A polymeric nanoparticle formulation of curcumin (NanoCurc™) ameliorates CCl4-induced hepatic injury and fibrosis through reduction of pro-inflammatory cytokines and stellate cell activation

Brenner, 2009, Molecular pathogenesis of liver fibrosis, Trans Am Clin Climatol Assoc, 120, 361 Hellerbrand, 1999, The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo, J Hepatol, 30, 77, 10.1016/S0168-8278(99)80010-5 Sinha, 2003, Cancer risk and diet in India, J Postgrad Med, 49, 222 Huang, 1988, Inhibitory effect of curcumin, chlorogenic acid, caffeic acid, and ferulic acid on tumor promotion in mouse skin by 12-O-tetradecanoylphorbol-13-acetate, Cancer Res, 48, 5941 Sharma, 1976, Antioxidant activity of curcumin and related compounds, Biochem Pharmacol, 25, 1811, 10.1016/0006-2952(76)90421-4 Rao, 1982, Anti-inflammatory activity of curcumin analogues, Indian J Med Res, 75, 574 Brouet, 1995, Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages, Biochem Biophys Res Commun, 206, 533, 10.1006/bbrc.1995.1076 Kulkarni, 2008, Antidepressant activity of curcumin: involvement of serotonin and dopamine system, Psychopharmacology (Berl), 201, 435, 10.1007/s00213-008-1300-y Xu, 2005, The effects of curcumin on depressive-like behaviors in mice, Eur J Pharmacol, 518, 40, 10.1016/j.ejphar.2005.06.002 Fu, 2008, Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation, Mol Pharmacol, 73, 399, 10.1124/mol.107.039818 Park, 2000, Protective effect of curcumin in rat liver injury induced by carbon tetrachloride, J Pharm Pharmacol, 52, 437, 10.1211/0022357001774048 Donatus, 1990, Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes, Biochem Pharmacol, 39, 1869, 10.1016/0006-2952(90)90603-I Kiso, 1983, Antihepatotoxic principles of Curcuma longa rhizomes, Planta Med, 49, 185, 10.1055/s-2007-969845 Xu, 2003, Activation of peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth, Am J Physiol Gastrointest Liver Physiol, 285, G20, 10.1152/ajpgi.00474.2002 Zheng, 2004, Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro, Biochem J, 384, 149, 10.1042/BJ20040928 Kidd, 2009, Bioavailability and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea, and grape seed extracts, Altern Med Rev, 14, 226 Marczylo, 2007, Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine, Cancer Chemother Pharmacol, 60, 171, 10.1007/s00280-006-0355-x Pan, 1999, Biotransformation of curcumin through reduction and glucuronidation in mice, Drug Metab Dispos, 27, 486 Sharma, 2007, Pharmacokinetics and pharmacodynamics of curcumin, Adv Exp Med Biol, 595, 453, 10.1007/978-0-387-46401-5_20 Anand, 2007, Bioavailability of curcumin: problems and promises, Mol Pharm, 4, 807, 10.1021/mp700113r Garcea, 2005, Consumption of the putative chemopreventive agent curcumin by cancer patients: assessment of curcumin levels in the colorectum and their pharmacodynamic consequences, Cancer Epidemiol Biomarkers Prev, 14, 120, 10.1158/1055-9965.120.14.1 Bisht, 2010, Systemic administration of polymeric nanoparticle-encapsulated curcumin (NanoCurc) blocks tumor growth and metastases in preclinical models of pancreatic cancer, Mol Cancer Ther, 9, 2255, 10.1158/1535-7163.MCT-10-0172 Garcea, 2004, Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration, Br J Cancer, 90, 1011, 10.1038/sj.bjc.6601623 Dhillon, 2008, Phase II trial of curcumin in patients with advanced pancreatic cancer, Clin Cancer Res, 14, 4491, 10.1158/1078-0432.CCR-08-0024 Bisht, 2008, In vivo characterization of a polymeric nanoparticle platform with potential oral drug delivery capabilities, Mol Cancer Ther, 7, 3878, 10.1158/1535-7163.MCT-08-0476 Bisht, 2007, Polymeric nanoparticle-encapsulated curcumin (‘nanocurcumin'): a novel strategy for human cancer therapy, J Nanobiotechnology, 5, 3, 10.1186/1477-3155-5-3 Anders, 2005, Contribution of the lymphotoxin beta receptor to liver regeneration, J Immunol, 175, 1295, 10.4049/jimmunol.175.2.1295 Vogel, 2000, An immortalized rat liver stellate cell line (HSC-T6): a new cell model for the study of retinoid metabolism in vitro, J Lipid Res, 41, 882, 10.1016/S0022-2275(20)32030-7 Aggarwal, 2007, Curcumin: the Indian solid gold, Adv Exp Med Biol, 595, 1, 10.1007/978-0-387-46401-5_1 Bisht, 2009, Systemic delivery of curcumin: 21st century solutions for an ancient conundrum, Curr Drug Discov Technol, 6, 192, 10.2174/157016309789054933 Sudo, 2005, Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice, Cytokine, 29, 236, 10.1016/j.cyto.2004.11.001 Adams, 2010, Mechanisms of immune-mediated liver injury, Toxicol Sci, 115, 307, 10.1093/toxsci/kfq009 Li, 2003, Innate immunity in the liver, Curr Opin Gastroenterol, 19, 565, 10.1097/00001574-200311000-00009 Szabo, 2007, Innate immune response and hepatic inflammation, Semin Liver Dis, 27, 339, 10.1055/s-2007-991511 Marra, 2009, Mononuclear cells in liver fibrosis, Semin Immunopathol, 31, 345, 