T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
Tài liệu tham khảo
Zou, 2005, Immunosuppressive networks in the tumour environment and their therapeutic relevance, Nat Rev Cancer, 5, 263, 10.1038/nrc1586
Vanneman, 2012, Combining immunotherapy and targeted therapies in cancer treatment, Nat Rev Cancer, 12, 237, 10.1038/nrc3237
Pardoll, 2012, The blockade of immune checkpoints in cancer immunotherapy, Nat Rev Cancer, 12, 252, 10.1038/nrc3239
Schwartz, 1990, A cell culture model for T lymphocyte clonal anergy, Science, 248, 1349, 10.1126/science.2113314
Schwartz, 2003, T cell anergy, Annu Rev Immunol, 21, 305, 10.1146/annurev.immunol.21.120601.141110
Wells, 2009, New insights into the molecular basis of T cell anergy: anergy factors, avoidance sensors, and epigenetic imprinting, J Immunol, 182, 7331, 10.4049/jimmunol.0803917
Zou, 2008, Inhibitory B7-family molecules in the tumour microenvironment, Nat Rev Immunol, 8, 467, 10.1038/nri2326
Blank, 2004, PD-L1/B7H-1 inhibits the effector phase of tumor rejection by T cell receptor (TCR) transgenic CD8+ T cells, Cancer Res, 64, 1140, 10.1158/0008-5472.CAN-03-3259
Curiel, 2003, Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity, Nat Med, 9, 562, 10.1038/nm863
Kryczek, 2006, B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma, J Exp Med, 203, 871, 10.1084/jem.20050930
Chen, 1992, Costimulation of antitumor immunity by the B7 counterreceptor for the T lymphocyte molecules CD28 and CTLA-4, Cell, 71, 1093, 10.1016/S0092-8674(05)80059-5
Gajewski, 1996, B7-1 but not B7-2 efficiently costimulates CD8+ T lymphocytes in the P815 tumor system in vitro, J Immunol, 156, 465, 10.4049/jimmunol.156.2.465
Blank, 2006, Blockade of PD-L1 (B7-H1) augments human tumor-specific T cell responses in vitro, Int J Cancer, 119, 317, 10.1002/ijc.21775
Brown, 2006, Homeostatic proliferation as an isolated variable reverses CD8+ T cell anergy and promotes tumor rejection, J Immunol, 177, 4521, 10.4049/jimmunol.177.7.4521
Nazareth, 2007, Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells, J Immunol, 178, 5552, 10.4049/jimmunol.178.9.5552
Broderick, 2006, IL-12 reverses anergy to T cell receptor triggering in human lung tumor-associated memory T cells, Clin Immunol, 118, 159, 10.1016/j.clim.2005.09.008
Greenwald, 2001, CTLA-4 regulates induction of anergy in vivo, Immunity, 14, 145, 10.1016/S1074-7613(01)00097-8
Zheng, 2012, Transcriptional regulator early growth response gene 2 (Egr2) is required for T cell anergy in vitro and in vivo, J Exp Med, 10.1084/jem.20120342
Boussiotis, 1997, Maintenance of human T cell anergy: blocking of IL-2 gene transcription by activated Rap1, Science, 278, 124, 10.1126/science.278.5335.124
Dolmetsch, 1998, Calcium oscillations increase the efficiency and specificity of gene expression, Nature, 392, 933, 10.1038/31960
Anandasabapathy, 2003, GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells, Immunity, 18, 535, 10.1016/S1074-7613(03)00084-0
Soto-Nieves, 2009, Transcriptional complexes formed by NFAT dimers regulate the induction of T cell tolerance, J Exp Med, 206, 867, 10.1084/jem.20082731
Jeon, 2004, Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction, Immunity, 21, 167, 10.1016/j.immuni.2004.07.013
Mueller, 2004, E3 ubiquitin ligases as T cell anergy factors, Nat Immunol, 5, 883, 10.1038/ni1106
Thomas, 2007, Ikaros enforces the costimulatory requirement for IL2 gene expression and is required for anergy induction in CD4+ T lymphocytes, J Immunol, 179, 7305, 10.4049/jimmunol.179.11.7305
