Efficient and reproducible large-scale isolation of human CD4+ CD25+ regulatory T cells with potent suppressor activity

Journal of Immunological Methods - Tập 315 - Trang 27-36 - 2006
David G. Wichlan1, Philippa L. Roddam1, Paul Eldridge2, Rupert Handgretinger1, Janice M. Riberdy1
1Department of Hematology/Oncology, Division of Stem Cell Transplantation, Mail Stop 321, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA
2Human Applications Laboratory, St. Jude Children's Research Hospital, Memphis, TN 38105, USA

Tài liệu tham khảo

Baecher-Allan, 2001, CD4+CD25high regulatory cells in human peripheral blood, J. Immunol., 167, 1245, 10.4049/jimmunol.167.3.1245 Baecher-Allan, 2004, Human CD4+CD25+regulatory T cells, Semin. Immunol., 16, 89, 10.1016/j.smim.2003.12.005 Earle, 2005, In vitro expanded human CD4+CD25+regulatory T cells suppress effector T cell proliferation, Clin. Immunol., 115, 3, 10.1016/j.clim.2005.02.017 Fontenot, 2005, Regulatory T cell lineage specification by the fork head transcription factor Foxp3, Immunity, 22, 329, 10.1016/j.immuni.2005.01.016 Godfrey, 2004, In vitro expanded human CD4+CD25+T regulatory cells can markedly inhibit allogeneic dendritic cell stimulated MLR cultures, Blood, 10.1182/blood-2004-01-0151 Handgretinger, 2001, Megadose transplantation of purified peripheral blood CD34(+) progenitor cells from HLA-mismatched parental donors in children, Bone Marrow Transplant., 27, 777, 10.1038/sj.bmt.1702996 Hoffmann, 2002, Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation, J. Exp. Med., 196, 389, 10.1084/jem.20020399 Hoffmann, 2004, Large-scale in vitro expansion of polyclonal human CD4(+)CD25high regulatory T cells, Blood, 104, 895, 10.1182/blood-2004-01-0086 Hoffmann, 2006, Isolation of CD4+CD25+regulatory T cells for clinical trials, Biol. Blood Marrow Transplant., 12, 267, 10.1016/j.bbmt.2006.01.005 Joffre, 2004, Induction of antigen-specific tolerance to bone marrow allografts with CD4+CD25+T lymphocytes, Blood, 103, 4216, 10.1182/blood-2004-01-0005 Kasow, 2004, Human CD4+CD25+regulatory T cells share equally complex and comparable repertoires with CD4+, J. Immunol., 172, 6123, 10.4049/jimmunol.172.10.6123 Kohm, 2002, Cutting edge: CD4+CD25+regulatory T cells suppress antigen-specific autoreactive immune responses and central nervous system inflammation during active experimental autoimmune encephalomyelitis, J. Immunol., 169, 4712, 10.4049/jimmunol.169.9.4712 Lang, 2003, Transplantation of highly purified CD34+ progenitor cells from unrelated donors in pediatric leukemia, Blood, 101, 1630, 10.1182/blood-2002-04-1203 Lang, 2004, Transplantation of highly purified peripheral-blood CD34+ progenitor cells from related and unrelated donors in children with nonmalignant diseases, Bone Marrow Transplant., 33, 25, 10.1038/sj.bmt.1704303 Laurie, 2002, The role of CD4+CD25+immunoregulatory T cells in the induction of autoimmune gastritis, Immunol. Cell Biol., 80, 567, 10.1046/j.1440-1711.2002.01127.x Liu, 2003, CD4+CD25+regulatory T cells cure murine colitis: the role of IL-10, TGF-beta, and CTLA4, J. Immunol., 171, 5012, 10.4049/jimmunol.171.10.5012 Maloy, 2001, Regulatory T cells in the control of immune pathology, Nat. Immunol., 2, 816, 10.1038/ni0901-816 Mottet, 2003, Cutting edge: cure of colitis by CD4+CD25+regulatory T cells, J. Immunol., 170, 3939, 10.4049/jimmunol.170.8.3939 Piccirillo, 2001, Cutting edge: control of CD8+T cell activation by CD4+CD25+immunoregulatory cells, J. Immunol., 167, 1137, 10.4049/jimmunol.167.3.1137 Powell, 2005, Large-scale depletion of CD25+ regulatory T cells from patient leukapheresis samples, J. Immunother., 28, 403, 10.1097/01.cji.0000170363.22585.5a Sakaguchi, 1995, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J. Immunol., 155, 1151, 10.4049/jimmunol.155.3.1151 Sakaguchi, 2001, Immunologic tolerance maintained by CD25+CD4+regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance, Immunol. Rev., 182, 18, 10.1034/j.1600-065X.2001.1820102.x Salomon, 2000, B7/CD28 costimulation is essential for the homeostasis of the CD4+ CD25+ immunoregulatory T cells that control autoimmune diabetes, Immunity, 12, 431, 10.1016/S1074-7613(00)80195-8 Singh, 2001, Control of intestinal inflammation by regulatory T cells, Immunol. Rev., 182, 190, 10.1034/j.1600-065X.2001.1820115.x Szanya, 2002, The subpopulation of CD4+CD25+splenocytes that delays adoptive transfer of diabetes expresses l-selectin and high levels of CCR7, J. Immunol., 169, 2461, 10.4049/jimmunol.169.5.2461 Taylor, 2002, The infusion of ex vivo activated and expanded CD4(+)CD25(+) immune regulatory cells inhibits graft-versus-host disease lethality, Blood, 99, 3493, 10.1182/blood.V99.10.3493 Thornton, 1998, CD4+CD25+immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production, J. Exp. Med., 188, 287, 10.1084/jem.188.2.287 Thornton, 2000, Suppressor effector function of CD4+CD25+immunoregulatory T cells is antigen nonspecific, J. Immunol., 164, 183, 10.4049/jimmunol.164.1.183 Wood, 2003, Regulatory T cells in transplantation tolerance, Nat. Rev., Immunol., 3, 199, 10.1038/nri1027