Cotransplantation of HLA-Identical Sibling Culture-Expanded Mesenchymal Stem Cells and Hematopoietic Stem Cells in Hematologic Malignancy Patients

Armitage, 1994, Bone marrow transplantation, N Engl J Med., 330, 827, 10.1056/NEJM199403243301206 Tabbara, 2002, Allogeneic hematopoietic stem cell transplantation, Arch Intern Med., 162, 1558, 10.1001/archinte.162.14.1558 Caplan, 1991, Mesenchymal stem cells, J Orthop Res., 9, 641, 10.1002/jor.1100090504 Deans, 2000, Mesenchymal stem cells, Exp Hematol., 28, 875, 10.1016/S0301-472X(00)00482-3 Haynesworth, 1996, Cytokine expression by human marrow derived mesenchymal progenitor cells in vitro, J Cell Physiol., 166, 585, 10.1002/(SICI)1097-4652(199603)166:3<585::AID-JCP13>3.0.CO;2-6 Majumdar, 1998, Phenotypic and functional comparison of cultures of marrow-derived mesenchymal stem cells (MSCs) and stromal cells, J Cell Physiol., 176, 186, 10.1002/(SICI)1097-4652(199807)176:1<57::AID-JCP7>3.0.CO;2-7 Almeida-Porada, 1999, Cotransplantation of stroma results in enrichment of engraftment and early expression of donor hematopoietic stem cells in utero, Exp Hematol., 27, 1569, 10.1016/S0301-472X(99)00090-9 Klyushnenkova, 1998, Human mesenchymal stem cells suppress allogeneic T cell responses in vitro, Blood, 92, 642a McIntosh, 1999, Suppression of alloreactive T cell responses by human mesenchymal stem cells involves CD8+ cells, Blood, 94, 133a Bartholomew, 2002, Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo, Exp Hematol., 30, 42, 10.1016/S0301-472X(01)00769-X Di Nicola, 2002, Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli, Blood, 99, 3838, 10.1182/blood.V99.10.3838 McMannus, 1984, Busulfan-induced chronic bone marrow failure, Blood, 64, 1036, 10.1182/blood.V64.5.1036.1036 Uhlman, 1991, BCNU treatment of marrow stromal monolayers reversibly alters haematopoiesis, Br J Haematol., 78, 3304, 10.1111/j.1365-2141.1991.tb04441.x Domenech, 1994, Haemopoiesis of transplanted patients with autologous marrows assessed by long-term marrow culture, Br J Haematol., 88, 488, 10.1111/j.1365-2141.1994.tb05064.x O’Flaherty, 1995, Bone marrow stromal function from patients after bone marrow transplantation, Bone Marrow Transplant., 15, 207 Simmons, 1987, Host origin of marrow stromal cells following allogeneic bone marrow transplantation, Nature, 328, 429, 10.1038/328429a0 Koc, 1999, Bone marrow-derived mesenchymal stem cells remain host-derived despite successful hematopoietic engraftment after allogeneic transplantation in patients with lysosomal and peroxisomal storage diseases, Exp Hematol., 27, 1675, 10.1016/S0301-472X(99)00101-0 Agematsu, 1991, Recipient origin of bone marrow-derived fibroblastic stromal cells during all periods following bone marrow transplantation in humans, Br J Haematol., 79, 359, 10.1111/j.1365-2141.1991.tb08041.x Stute, 2002, Human mesenchymal stem cells are not of donor origin in patients with severe aplastic anemia who underwent sex-mismatched allogeneic bone marrow transplant, J Hematother Stem Cell Res., 11, 977, 10.1089/152581602321080646 Keating, 1982, Donor origin of the in vitro haematopoietic microenvironment after marrow transplantation in man, Nature, 298, 280, 10.1038/298280a0 Lazarus, 1995, Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells) [MPCs], Bone Marrow Transplant., 16, 557 Koç, 2000, Rapid hematopoietic recovery after co-infusion of autologous culture-expanded human mesenchymal stem cells (hMSCs) and PBPCs in breast cancer patients receiving high dose chemotherapy, J Clin Oncol., 18, 307, 10.1200/JCO.2000.18.2.307 