Reported adverse drug reactions in women and men: Aggregated evidence from globally collected individual case reports during half a century

Anthony, 2008, Gender and age differences in medications dispensed from a national chain drugstore, J Womens Health, 17, 735, 10.1089/jwh.2007.0731 Correa-de-Araujo RM, 2005, Gender differences in drug use and expenditures in a privately insured population of older adults, J Womens Health, 14, 73, 10.1089/jwh.2005.14.73 Stock, 2008, Sex differences in treatment patterns of six chronic diseases: an analysis from the German statutory health insurance, J Womens Health, 17, 343, 10.1089/jwh.2007.0422 Thorell, 2012, Licit prescription drug use in a Swedish population according to age, gender and socioeconomic status after adjusting for level of multi-morbidity, BMC Public Health, 12, 575, 10.1186/1471-2458-12-575 Redondo-Sendino, 2006, Gender differences in the utilization of health-care services among the older adult population of Spain, BMC Public Health, 6, 155, 10.1186/1471-2458-6-155 Schappert, 2006, Ambulatory care visits to physician offices, hospital outpatient departments, and emergency departments: United States, 2001–02, Vital Health Stat, 13, 1 Osika Friberg, 2016, Sex differences in health care consumption in Sweden: a register-based cross-sectional study, Scand J Public Health, 44, 264, 10.1177/1403494815618843 Ladwig, 2000, Gender differences of symptom reporting and medical health care utilization in the German population, Eur J Epidemiol, 16, 511, 10.1023/A:1007629920752 Zopf, 2008, Women encounter ADRs more often than do men, Eur J Clin Pharmacol, 64, 999, 10.1007/s00228-008-0494-6 Martin, 1998, Age and sex distribution of suspected adverse drug reactions to newly marketed drugs in general practice in England: analysis of 48 cohort studies, Br J Clin Pharmacol, 46, 505, 10.1046/j.1365-2125.1998.00817.x Rodenburg, 2011, Sex-related differences in hospital admissions attributed to adverse drug reactions in the Netherlands, Br J Clin Pharmacol, 71, 95, 10.1111/j.1365-2125.2010.03811.x Onder, 2002, Adverse drug reactions as cause of hospital admissions: results from the Italian Group of Pharmacoepidemiology in the Elderly (GIFA), J Am Geriatr Soc, 50, 1962, 10.1046/j.1532-5415.2002.50607.x Pirmohamed, 2004, Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients, BMJ, 329, 15, 10.1136/bmj.329.7456.15 Soldin, 2009, Sex differences in pharmacokinetics and pharmacodynamics, Clin Pharmacokinet, 48, 143, 10.2165/00003088-200948030-00001 Anderson, 2005, Sex and racial differences in pharmacological response: where is the evidence? Pharmacogenetics, pharmacokinetics, and pharmacodynamics, J Womens Health, 14, 19, 10.1089/jwh.2005.14.19 Anderson, 2008, Gender differences in pharmacological response, Int Rev Neurobiol, 83, 1, 10.1016/S0074-7742(08)00001-9 Holm, 2017, Influence of age, sex and seriousness on reporting of adverse drug reactions in Sweden, Pharmacoepidemiol Drug Saf, 26, 335, 10.1002/pds.4155 Formica, 2018, The economic burden of preventable adverse drug reactions: a systematic review of observational studies, Expert Opin Drug Saf, 17, 681, 10.1080/14740338.2018.1491547 Leporini, 2014, Adherence to therapy and adverse drug reactions: is there a link?, Expert Opin Drug Saf, 13, S41, 10.1517/14740338.2014.947260 Thunander Sundbom, 2012, Women and men report different behaviours in, and reasons for medication non-adherence: a nationwide Swedish survey, Pharm Pract, 10, 207, 10.4321/S1886-36552012000400005 Lindquist, 2008, VigiBase, the WHO global ICSR database system: basic facts, Drug Inf J, 42, 409, 10.1177/009286150804200501 Montastruc, 2002, Gender differences in adverse drug reactions: analysis of spontaneous reports to a Regional Pharmacovigilance Centre in France, Fundam Clin Pharmacol, 16, 343, 10.1046/j.1472-8206.2002.00100.x Aagaard, 2010, Adverse drug reactions in the paediatric population in Denmark: a retrospective analysis of reports made to the Danish Medicines Agency from 1998 to 2007, Drug Saf, 33, 327, 10.2165/11319100-000000000-00000 Norén, 2007, Duplicate detection in adverse drug reaction surveillance, Data Min Knowl Discov, 14, 305, 10.1007/s10618-006-0052-8 2019 2018 2001 Juhlin, 2017, A method for data-driven exploration to pinpoint key features in medical data and facilitate expert review, Pharmacoepidemiol Drug Saf, 26, 1256, 10.1002/pds.4285 Saikia, 2016, Gender difference in health-care expenditure: evidence from India human development survey, PLoS One, 11, 10.1371/journal.pone.0158332 Aagaard, 2012, Global patterns of adverse drug reactions over a decade: analyses of spontaneous reports to Vigibase, Drug Saf, 35, 1171, 10.1007/BF03262002 Star, 2011, Suspected adverse drug reactions reported for children worldwide: an exploratory study using Vigibase, Drug Saf, 34, 415, 10.2165/11587540-000000000-00000 Ferrajolo, 2019, Gender differences in outpatient pediatric drug utilization: a cohort study from Southern Italy, Front Pharmacol, 10, 11, 10.3389/fphar.2019.00011 Salvi, 2012, Adverse drug events as a cause of hospitalization in older adults, Drug Saf, 35, 29, 10.1007/BF03319101 D'Incau, 2014, No differences between men and women in adverse drug reactions related to psychotropic drugs: a survey from France, Italy and Spain, Fundam Clin Pharmacol, 28, 342, 10.1111/fcp.12032 Bots SH, 2019, Adverse drug reactions to guideline-recommended heart failure drugs in women: a systematic review of the literature, JACC Heart Fail, 7, 258, 10.1016/j.jchf.2019.01.009 Kim, 2008, Enrollment of women in National Heart, Lung, and Blood Institute-funded cardiovascular randomized controlled trials fails to meet current federal mandates for inclusion, J Am Coll Cardiol, 52, 672, 10.1016/j.jacc.2008.05.025 Vitale, 2017, Under-representation of elderly and women in clinical trials, Int J Cardiol, 232, 216, 10.1016/j.ijcard.2017.01.018 Hazell, 2006, Under-reporting of adverse drug reactions : a systematic review, Drug Saf, 29, 385, 10.2165/00002018-200629050-00003 McLernon, 2010, Adverse drug reaction reporting in the UK: a retrospective observational comparison of yellow card reports submitted by patients and healthcare professionals, Drug Saf, 33, 775, 10.2165/11536510-000000000-00000 Watson, 2018, Safety concerns reported by patients identified in a collaborative signal detection workshop using Vigibase: results and reflections from Lareb and Uppsala monitoring centre, Drug Saf, 41, 203, 10.1007/s40264-017-0594-2 Watson, 2019, A vigiPoint characterisation of female versus male reports in VigiBase, the WHO global database of individual case safety reports, Dryad, Dataset Rolfes, 2015, Adverse drug reaction reports of patients and healthcare professionals-differences in reported information, Pharmacoepidemiol Drug Saf, 24, 152, 10.1002/pds.3687 Rolfes, 2018, Does patient reporting lead to earlier detection of drug safety signals? A retrospective comparison of time to reporting between patients and healthcare professionals in a global database, Br J Clin Pharmacol, 84, 1514, 10.1111/bcp.13576