Anti-inflammatory activity of 1.8-cineol (eucalyptol) in bronchial asthma: a double-blind placebo-controlled trial

Respiratory Medicine - Tập 97 - Trang 250-256 - 2003
U.R JUERGENS1, U DETHLEFSEN2, G STEINKAMP3, A GILLISSEN4, R REPGES5, H VETTER1
1Department of Pneumology, Medical Outpatient Clinic, Bonn University Hospital, Germany
2MKL Institute for Clinical Research, Aachen, Germany
3Clinical Research Lübeck, Germany
4Robert-Koch Klinik, Leipzig, Germany
5Institute for Biometrics and Statistics, RWTH Aachen, Germany

Tài liệu tham khảo

Dewhirst, 1980, Structure–activity relationships for inhibition of prostaglandin cyclooxygenase by phenolic compounds, Prostaglandins, 20, 209, 10.1016/S0090-6980(80)80040-2 Lundgren, 1990, Pathogenesis of airway mucus hypersecretion, J Allergy Clin Immunol, 85, 399, 10.1016/0091-6749(90)90147-V Marom, 1982, Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro, Am Rev Respir Dis, 126, 449 Juergens, 1998, Inhibition of cytokine production and arachidonic acid metabolism by eucalyptol (1.8-cineol) in human blood monocytesin vitro, Eur J Med Res, 3, 508 Juergens, 1998, Steroid-like inhibition of monocyte arachidonic acid metabolism and IL-1 β production by eucalyptol (1.8-cineol) (in German), Atemw-Lungenkrkh, 24, 3 Wittmann, 1998, Therapy with expectorants: a double-blind randomised study comparing ambroxol and cineol (in German), Atemw-Lungenkrkh, 24, 67 Kasper, 1994, Comparison of secretolytics Change of ciliary frequency and lung function after therapy with cineol and ambroxol (in German), Z Atemweg/Lungenerkr, 20, 605 Juergens, 1998, Anti-inflammatory effects of eucalyptol (1.8-cineol) in bronchial asthma: inhibition of arachidonic acid metabolism in human blood monocytes ex vivo, Eur J Med Res, 3, 407 National Asthma Education and Prevention Program, 2, Bethesda (MD), NIH/ National Heart, Lung, and Blood Institute; April 1997 Santos, 2000, Antiinflammatory and antinociceptive effects of 1.8-cineol a terpenoid oxide present in many plant essential oils, Phytother Res, 14, 240, 10.1002/1099-1573(200006)14:4<240::AID-PTR573>3.0.CO;2-X Juergens, 1998, The anti-inflammatory activity of L-menthol compared to mint oil in human monocytes in vitro: a novel perspective for its therapeutic use in inflammatory diseases, Eur J Med Res, 3, 539 Tamaoki, 1995, Effect of menthol vapour on airway hyperresponsiveness in patients with mild asthma, Respir Med, 89, 503, 10.1016/0954-6111(95)90127-2 Marom, 1983, Human airway mono-hydroxyeicosatetraenoic acid generation and mucus release, J Clin Invest, 72, 122, 10.1172/JCI110949 Rich, 1984, Effects of prostaglandins E1, E2, and F2 α on mucin secretion from human bronchi in vitro, Thorax, 39, 420, 10.1136/thx.39.6.420