importance of aspects of treatment for fibromyalgia (fibrositis).Arthritis Care and Research. 1990,3(1): 11–18.
Lipsey MW, Wilson DB: The efficacy of psychological, educational, and behavioral treatment: Confirmation from meta-analysis.American Psychologist. 1993,48(12):1181–1209.
Felson DT, Anderson JJ, Meenan RF: The comparative efficacy and toxicity of second-line drugs in rheumatoid arthritis.Journal of the American College of Rheumatology. 1990,33:1449–1461.
Blanchard EB, Andrasik F, Ahles TI, Teders SJ, O'Keefe D: Migraine and tension headache: A meta-analytic review.Behavior Therapy. 1980,11:613–631.