TLR-4 deficiency protects against focal cerebral ischemia and axotomy-induced neurodegeneration

Neurobiology of Disease - Tập 31 Số 1 - Trang 33-40 - 2008
Ülkan Kılıç1, Ertuğrul Kılıç2,3, Christian M. Matter4, Claudio L. Bassetti1, Dirk M. Hermann5,2
1Department of Neurology, University Hospital Zurich, Frauenklinikstr. 26, CH-8091 Zürich, Switzerland
2Department of Neurology, University Hospital Zürich, Frauenklinikstr. 26, CH-8091 Zürich, Switzerland
3Department of Physiology, Faculty of Medicine, Yeditepe University, TR-34755 Kayisdagı, Istanbul, Turkey
4Cardiovascular Research, Institute of Physiology, University Hospital Zürich, Wintherturerstrasse 190, CH-8057 Zurich, Switzerland
5Department of Neurology, University Hospital Essen, Hufelandstr. 55, D-45122 Essen, Germany

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Bechmann, 2007, What is the blood-brain barrier (not)?, Trends Immunol., 28, 5, 10.1016/j.it.2006.11.007

Begley, 2004, Delivery of therapeutic agents to the central nervous system: the problems and the possibilities, Pharmacol. Ther., 104, 29, 10.1016/j.pharmthera.2004.08.001

Bermpohl, 2005, Bacterial programmed cell death of cerebral endothelial cells involves dual death pathways, J. Clin. Invest., 115, 1607, 10.1172/JCI23223

Caso, 2007, Toll-like receptor-4 is involved in brain damage and inflammation after experimental stroke, Circulation, 115, 1599, 10.1161/CIRCULATIONAHA.106.603431

Chakravarty, 2005, Toll-like receptor 4 on nonhematopoietic cells sustains CNS inflammation during endotoxemia, independent of systemic cytokines, J. Neurosci., 25, 1788, 10.1523/JNEUROSCI.4268-04.2005

Chan, 2001, Reactive oxygen radicals in signaling and damage in the ischemic brain, J. Cereb. Blood Flow Metab., 21, 2, 10.1097/00004647-200101000-00002

Dalkara, 1994, The complex role of nitric oxide in the pathophysiology of focal cerebral ischemia, Brain Pathol., 4, 49, 10.1111/j.1750-3639.1994.tb00810.x

Hata, 2000, Dynamics of regional brain metabolism and gene expression after middle cerebral artery occlusion in mice, J. Cereb. Blood Flow Metab., 20, 306, 10.1097/00004647-200002000-00012

Hermann, 2007, Implications of ATP-binding cassette transporters for brain pharmacotherapies, Trends Pharmacol. Sci., 28, 128, 10.1016/j.tips.2007.01.007

Hermann, 2001, Relationship between metabolic changes, gene responses and delayed ischemic injury after mild focal cerebral ischemia in mice, Neuroscience, 104, 947, 10.1016/S0306-4522(01)00125-7

Hermann, 2006, Role of drug efflux carriers in the healthy and diseased brain, Ann. Neurol., 60, 489, 10.1002/ana.21012

Isenmann, 1997, Up-regulation of Bax protein in degenerating retinal ganglion cells precedes apoptotic cell death after optic nerve lesion in the rat, Eur. J. Neurosci., 9, 1763, 10.1111/j.1460-9568.1997.tb01534.x

Kilic, 2005, Erythropoietin protects from axotomy-induced degeneration of retinal ganglion cells by activating ERK-1/-2, FASEB J., 19, 249, 10.1096/fj.04-2493fje

Kilic, 2005, Post-ischemic delivery of the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor rosuvastatin protects against focal cerebral ischemia in mice by mechanisms involving inhibition of extracellular-regulated kinase-1/-2, Neuroscience, 106, 901, 10.1016/j.neuroscience.2005.04.063

Kilic, 2006, The phosphatidylinositol-3 kinase/Akt pathway mediates VEGF's neuroprotective activity and induces blood brain barrier permeability after focal cerebral ischemia, FASEB J., 20, 1185, 10.1096/fj.05-4829fje

Kilic, 2006, Human vascular endothelial growth factor protects axotomized retinal ganglion cells in vivo by activating ERK-1/2 and Akt pathways, J. Neurosci., 26, 12439, 10.1523/JNEUROSCI.0434-06.2006

Klöcker, 1998, Free radical scavenging and inhibition of nitric oxide synthase potentiates the neurotrophic effects of BDNF on axotomized retinal ganglion cells in vivo, J. Neurosci., 18, 1038, 10.1523/JNEUROSCI.18-03-01038.1998

Lee, 2007, Signaling pathways downstream of pattern-recognition receptors and their cross talk, Annu. Rev. Biochem., 76, 447, 10.1146/annurev.biochem.76.060605.122847

Lemaitre, 1996, The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults, Cell, 86, 973, 10.1016/S0092-8674(00)80172-5

Löscher, 2005, Drug resistance in brain diseases and the role of drug efflux transporters, Nat. Rev., Neurosci., 6, 591, 10.1038/nrn1728

Poltorak, 1998, Detective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene, Science, 282, 2085, 10.1126/science.282.5396.2085

Prass, 2006, Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia, Stroke, 37, 2607, 10.1161/01.STR.0000240409.68739.2b

Sansonetti, 2006, The innate signaling of dangers and the dangers of innate signalling, Nat. Immunol., 7, 1237, 10.1038/ni1420

Spudich, 2006, Inhibition of multidrug resistance transporter-1 facilitates neuroprotective therapies after focal cerebral ischemia, Nat. Neurosci., 9, 487, 10.1038/nn1676

Sutmuller, 2006, Toll-like receptors on regulatory T cells: expanding immune regulation, Trends Immunol., 27, 387, 10.1016/j.it.2006.06.005

Schröder, 2001, Activation of mitogen-activated protein kinases p42/44, p38, and stress-activated protein kinases in myelo-monocytic cells by Treponema lipoteichoic acid, J. Biol. Chem., 276, 9713, 10.1074/jbc.M008954200

Wang, 2005, VEGF overexpression induces post-ischaemic neuroprotection, but facilitates haemodynamic steal phenomena, Brain, 128, 52, 10.1093/brain/awh325

Zipp, 2006, The brain as a target of inflammation: common pathways link inflammatory and neurodegenerative diseases, Trends Neurosci., 29, 518, 10.1016/j.tins.2006.07.006