10.1007/s00281-009-0169-0 Ginsburg, 2009, Amelioration of hepatic fibrosis via Padma Hepaten is associated with altered natural killer T lymphocytes, Clin Exp Immunol, 157, 155, 10.1111/j.1365-2249.2009.03936.x Ishikawa, 2010, CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice., J Hepatol, 10.1016/S0168-8278(10)60105-5 Park, 2009, Diverse roles of invariant natural killer T cells in liver injury and fibrosis induced by carbon tetrachloride, Hepatology, 49, 1683, 10.1002/hep.22813 Safadi, 2007, Amelioration of hepatic fibrosis via beta-glucosylceramide-mediated immune modulation is associated with altered CD8 and NKT lymphocyte distribution, Int Immunol, 19, 1021, 10.1093/intimm/dxm069 Melhem, 2006, Anti-fibrotic activity of NK cells in experimental liver injury through killing of activated HSC, J Hepatol, 45, 60, 10.1016/j.jhep.2005.12.025 Radaeva, 2006, Natural killer cells ameliorate liver fibrosis by killing activated stellate cells in NKG2D-dependent and tumor necrosis factor-related apoptosis-inducing ligand-dependent manners, Gastroenterology, 130, 435, 10.1053/j.gastro.2005.10.055 Daley, 2008, Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice, J Leukocyte Biol, 83, 64, 10.1189/jlb.0407247 Karlmark, 2009, Hepatic recruitment of the inflammatory Gr1+ monocyte subset upon liver injury promotes hepatic fibrosis, Hepatology, 50, 261, 10.1002/hep.22950 Weiler-Normann, 2007, Mouse models of liver fibrosis, Z Gastroenterol, 45, 43, 10.1055/s-2006-927387 Burk, 1984, Relationship of oxygen and glutathione in protection against carbon tetrachloride-induced hepatic microsomal lipid peroxidation and covalent binding in the rat. Rationale for the use of hyperbaric oxygen to treat carbon tetrachloride ingestion, J Clin Invest, 74, 1996, 10.1172/JCI111621 Burk, 1983, Reduced glutathione protection against rat liver microsomal injury by carbon tetrachloride. Dependence on O2, Biochem J, 215, 441, 10.1042/bj2150441 Zheng, 2007, De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation, Free Radic Biol Med, 43, 444, 10.1016/j.freeradbiomed.2007.04.016 Friedman, 1997, Molecular mechanisms of hepatic fibrosis and principles of therapy, J Gastroenterol, 32, 424, 10.1007/BF02934504 Friedman, 1985, Hepatic lipocytes: the principal collagen-producing cells of normal rat liver, Proc Natl Acad Sci USA, 82, 8681, 10.1073/pnas.82.24.8681 Kawase, 1986, Collagen production by rat liver fat-storing cells in primary culture, Exp Cell Biol, 54, 183 Ramadori, 1992, Synthesis of cellular fibronectin by rat liver fat-storing (Ito) cells: regulation by cytokines, Gastroenterology, 103, 1313, 10.1016/0016-5085(92)91522-6 Neubauer, 1995, Accumulation and cellular localization of fibrinogen/fibrin during short-term and long-term rat liver injury, Gastroenterology, 108, 1124, 10.1016/0016-5085(95)90211-2 Garcia-Trevijano, 1999, Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells, Hepatology, 29, 960, 10.1002/hep.510290346 Gressner, 1996, Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis, Kidney Int Suppl, 54, S39 Galli, 2000, Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells, Hepatology, 31, 101, 10.1002/hep.510310117 Marra, 2000, Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells, Gastroenterology, 119, 466, 10.1053/gast.2000.9365 Miyahara, 2000, Peroxisome proliferator-activated receptors and hepatic stellate cell activation, J Biol Chem, 275, 35715, 10.1074/jbc.M006577200 Lin, 2009, Curcumin attenuates the effects of insulin on stimulating hepatic stellate cell activation by interrupting insulin signaling and attenuating oxidative stress, Lab Invest, 89, 1397, 10.1038/labinvest.2009.115 Jiao, 2009, Hepatic fibrosis, Curr Opin Gastroenterol, 25, 223, 10.1097/MOG.0b013e3283279668 Everhart, 2008 van Vlerken, 2006, Multi-functional polymeric nanoparticles for tumour-targeted drug delivery, Expert Opin Drug Deliv, 3, 205, 10.1517/17425247.3.2.205 Vicent, 2006, Polymer conjugates: nanosized medicines for treating cancer, Trends Biotechnol, 24, 39, 10.1016/j.tibtech.2005.11.006 Vasir, 2005, Targeted drug delivery in cancer therapy, Technol Cancer Res Treat, 4, 363, 10.1177/153303460500400405 Ganta, 2010, Curcumin enhances oral bioavailability and anti-tumor therapeutic efficacy of paclitaxel upon administration in nanoemulsion formulation, J Pharm Sci, 99, 4630, 10.1002/jps.22157 Appiah-Opong, 2008, Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues, Eur J Med Chem, 43, 1621, 10.1016/j.ejmech.2007.10.034 Volak, 2008, Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor, Drug Metab Dispos, 36, 1594, 10.1124/dmd.108.020552 Lin, 2008, Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells, Lab Invest, 88, 529, 10.1038/labinvest.2008.20 Jaeschke, 2011, Reactive oxygen and mechanisms of inflammatory liver injury: Present concepts, J Gastroenterol Hepatol, 26, 173, 10.1111/j.1440-1746.2010.06592.x