Icaritin induces cell death in activated hepatic stellate cells through mitochondrial activated apoptosis and ameliorates the development of liver fibrosis in rats

Alpini, 1997, Molecular and functional heterogeneity of cholangiocytes from rat liver after bile duct ligation, American Journal of Physiology, 272, G289 Aouacheria, 2007, Modulating mitochondria-mediated apoptotic cell death through targeting of Bcl-2 family proteins, Recent Pat DNA Sequence, 1, 43, 10.2174/187221507779814434 Bataller, 2001, Hepatic stellate cells as a target for the treatment of liver fibrosis, Seminars in Liver Disease, 21, 437, 10.1055/s-2001-17558 Bataller, 2005, Liver fibrosis, Journal of Clinical Investigation, 115, 209, 10.1172/JCI24282 Brenner, 2009, Molecular pathogenesis of liver fibrosis, Transactions of the American Clinical and Climatological Association, 120, 361 Chen, 2003, The antioxidant (−)-epigallocatechin-3-gallate inhibits rat hepatic stellate cell proliferation in vitro by blocking the tyrosine phosphorylation and reducing the gene expression of platelet-derived growth factor-beta receptor, Journal of Biological Chemistry, 278, 23381, 10.1074/jbc.M212042200 Chen, 2008, Intestinal absorption mechanisms of prenylated flavonoids present in the heat-processed Epimedium koreanum Nakai (Yin Yanghuo), Pharmaceutical Research, 25, 2190, 10.1007/s11095-008-9602-7 Chor, 2005, Anti-proliferative and pro-apoptotic effects of herbal medicine on hepatic stellate cell, Journal of Ethnopharmacology, 22, 180, 10.1016/j.jep.2005.02.036 Daniel, 2003, Guardians of cell death: the Bcl-2 family proteins, Essays in Biochemistry, 39, 73, 10.1042/bse0390073 Domitrović, 2009, Liver fibrosis in mice induced by carbon tetrachloride and its reversion by luteolin, Toxicology and Applied Pharmacology, 241, 311, 10.1016/j.taap.2009.09.001 Friedman, 2003, Liver fibrosis-from bench to bedside, Journal of Hepatology, 38, 38, 10.1016/S0168-8278(02)00429-4 Friedman, 2008, Mechanisms of hepatic fibrogenesis, Gastroenterology, 134, 1655, 10.1053/j.gastro.2008.03.003 Friedman, 2008, Hepatic stellate cells protean multifunctional and enigmatic, Physiological Reviews, 88, 125, 10.1152/physrev.00013.2007 Gressner, 2006, Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets, Journal of Cellular and Molecular Medicine, 10, 76, 10.1111/j.1582-4934.2006.tb00292.x Gui, 2006, Effects and mechanisms of crude astragalosides extraction on liver fibrosis in rats, Journal of Ethnopharmacology, 103, 154, 10.1016/j.jep.2005.07.025 Havsteen, 2002, The biochemistry and medical significance of the flavonoids, Pharmacology & Therapeutics, 96, 67, 10.1016/S0163-7258(02)00298-X Henderson, 2007, Liver fibrosis: cellular mechanisms of progression and resolution, Clinical Science, 112, 265, 10.1042/CS20060242 Henderson, 2008, Hepatic fibrogenesis: from within and without, Toxicology, 254, 130, 10.1016/j.tox.2008.08.017 Iredale, 2003, Cirrhosis: new research provides a basis for rational and targeted treatments, British Medical Journal, 327, 143, 10.1136/bmj.327.7407.143 Iredale, 2007, Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ, Journal of Clinical Investigation, 117, 539, 10.1172/JCI30542 Jenkins, 2006, Pseudomonas aeruginosa-induced human mast cell apoptosis is associated with up-regulation of endogenous Bcl-xS and down-regulation of Bcl-xL, Journal of Immunology, 177, 8000, 10.4049/jimmunol.177.11.8000 Jimenez, 1985, Measurement of fibrosis in needle liver biopsies: evaluation of a colorimetric method, Journal of Hepatology, 5, 815, 10.1002/hep.1840050517 Kisseleva, 2006, Hepatic stellate cells and the reversal of fibrosis, Journal of