The tumor-suppressive functions of the human INK4A locus

Cancer Cell - Tập 4 - Trang 311-319 - 2003
P.Mathijs Voorhoeve1, Reuven Agami1
1Division of Tumor Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands

Tài liệu tham khảo

Agami, 2000, Distinct initiation and maintenance mechanisms cooperate to induce G1 cell cycle arrest in response to DNA damage, Cell, 102, 55, 10.1016/S0092-8674(00)00010-6 Bothner, 2001, Defining the molecular basis of Arf and Hdm2 interactions, J. Mol. Biol, 314, 263, 10.1006/jmbi.2001.5110 Brummelkamp, 2002, Stable suppression of tumorigenicity by virus-mediated RNA interference, Cancer Cell, 2, 243, 10.1016/S1535-6108(02)00122-8 Brummelkamp, 2002, A system for stable expression of short interfering RNAs in mammalian cells, Science, 296, 550, 10.1126/science.1068999 Counter, 1998, Dissociation among in vitro telomerase activity, telomere maintenance, and cellular immortalization, Proc. Natl. Acad. Sci. USA, 95, 14723, 10.1073/pnas.95.25.14723 Eischen, 1999, Disruption of the ARF-Mdm2-p53 tumor suppressor pathway in Myc-induced lymphomagenesis, Genes Dev, 13, 2658, 10.1101/gad.13.20.2658 Hahn, 1999, Creation of human tumour cells with defined genetic elements, Nature, 400, 464, 10.1038/22780 Hahn, 2002, Enumeration of the simian virus 40 early region elements necessary for human cell transformation, Mol. Cell. Biol, 22, 2111, 10.1128/MCB.22.7.2111-2123.2002 Hanahan, 2000, The hallmarks of cancer, Cell, 100, 57, 10.1016/S0092-8674(00)81683-9 Huot, 2002, Biallelic mutations in p16(INK4a) confer resistance to Ras- and Ets-induced senescence in human diploid fibroblasts, Mol. Cell. Biol, 22, 8135, 10.1128/MCB.22.23.8135-8143.2002 Itahana, 2003, Control of the replicative life span of human fibroblasts by p16 and the polycomb protein Bmi-1, Mol. Cell. Biol, 23, 389, 10.1128/MCB.23.1.389-401.2003 Kamijo, 1997, Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF, Cell, 91, 649, 10.1016/S0092-8674(00)80452-3 Krimpenfort, 2001, Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice, Nature, 413, 83, 10.1038/35092584 Krug, 2002, Tumor suppressor genes in normal and malignant hematopoiesis, Oncogene, 21, 3475, 10.1038/sj.onc.1205322 Lowe, 2003, Tumor suppression by Ink4a-Arf, Curr. Opin. Genet. Dev, 13, 77, 10.1016/S0959-437X(02)00013-8 Pomerantz, 1998, The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2′s inhibition of p53, Cell, 92, 713, 10.1016/S0092-8674(00)81400-2 Ruas, 1998, The p16INK4a/CDKN2A tumor suppressor and its relatives, Biochim. Biophys. Acta, 1378, F115 Serrano, 1997, Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a, Cell, 88, 593, 10.1016/S0092-8674(00)81902-9 Sharpless, 2001, Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis, Nature, 413, 86, 10.1038/35092592 Srinivasan, 1997, The amino-terminal transforming region of simian virus 40 large T and small t antigens functions as a J domain, Mol. Cell. Biol, 17, 4761, 10.1128/MCB.17.8.4761 Wei, 2001, Role of p14(ARF) in replicative and induced senescence of human fibroblasts, Mol. Cell. Biol, 21, 6748, 10.1128/MCB.21.20.6748-6757.2001 Wei, 2003, Abolition of cyclin-dependent kinase inhibitor p16Ink4a and p21Cip1/Waf1 functions permits Ras-induced anchorage-independent growth in telomerase-immortalized human fibroblasts, Mol. Cell. Biol, 23, 2859, 10.1128/MCB.23.8.2859-2870.2003 Zalvide, 1995, Role of pRb-related proteins in simian virus 40 large-T-antigen-mediated transformation, Mol. Cell. Biol, 15, 5800, 10.1128/MCB.15.10.5800