Tissue factor is an angiogenic-specific receptor for factor VII-targeted immunotherapy and photodynamic therapy

Folkman J (1995) Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med 1(1):27–31

McDonald DM, Choyke PL (2003) Imaging of angiogenesis: from microscope to clinic. Nat Med 9(6):713–725

Carmeliet P, Jain RK (2000) Angiogenesis in cancer and other diseases. Nature 407(6801):249–257

Contrino J, Hair G, Kreutzer DL, Rickles FR (1996) In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 2(2):209–215

Hu Z, Sun Y, Garen A (1999) Targeting tumor vasculature endothelial cells and tumor cells for immunotherapy of human melanoma in a mouse xenograft model. Proc Natl Acad Sci USA 96(14):8161–8166

Cheng J, Xu J, Duanmu J, Zhou H, Booth CJ, Hu Z (2011) Effective treatment of human lung cancer by targeting tissue factor with a factor VII-targeted photodynamic therapy. Curr Cancer Drug Targets 11(9):1069–1081

Duanmu J, Cheng J, Xu J, Booth CJ, Hu Z (2011) Effective treatment of chemoresistant breast cancer in vitro and in vivo by a factor VII-targeted photodynamic therapy. Br J Cancer 104(9):1401–1409. doi: 10.1038/bjc.2011.88

Konigsberg WH, Nemerson Y (1988) Molecular cloning of the cDNA for human tissue factor. Cell 52(5):639–640. doi: 10.1016/0092-8674(88)90400-X

Folkman J (1996) Tumor angiogenesis and tissue factor. Nat Med 2(2):167–168

Morrissey JH, Fakhrai H, Edgington TS (1987) Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. Cell 50(1):129–135

Spicer EK, Horton R, Bloem L, Bach R, Williams KR, Guha A, Kraus J, Lin TC, Nemerson Y, Konigsberg WH (1987) Isolation of cDNA clones coding for human tissue factor: primary structure of the protein and cDNA. Proc Natl Acad Sci USA 84(15):5148–5152

Banner DW, D’Arcy A, Chene C, Winkler FK, Guha A, Konigsberg WH, Nemerson Y, Kirchhofer D (1996) The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor. Nature 380(6569):41–46. doi: 10.1038/380041a0

Hu Z, Garen A (2000) Intratumoral injection of adenoviral vectors encoding tumor-targeted immunoconjugates for cancer immunotherapy. Proc Natl Acad Sci USA 97(16):9221–9225

Hu Z, Garen A (2001) Targeting tissue factor on tumor vascular endothelial cells and tumor cells for immunotherapy in mouse models of prostatic cancer. Proc Natl Acad Sci USA 98(21):12180–12185

Hu Z, Rao B, Chen S, Duanmu J (2010) Targeting tissue factor on tumour cells and angiogenic vascular endothelial cells by factor VII-targeted verteporfin photodynamic therapy for breast cancer in vitro and in vivo in mice. BMC Cancer 10:235. doi: 10.1186/1471-2407-10-235

Hu Z, Rao B, Chen S, Duanmu J (2011) Selective and effective killing of angiogenic vascular endothelial cells and cancer cells by targeting tissue factor using a factor VII-targeted photodynamic therapy for breast cancer. Breast Cancer Res Treat 126(3):589–600. doi: 10.1007/s10549-010-0957-1

Hu Z, Li J (2010) Natural killer cells are crucial for the efficacy of Icon (factor VII/human IgG1 Fc) immunotherapy in human tongue cancer. BMC Immunol 11:49. doi: 10.1186/1471-2172-11-49

Bora PS, Hu Z, Tezel TH, Sohn JH, Kang SG, Cruz JM, Bora NS, Garen A, Kaplan HJ (2003) Immunotherapy for choroidal neovascularization in a laser-induced mouse model simulating exudative (wet) macular degeneration. Proc Natl Acad Sci USA 100(5):2679–2684

Tezel TH, Bodek E, Sonmez K, Kaliappan S, Kaplan HJ, Hu Z, Garen A (2007) Targeting tissue factor for immunotherapy of choroidal neovascularization by intravitreal delivery of factor VII-Fc chimeric antibody. Ocul Immunol Inflamm 15(1):3–10

Lu F, Hu Z, Sinard J, Garen A, Adelman RA (2009) Factor VII-verteporfin for targeted photodynamic therapy in a rat model of choroidal neovascularization. Investig Ophthalmol Vis Sci 50(8):3890–3896. doi: 10.1167/iovs.08-2833

Krikun G, Hu Z, Osteen K, Bruner-Tran KL, Schatz F, Taylor HS, Toti P, Arcuri F, Konigsberg W, Garen A, Booth CJ, Lockwood CJ (2010) The immunoconjugate “icon” targets aberrantly expressed endothelial tissue factor causing regression of endometriosis. Am J Pathol 176(2):1050–1056. doi: 10.2353/ajpath.2010.090757

Courty J, Loret C, Moenner M, Chevallier B, Lagente O, Courtois Y, Barritault D (1985) Bovine retina contains three growth factor activities with different affinity to heparin: eye derived growth factor I, II, III. Biochimie 67(2):265–269