Gao, 2012, Analysis of sirtuin 1 expression reveals a molecular explanation of IL-2-mediated reversal of T-cell tolerance, Proc Natl Acad Sci U S A, 109, 899, 10.1073/pnas.1118462109
Bandyopadhyay, 2007, Interleukin 2 gene transcription is regulated by Ikaros-induced changes in histone acetylation in anergic T cells, Blood, 109, 2878, 10.1182/blood-2006-07-037754
Wherry, 2011, T cell exhaustion, Nat Immunol, 12, 492, 10.1038/ni.2035
Barber, 2006, Restoring function in exhausted CD8 T cells during chronic viral infection, Nature, 439, 682, 10.1038/nature04444
Wu, 2009, Kupffer cell suppression of CD8+ T cells in human hepatocellular carcinoma is mediated by B7-H1/programmed death-1 interactions, Cancer Res, 69, 8067, 10.1158/0008-5472.CAN-09-0901
Baitsch, 2011, Exhaustion of tumor-specific CD8(+) T cells in metastases from melanoma patients, J Clin Invest, 121, 2350, 10.1172/JCI46102
Brahmer, 2012, Safety and activity of anti-PD-L1 antibody in patients with advanced cancer, N Engl J Med, 10.1056/NEJMoa1200694
Topalian, 2012, Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N Engl J Med, 10.1056/NEJMoa1200690
Riley, 2009, PD-1 signaling in primary T cells, Immunol Rev, 229, 114, 10.1111/j.1600-065X.2009.00767.x
Haymaker, 2012, PD-1 and BTLA and CD8(+) T-cell ‘exhaustion’ in cancer: ‘exercising’ an alternative viewpoint, Oncoimmunology, 1, 735, 10.4161/onci.20823
Goldberg, 2007, Role of PD-1 and its ligand, B7-H1, in early fate decisions of CD8 T cells, Blood, 110, 186, 10.1182/blood-2006-12-062422
Wherry, 2007, Molecular signature of CD8+ T cell exhaustion during chronic viral infection, Immunity, 27, 670, 10.1016/j.immuni.2007.09.006
Blackburn, 2009, Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection, Nat Immunol, 10, 29, 10.1038/ni.1679
Sakuishi, 2010, Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity, J Exp Med, 207, 2187, 10.1084/jem.20100643
Li, 2012, Tim-3/galectin-9 signaling pathway mediates T-cell dysfunction and predicts poor prognosis in patients with hepatitis B virus-associated hepatocellular carcinoma, Hepatology, 56, 1342, 10.1002/hep.25777
Zhou, 2011, Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia, Blood, 117, 4501, 10.1182/blood-2010-10-310425
Fourcade, 2012, CD8(+) T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1, Cancer Res, 72, 887, 10.1158/0008-5472.CAN-11-2637
Derre, 2010, BTLA mediates inhibition of human tumor-specific CD8+ T cells that can be partially reversed by vaccination, J Clin Invest, 120, 157, 10.1172/JCI40070
Jin, 2010, Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection, Proc Natl Acad Sci U S A, 107, 14733, 10.1073/pnas.1009731107
Woo, 2012, Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape, Cancer Res, 72, 917, 10.1158/0008-5472.CAN-11-1620
Adibzadeh, 1995, Long-term culture of monoclonal human T lymphocytes: models for immunosenescence?, Mech Ageing Dev, 83, 171, 10.1016/0047-6374(95)01625-A
Effros, 1998, Replicative senescence in the immune system: impact of the Hayflick limit on T-cell function in the elderly, Am J Hum Genet, 62, 1003, 10.1086/301845
Hayflick, 1961, The serial cultivation of human diploid cell strains, Exp Cell Res, 25, 585, 10.1016/0014-4827(61)90192-6
Passos, 2010, Feedback between p21 and reactive oxygen production is necessary for cell senescence, Mol Syst Biol, 6, 347, 10.1038/msb.2010.5
Rodier, 2009, Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion, Nat Cell Biol, 11, 973, 10.1038/ncb1909
Beausejour, 2003, Reversal of human cellular senescence: roles of the p53 and p16 pathways, EMBO J, 22, 4212, 10.1093/emboj/cdg417
