Matrix metalloproteinases: they're not just for matrix anymore!

Woessner, 2000 McCawley, 2000, Matrix metalloproteinases: multifunctional contributors to tumor progression, Mol Med Today, 6, 149, 10.1016/S1357-4310(00)01686-5 Vu, 2000, Matrix metalloproteinases: effectors of development and normal physiology, Genes Dev, 14, 2123, 10.1101/gad.815400 Greenwald, 1999 Hulboy, 1997, Matrix metalloproteinases as mediators of reproductive function, Mol Hum Reprod, 3, 27, 10.1093/molehr/3.1.27 Holmbeck, 1999, MT1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover, Cell, 99, 81, 10.1016/S0092-8674(00)80064-1 Zhou, 2000, Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I, Proc Natl Acad Sci USA, 97, 4052, 10.1073/pnas.060037197 Bullard, 1999, Impaired wound contraction in stromelysin-1-deficient mice, Ann Surg, 230, 260, 10.1097/00000658-199908000-00017 Dunsmore, 1998, Matrilysin expression and function in airway epithelium, J Clin Invest, 102, 1321, 10.1172/JCI1516 Boudreau, 1998, Extracellular matrix signaling: integration of form and function in normal and malignant cells, Curr Opin Cell Biol, 10, 640, 10.1016/S0955-0674(98)80040-9 Werb, 1997, ECM and cell surface proteolysis: regulating cellular ecology, Cell, 91, 439, 10.1016/S0092-8674(00)80429-8 Whitelock, 1996, The degradation of human endothelial cell-derived perlecan and release of bound basic fibroblast growth factor by stromelysin, collagenase, plasmin, and heparanases, J Biol Chem, 271, 10079, 10.1074/jbc.271.17.10079 Imai, 1997, Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta 1 release, Biochem J, 322, 809, 10.1042/bj3220809 Fowlkes, 1994, Matrix metalloproteinases degrade insulin-like growth factor-binding protein-3 in dermal fibroblast cultures, J Biol Chem, 269, 25742, 10.1016/S0021-9258(18)47310-3 Fowlkes, 1994, Proteolysis of insulin-like growth factor binding protein-3 during rat pregnancy: a role for matrix metalloproteinases, Endocrinology, 135, 2810, 10.1210/en.135.6.2810 Thrailkill, 1995, Characterization of insulin-like growth factor-binding protein 5-degrading proteases produced throughout murine osteoblast differentiation, Endocrinology, 136, 3527, 10.1210/en.136.8.3527 Martin, 1999, Insulin-like growth factor II signaling in neoplastic proliferation is blocked by transgenic expression of the metalloproteinase inhibitor TIMP-1, J Cell Biol, 146, 881, 10.1083/jcb.146.4.881 Suzuki, 1997, Matrix metalloproteinase-3 releases active heparin-binding EGF-like growth factor by cleavage at a specific juxtamembrane site, J Biol Chem, 272, 31730, 10.1074/jbc.272.50.31730 Vecchi, 1998, Tyrosine phosphorylation and proteolysis. Pervanadate-induced, metalloprotease-dependent cleavage of the ErbB-4 receptor and amphiregulin, J Biol Chem, 273, 20589, 10.1074/jbc.273.32.20589 Yu, 2000, Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-( and promotes tumor invasion and angiogenesis, Genes Dev, 14, 163, 10.1101/gad.14.2.163 Schonbeck, 1998, Generation of biologically active IL-1β by matrix metalloproteinases: a novel caspase-1-independent pathway of IL-1β processing, J Immunol, 161, 3340, 10.4049/jimmunol.161.7.3340 Sheu, 2001, A novel role of metalloproteinase in cancer-mediated immunosuppression, Cancer Res, 61, 237 Levi, 1996, Matrix metalloproteinase 2 releases active soluble ectodomain of fibroblast growth factor receptor 1, Proc Natl Acad Sci USA, 93, 7069, 10.1073/pnas.93.14.7069 Frisch, 1997, Integrins and anoikis, Curr Opin Cell Biol, 9, 701, 10.1016/S0955-0674(97)80124-X Alexander, 1996, Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinase-1 transgene, J Cell Biol, 135, 1669, 10.1083/jcb.135.6.1669 Kayagaki, 1995, Metalloproteinase-mediated release of human Fas ligand, J Exp Med, 182, 1777, 10.1084/jem.182.6.1777 Powell, 1999, The metalloproteinase matrilysin (MMP-7) proteolytically