Pittenger, 1999, Multilineage potential of adult human mesenchymal stem cells, Science, 284, 143, 10.1126/science.284.5411.143 Lennon, 1996, Development of a serum screen for mesenchymal progenitor cells from bone marrow, In Vitro Cell Dev Biol., 32, 602, 10.1007/BF02724045 Mickelson, 1993, A comparative study of HLA-DRB1 typing by standard serology and hybridization of non-radioactive sequence-specific oligonucleotide probes to PCR-amplified DNA, Tissue Antigens, 41, 86, 10.1111/j.1399-0039.1993.tb01984.x Petersdorf, 1991, Ten HLA-DR4 alleles defined by sequence polymorphisms within the DRB1 first domain, Immunogenetics, 33, 267, 10.1007/BF00230505 Copelan, 1993, Allogeneic bone marrow transplantation for acute myelogenous leukemia, acute lymphocytic leukemia, and multiple myeloma following preparation with busulfan and cyclophosphamide (BuCy2), Semin Oncol., 20, 33 Socié, 2001, Busulfan plus cyclophosphamide compared with total-body irradiation plus cyclophosphamide before marrow transplantation for myeloid leukemia, Blood, 98, 3569, 10.1182/blood.V98.13.3569 Clift, 1994, Marrow transplantation for chronic myeloid leukemia, Blood, 84, 2036, 10.1182/blood.V84.6.2036.2036 Mills, 1995, BEAM chemotherapy and autologous bone marrow transplantation for patients with relapsed or refractory non-Hodgkin’s lymphoma, J Clin Oncol., 13, 588, 10.1200/JCO.1995.13.3.588 Blume, 1993, A prospective randomized comparison of total body irradiation-etoposide versus busulfan-cyclophosphamide as preparatory regimens for bone marrow transplantation in patients with leukemia who were not in first remission, Blood, 81, 2187, 10.1182/blood.V81.8.2187.2187 Bacigalupo, 1999, Early predictors of transplant-related mortality (TRM) after allogeneic bone marrow transplants (BMT), Bone Marrow Transplant., 24, 653, 10.1038/sj.bmt.1701953 Storb, 1986, Methotrexate and cyclosporine compared with cyclosporine alone for prophylaxis of acute graft versus host disease after marrow transplantation for leukemia, N Engl J Med., 314, 729, 10.1056/NEJM198603203141201 Sullivan, 1981, Chronic graft-versus-host disease in 52 patients, Blood, 57, 267, 10.1182/blood.V57.2.267.267 Atkinson, 1989, Consensus among bone marrow transplanters for diagnosis, grading and treatment of chronic graft-versus-host disease, Bone Marrow Transplant., 4, 247 Bowden, 1991, Use of leukocyte-depleted platelets and cytomegalovirus-seronegative red blood cells for prevention of primary cytomegalovirus infection after marrow transplant, Blood, 78, 246, 10.1182/blood.V78.1.246.246 Sokos, 2002, Intravenous immunoglobulin (IVIG), Biol Blood Marrow Transplant., 8, 117, 10.1053/bbmt.2002.v8.pm11939601 Goodrich, 1993, Ganciclovir prophylaxis to prevent cytomegalovirus disease after allogeneic marrow transplant, Ann Intern Med., 118, 173, 10.7326/0003-4819-118-3-199302010-00003 Kaplan, 1958, Nonparametric estimation from incomplete observations, J Am Stat Assoc., 53, 457, 10.1080/01621459.1958.10501452 Vigorito, 1998, A randomised, prospective comparison of allogeneic bone marrow and peripheral blood progenitor cell transplantation in the treatment of haematological malignancies, Bone Marrow Transplant., 22, 1145, 10.1038/sj.bmt.1701510 Schmitz, 1998, Allogeneic bone marrow transplantation vs filgrastim-mobilised peripheral blood progenitor cell transplantation in patients with early leukaemia, Bone Marrow Transplant., 21, 995, 10.1038/sj.bmt.1701234 Blaise, 2000, Randomized trial of bone marrow versus lenograstim-primed blood cell allogeneic transplantation in patients with