Berberine reduces methylation of the MTTP promoter and alleviates fatty liver induced by a high-fat diet in rats

Journal of Lipid Research - Tập 51 - Trang 2504-2515 - 2010
XinXia Chang1, HongMei Yan1, Jing Fei2, MingHong Jiang2, HongGuang Zhu3, DaRu Lu2, Xin Gao1
1Department of Endocrinology and Metabolism, Zhongshan Hospital
2State Key Laboratory of Genetic Engineering, School of Life Science and Institute of Biomedical Sciences
3Department of Pathology, Shanghai Medical College, Fudan University, Shanghai, China

Tài liệu tham khảo

Kohjima, 2007, Re-evaluation of fatty acid metabolism-related gene expression in nonalcoholic fatty liver disease, Int. J. Mol. Med., 20, 351 Adams, 2005, Nonalcoholic fatty liver disease, CMAJ., 172, 899, 10.1503/cmaj.045232 Leung, 2009, Age- and ethnic-specific elevation of ALT among obese children at risk for nonalcoholic steatohepatitis (NASH): implications for screening, Clin. Pediatr. (Phila.)., 48, 50, 10.1177/0009922808321678 Hanley, 2004, Elevations in markers of liver injury and risk of type 2 diabetes: the insulin resistance atherosclerosis study, Diabetes., 53, 2623, 10.2337/diabetes.53.10.2623 Vozarova, 2002, High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes, Diabetes., 51, 1889, 10.2337/diabetes.51.6.1889 Yan, 2006, Study of the association between non-alcoholic fatty liver disease and metabolic syndrome, Chin. J. Diabetes., 14, 326 Samuel, 2004, Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease, J. Biol. Chem., 279, 32345, 10.1074/jbc.M313478200 Petersen, 2005, Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes, Diabetes., 54, 603, 10.2337/diabetes.54.3.603 Schindhelm, 2007, Alanine aminotransferase predicts coronary heart disease events: a 10-year follow-up of the Hoorn Study, Atherosclerosis., 191, 391, 10.1016/j.atherosclerosis.2006.04.006 Postic, 2008, Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice, J. Clin. Invest., 118, 829, 10.1172/JCI34275 Lee, 2006, Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states, Diabetes., 55, 2256, 10.2337/db06-0006 Kong, 2004, Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statins, Nat. Med., 10, 1344, 10.1038/nm1135 Zhang, 2008, Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine, J. Clin. Endocrinol. Metab., 93, 2559, 10.1210/jc.2007-2404 Kim, 2009, Berberine improves lipid dysregulation in obesity by controlling central and peripheral AMPK activity, Am. J. Physiol. Endocrinol. Metab., 296, E812, 10.1152/ajpendo.90710.2008 Ling, 2007, Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle, J. Clin. Invest., 117, 3427, 10.1172/JCI30938 Ronn, 2008, Age influences DNA methylation and gene expression of COX7A1 in human skeletal muscle, Diabetologia., 51, 1159, 10.1007/s00125-008-1018-8 Ling, 2008, Epigenetic regulation of PPARGC1A in human type 2 diabetic islets and effect on insulin secretion, Diabetologia., 51, 615, 10.1007/s00125-007-0916-5 Folch, 1957, A simple method for the isolation and purification of total lipides from animal tissues, J. Biol. Chem., 226, 497, 10.1016/S0021-9258(18)64849-5 Cnop, 2001, Inverse relationship between cytotoxicity of free fatty acids in pancreatic islet cells and cellular triglyceride accumulation, Diabetes., 50, 1771, 10.2337/diabetes.50.8.1771 Jiang, 2008, Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential, Diabetologia., 51, 1525, 10.1007/s00125-008-1034-8 Millar, 2005, Determining hepatic triglyceride production in mice: comparison of poloxamer 407 with Triton WR-1339, J. Lipid Res., 46, 2023, 10.1194/jlr.D500019-JLR200 Raabe, 1999, Analysis of the role of microsomal triglyceride transfer protein in the liver of tissue-specific knockout mice, J. Clin. Invest., 103, 1287, 10.1172/JCI6576 Miyake, 2001, Increased production of apolipoprotein B-containing lipoproteins in the absence of hyperlipidemia in transgenic mice expressing cholesterol 7 alpha-hydroxylase, J. Biol. Chem., 276, 23304, 10.1074/jbc.M101853200 Wetterau, 1997, Microsomal triglyceride transfer protein, Biochim. Biophys. Acta., 1345, 136, 10.1016/S0005-2760(96)00168-3 Bernard, 2000, Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with type II diabetes, Diabetologia., 43, 995, 10.1007/s001250051481 Merriman, 2006, Genetic influences in nonalcoholic fatty liver disease, J. Clin. Gastroenterol., 40, S30 Namikawa, 2004, Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis, J. Hepatol., 40, 781, 10.1016/j.jhep.2004.01.028 Gambino, 2007, Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?, Hepatology., 45, 1097, 10.1002/hep.21631 Stefano, 2007, Nonalcoholic steatohepatitis (NASH) in ob/ob mice treated with yo jyo hen shi ko (YHK): effects on peroxisome proliferator-activated receptors (PPARs) and microsomal triglyceride transfer protein (MTP), Dig. Dis. Sci., 52, 3448, 10.1007/s10620-007-9810-8 Abidi, 2005, Extracellular signal-regulated kinase-dependent stabilization of hepatic low-density lipoprotein receptor mRNA by herbal medicine berberine, Arterioscler. Thromb. Vasc. Biol., 25, 2170, 10.1161/01.ATV.0000181761.16341.2b Gutierrez-Juarez, 2006, Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance, J. Clin. Invest., 116, 1686, 10.1172/JCI26991 Mar-Heyming, 2008, Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia, Arterioscler. Thromb. Vasc. Biol., 28, 1193, 10.1161/ATVBAHA.107.160150 Dobrzyn, 2004, Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver, Proc. Natl. Acad. Sci. USA., 101, 6409, 10.1073/pnas.0401627101 Stefanovic-Racic, 2008, A moderate increase in carnitine palmitoyltransferase 1a activity is sufficient to substantially reduce hepatic triglyceride levels, Am. J. Physiol. Endocrinol. Metab., 294, E969, 10.1152/ajpendo.00497.2007 Hussain, 2008, Microsomal triglyceride transfer protein in plasma and cellular lipid metabolism, Curr. Opin. Lipidol., 19, 277, 10.1097/MOL.0b013e3282feea85 Knutson, 2008, Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks, EMBO J., 27, 1017, 10.1038/emboj.2008.51 Kuriyama, 1998, Enhanced expression of hepatic acyl-coenzyme A synthetas and microsomal triglyceride transfer protein messenger RNAs in the obese and hypertriglyceridemic rat with visceral fat accumulation, Hepatology., 27, 557, 10.1002/hep.510270233 Bennett, 1995, Regulation of hamster hepatic microsomal triglyceride transfer protein mRNA levels by dietary fats, Biochem. Biophys. Res. Commun., 212, 473, 10.1006/bbrc.1995.1994 Quesada, 2009, Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver, Int. J. Obes., 33, 1007, 10.1038/ijo.2009.136 Liang, 2002, Analysis of gene induction in human fibroblasts and bladder cancer cells exposed to the methylation inhibitor 5-aza-2'-deoxycytidine, Cancer Res., 62, 961 Momparler, 2001, Potential of 5-aza-2'-deoxycytidine (Decitabine) a potent inhibitor of DNA methylation for therapy of advanced non-small cell lung cancer, Lung Cancer., 34, S111, 10.1016/S0169-5002(01)00397-X