generates active soluble Fas ligand and potentiates epithelial cell apoptosis, Curr Biol, 9, 1441, 10.1016/S0960-9822(00)80113-X Mitsiades, 2001, Matrix metalloproteinase-7-mediated cleavage of Fas ligand protects tumor cells from chemotherapeutic drug cytotoxicity, Cancer Res, 61, 577 Giannelli, 1997, Induction of cell migration by matrix metalloprotease-2 cleavage of laminin-5, Science, 277, 225, 10.1126/science.277.5323.225 Koshikawa, 2000, Role of cell surface metalloprotease MT1-MMP in epithelial cell migration over laminin-5, J Cell Biol, 148, 615, 10.1083/jcb.148.3.615 Von Bredow, 1997, Cleavage of β4 integrin by matrilysin, Exp Cell Res, 236, 341, 10.1006/excr.1997.3711 Lochter, 1997, Matrix metalloproteinase stromelysin-1 triggers a cascade of molecular alterations that leads to stable epithelial-to-mesenchymal conversion and a premalignant phenotype in mammary epithelial cells, J Cell Biol, 139, 1861, 10.1083/jcb.139.7.1861 Noe, 2001, Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1, J Cell Sci, 114, 111, 10.1242/jcs.114.1.111 Engsig, 2000, Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones, J Cell Biol, 151, 879, 10.1083/jcb.151.4.879 Haro, 2000, Matrix metalloproteinase-3-dependent generation of a macrophage chemoattractant in a model of herniated disc resorption, J Clin Invest, 105, 133, 10.1172/JCI7090 McQuibban, 2000, Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3, Science, 289, 1202, 10.1126/science.289.5482.1202 Bergers, 2000, Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis, Nat Cell Biol, 2, 737, 10.1038/35036374 Vu, 1998, MMP-9/Gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes, Cell, 93, 411, 10.1016/S0092-8674(00)81169-1 Haro, 2000, Matrix metalloproteinase-7-dependent release of tumor necrosis factor-α in a model of herniated disc resorption, J Clin Invest, 105, 143, 10.1172/JCI7091 Lopez-Boado, 2000, Bacterial exposure induces and activates matrilysin in mucosal epithelial cells, J Cell Biol, 148, 1305, 10.1083/jcb.148.6.1305 Wilson, 1999, Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense, Science, 286, 113, 10.1126/science.286.5437.113 Ossowski, 1983, Antibodies to plasminogen activator inhibit human tumor metastasis, Cell, 35, 611, 10.1016/0092-8674(83)90093-4 Liotta, 1980, Metastatic potential correlates with enzymatic degradation of basement membrane collagen, Nature, 284, 67, 10.1038/284067a0 Chambers, 1997, Changing views of the role of matrix metalloproteinases in metastasis, J Natl Cancer Inst, 89, 1260, 10.1093/jnci/89.17.1260 Nelson, 2000, Matrix metalloproteinases: biologic activity and clinical implications, J Clin Oncol, 18, 1135, 10.1200/JCO.2000.18.5.1135 Sternlicht, 2000, Matrix metalloproteinases as emerging targets in anticancer therapy: status and prospects, Emerging Therapeutic Targets, 4, 609, 10.1517/14728222.4.5.609 D'Armiento, 1995, Collagenase expression in transgenic mouse skin causes hyperkeratosis and acanthosis and increases susceptibility to tumorigenesis, Mol Cell Biol, 15, 5732, 10.1128/MCB.15.10.5732 Rudolph-Owen, 1998, The matrix metalloproteinase matrilysin influences early-stage mammary tumorigenesis, Cancer Res, 58, 5500 Sternlicht, 1999, The stromal proteinase MMP3/stromelysin-1 promotes mammary carcinogenesis, Cell, 98, 137, 10.1016/S0092-8674(00)81009-0 Ha, 2001, Overexpression of membrane-type matrix metalloproteinase-1 gene induces mammary gland abnormalities and adenocarcinoma in transgenic mice, Cancer Res, 61, 984 Wilson, 1997, Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin, Proc Natl Acad Sci USA, 94, 1402, 10.1073/pnas.94.4.1402 Masson, 1998, In vivo evidence that the stromelysin-3 metalloproteinase contributes in a paracrine manner to epithelial cell malignancy, J Cell Biol, 140, 1535, 10.1083/jcb.140.6.1535 Coussens, 2000, MMP-9 supplied by bone