Gestational diabetes mellitus and later cardiovascular disease: a Swedish population based case–control study

BJOG: An International Journal of Obstetrics and Gynaecology - Tập 121 Số 12 - Trang 1530-1536 - 2014
Helena Fadl1, Anders Magnuson2, Ingrid Östlund1, Scott Montgomery3,2, Ulf Hanson1,4, Erik Schwarcz5
1Department of Obstetrics and Gynaecology School of Health and Medical Sciences Örebro University Örebro Sweden
2Clinical Epidemiology and Biostatistics Örebro University Hospital School of Medical Health and Sciences Örebro University Örebro Sweden
3Clinical Epidemiology Unit Karolinska Institutet, Stockholm, Sweden
4Department of Women’s and Children’s Health, Uppsala University, Uppsala, Sweden
5Department of Internal Medicine School of Health and Medical Sciences Örebro University Örebro Sweden

Tóm tắt

ObjectiveTo identify if gestational diabetes mellitus (GDM) is a clinically useful marker of future cardiovascular disease (CVD) risk and if GDM combined with other risks (smoking, hypertension or body mass) identifies high‐risk groups.DesignPopulation‐based matched case–control study.SettingNational Swedish register data from 1991 to 2008.PopulationA total of 2639 women with a cardiovascular event and matched controls.MethodsConditional logistic regression examined associations with CVD before and after adjustment for conventional risk factors and confounders. Effect modification for the association of GDM with CVD by body mass index (BMI), smoking and chronic hypertension was assessed by stratification and interaction testing. Adjustment for diabetes post‐pregnancy evaluated its mediating role.Main outcome measuresInpatient diagnoses or causes of death identifying ischemic heart disease, ischemic stroke, atherosclerosis or peripheral vascular disease.ResultsThe adjusted odds ratios (and 95% confidence intervals) for the association of CVD with GDM are 1.51 (1.07–2.14), 2.23 (2.01–2.48) for smoking, 1.98 (1.71–2.29) for obesity and 5.10 (3.18–8.18) for chronic hypertension. In stratified analysis the association of CVD with GDM was only seen among women with BMI ≥25, with an odds ratio of 2.39 (1.39–4.10), but only women with a BMI <30 accounted for this increased risk. Adjustment for post‐pregnancy diabetes attenuated it somewhat to 1.99 (1.13–3.52).ConclusionsIn the absence of other recognised cardiovascular risk factors, such as smoking, obesity or chronic hypertension, GDM is a useful marker of raised CVD risk among women with BMI between 25 and 29.

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BJOG: An International Journal of Obstetrics and Gynaecology

Tập 121 Số 12

1530-1536

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