Appay, 2000, HIV-specific CD8(+) T cells produce antiviral cytokines but are impaired in cytolytic function, J Exp Med, 192, 63, 10.1084/jem.192.1.63
Akbar, 2011, Are senescence and exhaustion intertwined or unrelated processes that compromise immunity?, Nat Rev Immunol, 11, 289, 10.1038/nri2959
Pawelec, 2001, Immunoageing—the cause or effect of morbidity, Trends Immunol, 22, 348, 10.1016/S1471-4906(01)01956-1
Vallejo, 2004, T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection, Trends Mol Med, 10, 119, 10.1016/j.molmed.2004.01.002
Montes, 2008, Tumor-induced senescent T cells with suppressor function: a potential form of tumor immune evasion, Cancer Res, 68, 870, 10.1158/0008-5472.CAN-07-2282
Meloni, 2006, Foxp3 expressing CD4+ CD25+ and CD8+CD28− T regulatory cells in the peripheral blood of patients with lung cancer and pleural mesothelioma, Hum Immunol, 67, 1, 10.1016/j.humimm.2005.11.005
Tsukishiro, 2003, Rapid turnover of the CD8(+)CD28(−) T-cell subset of effector cells in the circulation of patients with head and neck cancer, Cancer Immunol Immunother, 52, 599, 10.1007/s00262-003-0395-6
Van Nguyen, 2007, DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model, J Exp Med, 204, 1453, 10.1084/jem.20062453
Brenchley, 2003, Expression of CD57 defines replicative senescence and antigen-induced apoptotic death of CD8+ T cells, Blood, 101, 2711, 10.1182/blood-2002-07-2103
Heffner, 2007, Loss of T cell receptor-induced Bmi-1 in the KLRG1(+) senescent CD8(+) T lymphocyte, Proc Natl Acad Sci U S A, 104, 13414, 10.1073/pnas.0706040104
Voehringer, 2001, Viral infections induce abundant numbers of senescent CD8 T cells, J Immunol, 167, 4838, 10.4049/jimmunol.167.9.4838
Fourcade, 2010, Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients, J Exp Med, 207, 2175, 10.1084/jem.20100637
Huang, 2010, Lymphoma endothelium preferentially expresses Tim-3 and facilitates the progression of lymphoma by mediating immune evasion, J Exp Med, 207, 505, 10.1084/jem.20090397
Zhu, 2005, The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity, Nat Immunol, 6, 1245, 10.1038/ni1271
Rangachari, 2012, Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion, Nat Med, 18, 1394, 10.1038/nm.2871
Fearon, 2001, Arrested differentiation, the self-renewing memory lymphocyte, and vaccination, Science, 293, 248, 10.1126/science.1062589
Lanzavecchia, 2002, Progressive differentiation and selection of the fittest in the immune response, Nat Rev Immunol, 2, 982, 10.1038/nri959
Zhang, 2005, Host-reactive CD8+ memory stem cells in graft-versus-host disease, Nat Med, 11, 1299, 10.1038/nm1326
Gattinoni, 2009, Wnt signaling arrests effector T cell differentiation and generates CD8+ memory stem cells, Nat Med, 15, 808, 10.1038/nm.1982
Kryczek, 2011, Human TH17 cells are long-lived effector memory cells, Sci Transl Med, 3, 104ra100, 10.1126/scitranslmed.3002949
Muranski, 2011, Th17 cells are long lived and retain a stem cell-like molecular signature, Immunity, 35, 972, 10.1016/j.immuni.2011.09.019
Wei, 2012, Th17 cells have stem cell-like features and promote long-term tumor immunity, OncoImmunology, 1
Workman, 2004, Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo, J Immunol, 172, 5450, 10.4049/jimmunol.172.9.5450
Huang, 2004, Role of LAG-3 in regulatory T cells, Immunity, 21, 503, 10.1016/j.immuni.2004.08.010
Bengsch, 2010, Coexpression of PD-1, 2B4, CD160 and KLRG1 on exhausted HCV-specific CD8+ T cells is linked to antigen recognition and T cell differentiation, PLoS Pathog, 6, e1000947, 10.1371/journal.ppat.1000947