Integrated Geriatric Assessment and Treatment Effectiveness (INTEGERATE) in older people with cancer starting systemic anticancer treatment in Australia: a multicentre, open-label, randomised controlled trial

Mohile, 2018, Practical assessment and management of vulnerabilities in older patients receiving chemotherapy: ASCO guideline for geriatric oncology, J Clin Oncol, 36, 2326, 10.1200/JCO.2018.78.8687 DuMontier, 2020, Arti Hurria and the progress in integrating the geriatric assessment into oncology: Young International Society of Geriatric Oncology review paper, J Geriatr Oncol, 11, 203, 10.1016/j.jgo.2019.08.005 Quinten, 2020, The prognostic value of patient-reported Health-Related Quality of Life and Geriatric Assessment in predicting early death in 6769 older (≥70 years) patients with different cancer tumors, J Geriatr Oncol, 11, 926, 10.1016/j.jgo.2020.03.017 Bruijnen, 2019, Predictive value of each geriatric assessment domain for older patients with cancer: a systematic review, J Geriatr Oncol, 10, 859, 10.1016/j.jgo.2019.02.010 Williams, 2019, Geriatric assessment predicts hospitalization frequency and long-term care use in older adult cancer survivors, J Oncol Pract, 15, e399, 10.1200/JOP.18.00368 Wildiers, 2014, International Society of Geriatric Oncology consensus on geriatric assessment in older patients with cancer, J Clin Oncol, 32, 2595, 10.1200/JCO.2013.54.8347 Battisti, 2021, Bridging the age gap in breast cancer: impact of chemotherapy on quality of life in older women with early breast cancer, Eur J Cancer, 144, 269, 10.1016/j.ejca.2020.11.022 Wildiers, 2013, End points and trial design in geriatric oncology research: a joint European organisation for research and treatment of cancer—Alliance for Clinical Trials in Oncology—International Society of Geriatric Oncology position article, J Clin Oncol, 31, 3711, 10.1200/JCO.2013.49.6125 Tremblay, 2012, Integrated oncogeriatric approach: a systematic review of the literature using concept analysis, BMJ Open, 2, 10.1136/bmjopen-2012-001483 Parker, 2018, What is Comprehensive Geriatric Assessment (CGA)? An umbrella review, Age Ageing, 47, 149, 10.1093/ageing/afx166 Gardner, 2019 Garcia, 2021, Screening tools for identifying older adults with cancer who may benefit from a geriatric assessment: a systematic review, JAMA Oncol, 7, 616, 10.1001/jamaoncol.2020.6736 Hamaker, 2022, Geriatric assessment in the management of older patients with cancer—a systematic review (update), J Geriatr Oncol, 10.1016/j.jgo.2022.04.008 Decoster, 2015, Screening tools for multidimensional health problems warranting a geriatric assessment in older cancer patients: an update on SIOG recommendations, Ann Oncol, 26, 288, 10.1093/annonc/mdu210 Dotan, 2021, NCCN Guidelines® insights: older adult oncology, version 1.2021, J Natl Compr Canc Netw, 19, 1006, 10.6004/jnccn.2021.0043 Charlson, 1987, A new method of classifying prognostic comorbidity in longitudinal studies: development and validation, J Chronic Dis, 40, 373, 10.1016/0021-9681(87)90171-8 Bellera, 2012, Screening older cancer patients: first evaluation of the G-8 geriatric screening tool, Ann Oncol, 23, 2166, 10.1093/annonc/mdr587 Rockwood, 2005, A global clinical measure of fitness and frailty in elderly people, CMAJ, 173, 489, 10.1503/cmaj.050051 Kenis, 2014, Performance of two geriatric screening tools in older patients with cancer, J Clin Oncol, 32, 19, 10.1200/JCO.2013.51.1345 Soo, 2021, The Elderly Functional Index (ELFI), a patient-reported outcome measure of functional status in patients with cancer: a multicentre, prospective validation study, Lancet Healthy Longev, 2, e24, 10.1016/S2666-7568(20)30036-2 Aaronson, 1993, The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology, J Natl Cancer Inst, 85, 365, 10.1093/jnci/85.5.365 Wheelwright, 2013, International validation of the EORTC QLQ-ELD14 questionnaire for assessment of health-related quality of life elderly patients with cancer, Br J Cancer, 109, 852, 10.1038/bjc.2013.407 Herdman, 2011, Development and preliminary testing of the new five-level version of EQ-5D (EQ-5D-5L), Qual Life Res, 20, 1727, 10.1007/s11136-011-9903-x Cohen, 1998 Cocks, 2011, Evidence-based guidelines for determination of sample size and interpretation of the European Organisation for the Research and Treatment of Cancer Quality of Life Questionnaire Core 30, J Clin Oncol, 29, 89, 10.1200/JCO.2010.28.0107 Fayers, 2001 Giesinger, 2016, Replication and validation of higher order models demonstrated that a summary score for the EORTC QLQ-C30 is robust, J Clin Epidemiol, 69, 79, 10.1016/j.jclinepi.2015.08.007 King, 2018, Australian utility weights for the EORTC QLU-C10D, a multi-attribute utility instrument derived from the cancer-specific quality of life questionnaire, EORTC QLQ-C30, PharmacoEconomics, 36, 225, 10.1007/s40273-017-0582-5 Viney, 2011, Time trade-off derived EQ-5D weights for Australia, Value Health, 14, 928, 10.1016/j.jval.2011.04.009 Cnaan, 1997, Using the general linear mixed model to analyse unbalanced repeated measures and longitudinal data, Stat Med, 16, 2349, 10.1002/(SICI)1097-0258(19971030)16:20<2349::AID-SIM667>3.0.CO;2-E Hochberg, 1988, A sharper Bonferroni procedure for multiple tests of significance, Biometrika, 75, 800, 10.1093/biomet/75.4.800 2009 Balducci, 2000, Management of cancer in the older person: a practical approach, Oncologist, 5, 224, 10.1634/theoncologist.5-3-224 Lund, 2021, The effect of geriatric intervention in frail older patients receiving chemotherapy for colorectal cancer: a randomised trial (GERICO), Br J Cancer, 124, 1949, 10.1038/s41416-021-01367-0 Mohile, 2021, Evaluation of geriatric assessment and management on the toxic effects of cancer treatment (GAP70+): a cluster-randomised study, Lancet, 398, 1894, 10.1016/S0140-6736(21)01789-X Li, 2021, Geriatric Assessment-Driven Intervention (GAIN) on chemotherapy-related toxic effects in older adults with cancer: a randomized clinical trial, JAMA Oncol, 7, 10.1001/jamaoncol.2021.4158 Corre, 2016, Use of a Comprehensive Geriatric Assessment for the management of elderly patients with advanced non-small-cell lung cancer: the phase III randomized ESOGIA-GFPC-GECP 08-02 study, J Clin Oncol, 34, 1476, 10.1200/JCO.2015.63.5839 Mohile, 2020, Communication with older patients with cancer using geriatric assessment: a cluster-randomized clinical trial from the National Cancer Institute Community Oncology Research Program, JAMA Oncol, 6, 196, 10.1001/jamaoncol.2019.4728 Puts, 2021, Comprehensive geriatric assessment and management for Canadian elders with cancer: The 5C study, J Clin Oncol, 39 Alibhai, 2022, Economic evaluation of a geriatric oncology clinic, Cancers (Basel), 14, 789, 10.3390/cancers14030789