Tang Y, Borgstrom P, Maynard J, Koziol J, Hu Z, Garen A, Deisseroth A (2007) Mapping of angiogenic markers for targeting of vectors to tumor vascular endothelial cells. Cancer Gene Ther 14(4):346–353

Ferrara N (2002) VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2(10):795–803. doi: 10.1038/nrc909

Klagsbrun M, Sullivan R, Smith S, Rybka R, Shing YE (1987) Purification of endothelial cell growth factors by heparin affinity chromatography. Methods Enzymol 147:95–105

Afuwape AO, Kiriakidis S, Paleolog EM (2002) The role of the angiogenic molecule VEGF in the pathogenesis of rheumatoid arthritis. Histol Histopathol 17(3):961–972

Fujimoto J, Sakaguchi H, Hirose R, Wen H, Tamaya T (1999) Angiogenesis in endometriosis and angiogenic factors. Gynecol Obstet Investig 48(Suppl 1):14–20. doi: 10.1159/000052864

Zucker S, Mirza H, Conner CE, Lorenz AF, Drews MH, Bahou WF, Jesty J (1998) Vascular endothelial growth factor induces tissue factor and matrix metalloproteinase production in endothelial cells: conversion of prothrombin to thrombin results in progelatinase a activation and cell proliferation. Int J Cancer 75(5):780–786

Carson SD, Ross SE, Bach R, Guha A (1987) An inhibitory monoclonal antibody against human tissue factor. Blood 70(2):490–493

Ye X, Fukudome K, Tsuneyoshi N, Satoh T, Tokunaga O, Sugawara K, Mizokami H, Kimoto M (1999) The endothelial cell protein C receptor (EPCR) functions as a primary receptor for protein C activation on endothelial cells in arteries, veins, and capillaries. Biochem Biophys Res Commun 259(3):671–677. doi: 10.1006/bbrc.1999.0846

Yoneda Y, Arioka T, Imamoto-Sonobe N, Sugawa H, Shimonishi Y, Uchida T (1987) Synthetic peptides containing a region of SV 40 large T-antigen involved in nuclear localization direct the transport of proteins into the nucleus. Exp Cell Res 170(2):439–452

Cheng J, Xu J, Duanmu J, Zhou H, Booth CJ, Hu Z (2011) Effective treatment of human lung cancer by targeting tissue factor with a factor VII-targeted photodynamic therapy. Curr Cancer Drug Targets 11:1069–1081. doi: 10.2174/156800911798073023

Watanabe T, Yasuda M, Yamamoto T (1999) Angiogenesis induced by tissue factor in vitro and in vivo. Thromb Res 96(3):183–189

Ghosh S, Pendurthi UR, Steinoe A, Esmon CT, Rao LV (2007) Endothelial cell protein C receptor acts as a cellular receptor for factor VIIa on endothelium. J Biol Chem 282(16):11849–11857. doi: 10.1074/jbc.M609283200

Disse J, Petersen HH, Larsen KS, Persson E, Esmon N, Esmon CT, Teyton L, Petersen LC, Ruf W (2011) The endothelial protein C receptor supports tissue factor ternary coagulation initiation complex signaling through protease-activated receptors. J Biol Chem 286(7):5756–5767. doi: 10.1074/jbc.M110.201228

Smith NR, Baker D, James NH, Ratcliffe K, Jenkins M, Ashton SE, Sproat G, Swann R, Gray N, Ryan A, Jurgensmeier JM, Womack C (2010) Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers. Clin Cancer Res 16(14):3548–3561. doi: 10.1158/1078-0432.CCR-09-2797

Christofori G, Naik P, Hanahan D (1995) Vascular endothelial growth factor and its receptors, flt-1 and flk-1, are expressed in normal pancreatic islets and throughout islet cell tumorigenesis. Mol Endocrinol 9(12):1760–1770

Witmer AN, Dai J, Weich HA, Vrensen GF, Schlingemann RO (2002) Expression of vascular endothelial growth factor receptors 1, 2, and 3 in quiescent endothelia. J Histochem Cytochem 50(6):767–777

Hu Z (2011) Factor VII-targeted photodynamic therapy for breast cancer and its therapeutic potential for other solid cancers and leukemia. In: Gunduz E, Gunduz M (ed) Breast cancer—current and alternative therapeutic modalities. InTech, pp 175–196. doi: 10.5772/20398

Yang JC, Haworth L, Sherry RM, Hwu P, Schwartzentruber DJ, Topalian SL, Steinberg SM, Chen HX, Rosenberg SA (2003) A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. New Engl J Med 349(5):427–434. doi: 10.1056/NEJMoa021491

Alidzanovic L, Starlinger P, Schauer D, Maier T, Feldman A, Buchberger E, Stift J, Koeck U, Pop L, Gruenberger B, Gruenberger T, Brostjan C (2016) The VEGF rise in blood of bevacizumab patients is not based on tumor escape but a host-blockade of VEGF clearance. Oncotarget. doi: 10.18632/oncotarget.11084

Tong JP, Chan WM, Liu DT, Lai TY, Choy KW, Pang CP, Lam DS (2006) Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization. Am J Ophthalmol 141(3):456–462. doi: 10.1016/j.ajo.2005.10.012