marrow-derived cells contributes to skin carcinogenesis, Cell, 103, 481, 10.1016/S0092-8674(00)00139-2 Itoh, 1998, Reduced angiogenesis and tumor progression in gelatinase A-deficient mice, Cancer Res, 58, 1048 Giranda, 1999, The protease consortium: an alliance to advance the understanding of proteolytic enzymes as therapeutic targets for cancer, Mol Carcinog, 26, 139, 10.1002/(SICI)1098-2744(199911)26:3<139::AID-MC1>3.0.CO;2-S Lund, 1999, Functional overlap between two classes of matrix-degrading proteases in wound healing, EMBO J, 18, 4645, 10.1093/emboj/18.17.4645 Cornelius, 1998, Matrix metalloproteinases generate angiostatin: effects on neovascularization, J Immunol, 161, 6845, 10.4049/jimmunol.161.12.6845 Dong, 1997, Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma, Cell, 88, 801, 10.1016/S0092-8674(00)81926-1 Lijnen, 1998, Generation of an angiostatin-like fragment from plasminogen by stromelysin-1 (MMP-3), Biochemistry, 37, 4699, 10.1021/bi9731798 Patterson, 1997, Angiostatin-converting enzyme activities of human matrilysin (MMP-7) and gelatinase B/ type IV collagenase (MMP-9), J Biol Chem, 272, 28823, 10.1074/jbc.272.46.28823 Pozzi, 2000, Elevated matrix metalloprotease and angiostatin levels in integrin alpha 1 knockout mice cause reduced tumor vascularization, Proc Natl Acad Sci USA, 97, 2202, 10.1073/pnas.040378497 Park, 2000, Identification and characterization of human endometase (Matrix metalloproteinase-26) from endometrial tumor, J Biol Chem, 275, 20540, 10.1074/jbc.M002349200 Uria, 2000, Matrilysin-2, a new matrix metalloproteinase expressed in human tumors and showing the minimal domain organization required for secretion, latency, and activity, Cancer Res, 60, 4745 de Coignac, 2000, Cloning of MMP-26. A novel matrilysin-like proteinase, Eur J Biochem, 267, 3323, 10.1046/j.1432-1327.2000.01363.x StCroix, 1998, E-Cadherin-dependent growth suppression is mediated by the cyclin-dependent kinase inhibitor p27Kip1, J Cell Biol, 142, 557, 10.1083/jcb.142.2.557 Liu, 2000, The serpin α1-proteinase inhibitor is a critical substrate for gelatinase B/MMP-9 in vivo, Cell, 102, 647, 10.1016/S0092-8674(00)00087-8 Kajita, 2001, Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration, J Cell Biol, 153, 893, 10.1083/jcb.153.5.893 Belkin, 2001, Matrix-dependent proteolysis of surface transglutaminase by membrane-type metalloproteinase regulates cancer cell adhesion and locomotion, J Biol Chem, 276, 18415, 10.1074/jbc.M010135200 Llano, 1999, Identification and characterization of human MT5-MMP, a new membrane-bound activator of progelatinase a overexpressed in brain tumors, Cancer Res, 59, 2570 Pei, 1999, Identification and characterization of the fifth membrane-type matrix metalloproteinase MT5-MMP, J Biol Chem, 274, 8925, 10.1074/jbc.274.13.8925 Wang, 1999, Catalytic activities and substrate specificity of the human membrane type 4 matrix metalloproteinase catalytic domain, J Biol Chem, 274, 33043, 10.1074/jbc.274.46.33043 Velasco, 2000, Human MT6-matrix metalloproteinase: identification, progelatinase A activation, and expression in brain tumors, Cancer Res, 60, 877 English, 2001, Catalytic activities of membrane-type 6 matrix metalloproteinase (MMP25), FEBS Lett, 491, 137, 10.1016/S0014-5793(01)02150-0 Pei, 1999, CA-MMP: a matrix metalloproteinase with a novel cysteine array, but without the classic cysteine switch, FEBS Lett, 457, 262, 10.1016/S0014-5793(99)01046-7 Stracke, 2000, Biochemical characterization of the catalytic domain of human matrix metalloproteinase 19. Evidence for a role as a potent basement membrane degrading enzyme, J Biol Chem, 275, 14809, 10.1074/jbc.275.20.14809 Stracke, 2000, Matrix metalloproteinases 19 and 20 cleave aggrecan and cartilage oligomeric matrix protein (COMP), FEBS Lett, 478, 52, 10.1016/S0014-5793(00)01819-6