Model Analytical Development for Physical, Chemical, and Biological Characterization ofMomordica charantiaVegetable Drug

Journal of Analytical Methods in Chemistry - Tập 2016 - Trang 1-15 - 2016
Deysiane Oliveira Brandão1,2, Geovani Pereira Guimarães1,2, Ravely Lucena Santos1,2, Fernando José de Lima Ramos Júnior1,2, Karla Monik Alves da Silva1,2, Fábio Santos de Souza1,2, Rui Oliveira Macêdo1,2
1Department of Pharmaceutical Sciences, Postgraduate Program in Pharmaceutical Sciences, Federal University of Pernambuco, University City, Artur de Sá Avenue, 50740-521 Recife, PE, Brazil
2Unified Laboratories of Pharmaceutical Development and Assays, Department of Pharmaceutical Sciences, Federal University of Paraíba, Campus I, University City, 58059-970 João Pessoa, PB, Brazil

Tóm tắt

Momordica charantiais a species cultivated throughout the world and widely used in folk medicine, and its medicinal benefits are well documented, especially its pharmacological properties, including antimicrobial activities. Analytical methods have been used to aid in the characterization of compounds derived from plant drug extracts and their products. This paper developed a methodological model to evaluate the integrity of the vegetable drugM. charantiain different particle sizes, using different analytical methods.M. charantiawas collected in the semiarid region of Paraíba, Brazil. The herbal medicine raw material derived from the leaves and fruits in different particle sizes was analyzed using thermoanalytical techniques as thermogravimetry (TG) and differential thermal analysis (DTA), pyrolysis coupled to gas chromatography/mass spectrometry (PYR-GC/MS), and nuclear magnetic resonance (1H NMR), in addition to the determination of antimicrobial activity. The different particle surface area among the samples was differentiated by the techniques. DTA and TG were used for assessing thermal and kinetic parameters and PYR-GC/MS was used for degradation products chromatographic identification through the pyrograms. The infusions obtained from the fruit and leaves ofMomordica charantiapresented antimicrobial activity.

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Journal of Analytical Methods in Chemistry

Tập 2016

1-15

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