Kupffer Cell-Derived Tnf Triggers Cholangiocellular Tumorigenesis through JNK due to Chronic Mitochondrial Dysfunction and ROS

Cancer Cell - Tập 31 - Trang 771-789.e6 - 2017
Detian Yuan1,2, Shan Huang2, Emanuel Berger3, Lei Liu4, Nina Gross5, Florian Heinzmann6,7, Marc Ringelhan1,5, Tracy O. Connor1,2, Mira Stadler2, Michael Meister2, Julia Weber5, Rupert Öllinger5, Nicole Simonavicius1, Florian Reisinger1, Daniel Hartmann4, Rüdiger Meyer8, Maria Reich9, Marco Seehawer6,7, Valentina Leone1, Bastian Höchst10
1Institute of Virology, Technische Universität München and Helmholtz Zentrum München, 81675 Munich, Germany
2Division of Chronic Inflammation and Cancer, German Cancer Research Center (DKFZ), 69120 Heidelberg, Germany
3Chair of Nutrition and Immunology, Technische Universität München, Gregor-Mendel-Straße 2, 85350 Freising-Weihenstephan, Germany
4Department of Surgery, Technische Universität München, 81675 Munich, Germany
52nd Department of Internal Medicine, Klinikum Rechts der Isar, Technische Universität München, 81675 Munich, Germany
6Department of Internal Medicine VIII, University Hospital Tübingen, 72076 Tübingen, Germany
7Department of Physiology I, Institute of Physiology, Eberhard Karls University Tübingen, 72076 Tübingen, Germany
8Genome Technology Branch, National Human Genome Research Institute, U.S. National Institutes of Health, Bethesda, MD 20892, USA
9Clinic for Gastroenterology, Hepatology, and Infectious Diseases, Heinrich-Heine University, 40204 Düsseldorf, Germany
10Institute of Molecular Immunology, Klinikum rechts der Isar, Technische Universität München, 81675 Munich, Germany

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