Gastroenterology and Hepatology, 21, 84, 10.1111/j.1440-1746.2006.04584.x Kisseleva, 2007, Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis, Journal of Gastroenterology and Hepatology, 22, 73, 10.1111/j.1440-1746.2006.04658.x Liu, 2001, Chinese medicinal herbs for chronic hepatitis B: a systematic review, Liver, 21, 280, 10.1034/j.1600-0676.2001.021004280.x Luk, 2007, Traditional Chinese herbal medicines for treatment of liver fibrosis and cancer: from laboratory discovery to clinical evaluation, Liver International, 27, 879, 10.1111/j.1478-3231.2007.01527.x Manning, 2008, Diagnosis and quantitation of fibrosis, Gastroenterology, 134, 1670, 10.1053/j.gastro.2008.03.001 Minicis, 2007, Gene expression profiles during hepatic stellate cell activation in culture and in vivo, Gastroenterology, 132, 1937, 10.1053/j.gastro.2007.02.033 Mosmann, 1983, Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay, Journal of Immunological Methods, 65, 55, 10.1016/0022-1759(83)90303-4 Nakamuta, 2005, Epigallocatechin-3-gallate, a polyphenol component of green tea, suppresses both collagen production and collagenase activity in hepatic stellate cells, International Journal of Molecular Medicine, 16, 677 Prosser, 2006, Molecular therapy for hepatic injury and fibrosis: where are we?, World Journal of Gastroenterology, 28, 509, 10.3748/wjg.v12.i4.509 Schinoni, 2006, Apoptosis and progression of hepatic fibrosis in liver diseases, Acta Gastroenterologica Latinoamericana, 36, 211 Shen, 2007, Taxonomic, genetic, chemical and estrogenic characteristics of Epimedium species, Phytochemistry, 68, 1448, 10.1016/j.phytochem.2007.03.001 Shen, 2001, Anti-inflammatory effects of the partially purified extract of radix Stephaniae tetrandrae: comparative studies of its active principles tetrandrine and fangchinoline on human polymorphonuclear leukocyte functions, Molecular Pharmacology, 60, 1083, 10.1124/mol.60.5.1083 Skalli, 1989, Myofibroblasts from diverse pathologic settings are heterogeneous in their content of actin isoforms and intermediate filament proteins, Laboratory Investigation, 60, 275 Skulachev, 1998, Cytochrome c in the apoptotic and antioxidant cascades, FEBS Letters, 423, 275, 10.1016/S0014-5793(98)00061-1 Souza, 2008, Resveratrol inhibits cell growth by inducing cell cycle arrest in activated hepatic stellate cells, Molecular and Cellular Biochemistry, 315, 1, 10.1007/s11010-008-9781-x Takeji, 2006, Smooth muscle alpha actin deficiency in myofibroblasts leads to enhanced renal tissue fibrosis, Journal of Biological Chemistry, 281, 40193, 10.1074/jbc.M602182200 Thyagarajan, 2002, Herbal medicines for liver diseases in India, Journal of Gastroenterology and Hepatology, 17, 370, 10.1046/j.1440-1746.17.s3.30.x Wong, 2008, Bcl-2 family proteins: the sentinels of the mitochondrial apoptosis pathway, IUBMB Life, 60, 390, 10.1002/iub.51 Wu, 2003, Chemical and pharmacological investigations of Epimedium species: a survey, Progress in Drug Research, 60, 1, 10.1007/978-3-0348-8012-1_1 Wang, 2000, Treatment of chronic liver diseases with traditional Chinese medicine, Journal of Gastroenterology and Hepatology, 15, S67, 10.1046/j.1440-1746.2000.02100.x Zhu, 2006, Icariin-mediated expression of cardiac genes and modulation of nitric oxide signaling pathway during differentiation of mouse embryonic stem cells into cardiomyocytes in vitro, Acta Pharmacologica Sinica, 27, 311, 10.1111/j.1745-7254.2006.00275.x Zimmermann, 1999, Myofibroblasts in the cirrhotic rat liver reflect hepatic remodeling and correlate with fibrosis and sinusoidal capillarization, Journal of Hepatology, 30, 646, 10.1016/S0168-8278(99)80195-0