Pentoxifylline for the treatment of non-alcoholic steatohepatitis: a randomized controlled trial

Annals of Hepatology - Tập 10 - Trang 277-286 - 2011
Lisa B. Van Wagner1, Sean W.P. Koppe1, Elizabeth M. Brunt2, Jeanne Gottstein1, Konstantina Gardikiotes1, Richard M. Green1, Mary E. Rinella1
1Departments of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
2Departments of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, USA.

Tài liệu tham khảo

Sanyal, 2010, Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis., N Engl J Med, 362, 1675, 10.1056/NEJMoa0907929 Belfort, 2006, A placebo-controlled trial of pioglitazone in subjects with nonalcoholic steatohepatitis., N Engl J Med, 355, 2297, 10.1056/NEJMoa060326 Aithal, 2008, Randomized, placebo-controlled trial of pioglitazone in nondiabetic subjects with nonalcoholic steatohepatitis., Gastroenterology, 135, 1176, 10.1053/j.gastro.2008.06.047 Ratziu, 2008, Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial., Gastroenterology, 135, 100, 10.1053/j.gastro.2008.03.078 Mannucci, 2010, Cardiac safety profile of rosiglitazone: a comprehensive meta-analysis of randomized clinical trials., Int J Cardiol, 143, 135, 10.1016/j.ijcard.2009.01.064 Hepgul, 2010, Preventive effect of pentoxifylline on acute radiation damage via antioxidant and anti-inflammatory pathways., Dig Dis Sci, 55, 617, 10.1007/s10620-009-0780-x Doherty, 1991, Pentoxifylline suppression of tumor necrosis factor gene transcription., Surgery, 110, 192 Duman, 2007, Effects of pentoxifylline on TNF-alpha production by peripheral blood mononuclear cells in patients with nonalcoholic steatohepatitis., Dig Dis Sci, 52, 2520, 10.1007/s10620-006-9723-y Koppe, 2004, Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet., J Hepatol, 41, 592, 10.1016/j.jhep.2004.06.030 Adams, 2004, A pilot trial of pentoxifylline in nonalcoholic steatohepatitis., Am J Gastroenterol, 99, 2365, 10.1111/j.1572-0241.2004.40064.x Satapathy, 2004, Beneficial effects of tumor necrosis factor-alpha inhibition by pentoxifylline on clinical, biochemical, and metabolic parameters of patients with nonalcoholic steatohepatitis., Am J Gastroenterol, 99, 1946, 10.1111/j.1572-0241.2004.40220.x Buranawati, 2007, Pentoxifylline for Treatment of Nonalcoholic Fatty Liver Disease (NA-FLD): A Randomized, Placebo-Controlled Study., Thai J Gastroenterol, 8, 57 Lee, 2008, A randomized controlled pilot study of Pentoxifylline in patients with non-alcoholic steatohepatitis (NASH)., Hepatol Int, 2, 196, 10.1007/s12072-008-9058-1 Ozawa, 2005, The endoplasmic reticulum chaperone improves insulin resistance in type 2 diabetes., Diabetes, 54, 657, 10.2337/diabetes.54.3.657 Ozcan, 2004, Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes., Science, 306, 457, 10.1126/science.1103160 Ozcan, 2006, Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes., Science, 313, 1137, 10.1126/science.1128294 Puri, 2008, Activation and dysregulation of the unfolded protein response in nonalcoholic fatty liver disease., Gastroenterology, 134, 568, 10.1053/j.gastro.2007.10.039 Xue, 2005, Tumor necrosis factor alpha (TNFalpha) induces the unfolded protein response (UPR) in a reactive oxygen species (ROS)-dependent fashion, and the UPR counteracts ROS accumulation by TNFalpha., J Biol Chem, 280, 33917, 10.1074/jbc.M505818200 Brunt, 1999, Nonalcoholic steatohepatitis (NASH): further expansion of this clinical entity?, Liver, 19, 263, 10.1111/j.1478-3231.1999.tb00047.x Kleiner, 2005, Design and validation of a histological scoring system for nonalcoholic fatty liver disease., Hepatology, 41, 1313, 10.1002/hep.20701 Prati, 2002, Updated definitions of healthy ranges for serum alanine aminotransferase levels., Ann Intern Med, 137, 1, 10.7326/0003-4819-137-1-200207020-00006 Kim, 2004, Normal serum aminotransferase concentration and risk of mortality from liver diseases: prospective cohort study., BMJ, 328, 983, 10.1136/bmj.38050.593634.63 Burra, 1992, Severity of alcoholic liver disease and markers of thyroid and steroid status., Postgrad Med J, 68, 804, 10.1136/pgmj.68.804.804 Brunt, 1999, Nonalcoholic steatohepatitis: a proposal for grading and staging the histological lesions., Am J Gastroenterol, 94, 2467, 10.1111/j.1572-0241.1999.01377.x Akriviadis, 2000, Pentoxifylline improves short-term survival in severe acute alcoholic hepatitis: a double-blind, placebo-controlled trial., Gastroenterology, 119, 1637, 10.1053/gast.2000.20189 Groesdonk, 2009, Urodilatin and pentoxifylline prevent the early onset of Escherichia coli-Induced acute renal failure in a model of isolated perfused rat kidney., Kidney Blood Press Res, 32, 81, 10.1159/000209378 Perkins, 2009, Effect of pentoxifylline on GFR decline in CKD: a pilot, double-blind, randomized, placebo-controlled trial., Am J Kidney Dis, 53, 606, 10.1053/j.ajkd.2008.11.026