early-stage leukemia, J Clin Oncol., 18, 537, 10.1200/JCO.2000.18.3.537 Powles, 2000, Allogeneic blood and bone-marrow stem-cell transplantation in haematological malignant diseases, Lancet, 355, 1231, 10.1016/S0140-6736(00)02090-0 Bensinger, 2001, Transplantation of bone marrow as compared with peripheral-blood cells from HLA-identical relatives in patients with hematologic cancers, N Engl J Med., 344, 175, 10.1056/NEJM200101183440303 Russell, 1999, Allogeneic blood stem cell and bone marrow transplantation for acute myelogenous leukemia and myelodysplasia, Bone Marrow Transplant., 24, 1177, 10.1038/sj.bmt.1702051 Champlin, 2000, Blood stem cells compared with bone marrow as a source of hematopoietic cells for allogeneic transplantation, Blood, 95, 3702 Couban, 2002, A randomized multicenter comparison of bone marrow and peripheral blood in recipients of matched sibling allogeneic transplants for myeloid malignancies, Blood, 100, 1525, 10.1182/blood-2002-01-0048 Solano, 1998, Chronic graft-versus-host disease after allogeneic peripheral blood progenitor cell or bone marrow transplantation from matched related donors. A case-control study. Spanish Group of Allo-PBT, Bone Marrow Transplant., 22, 1129, 10.1038/sj.bmt.1701500 Heldal, 2000, A randomised study of allogeneic transplantation with stem cells from blood or bone marrow, Bone Marrow Transplant., 25, 1129, 10.1038/sj.bmt.1702422 Lazarus, 2001, Culture-expanded human marrow-derived MSCs in clinical hematopoietic stem cell transplantation, Graft, 3, 329 Koc, 2001, Mesenchymal stem cells, Bone Marrow Transplant., 27, 235, 10.1038/sj.bmt.1702791 Nash, 1992, Acute graft-versus-host disease, Blood, 80, 1838, 10.1182/blood.V80.7.1838.1838 Kumar, 2002, Omission of day +11 methotrexate for graft-versus-host disease prophylaxis after allogeneic BMT increases the risk of severe acute graft-versus-host disease, Bone Marrow Transplant., 30, 161, 10.1038/sj.bmt.1703616 Mohty, 2002, Societe Francaise de Greffe de Moelle et de Therapie Cellulaire (SFGM-TC). Chronic graft-versus-host disease after allogeneic blood stem cell transplantation: long-term results of a randomized study, Blood, 100, 3128, 10.1182/blood.V100.9.3128 Rasmusson, 2003, Mesenchymal stem cells inhibit the formation of cytotoxic T lymphocytes, but not activated cytotoxic T lymphocytes or natural killer cells, Transplantation, 76, 1208, 10.1097/01.TP.0000082540.43730.80 Krampera, 2003, Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigen-specific T cells to their cognate peptide, Blood, 101, 3722, 10.1182/blood-2002-07-2104 Majumdar, 2003, Characterization and functionality of cell surface molecules on human mesenchymal stem cells, J Biomed Sci., 10, 228, 10.1007/BF02256058 Tse, 2003, Suppression of allogeneic T-cell proliferation by human marrow stromal cells, Transplantation, 75, 389, 10.1097/01.TP.0000045055.63901.A9 Maitra, 2004, Human mesenchymal stem cells support unrelated donor hematopoietic stem cells and suppress T-cell activation, Bone Marrow Transplant., 33, 597, 10.1038/sj.bmt.1704400 Le Blanc, 2004, Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells, Lancet, 363, 1439, 10.1016/S0140-6736(04)16104-7 Le Blanc, 2003, Immunomodulatory effects of fetal and adult mesenchymal stem cells, Cytotherapy, 5, 485, 10.1080/14653240310003611 Dalton, 2004, Targeting the bone marrow microenvironment in hematologic malignancies, Semin Hematol., 41, 1, 10.1053/j.seminhematol.2004.02.001 Konopleva, 2002, Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins, Leukemia, 16, 1713, 10.1038/sj.leu.2402608